WO2010104394A1 - Stigmasterol for the treatment of alzheimer's disease - Google Patents
Stigmasterol for the treatment of alzheimer's disease Download PDFInfo
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- WO2010104394A1 WO2010104394A1 PCT/NL2010/050133 NL2010050133W WO2010104394A1 WO 2010104394 A1 WO2010104394 A1 WO 2010104394A1 NL 2010050133 W NL2010050133 W NL 2010050133W WO 2010104394 A1 WO2010104394 A1 WO 2010104394A1
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- stigmasterol
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- 229940029339 inulin Drugs 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 206010023497 kuru Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 235000021243 milk fat Nutrition 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 150000002772 monosaccharides Chemical group 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000000926 neurological effect Effects 0.000 description 1
- 230000003955 neuronal function Effects 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 235000021140 nondigestible carbohydrates Nutrition 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 239000006014 omega-3 oil Substances 0.000 description 1
- 235000021578 orange juice drink Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000004203 pancreatic function Effects 0.000 description 1
- 150000002972 pentoses Chemical class 0.000 description 1
- 239000005426 pharmaceutical component Substances 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 description 1
- 150000003905 phosphatidylinositols Chemical class 0.000 description 1
- 235000017807 phytochemicals Nutrition 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229930000223 plant secondary metabolite Natural products 0.000 description 1
- 230000007824 polyneuropathy Effects 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- CWCXERYKLSEGEZ-KDKHKZEGSA-N procalcitonin Chemical compound C([C@@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)NCC(O)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H]1NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@@H](N)CSSC1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 CWCXERYKLSEGEZ-KDKHKZEGSA-N 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229940070376 protein Drugs 0.000 description 1
- 230000020978 protein processing Effects 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000021254 resistant starch Nutrition 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 208000008864 scrapie Diseases 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003431 steroids Chemical group 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 125000005457 triglyceride group Chemical group 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- 239000011675 vitamin B5 Substances 0.000 description 1
- 235000009492 vitamin B5 Nutrition 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000021119 whey protein Nutrition 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Botany (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10708409A EP2405773A1 (en) | 2009-03-12 | 2010-03-12 | Stigmasterol for the treatment of alzheimer's disease |
BRPI1009814-3A BRPI1009814A2 (en) | 2009-03-12 | 2010-03-12 | Use of stigmasterol, and, composition. |
CN2010800202802A CN102421304A (en) | 2009-03-12 | 2010-03-12 | Stigmasterol for the treatment of alzheimer's disease |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL2009050121 | 2009-03-12 | ||
NLPCT/NL2009/050121 | 2009-03-12 | ||
NLPCT/NL2009/050315 | 2009-06-08 | ||
PCT/NL2009/050315 WO2010104375A1 (en) | 2009-03-12 | 2009-06-08 | Stigmasterol for the treatment of alzheimer's disease |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010104394A1 true WO2010104394A1 (en) | 2010-09-16 |
Family
ID=41172380
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NL2009/050315 WO2010104375A1 (en) | 2009-03-12 | 2009-06-08 | Stigmasterol for the treatment of alzheimer's disease |
PCT/NL2010/050133 WO2010104394A1 (en) | 2009-03-12 | 2010-03-12 | Stigmasterol for the treatment of alzheimer's disease |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NL2009/050315 WO2010104375A1 (en) | 2009-03-12 | 2009-06-08 | Stigmasterol for the treatment of alzheimer's disease |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP2405773A1 (en) |
CN (1) | CN102421304A (en) |
BR (1) | BRPI1009814A2 (en) |
WO (2) | WO2010104375A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210236509A1 (en) * | 2018-07-26 | 2021-08-05 | Wista Laboratories Ltd. | Optimised dosage of diaminophenothiazines in populations |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104398523B (en) * | 2014-11-03 | 2017-01-25 | 南昌大学 | Application of (22-trans)-3beta-hydroxyl-cholester-5,22-diene-24-ketone in neuroprotection medicine |
