WO2010099247A2 - Methods and apparatus for fai surgeries - Google Patents
Methods and apparatus for fai surgeries Download PDFInfo
- Publication number
- WO2010099247A2 WO2010099247A2 PCT/US2010/025292 US2010025292W WO2010099247A2 WO 2010099247 A2 WO2010099247 A2 WO 2010099247A2 US 2010025292 W US2010025292 W US 2010025292W WO 2010099247 A2 WO2010099247 A2 WO 2010099247A2
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- WO
- WIPO (PCT)
- Prior art keywords
- implant
- acetabulum
- rim
- bone
- spoon
- Prior art date
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30721—Accessories
- A61F2/30728—Collars; Bone edge protectors
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61B17/17—Guides or aligning means for drills, mills, pins or wires
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- A61B17/1746—Guides or aligning means for drills, mills, pins or wires specially adapted for particular parts of the body for the hip for the acetabulum
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- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
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Definitions
- This invention relates generally to hip surgeries and, more particularly, relates to surgical methods, tools and implants for treating femoral acetabular impingement.
- FAI Femoroacetabular impingement or FAI is a condition of the hip joint where the femoral head and acetabulum rub abnormally creating damage to the hip joint.
- the damage can occur to the articular cartilage of the head or acetabulum or to the labral cartilage on and around the acetabular rim.
- FAI may take one of two forms: cam or pincer. The difference between the two forms is determined by the abnormality of the hip joint that is the cause of the damage.
- the cam form of FAI occurs when the femoral head and neck relationship is aspherical, or not perfectly round. This loss of roundness contributes to abnormal contact between the head and socket.
- the pincer form occurs when the the acetabulum has too much coverage of the femoral head.
- a partial rim implant for an acetabulum in a pelvic bone comprises a ridge, a bearing surface, and a fixation surface.
- the ridge is oriented to replace a labium.
- the bearing surface is configured to align with the articulating surface of the acetabulum.
- the bearing surface extends from the ridge toward the apex of the acetabulum.
- the fixation surface is configured to fix the implant to a prepared bone surface of the pelvic bone.
- the apex of the acetabulum has a central axis extending toward a plane defined by the rim of the acetabulum, further comprising a rim portion extending from the fixation portion to the ridge, the rim portion orienting the ridge.
- Another embodiment provides an implant made of a first compliant material and a second stiffer material.
- the fixation surface is made of the first compliant material.
- Another embodiment comprises an insertion portion extending generally perpendicularly from the bearing surface and a fixation flange extending from a rim portion of the implant.
- the insertion portion and the flange portion converge toward one another as the flange and insertion portion extend away from the acetabulum.
- the apex of the acetabulum has a central axis extending toward a plane defined by the rim of the acetabulum, the implant further comprising a transition portion located between the bearing portion and the rim portion, the transition portion extends the rim portion toward the central axis of the acetabulum.
- the implant is rolled onto the rim of the acetabulum.
- fixation surface which is a post extending into the pelvic bone.
- the implant is fixed to the bone with sutures.
- the spacer comprises a spoon and a plenum.
- the spoon portion is configured to wrap around the head of the femur.
- the plenum is attached to the spoon and configured to inflate the spoon. The spoon, when inflated, separates the acetabulum from the femur.
- the spoon further comprises a cutout portion configured to extend around the ligamentum teres.
- the spacer further comprises a stiff portion extending through the spoon, such that the spoon may be pushed into the hip joint.
- a stiff portion extending through the spoon, such that the spoon may be pushed into the hip joint.
- Another embodiment provides for the stiff portion to extend around the periphery of the spoon.
- the guide comprises a generally planar rectangular member and an axis.
- the generally rectangular planar member has an opening in the central portion. Edges of the opening form a cutting surface.
- the opening has a width and a height.
- the axis extends across the planar member. The axis forms a fold line upon which the planar member may be folded such that when the planar member is folded over an acetabular rim, the edges of the opening extend over the rim and are configured to direct a cutting member to remove bone to a depth defined by the height of the opening.
- the width of the opening is set to the width of the implant.
