WO2010110771A3 - Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof - Google Patents

Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof Download PDF

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Publication number
WO2010110771A3
WO2010110771A3 PCT/US2009/001857 US2009001857W WO2010110771A3 WO 2010110771 A3 WO2010110771 A3 WO 2010110771A3 US 2009001857 W US2009001857 W US 2009001857W WO 2010110771 A3 WO2010110771 A3 WO 2010110771A3
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WO
WIPO (PCT)
Prior art keywords
fatty acids
containing alkyl
substituted thiol
alkyl fatty
synthesizing derivatives
Prior art date
Application number
PCT/US2009/001857
Other languages
French (fr)
Other versions
WO2010110771A2 (en
Inventor
Frank Gibson
Lakmal W. Boteju
Robert Shorr
Robert Rodriguez
Original Assignee
Frank Gibson
Boteju Lakmal W
Robert Shorr
Robert Rodriguez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Frank Gibson, Boteju Lakmal W, Robert Shorr, Robert Rodriguez filed Critical Frank Gibson
Priority to PCT/US2009/001857 priority Critical patent/WO2010110771A2/en
Publication of WO2010110771A2 publication Critical patent/WO2010110771A2/en
Publication of WO2010110771A3 publication Critical patent/WO2010110771A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

An improved process for the synthesis of derivatives of substituted thiol-containing alkyl fatty acids, such as but not limited to lipoic acid, generates intermediate compounds and occurs in a temperature-controlled optimal sequence of monitored events to generate increased yield and purity of final product.
PCT/US2009/001857 2009-03-25 2009-03-25 Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof WO2010110771A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/US2009/001857 WO2010110771A2 (en) 2009-03-25 2009-03-25 Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2009/001857 WO2010110771A2 (en) 2009-03-25 2009-03-25 Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof

Publications (2)

Publication Number Publication Date
WO2010110771A2 WO2010110771A2 (en) 2010-09-30
WO2010110771A3 true WO2010110771A3 (en) 2012-04-26

Family

ID=42781707

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/001857 WO2010110771A2 (en) 2009-03-25 2009-03-25 Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof

Country Status (1)

Country Link
WO (1) WO2010110771A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2819175T3 (en) 2014-06-19 2021-04-15 Rafael Pharmaceuticals Inc Pharmaceutical compounds
CA2965898C (en) 2014-06-19 2021-07-06 Robert Shorr Fatty acid analogs

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5281722A (en) * 1991-11-16 1994-01-25 Degussa Ag Preparation and use of salts of the pure enantiomers of alpha-lipoic acid
US6951887B2 (en) * 1998-10-26 2005-10-04 The Research Foundation Of State University Of New York Lipoic acid derivatives and their use in treatment of disease
US20080262077A1 (en) * 2007-04-18 2008-10-23 Shorr Robert G L Pharmaceutical formulations containing lipoic acid derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5281722A (en) * 1991-11-16 1994-01-25 Degussa Ag Preparation and use of salts of the pure enantiomers of alpha-lipoic acid
US6951887B2 (en) * 1998-10-26 2005-10-04 The Research Foundation Of State University Of New York Lipoic acid derivatives and their use in treatment of disease
US20080262077A1 (en) * 2007-04-18 2008-10-23 Shorr Robert G L Pharmaceutical formulations containing lipoic acid derivatives

Also Published As

Publication number Publication date
WO2010110771A2 (en) 2010-09-30

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