WO2010128519A1 - Procédé de détection d'une neuropathie et de prédiction de l'apparition d'un ulcère du pied chez des êtres humains atteints de pahtologies telles que le diabète sucré - Google Patents

Procédé de détection d'une neuropathie et de prédiction de l'apparition d'un ulcère du pied chez des êtres humains atteints de pahtologies telles que le diabète sucré Download PDF

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Publication number
WO2010128519A1
WO2010128519A1 PCT/IN2009/000720 IN2009000720W WO2010128519A1 WO 2010128519 A1 WO2010128519 A1 WO 2010128519A1 IN 2009000720 W IN2009000720 W IN 2009000720W WO 2010128519 A1 WO2010128519 A1 WO 2010128519A1
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WIPO (PCT)
Prior art keywords
patient
diabetic
pressure
predicting
foot
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PCT/IN2009/000720
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English (en)
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WO2010128519A4 (fr
Inventor
C. Jairaj Kumar
Original Assignee
Kumar C Jairaj
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Publication date
Application filed by Kumar C Jairaj filed Critical Kumar C Jairaj
Publication of WO2010128519A1 publication Critical patent/WO2010128519A1/fr
Publication of WO2010128519A4 publication Critical patent/WO2010128519A4/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
    • A61B5/1036—Measuring load distribution, e.g. podologic studies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
    • A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
    • A61B5/447—Skin evaluation, e.g. for skin disorder diagnosis specially adapted for aiding the prevention of ulcer or pressure sore development, i.e. before the ulcer or sore has developed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6829—Foot or ankle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00—ICT specially adapted for the handling or processing of medical images
    • G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

Definitions

  • This present invention relates to development of a new device using the revolutionary chaos theory to diagnose conditions like neuropathy and predict possibility of ulcer development in various health conditions especially like diabetes etc.
  • the object of the invention is to prove that foot ulceration is linked to the sustenance of pressure rather than the degree plantar pressure, since very little pressure is required to cause capillary blanching. Tissue anoxia thus should occur if the pressure continues to cause blanching rather than a large pressure that disappears occasionally and does not cause sustained tissue anoxia.
  • the further object of the invention is to show the effect that there is a continuous temporal plantar weight bearing foci in healthy individuals, which ensures that high pressure is exerted on the feet which do not hinder the capillary circulation of blood to any part of the feet continuously for extended periods even while standing.
  • the invention provides a method for detecting neuropathy and predicting foot ulcer development in human beings with health conditions like diabetes mellitus, consisting of glass slab, mounting stand, a camera, led light and computer equipped with CGN Data analyzer and report generator software.
  • the present invention also quantifies the amount of temporal, variation and shift of plantar pressure bearing points by using skin capillary colour change
  • Figure 1 represents the overall assembly of Glass Slab (1), measuring 12 mm thick and 40 cm length and 40 cm breadth.
  • the glass with tolerance of weight up to 200 Kg
  • mounting stand (2) made of metal, plastic or wood with dimensions 45cm in breadth and 45cm length and 50cm in height, capable bearing of upto 300kg
  • camera (3) placed beneath the glass slab.
  • the camera should be of 5 megapixels or above.
  • the camera should be positioned to record the video of both feet when a patient stands on the glass slab (1).
  • the camera should view from the operator's computer and the person standing on the glass slab should be instructed to expose their feet to the camera.
  • Light emitting diode (LED) lights (4) are placed below the mounting stand to supply light for camera recording. Usually 10 LED lights on right and 10 LED lights on left are sufficient are enough to allow camera recording and computer (5) for primation of graph.
  • LED Light emitting diode
  • FIG. 2 illustrates the computer ( 5) equipped with CGN Video to Image converter & CGN Data analyzer and report generator, where the image of the feet of patient is displayed (6).
  • Figure 3 illustrate the graph (8) obtained when normal healthy person stand on the arrangement referred in figure 1, graph (9) obtained when diabetic patient stand on the same.
  • Figure 4 Illustrate the mean distances of the centre of these points with reference to Mayer's line in controls (4a) and diabetic individuals (4b.)
  • the DI (diabetic individual), time series has fewer fluctuations and lower magnitude that that of controls.
  • the patient is made to stand on the glass slab (1), mounted on a mounting stand (2), the camera (3) fixed beneath the glass slab, connected to the computer (5).
  • the camera after recording the video of the patient feet transfers the images to the computer at specific intervals of time.
  • at least ten markings (points) are made (7) .
  • comparison a graph (9) is displayed on all nonlinear of all the selected points, predicting the nerve condition of the possibility of the ulcer development in the diabetic patient.
  • Diabetic foot syndrome is perhaps one of the most important complications of diabetes mellitus.
  • the prevalence of diabetic foot ulcers ranges between 4- 10%, while the lifetime incidence rates may be as high as 25% (Ref-1).
  • a number of factors like the peripheral vascular disease, changes in foot architecture, peripheral sensory neuropathy and the plantar pressure are considered to be the prime etiological factors for the development of ulcers
  • the present invention is of the aim to compare and quantify temporal redistribution of plantar pressure points (areas of capillary blanching) between normal subjects and DI with no clinical signs of neuropathy.
  • the points were: a) The lowest point of the pale area on the 2 nd toe. b) The lowest point of the pale area on the 3 rd toe. c) The lowest point of the pale area on the 4 th toe. d) The lowest point of the pale area on the 5 th toe. e) A point to the left of the mid-point of the Meyer's lines (an anatomical line passing through the middle of the great toe and the heel). f) A point to the right of the mid-point of the Meyer's line. g) A point 2 cm above the base of heel, to the left of Meyer's line. h) A point 2cm above the base of heel, to the right of Meyer's line. i) A point on the Meyer's line corresponding to the lower limit of the pale area on the foot. j) A point on the Meyer's line corresponding to 5 the upper limit of the pale area on the foot
  • SDPP standard deviation of difference between consecutive redistribution of centre of the pressure point (SDPP) in cm. SDPP was used rattier than raw distances since it is invariant to foot size.
  • Table 1 Demographic data of controls and diabetic patients.
  • SDPP Standard deviation of difference between consecutive pressure points in cms.;FD: Fractal dimension; DI: Diabetic individuals.
  • the variation in the frequency of redistribution in different areas of the foot may pose a higher risk of ulcer formation in some specific parts of the foot.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention porte sur un procédé de détection d'une neuropathie et de prédiction de l'apparition d'un ulcère du pied chez des êtres humains atteints de pathologies telles que le diabète sucré, qui consiste à fournir un agencement destiné à enregistrer l'image des pieds d'un patient, comprenant une plateforme de montage transparente (2), une caméra (3) connectée à un ordinateur (5) équipé d'un convertisseur vidéo vers image, d'un analyseur de données et d'un générateur de rapport. Une fois que le patient est debout sur la plateforme de montage, des images sont affichées sur l'ordinateur et des repères sur les images affichées permettent de prédire l'apparition d'un ulcère chez le patient diabétique.
PCT/IN2009/000720 2009-05-04 2009-12-15 Procédé de détection d'une neuropathie et de prédiction de l'apparition d'un ulcère du pied chez des êtres humains atteints de pahtologies telles que le diabète sucré WO2010128519A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1028/CHE/2009 2009-05-04
IN1028CH2009 2009-05-04

