WO2010111443A3 - Omentum as a source of stromal/stem cells and medical treatments using omentum stromal/stem cells - Google Patents

Omentum as a source of stromal/stem cells and medical treatments using omentum stromal/stem cells Download PDF

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Publication number
WO2010111443A3
WO2010111443A3 PCT/US2010/028577 US2010028577W WO2010111443A3 WO 2010111443 A3 WO2010111443 A3 WO 2010111443A3 US 2010028577 W US2010028577 W US 2010028577W WO 2010111443 A3 WO2010111443 A3 WO 2010111443A3
Authority
WO
WIPO (PCT)
Prior art keywords
omental
tissue
stem cells
omentum
cells
Prior art date
Application number
PCT/US2010/028577
Other languages
French (fr)
Other versions
WO2010111443A2 (en
Inventor
Makio Iwashima
Robert Love
Rudolf Karl Braun
Perianna Sethupathi
Katherine Lathrop Knight
Original Assignee
Loyola University Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Loyola University Chicago filed Critical Loyola University Chicago
Publication of WO2010111443A2 publication Critical patent/WO2010111443A2/en
Publication of WO2010111443A3 publication Critical patent/WO2010111443A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)

Abstract

Methods for generating and using omentum cells, particularly stromal cells and/or omentum stem cells, in medical treatments such as tissue repair and regeneration to facilitate healing from traumatic injury to an abdominal organ, immune modulation treatments such as suppression of immune responses and inflammation/prevention of tissue fibrosis. A medical procedure is performed on a patient involving harvesting omental tissue from the patient, then transferring the omental tissue to an organ of the patient. A portion of the harvested omental tissue may be activated prior to transferring the omental tissue to the organ. The transferred omental tissue may comprise non-lymphoid cells isolated from the omentum tissue and obtained by homogenizing a portion of the harvested omental tissue. The invention also encompasses a medical procedure comprising the transfer of omental stem cells to a patient, and a procedure comprising in vitro activation of omental stem cells by T cells to enhance immunomodulatory functions of the omental stem cells.
PCT/US2010/028577 2009-03-25 2010-03-25 Omentum as a source of stromal/stem cells and medical treatments using omentum stromal/stem cells WO2010111443A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US16326309P 2009-03-25 2009-03-25
US61/163,263 2009-03-25
US24199609P 2009-09-14 2009-09-14
US61/241,996 2009-09-14
US12/730,701 US9029139B2 (en) 2009-03-25 2010-03-24 Omentum as a source of stromal/stem cells and medical treatment using stromal/stem cells
US12/730,701 2010-03-24

Publications (2)

Publication Number Publication Date
WO2010111443A2 WO2010111443A2 (en) 2010-09-30
WO2010111443A3 true WO2010111443A3 (en) 2011-02-24

Family

ID=42781869

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/028577 WO2010111443A2 (en) 2009-03-25 2010-03-25 Omentum as a source of stromal/stem cells and medical treatments using omentum stromal/stem cells

Country Status (2)

Country Link
US (1) US9029139B2 (en)
WO (1) WO2010111443A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011156642A1 (en) * 2010-06-11 2011-12-15 Tengion, Inc. Erythropoietin-expressing adipose cell populations

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005028626A2 (en) * 2003-09-18 2005-03-31 Raven Biotechnologies, Inc. Cell culture media

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7785582B2 (en) * 2004-09-07 2010-08-31 Johnson Lanny L Use of synovium and omentum for tissue engineering

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005028626A2 (en) * 2003-09-18 2005-03-31 Raven Biotechnologies, Inc. Cell culture media

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KUYPERS, F. A. ET AL.: "Stem cell transplantation with S-59 photochemically treated T-cell add-backs to establish allochimerism in murine thalassemia", ANN. N.Y.ACAD.SCI., vol. 1054, 2005, pages 214 - 222 *
LEVICAR, N. ET AL.: "Stem cells as a treatment for chronic liver disease and diabetes", HEP, vol. 180, 2007, pages 243 - 262 *
LITBARG, N. 0. ET AL.: "Activated omentum becomes rich in factors that promote healing and tissue regeneration", CELL TISSUE RES., vol. 328, 2007, pages 487 - 497 *

Also Published As

Publication number Publication date
WO2010111443A2 (en) 2010-09-30
US9029139B2 (en) 2015-05-12
US20110081321A1 (en) 2011-04-07

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