- Another embodiment provides the curved fold line is curved relative to the radius of the acetabulum.
- Figure 1 is a view of an embodiment of an acetabular implant for treating FAI
- Figure 2 is another view of the embodiment of Fig. 1 ;
- Figure 3 is another view of the embodiment of Fig. 1;
- Figures 4A through 4F are views of embodiments of an acetabular implant similar to the embodiment of Fig. 1;
- Figure 5 A and 5B are views of the implant of Figure 1 on an acetabulum;
- Figure 6 is a cut away view of the implant and acetabulum of Fig. 5;
- Figure 7A is a view of another embodiment of an acetabular implant for treating FAI;
- Figure 8A and 8B are views of another embodiment of an acetabular implant for treating FAI implanted on an acetabulum;
- FIG. 1OA is a view of another embodiment of an acetabular implant for treating FAI implanted on an acetabulum;
- Figure 1OB is an exploded view of the acetabulum and implant of Fig. 1OA;
- Figure 11 is a view of another embodiment of an acetabular implant for treating FAI implanted on an acetabulum
- Figure 12 is an exploded view of the acetabulum and implant of Fig. 11;
- Figure 20 is a view of another embodiment of an acetabular implant for treating FAI
- Figure 21 is a view of another embodiment of an acetabular implant for treating FAI
- Figure 28 is an exploded view of an embodiment of an acetabular implant and fixation screws
- Figure 3OB is another view of an embodiment of an implant that may be implanted as shown in Fig. 29;
- Figure 32 is another view of the guide marker of Figure 31;
- Figure 33 is a view of the guide marker of Fig. 31 placed on the surface of an acetabulum;
- Figure 34 is a view of a bone cutting guide;
- Figure 35 is a view of a cutter and the bone cutting guide of Fig. 34 folded into a proper orientation to be received on an acetabulum;
- Figure 36 is a view of a measuring instrument oriented in the acetabulum
- Figure 37 is another view of the measuring instrument of Fig. 36 oriented in the acetabulum;
- Figure 38 is a view of another embodiment of a measuring instrument
- Figure 40 is a partial view of the spacer instrument of Fig. 39 inserted into the hip joint around the ligamentum teres;
- Figure 42 is another view of the acetabulum of Fig. 41 showing pathways from the iliac crest to labral or acetabular defects;
- Figures 43 A to 43F are views of different embodiments of acetabular implants to insert into the pathways shown in Fig. 41 and Fig. 42;
- Figure 44 is a view of a plurality of bone mating surfaces of acetabular implants having varius radii.
- Figure 1 is a view of an embodiment of an acetabular implant
- the implant 10 for treating FAI.
- the implant 10 has an insertion portion 12, a flange portion 14, a ridge 15, a rim portion 16, a rim curvature 17, a bearing surface 18 and a rim-bearing transition 19.
- Figure 2 is another view of the embodiment of Fig. 1
- Figure 3 is yet another view of the embodiment of Fig. 1.
- mounting holes 11 are positioned on the flange portion 14.
- the insertion portion 12 may be configured to insert into the acetabulum generally perpendicular to the bearing surface of the acetabulum.
- the bearing surface 19, then, would lie generally flush with the bearing surface of the acetabulum.
- the rim-bearing transition 19 may generally be a curved portion of the bearing surface 19 that transitions the bearing surface 19 into the rim portion 16.
- the rim portion 16 extends inward toward a central axis of the acetabulum from the bearing surface 19. This rim portion 16 may then be used to help capture the head of the femur (which was the function of the surface that was removed, albeit the removed surface was damaged necessitating its removal.
- the implant may restore the function of the damaged surfaces that were removed without causing the negative pathological response that was generated from the damaged tissue, bone or cartilage.
- the rim portion 16 has a ridge that transitions the rim portion 16 from the bearing surface side of the implant 10 to a fixation side (through the flange portion 14).
- the flange portion 14 may be fixed to the acetabulum by screws or pins through screw holes 11 (as shown in this embodiment) or by other means as discussed with respect to other embodiments.
