WO2010108245A3 - Use of leishmania antigens in a diagnostic method, vaccine and therapy for leishmaniasis - Google Patents

Use of leishmania antigens in a diagnostic method, vaccine and therapy for leishmaniasis Download PDF

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Publication number
WO2010108245A3
WO2010108245A3 PCT/BR2010/000083 BR2010000083W WO2010108245A3 WO 2010108245 A3 WO2010108245 A3 WO 2010108245A3 BR 2010000083 W BR2010000083 W BR 2010000083W WO 2010108245 A3 WO2010108245 A3 WO 2010108245A3
Authority
WO
WIPO (PCT)
Prior art keywords
genes
leishmania
antigens
leishmaniasis
vaccine
Prior art date
Application number
PCT/BR2010/000083
Other languages
French (fr)
Portuguese (pt)
Other versions
WO2010108245A2 (en
Inventor
Lain Carlos Pontes De Carvalho
Geraldo Gileno de Sá OLIVEIRA
Washington Luis Conrado Dos Santos
Marcia Cristina Aquino Teixeira
Lenita Ramires Dos Santos
Andrea Mendes Pereira
Nathanael De Freitas Pinheiro Jr.
Patricia Oliveira Meira Santos
Cristiane Garboggini Melo De Pinheiro
Ricardo Evangelista Fraga
Oswaldo Pompilio De Melo Neto
Franklin Barbalho MAGALHÃES
Edimilson Rodrigues Da Silva
Antonio Gomes Pinto Ferreira
Marco Antonio Araujo Silvany
Original Assignee
Fundação Oswaldo Cruz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundação Oswaldo Cruz filed Critical Fundação Oswaldo Cruz
Publication of WO2010108245A2 publication Critical patent/WO2010108245A2/en
Publication of WO2010108245A3 publication Critical patent/WO2010108245A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/6893—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to the use of different recombinant antigens obtained from Leishmania chagasi or Leishmania infantum genes in assays for identifying, detecting and quantifying specific antibodies in biological material, including serum, plasma, saliva and urine from human beings, dogs and other Leishmania vertebrate hosts. These recombinant antigens, or genes or parts of genes that encode same, can be used for diagnosing leishmaniases, both the infection and/or disease. The present invention further relates to the use of these recombinant antigens, or genes or parts of genes that encode same, or formulations containing these antigens, for the treatment and/or immunisation of human beings, dogs and other vertebrate hosts, against leishmaniases.
PCT/BR2010/000083 2009-03-23 2010-03-22 Use of leishmania antigens in a diagnostic method, vaccine and therapy for leishmaniasis WO2010108245A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI0900961-2 2009-03-23
BRPI0900961A BRPI0900961B8 (en) 2009-03-23 2009-03-23 Leishmaniasis diagnostic methods and kit

Publications (2)

Publication Number Publication Date
WO2010108245A2 WO2010108245A2 (en) 2010-09-30
WO2010108245A3 true WO2010108245A3 (en) 2011-05-12

Family

ID=42781588

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2010/000083 WO2010108245A2 (en) 2009-03-23 2010-03-22 Use of leishmania antigens in a diagnostic method, vaccine and therapy for leishmaniasis

Country Status (2)

Country Link
BR (1) BRPI0900961B8 (en)
WO (1) WO2010108245A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015024877A2 (en) * 2013-03-28 2017-10-10 Infectious Disease Res Inst vaccines comprising leishmania polypeptides for the treatment and diagnosis of leishmaniasis
WO2016055836A1 (en) * 2014-10-09 2016-04-14 Universidade Federal De Minas Gerais - Ufmg Method for producing and using the rk39-kddr protein and leishmaniasis diagnostic kit
BR102019003639A2 (en) * 2019-02-22 2021-11-16 Fundação Oswaldo Cruz CHIMERIC PROTEIN, ITS METHOD FOR PRODUCTION AND USE, AS WELL AS NUCLEIC ACID MOLECULE, EXPRESSION CASSETTE, EXPRESSION VECTOR, HOST CELL, COMPOSITION FOR LEISHMANIASIS DIAGNOSIS, LEISHMANIASIS DIAGNOSTIC KIT AND LEISHMANIOSIS INNOVATIVE METHOD

