WO2010094964A1 - Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd - Google Patents
Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd Download PDFInfo
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- WO2010094964A1 WO2010094964A1 PCT/GB2010/050271 GB2010050271W WO2010094964A1 WO 2010094964 A1 WO2010094964 A1 WO 2010094964A1 GB 2010050271 W GB2010050271 W GB 2010050271W WO 2010094964 A1 WO2010094964 A1 WO 2010094964A1
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- Prior art keywords
- compound
- tosylate
- methyl
- parts
- pharmaceutical composition
- Prior art date
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- 125000005490 tosylate group Chemical class 0.000 title description 148
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- CXGTZJYQWSUFET-IBGZPJMESA-N tesaglitazar Chemical compound C1=CC(C[C@H](OCC)C(O)=O)=CC=C1OCCC1=CC=C(OS(C)(=O)=O)C=C1 CXGTZJYQWSUFET-IBGZPJMESA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
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JP2011550649A JP5543982B2 (en) | 2009-02-20 | 2010-02-18 | Tosylate salt of 5-pyrazolyl-2-pyridone derivative useful for the treatment of COPD |
EP10705178.1A EP2398792B1 (en) | 2009-02-20 | 2010-02-18 | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd |
ES10705178.1T ES2469916T3 (en) | 2009-02-20 | 2010-02-18 | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of epoc |
RU2011135627/04A RU2526038C2 (en) | 2009-02-20 | 2010-02-18 | Tosylate salt of 5-pyrazolyl-2-pyridone derivative effective in copd treatment |
MX2011008389A MX2011008389A (en) | 2009-02-20 | 2010-02-18 | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd. |
BRPI1008396A BRPI1008396B8 (en) | 2009-02-20 | 2010-02-18 | tosylate salt compound of a 5-pyrazolyl-2-pyridone derivative, pharmaceutical composition, use and process for preparing said compound |
CA2752319A CA2752319C (en) | 2009-02-20 | 2010-02-18 | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd |
AU2010215269A AU2010215269B2 (en) | 2009-02-20 | 2010-02-18 | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of COPD |
CN2010800174198A CN102405219B (en) | 2009-02-20 | 2010-02-18 | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of COPD |
HK12102965.3A HK1162498A1 (en) | 2009-02-20 | 2012-03-26 | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd copd 5--2- |
Applications Claiming Priority (2)
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US15409909P | 2009-02-20 | 2009-02-20 | |
US61/154,099 | 2009-02-20 |
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PCT/GB2010/050271 WO2010094964A1 (en) | 2009-02-20 | 2010-02-18 | Tosylate salt of a 5-pyrazolyl-2-pyridone derivative, useful in the treatment of copd |
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US (2) | US8232296B2 (en) |
EP (1) | EP2398792B1 (en) |
JP (1) | JP5543982B2 (en) |
KR (1) | KR20110127158A (en) |
CN (1) | CN102405219B (en) |
AR (1) | AR075523A1 (en) |
AU (1) | AU2010215269B2 (en) |
BR (1) | BRPI1008396B8 (en) |
CA (1) | CA2752319C (en) |
ES (1) | ES2469916T3 (en) |
HK (1) | HK1162498A1 (en) |
MX (1) | MX2011008389A (en) |
RU (1) | RU2526038C2 (en) |
TW (1) | TW201036957A (en) |
UY (1) | UY32461A (en) |
WO (1) | WO2010094964A1 (en) |
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US8063073B2 (en) | 2003-09-18 | 2011-11-22 | Astrazeneca Ab | 2-pyridone derivatives as neutrophil elastase inhibitors and their use |
US8114881B2 (en) | 2006-05-08 | 2012-02-14 | Astrazeneca Ab | 2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial |
US8232296B2 (en) | 2009-02-20 | 2012-07-31 | Astrazeneca Ab | Salt 628 |
US8436024B2 (en) | 2009-10-02 | 2013-05-07 | Astrazeneca Ab | 2-pyridone compounds |
US8466284B2 (en) | 2007-11-06 | 2013-06-18 | Astra Zeneca Ab | Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase |
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CN102405219B (en) | 2013-11-06 |
AU2010215269B2 (en) | 2013-06-27 |
JP5543982B2 (en) | 2014-07-09 |
KR20110127158A (en) | 2011-11-24 |
MX2011008389A (en) | 2011-09-01 |
ES2469916T3 (en) | 2014-06-20 |
JP2012518623A (en) | 2012-08-16 |
US20120269872A1 (en) | 2012-10-25 |
AR075523A1 (en) | 2011-04-06 |
RU2526038C2 (en) | 2014-08-20 |
CN102405219A (en) | 2012-04-04 |
EP2398792A1 (en) | 2011-12-28 |
EP2398792B1 (en) | 2014-04-09 |
BRPI1008396B8 (en) | 2021-05-25 |
UY32461A (en) | 2010-09-30 |
TW201036957A (en) | 2010-10-16 |
CA2752319C (en) | 2016-10-04 |
US8232296B2 (en) | 2012-07-31 |
BRPI1008396A2 (en) | 2017-06-27 |
CA2752319A1 (en) | 2010-08-26 |
RU2011135627A (en) | 2013-03-27 |
AU2010215269A1 (en) | 2011-08-25 |
US20100216843A1 (en) | 2010-08-26 |
HK1162498A1 (en) | 2012-08-31 |
BRPI1008396B1 (en) | 2020-11-10 |
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