- the rim curvature 17 of the implant 10 is sized to fit the acetabulum. Thus, varying diameters of different acetabulums may require various rim curvatures 17 of the implant. Additionally, depending on the size of the damaged region, the thickness of the implant 10, the width of the implant 10 and the depth of the rim portion 16 may be changed to fit the specific anatomy of the patient.
- the embodiments generally share some common features, namely, a bearing portion, a rim portion for replacing the labrum, and a fixation portion. It is contemplated within the scope of this disclosure that different variations as described herein may achieve a desired implant embodiment by providing these features as described and then combined.
- the majority of the implant is made from the stiffer material 20.
- the dynamics may produce larger loads across the implant than an implant such as the one shown in Fig. 4E, where only the rim portion is made of the stiffer material 20.
- a continuum between exerted loads, implant stiffness, and conformity may all contribute to the material composition of the implant 10 such that an implant may be made from a stiffer material 20 (shown in Fig. 4A) or entirely from the more compliant material (as shown in Fig. 4F).
- Figure 6 is a cut away view of the implant and acetabulum of Fig. 5.
- the implant 10 is fixed to the acetabulum by a mechanical interference fit.
- the portions 12 and 14 converge toward one another in the pelvic bone.
- the implant will not dislodge as the converging surfaces grip the bone in between the insertion portion 12 and the flange 14.
- Such an interference fit may be achieved by rolling the implant 10 from inside the acetabulum 1002 over the rim.
- Such a method requires the insertion portion 12 to first engage the bone, then rolling the flange 14 over the top of the bone.
- FIGS. 8A and 8B are views of another embodiment of an acetabular implant 40 for treating FAI implanted on an acetabulum 1002.
- This embodiment may be a hard bearing material (such as Oxinium) that may be press fit into the bone.
- Such an embodiment may require very precise bone preparation and a specifically sized match for the shape of the preparation accounting for the natural characteristics of the acetabulum 1002.
- the bearing surface 48 of the implant 40 may then be a hard bearing just as the whole implant 40 is a hard material.
- the bone for receiving such an implant may be prepared with an instrument having the shape desired for the bone contacting surface of the implant 40 so that the preparation may occur at one time, instead of a more fitted procedure where different portions of bone may be prepared based upon earlier preparation of other bone portions.
- Figure 1OA is a view of another embodiment of an acetabular implant 60 for treating FAI implanted on an acetabulum.
- Figure 1OB is an exploded view of the acetabulum and implant 60 of Fig. 1OA.
- Mounting holes 61 may be positioned on flange 64 to mount the implant 60 to the bone.
- a ridge 65 on a rim portion of the implant 60 provides the constraining feature of the implant 60.
- a bearing surface 68 extends into the acetabulum to mate with the natural bearing surface of the acetabulum.
- bone preparation surfaces 1010, 1012c are prepared to receive the implant 60.
- FIG 11 is a view of another embodiment of an acetabular implant 70 for treating FAI implanted on an acetabulum.
- Figure 12 is an exploded view of the acetabulum and implant 70 of Fig. 11.
- Mounting holes 71 may be positioned on the implant 70 to mount the implant 70 to the bone.
- a ridge 75 on a rim portion of the implant 70 provides the labrum replacement feature of the implant 70.
- a bearing surface 78 extends into the acetabulum to mate with the natural bearing surface of the acetabulum.
- bone preparation surfaces 1010 are prepared to receive the implant 70.
- the bone preparation matches the implant surfaces without a compliant material in use.
- the bone preparation would likely be from guided stamps or cutting surfaces, and not from free hand cutting using burrs or the like.
- the prepared surfaces direct the position of the entire implant, the prepared surfaces must take into account not only the underlying bone but also the rim characteristics and bearing surface characteristics of the implant.
- Figure 13 is a view of a femur 2000 showing an affected area 2004 for cam type FAI.
- An a spherical femoral head 2002 may create the affected area 2004. It may be necessary to treat the affected area first with debridement and then with an implant designed to limit osseus overgrowth (as would occur from continued stress from contact with the acetabulum.
