WO2010127645A3 - The method of biotechnological preparation of lincomycin derivatives and its using - Google Patents

The method of biotechnological preparation of lincomycin derivatives and its using Download PDF

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Publication number
WO2010127645A3
WO2010127645A3 PCT/CZ2010/000057 CZ2010000057W WO2010127645A3 WO 2010127645 A3 WO2010127645 A3 WO 2010127645A3 CZ 2010000057 W CZ2010000057 W CZ 2010000057W WO 2010127645 A3 WO2010127645 A3 WO 2010127645A3
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WO
WIPO (PCT)
Prior art keywords
lincomycin derivatives
lincomycin
produced
derivatives
biotechnological preparation
Prior art date
Application number
PCT/CZ2010/000057
Other languages
French (fr)
Other versions
WO2010127645A2 (en
Inventor
Dana Ulanova
Jitka Novotna
Yvona Smutna
Zdenek Kamenik
Radek Gazak
Jiri Janata
Jan Kopecky
Jaroslav Spizek
Original Assignee
Institute Of Microbiology As Cr, V. V. I.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute Of Microbiology As Cr, V. V. I. filed Critical Institute Of Microbiology As Cr, V. V. I.
Publication of WO2010127645A2 publication Critical patent/WO2010127645A2/en
Publication of WO2010127645A3 publication Critical patent/WO2010127645A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Lincomycin derivatives are produced by biotechnological cultivation of Streptomyces lincolnensis ATCC 25466 with at least one gene of the 4-L-propylproline biosynthesis coding cluster inactivated. A substitute of the component whose synthesis is blocked by inactivation is added to the medium. In this way new, biologically active lincomycin derivatives are produced biosynthetically.
PCT/CZ2010/000057 2009-05-04 2010-05-04 The method of biotechnological preparation of lincomycin derivatives and its using WO2010127645A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZPV2009-277 2009-05-04
CZ20090277A CZ302256B6 (en) 2009-05-04 2009-05-04 Biotechnological preparation method of lincomycin derivatives

Publications (2)

Publication Number Publication Date
WO2010127645A2 WO2010127645A2 (en) 2010-11-11
WO2010127645A3 true WO2010127645A3 (en) 2011-01-20

Family

ID=43050536

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CZ2010/000057 WO2010127645A2 (en) 2009-05-04 2010-05-04 The method of biotechnological preparation of lincomycin derivatives and its using

Country Status (2)

Country Link
CZ (1) CZ302256B6 (en)
WO (1) WO2010127645A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105566411B (en) * 2014-11-07 2020-11-13 中国科学院上海有机化学研究所 Lincomycin biosynthesis intermediate product and preparation method and application thereof
CZ2017137A3 (en) * 2017-03-10 2018-05-23 Mikrobiologický ústav AV ČR, v. v. i. Linkosamides, their preparation and use
CN107881190B (en) * 2017-11-15 2021-02-09 安徽大学 Method for improving lincomycin yield by modifying streptomyces lincolnensis SLCG _2919 gene
CN111117942B (en) * 2020-01-16 2021-05-25 华东理工大学 Genetic engineering bacterium for producing lincomycin and construction method and application thereof
CN114540212B (en) * 2020-11-26 2023-11-03 浙江珲达生物科技有限公司 Streptomyces and method for producing leptomycin B by fermentation of streptomyces

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674647A (en) * 1970-10-07 1972-07-04 Upjohn Co Preparation of lincomycin analogues

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674647A (en) * 1970-10-07 1972-07-04 Upjohn Co Preparation of lincomycin analogues

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KOBERSKA M ET AL: "Sequence Analysis and Heterologous Expression of the Lincomycin Biosynthetic Cluster of the Type Strain Streptomyces lincolnensis ATCC 25466", FOLIA MICROBIOLOGICA, vol. 53, no. 5, September 2008 (2008-09-01), pages 395 - 401, XP002609682, ISSN: 0015-5632 *
SPIZEK J ET AL: "Lincomycin, cultivation of producing strains and biosynthesis.", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 63, no. 5, February 2004 (2004-02-01), pages 510 - 519, XP002609683, ISSN: 0175-7598 *
ULANOVA D ET AL: "Mutasynthesis of lincomycin derivatives with activity against drug-resistant staphylococci", February 2010, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2010 AMERICAN SOCIETY FOR MICROBIOLOGY USA LNKD- DOI:10.1128/AAC.00918-09, VOL. 54, NR. 2, PAGE(S) 927 - 930, ISSN: 0066-4804, XP002609684 *

Also Published As

Publication number Publication date
CZ2009277A3 (en) 2010-11-18
CZ302256B6 (en) 2011-01-12
WO2010127645A2 (en) 2010-11-11

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