WO2010119387A3 - A medicinal cream made using miconazole nitrate, fluticasone propionate, and chitosan, and a process to make the same - Google Patents

A medicinal cream made using miconazole nitrate, fluticasone propionate, and chitosan, and a process to make the same Download PDF

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Publication number
WO2010119387A3
WO2010119387A3 PCT/IB2010/051556 IB2010051556W WO2010119387A3 WO 2010119387 A3 WO2010119387 A3 WO 2010119387A3 IB 2010051556 W IB2010051556 W IB 2010051556W WO 2010119387 A3 WO2010119387 A3 WO 2010119387A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin
chitosan
miconazole nitrate
infections
composition
Prior art date
Application number
PCT/IB2010/051556
Other languages
French (fr)
Other versions
WO2010119387A2 (en
Inventor
Sulur Subramaniam Vanangamudi
Madhavan Srinivasan
Neelakandan Narayanan Chulliel
Kuppusamy Senthilkumar
Original Assignee
Sulur Subramaniam Vanangamudi
Madhavan Srinivasan
Neelakandan Narayanan Chulliel
Kuppusamy Senthilkumar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sulur Subramaniam Vanangamudi, Madhavan Srinivasan, Neelakandan Narayanan Chulliel, Kuppusamy Senthilkumar filed Critical Sulur Subramaniam Vanangamudi
Publication of WO2010119387A2 publication Critical patent/WO2010119387A2/en
Publication of WO2010119387A3 publication Critical patent/WO2010119387A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention is directed to a composition for treating bacterial skin infections & skin inflammation, along with skin rejuvenation. More particularly, the present invention relates to a pharmaceutical cream comprising a biopolymer, a corticosteroid and an antibacterial active ingredient. It discloses a composition for treating fungal skin infections & skin inflammation, along with skin rejuvenation containing a) a biopolymer in the form of chitosan, b) a combination of active pharmaceutical ingredients (APIs), fluticasone proprionate & miconazole nitrate used in treating bacterial skin infections & skin inflammations, c) a cream base containing primary and secondary emulsifiers, waxy materials, co-solvents, acids, preservatives, buffering agents, anti oxidants, chelating agents, and humectants and d) water. The active ingredients, namely chitosan, a corticosteroid Fluticasone propionate, and an antibacterial agent miconazole nitrate, are incorporated in cream base for use in treating bacterial skin infections and skin inflammation due to allergy & itching, & wounds on human skin involving contacting human skin with the above identified composition.
PCT/IB2010/051556 2009-04-13 2010-04-12 A medicinal cream made using miconazole nitrate, fluticasone propionate, and chitosan, and a process to make the same WO2010119387A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN955MU2009 2009-04-13
IN955/MUM/2009 2009-04-13

Publications (2)

Publication Number Publication Date
WO2010119387A2 WO2010119387A2 (en) 2010-10-21
WO2010119387A3 true WO2010119387A3 (en) 2011-05-26

Family

ID=42288574

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2010/051556 WO2010119387A2 (en) 2009-04-13 2010-04-12 A medicinal cream made using miconazole nitrate, fluticasone propionate, and chitosan, and a process to make the same

Country Status (1)

Country Link
WO (1) WO2010119387A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058262A1 (en) * 2002-12-31 2004-07-15 Wockhardt Limited Benzoquinolizine-2-carboxylic acid-containing compositions
WO2005074883A1 (en) * 2004-01-29 2005-08-18 Sinclair Pharmaceuticals Limited Aqueous compositions containing mixtures of synthetic polymers and biopolymers, useful in the treatment of skin and mucosal tissues dryness, and suitable as vehicles of active ingredients
US20080050434A1 (en) * 2004-03-18 2008-02-28 Rajesh Jain Novel Composition for Topical Delivery
WO2010109423A1 (en) * 2009-03-25 2010-09-30 Sulur Subramaniam Vanangamudi A medicinal antifungal and steroids cream comprising chitosan and a process to make it
WO2010109434A2 (en) * 2009-03-25 2010-09-30 Sulur Subramaniam Vanangamudi A medicinal antibacterial, antifungal and steroids cream and a process to make it

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058262A1 (en) * 2002-12-31 2004-07-15 Wockhardt Limited Benzoquinolizine-2-carboxylic acid-containing compositions
WO2005074883A1 (en) * 2004-01-29 2005-08-18 Sinclair Pharmaceuticals Limited Aqueous compositions containing mixtures of synthetic polymers and biopolymers, useful in the treatment of skin and mucosal tissues dryness, and suitable as vehicles of active ingredients
US20080050434A1 (en) * 2004-03-18 2008-02-28 Rajesh Jain Novel Composition for Topical Delivery
WO2010109423A1 (en) * 2009-03-25 2010-09-30 Sulur Subramaniam Vanangamudi A medicinal antifungal and steroids cream comprising chitosan and a process to make it
WO2010109434A2 (en) * 2009-03-25 2010-09-30 Sulur Subramaniam Vanangamudi A medicinal antibacterial, antifungal and steroids cream and a process to make it

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RAVI KUMAR M N V: "A review of chitin and chitosan applications", REACTIVE & FUNCTIONAL POLYMERS, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 46, no. 1, 1 November 2000 (2000-11-01), pages 1 - 27, XP004224437, ISSN: 1381-5148, DOI: DOI:10.1016/S1381-5148(00)00038-9 *
SHAHANI S R ET AL: "Anti-inflammatory effects of fluticasone, a topically active synthetic corticosteroid and its combination formulations in histamine induced cutaneous responses in healthy human volunteers", INDIAN JOURNAL OF PHARMACOLOGY, MEDKNOW PUBLICATIONS AND MEDIA PVT. LTD, IN, vol. 30, no. 4, 1 January 1998 (1998-01-01), pages 245 - 248, XP008132457, ISSN: 0253-7613 *

Also Published As

Publication number Publication date
WO2010119387A2 (en) 2010-10-21

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