- Figures 14A through 14D are views of embodiments of femoral implants 80a, 80b, 80c, and 80d for treating FAI on the femur.
- Mounting holes 81a, 81b, 81c, and 8 Id may be used to mount the implant onto the femur.
- the implant shape may be molded intraoperatively or from radiographic scans of the femur prior to surgery.
- the implants may be made of a rigid or flexible material and mounted with any of the mounting means discussed herein.
- FIG 15 is a view of another embodiment of an acetabular implant 90 for treating FAI implanted on an acetabulum.
- Figure 16 is a cutaway view of the embodiment of Fig. 15.
- the implant 90 is made from a flexible material that may bend at a transition 97 so that a screw 300 having a head 302 greater in diameter than a hole 91 through a flange portion 94 of the implant 90 may fix the implant to the bone.
- a ridge 95 of a rim portion 96 replaces the labrum.
- a bearing surface 98 contacts the femoral head.
- the transition 97 also transitions the bearing surface between the acetabulum 1002 and the bearing surface 98 of the implant 90.
- the bone preparation may include a single planar surface cutting a portion of the rim of the acetabulum away.
- the screw 300 may compress the flange 94 against a bone surface 1014 to fix the implant 90 to the bone through fixation elements 306 on a shaft 304 of the screw 300.
- the rim portion 96 of the implant 90 may then be moved into position over the screw head 302.
- the rim portion 96 may also be fixed tot eh flange 94 with sutures or other fixation elements so that the rim portion 96 is stiffened relative to the flange 94.
- FIG 17 is a view of another embodiment of an acetabular implant 100 for treating FAI.
- This wedge type implant (similar to the implant of Fig. 15) may be implanted after having made a single planar cut of the acetabular rim.
- the implant 100 of Fig. 17, as well as Figs. 18 and 19, may be fixed to the acetabulum with sutures or wire.
- Figure 18 is a view of the embodiment of Fig. 17 with sutures 310.
- Figure 19 is a view of the embodiment of Fig. 17 with sutures 310 attached to an acetabulum 1002.
- the sutures 310 may extend through suture guides 101 through the implant 100 and into suture guides 1016 in the bone.
- a bone mating surface 104, a rim portion 106, terminating in a ridge 105 extends along a bearing surface 108.
- a bearing surface 108 there is labium replacement in a rim portion, a bearing surface transitioning to the natural cartilage in the acetabulum, and fixation means in the implant 100.
- Figure 20 and 21 are views of other embodiments of an acetabular implant for treating FAI. Similar to previous embodiments, this embodiment is a wedge type design with a bi-material structure. A more rigid portion 20 and a more flexible portion 22. As previously described, such features may give the implant some compliance when implanted. As shown in Fig 22, Figure 22 is a view of another embodiment of an acetabular implant for treating FAI implanted on an acetabulum where the compliant material 22 is a bone interface surface. Figs. 23 and 24 similarly show bi-material combinations where the more compliant and more rigid portions of the implant comprise different portions of the implants.
- Figure 25 is a view of another embodiment of an acetabular implant 160 for treating FAI.
- the implant includes more rigid material 20 and more flexible material 22.
- Mounting means 161 may fix the implant to the bone.
- a notch 166 may allow the implant to be bent.
- a relief 163 may be positioned opposite the notch 166 to relieve stress in the implant when it is bent.
- Opposing surfaces 168 and 169 may contact each other when the implant is bent.
- a chanmfer 167 may transition the bearing surface of the implant to the bone.
- Figure 26 is an exploded view of the implant of Fig. 25 bent into the proper shape for implantation and fixation screws.
- Figure 27 is a cutaway view of the implant and screws of Fig. 26.
- the implant may form bone interfacing surfaces 1024 and 1026 to contact the bone. Screws 300 may then pass through the mounting means 161 to fix the impant 160 to the acetabulum 1002. A ridge 165 is formed when the implant is bent onto the acetabulum 1002.
- Figure 28 is an exploded view of an embodiment of an acetabular implant 170 and fixation screws 300.
- the implant may be made of a bi-material of more rigid material 20 and more flexible material 22.
