WO2010108008A3 - Bsc cell differentiation and use in therapy - Google Patents
Bsc cell differentiation and use in therapy Download PDFInfo
- Publication number
- WO2010108008A3 WO2010108008A3 PCT/US2010/027824 US2010027824W WO2010108008A3 WO 2010108008 A3 WO2010108008 A3 WO 2010108008A3 US 2010027824 W US2010027824 W US 2010027824W WO 2010108008 A3 WO2010108008 A3 WO 2010108008A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cells
- bsc
- progenitor
- neural
- novel
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The present invention relates to the discovery of a novel multipotent progenitor cell termed pre-rosette stage ectoderm progenitor cells or BSC cells. These cells may be isolated, grown stably for a number of which are novel, self-renewing early ectodermal cell types (pre-rosette stage ectoderm progenitors) exhibiting neural progenitor-like characteristics generations and cryopreserved for stable storage. These cells may be further differentiated into neural cells such as neurons and glia cells, and other cells including neural crest derivative cells, among others, which may be used for transplantation and other therapies. Methods of producing these cells from BSC cells are also disclosed.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21036509P | 2009-03-18 | 2009-03-18 | |
US61/210,365 | 2009-03-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010108008A2 WO2010108008A2 (en) | 2010-09-23 |
WO2010108008A3 true WO2010108008A3 (en) | 2011-03-24 |
Family
ID=42740232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/027824 WO2010108008A2 (en) | 2009-03-18 | 2010-03-18 | Bsc cell differentiation and use in therapy |
Country Status (1)
Country | Link |
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WO (1) | WO2010108008A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11261425B2 (en) | 2009-08-12 | 2022-03-01 | Kyoto University | Method for inducing differentiation of pluripotent stem cells into neural precursor cells |
CA2770753C (en) * | 2009-08-12 | 2019-01-15 | Kyoto University | Method for inducing differentiation of pluripotent stem cells into neural precursor cells |
EP2658966B1 (en) | 2010-12-31 | 2017-04-05 | University of Georgia Research Foundation, Inc. | Differentiation of human pluripotent stem cells to multipotent neural crest cells |
CN102228016B (en) * | 2011-04-18 | 2012-07-18 | 上海安集协康生物技术有限公司 | Cryopreservation and resuscitation method of neural stem cells |
TWI493034B (en) * | 2011-12-14 | 2015-07-21 | Nat Univ Chung Hsing | Neuronal epithelial cells differentiated by universal stem cells and the medium used and their differentiation methods |
CA2920287C (en) * | 2013-08-06 | 2022-03-08 | Takeda Pharmaceutical Company Limited | Method for producing dopaminergic neurons |
MX2020005668A (en) | 2017-11-30 | 2020-11-24 | Univ Kyoto | Method for culture of cells. |
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2010
- 2010-03-18 WO PCT/US2010/027824 patent/WO2010108008A2/en active Application Filing
Non-Patent Citations (5)
Title |
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ABRANCHES, E. ET AL.: "Neural differentiation of embryonic stem cells in vitro: a road map to neurogenesis in the embryo. e6286", PLOS ONE, vol. 4, no. ISS.7, July 2009 (2009-07-01), pages 1 - 14 * |
BAJPAI, R. ET AL.: "Molecular stages of rapid and uniform neuralization of human embryonic stem cells.", CELL DEATH AND DIFFERENTIATION, vol. 16, 13 March 2009 (2009-03-13), pages 807 - 825 * |
LEE, G. ET AL.: "Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells.", NATURE BIOTECHNOLOGY, vol. 25, no. 12, 2007, pages 1468 - 1475 * |
PANKRATZ, M. ET AL.: "Directed neural differentiation of human embryonic stem cells an obligated primitive anterior stage.", STEM CELLS, vol. 25, 2007, pages 1511 - 1520 * |
WILSON, P. G. ET AL.: "Development and differentiation of neural rosettes derived from human embryonic stem cells.", STEM CELL REV., vol. 2, 2006, pages 67 - 77 * |
Also Published As
Publication number | Publication date |
---|---|
WO2010108008A2 (en) | 2010-09-23 |
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