Publications (2)

Publication Number Publication Date
WO2010128519A1 true WO2010128519A1 (fr) 2010-11-11
WO2010128519A4 WO2010128519A4 (fr) 2011-01-06

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8293912B2 (en) 2007-05-01 2012-10-23 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
US8354537B2 (en) 2007-10-29 2013-01-15 Chemagis Ltd. R,R1-atracurium salts
US8357805B2 (en) 2007-06-18 2013-01-22 Chemagis Ltd. (1R,1′R)-atracurium salts separation process
US8357807B2 (en) 2007-05-01 2013-01-22 Chemagis Ltd. Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
US8461338B2 (en) 2007-03-08 2013-06-11 Chemagis Ltd. (1R, 1′R)-atracurium salts separation process
US9301688B2 (en) 2011-10-26 2016-04-05 The United States of America, as Represented by Dept. of Veterans Affairs System for screening the skin condition of the plantar surface of the feet
US9737263B1 (en) 2016-02-15 2017-08-22 Wipro Limited Footwear for monitoring health condition of foot of a user and a method thereof
WO2020058217A1 (fr) 2018-09-17 2020-03-26 Chiesi Farmaceutici S.P.A. Agent de traitement de troubles dermatologiques
CN111329484A (zh) * 2020-02-24 2020-06-26 华南理工大学 基于足底压力信息时空域特征的糖尿病足风险预警装置

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012352A1 (fr) * 1993-11-04 1995-05-11 Paromed Medizintechnik Gmbh Dispositif et procede pour la prophylaxie de l'ulcere et pour le diagnostic precoce de la neuropathie dans le pied d'un diabetique
WO2004002309A1 (fr) * 2002-06-12 2004-01-08 Medavinci Development B.V. Dispositif et procede d'examen de pied de diabetique
WO2005044105A1 (fr) * 2003-11-06 2005-05-19 Sundaram Medical Foundation Dispositif de mesure de puissance de pied portable

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012352A1 (fr) * 1993-11-04 1995-05-11 Paromed Medizintechnik Gmbh Dispositif et procede pour la prophylaxie de l'ulcere et pour le diagnostic precoce de la neuropathie dans le pied d'un diabetique
WO2004002309A1 (fr) * 2002-06-12 2004-01-08 Medavinci Development B.V. Dispositif et procede d'examen de pied de diabetique
WO2005044105A1 (fr) * 2003-11-06 2005-05-19 Sundaram Medical Foundation Dispositif de mesure de puissance de pied portable

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RAHMAN M A ET AL.: "Analysis of plantar pressure in diabetic type 2 subjects with and without neuropathy", ITBM-RBM, EDITIONS SCIENTIFIQUES ET MEDICALES ELSEVIER, vol. 27, no. 2, 1 May 2006 (2006-05-01), pages 46 - 55, XP028073094, DOI: doi:10.1016/j.rbmret.2006.03.001 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8461338B2 (en) 2007-03-08 2013-06-11 Chemagis Ltd. (1R, 1′R)-atracurium salts separation process
US8293912B2 (en) 2007-05-01 2012-10-23 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
US8357807B2 (en) 2007-05-01 2013-01-22 Chemagis Ltd. Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
US8357805B2 (en) 2007-06-18 2013-01-22 Chemagis Ltd. (1R,1′R)-atracurium salts separation process
US8354537B2 (en) 2007-10-29 2013-01-15 Chemagis Ltd. R,R1-atracurium salts
US9301688B2 (en) 2011-10-26 2016-04-05 The United States of America, as Represented by Dept. of Veterans Affairs System for screening the skin condition of the plantar surface of the feet
US9737263B1 (en) 2016-02-15 2017-08-22 Wipro Limited Footwear for monitoring health condition of foot of a user and a method thereof
WO2020058217A1 (fr) 2018-09-17 2020-03-26 Chiesi Farmaceutici S.P.A. Agent de traitement de troubles dermatologiques
CN111329484A (zh) * 2020-02-24 2020-06-26 华南理工大学 基于足底压力信息时空域特征的糖尿病足风险预警装置

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