- the screws 300 may be countersunk 171b with mounting holes 171a.
- a ridge 175 may replace the labrum when the implant is fixed to bone.
- Figure 29 is a view of an acetabulum 1002 with an implant 180.
- the implant 180 may include a chamfer 187 between the bearing surface of the implant 180 and the articulating surface of the acetabulum.
- the implant may have a bone interfacing surface that runs more generally parallel to the articulating surface of the acetabulum. Two cuts that are generally perpendicular to each other form a generally rectangular recess in the bone.
- the load on the bone surface may be preferable in some instances with an implant design like this (as opposed to a wedge embodiment or a layover embodiment.)
- the general portions are still intact in such a design, namely, a bone contacting surface, a bearing surface and a constraining portion that replaces the labrurn.
- Figures 30A through 30C are views of embodiments of implants 180, 190, and 200 that may be implanted as shown in Fig. 29.
- a chamfer 187, 197 and 207 relieves the implant near the acetabular articulating surface and a gap 1030a, 1030b, and 1030c is formed between the implant and the acetabulum.
- a bearing surface 188, 198 and 208 aligns with the acetabular articulating surface.
- 186, 196, and 206 extends into the acetabular cavity and terminates in a ridge 185, 195 and 205 that replaces the labrum.
- Figure 31 is a view of a guide marker 400 for an acetabular implant.
- a handle 402 extends along a shaft 404 to a guide 406.
- Depth indicia 412 on the guide 406 may set the depth of the implant while radii (rl, r2, r3, and r4) by markings 408 a-d (shown in Fig. 32).
- Widths (wl, w2) may be determined through markings 410. Based upon the necessary bone removal, the markings may determine the size of the implant, the depth to which the bone must be removed in order for the implant to fit properly, and the correct radius of the implant.
- Figure 33 is a view of the guide marker of Fig. 31 placed on the surface of an acetabulum.
- the guide uses the radius markings to make sure the proper radius of the acetabulum is determined.
- the width markings may be used to measure the width of the implant.
- the depth may be determined from the markings 112 which may show the depth of removal necessary for the implant to sit flush with the articulating surface of the acetabulum.
- Figure 34 is a view of a bone cutting guide 500.
- An opening 502 in the guide 500 creates guide surfaces 504 for the depth of cutting.
- the guide 500 may be bent so that a lower portion 508 and an upper portion 506 overlie the rim of the acetabulum.
- Figure 35 is a view of a cutter 522 on a surgical tool 520 and the bone cutting guide of Fig. 34 folded into a proper orientation to be received on an acetabulum.
- Figure 36 is a view of a measuring instrument 600 oriented in the acetabulum 1002.
- the instrument 600 includes a shaft 604 attached to a hemispherical head 606. Depth marks 608 are located on the shaft 604.
- a stylus 610 slides along the shaft 604 in a shaft guide 612.
- the head 606 may be positioned within the acetabulum to orient the version and adduction of the shaft.
- the stylus may then measure the depth to the lesion 1004 by using the markings 608. Radius markings on the stylus may measure the radius of the acetabular rim.
- Figure 37 is another view of the measuring instrument of Fig. 36 oriented in the acetabulum.
- Figure 38 is a view of another embodiment of a measuring instrument 600.
- the stylus 610' may be reversible. Additionally a lesion depth paddle 611 may be placed on the end of the stylus. The stylus 610' may measure the depth from the shaft, and the paddle 611 may measure the depth of the lesion.
- FIG 39 is a view of a spacer instrument 700 for separating the femur from the acetabulum.
- the spacer instrument 700 includes a plenum 702 attached to a forked inflatable spoon 703 through a tube 704.
- the spoon 703 includes a first finger 705 and a second finger 707 separated by a cutout portion 706.
- a stiffening member 709 may stiffen the spoon 703 for insertion.
- a control module 710 includes a one way valve 712, a pressure release knob 714 and a pop-off valve 716.
- the plenum 702 may inflate the spoon 703 to inflate the finger portions 705 and 707.
- the spoon 705 and 707 may avoid the ligamentum teres.