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001079276A2 (en) * 2000-04-14 2001-10-25 Corixa Corporation Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
WO2006108720A2 (en) * 2005-04-08 2006-10-19 Institut Pasteur Polypeptides of leishmania major and polynucleotides encoding same and vaccinal, therapeutical and diagnostic applications thereof
WO2006110915A2 (en) * 2005-04-15 2006-10-19 University Of Iowa Research Foundation Vaccine formulations for leishmania
US20070237794A1 (en) * 2006-04-10 2007-10-11 The Infectious Disease Research Institute Compounds and Methods for Diagnosis and Treatment of Leishmaniasis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001079276A2 (en) * 2000-04-14 2001-10-25 Corixa Corporation Leishmania antigens for use in the therapy and diagnosis of leishmaniasis
WO2006108720A2 (en) * 2005-04-08 2006-10-19 Institut Pasteur Polypeptides of leishmania major and polynucleotides encoding same and vaccinal, therapeutical and diagnostic applications thereof
WO2006110915A2 (en) * 2005-04-15 2006-10-19 University Of Iowa Research Foundation Vaccine formulations for leishmania
US20070237794A1 (en) * 2006-04-10 2007-10-11 The Infectious Disease Research Institute Compounds and Methods for Diagnosis and Treatment of Leishmaniasis

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
CAMPOS, RM ET AL.: "Distinct mitochondrial HSP70 homologues conserved in various Leishmania species suggest novel biological functions.", MOL BIOCHEM PARASITOL., vol. 160, 2008, pages 157 - 162 *
DATABASE GENBANK 15 June 2005 (2005-06-15), "hypothetical protein, conserved [Leishmania major strain Friedlin].", Database accession no. CAJ05760. *
DATABASE GENBANK 15 June 2005 (2005-06-15), "hypothetical protein, conserved [Leishmania major strain Friedlin].", Database accession no. CAJ07774. *
DATABASE GENBANK 15 June 2005 (2005-06-15), "polyubiquitin, putative [Leishmania major strain Friedlin].", Database accession no. CAJ09316. *
DATABASE GENBANK 27 February 2007 (2007-02-27), "heat shock 70-related protein 1, mitochondrial precursor, putative [Leishmania infantum].", Database accession no. CAM70151. *
DATABASE GENBANK 27 February 2007 (2007-02-27), "hypothetical protein, conserved [Leishmania infantum].", Database accession no. CAM69556. *
DATABASE GENBANK 27 February 2007 (2007-02-27), "hypothetical protein, conserved [Leishmania infantum].", Database accession no. CAM72308. *
DATABASE GENBANK 27 February 2007 (2007-02-27), "hypothetical protein, unknown function [Leishmania infantum].", Database accession no. CAM71685. *
DATABASE GENBANK 27 February 2007 (2007-02-27), "kinesin K39 [Leishmania infantum JPCM5].", XP001464298, retrieved from http://www.ncbi.nlm.nih.gov/protein Database accession no. XP 001464298 *
DATABASE GENBANK 27 February 2007 (2007-02-27), "membrane associated protein-like protein [Leishmania infantum].", Database accession no. CAM70990. *
DATABASE GENBANK 27 February 2007 (2007-02-27), "mitotubule-associated protein Gb4, putative [Leishmania infantum].", Database accession no. CAM68912 *
DATABASE GENBANK 27 February 2007 (2007-02-27), "polyubiquitin, putative [Leishmania infantum].", Database accession no. CAM65917. *
DATABASE GENBANK 27 February 2007 (2007-02-27), Database accession no. CAM65800. *
GOTO, Y ET AL.: "Bioinformatic identification of tandem repeat antigens of the Leishmania donovani complex.", INFECT IMMUN., vol. 75, no. 2, February 2007 (2007-02-01), pages 846 - 851 *

Also Published As

Publication number Publication date
WO2010108245A2 (en) 2010-09-30
BRPI0900961A2 (en) 2010-12-21
BRPI0900961B8 (en) 2021-07-13
BRPI0900961B1 (en) 2020-10-06

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