CN109793783A (en) * | 2017-11-16 | 2019-05-24 | 西双版纳华坤生物科技有限责任公司 | A kind of application and preparation method for alzheimer's disease prevention and treatment substance |
Citations (10)
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---|---|---|---|---|
WO1999032097A2 (en) | 1997-12-18 | 1999-07-01 | Forbes Medi-Tech Inc. | Phytosterol composition for preventing alzheimer's disease |
WO2000030666A1 (en) | 1998-11-24 | 2000-06-02 | University Of Washington | Composition and methods for inhibiting the formation of brain amyloid deposits |
WO2000041491A2 (en) * | 1999-01-15 | 2000-07-20 | Nutrahealth Ltd (Uk) | Modified food products and beverages, and additives for food and beverages |
WO2001003712A1 (en) | 1999-07-09 | 2001-01-18 | Astion Development Aps | Composition containing extracts of butyrospermum parkii and the use as medicament or dietary supplement |
WO2005039597A2 (en) | 2003-10-24 | 2005-05-06 | N.V. Nutricia | Immunemodulating oligosaccharides |
WO2005049037A1 (en) * | 2003-10-24 | 2005-06-02 | The Coca-Cola Company | Process for preparing phytosterol dispersions for application in beverages |
WO2005094610A1 (en) | 2004-03-26 | 2005-10-13 | The Procter & Gamble Company | Stable coating agent comprising sterol |
WO2006121558A2 (en) | 2005-05-05 | 2006-11-16 | Osemwota Sota Omoigui | Method of prevention and treatment of aging, a related disorders and/or age-related manifestations includi r c erosis. |
WO2007124597A1 (en) | 2006-05-01 | 2007-11-08 | Forbes Medi-Tech Inc. | Composition comprising one or more esterified phytosterols and/or phytostanols into which are solubilized one or more unesterified phytosterols and/or phytostanols, in order to achieve therapeutic and formulation benefits |
EP2036444A1 (en) | 2007-09-05 | 2009-03-18 | Dietetics Pharma S.r.l. | Liquid nutraceutic preparation containing free plant sterols |
-
2009
- 2009-06-08 WO PCT/NL2009/050315 patent/WO2010104375A1/en active Application Filing
-
2010
- 2010-03-12 WO PCT/NL2010/050133 patent/WO2010104394A1/en active Application Filing
- 2010-03-12 CN CN2010800202802A patent/CN102421304A/en active Pending
- 2010-03-12 EP EP10708409A patent/EP2405773A1/en not_active Withdrawn
- 2010-03-12 BR BRPI1009814-3A patent/BRPI1009814A2/en not_active IP Right Cessation
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999032097A2 (en) | 1997-12-18 | 1999-07-01 | Forbes Medi-Tech Inc. | Phytosterol composition for preventing alzheimer's disease |
WO2000030666A1 (en) | 1998-11-24 | 2000-06-02 | University Of Washington | Composition and methods for inhibiting the formation of brain amyloid deposits |
WO2000041491A2 (en) * | 1999-01-15 | 2000-07-20 | Nutrahealth Ltd (Uk) | Modified food products and beverages, and additives for food and beverages |
WO2001003712A1 (en) | 1999-07-09 | 2001-01-18 | Astion Development Aps | Composition containing extracts of butyrospermum parkii and the use as medicament or dietary supplement |
WO2005039597A2 (en) | 2003-10-24 | 2005-05-06 | N.V. Nutricia | Immunemodulating oligosaccharides |
WO2005049037A1 (en) * | 2003-10-24 | 2005-06-02 | The Coca-Cola Company | Process for preparing phytosterol dispersions for application in beverages |
WO2005094610A1 (en) | 2004-03-26 | 2005-10-13 | The Procter & Gamble Company | Stable coating agent comprising sterol |
WO2006121558A2 (en) | 2005-05-05 | 2006-11-16 | Osemwota Sota Omoigui | Method of prevention and treatment of aging, a related disorders and/or age-related manifestations includi r c erosis. |
WO2007124597A1 (en) | 2006-05-01 | 2007-11-08 | Forbes Medi-Tech Inc. | Composition comprising one or more esterified phytosterols and/or phytostanols into which are solubilized one or more unesterified phytosterols and/or phytostanols, in order to achieve therapeutic and formulation benefits |
EP2036444A1 (en) | 2007-09-05 | 2009-03-18 | Dietetics Pharma S.r.l. | Liquid nutraceutic preparation containing free plant sterols |
Non-Patent Citations (3)
Title |
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VAN MIERLO ET AL., ABSTRACTS/CHEMISTRY AND PHYSICS OF LIPIDS, vol. 154S, 2008, pages S60 |
VOLPE ET AL., BRITISH JOURNAL OF NUTRITION, vol. 86, 2001, pages 233 - 239 |
VOLPE ET AL.: "Effects of yoghurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemia", BRITISH JOURNAL OF NUTRITION, vol. 86, 2001, pages 233 - 239, XP002551880 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210236509A1 (en) * | 2018-07-26 | 2021-08-05 | Wista Laboratories Ltd. | Optimised dosage of diaminophenothiazines in populations |
US20230115931A1 (en) * | 2018-07-26 | 2023-04-13 | Wista Laboratories Ltd. | Optimised dosage of diaminophenothiazines in populations |
Also Published As
Publication number | Publication date |
---|---|
WO2010104375A1 (en) | 2010-09-16 |
EP2405773A1 (en) | 2012-01-18 |
CN102421304A (en) | 2012-04-18 |
BRPI1009814A2 (en) | 2015-08-25 |
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