- the spoon When inflated, the spoon may separate the femur from the acetabulum without tearing the ligamentum teres.
- Stiffening means 709 may be placed along the edge of the spoon 703 so that the spoon may be pushed into the hip joint.
- Figure 41 is a view of an acetabulum showing pathways 1060 from the iliac crest to labral or acetabular defects.
- Figure 42 is another view of the acetabulum of Fig. 41 showing pathways from the iliac crest to labral or acetabular defects.
- the pathways 1060 allow for distal to proximal orientation of an implant or a proximal to distal orientation of an implant. By using these different pathways through the iliac crest, the implant orientation at the labrum may be controlled.
- the implants inserted through these pathways are shown in Figs.43A to 43F.
- FIGS 43 A to 43F are views of different embodiments of acetabular implants to insert into the pathways shown in Fig. 41 and Fig. 42.
- Each implant 210, 220, 230, 240, 250, and 260 have a post that extends along the pathway.
- Each implant has a ridge (like 215 in 43A), a bearing portion (e.g., 228 in Fig. 43B), and a rim portion
- the posts may be made of a compliant material 22, press fit into an implant, or threaded. Threaded designs may have rotational members 242 or 252 depending on proximal or distal direction of the implantation.
- the posts provide fixation for the implant in the bone 1000.
- Figure 44 is a view of a plurality of bone mating surfaces 278a, 278b, and
Abstract
Description
Claims
Priority Applications (10)
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RU2011137986/14A RU2011137986A (en) | 2009-02-24 | 2010-02-25 | METHOD AND DEVICE FOR OPERATIONS IN SEMOACETABULAR CONFLICT |
AU2010218061A AU2010218061B2 (en) | 2009-02-24 | 2010-02-25 | Methods and apparatus for FAI surgeries |
EP10746801.9A EP2490625B1 (en) | 2009-02-24 | 2010-02-25 | Apparatus for fai surgeries |
KR1020117020535A KR20120109990A (en) | 2009-02-24 | 2010-02-25 | Methods and apparatus for fai surgeries |
US13/202,612 US8900320B2 (en) | 2009-02-24 | 2010-02-25 | Methods and apparatus for FAI surgeries |
BRPI1007988A BRPI1007988A2 (en) | 2009-02-24 | 2010-02-25 | method and apparatus for fai surgeries. |
JP2011551320A JP5599827B2 (en) | 2009-02-24 | 2010-02-25 | FAI surgical method and apparatus |
CN201080017951.XA CN102421390B (en) | 2009-02-24 | 2010-02-25 | For the method and apparatus of FAI operation |
CA2753429A CA2753429A1 (en) | 2009-02-24 | 2010-02-25 | Method and apparatus for fai surgeries |
US14/534,751 US9504577B2 (en) | 2009-02-24 | 2014-11-06 | Methods and apparatus for FAI surgeries |
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Also Published As
Publication number | Publication date |
---|---|
EP2490625A4 (en) | 2014-09-17 |
CN102421390A (en) | 2012-04-18 |
EP2490625A2 (en) | 2012-08-29 |
JP2013520209A (en) | 2013-06-06 |
AU2016200524A1 (en) | 2016-03-10 |
CN102421390B (en) | 2016-01-20 |
JP5599827B2 (en) | 2014-10-01 |
BRPI1007988A2 (en) | 2016-03-01 |
WO2010099247A3 (en) | 2011-02-24 |
KR20120109990A (en) | 2012-10-09 |
CN105167888A (en) | 2015-12-23 |
EP2490625B1 (en) | 2020-01-22 |
CA2753429A1 (en) | 2010-09-02 |
CN105167888B (en) | 2018-04-20 |
US20150066151A1 (en) | 2015-03-05 |
US20120283840A1 (en) | 2012-11-08 |
RU2011137986A (en) | 2013-04-10 |
US9504577B2 (en) | 2016-11-29 |
AU2010218061A1 (en) | 2011-09-08 |
US8900320B2 (en) | 2014-12-02 |
AU2010218061B2 (en) | 2015-11-26 |
AU2017228660A1 (en) | 2017-10-05 |
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