WO2010094147A1 - 一种超低频磁刺激装置及其工作方法 - Google Patents

一种超低频磁刺激装置及其工作方法 Download PDF

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Publication number
WO2010094147A1
WO2010094147A1 PCT/CN2009/000162 CN2009000162W WO2010094147A1 WO 2010094147 A1 WO2010094147 A1 WO 2010094147A1 CN 2009000162 W CN2009000162 W CN 2009000162W WO 2010094147 A1 WO2010094147 A1 WO 2010094147A1
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Prior art keywords
output
ultra
low frequency
stimulation device
signal
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PCT/CN2009/000162
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English (en)
French (fr)
Inventor
徐建兰
刘恩平
侯建凯
侯兴凯
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梅州康立高科技有限公司
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Application filed by 梅州康立高科技有限公司 filed Critical 梅州康立高科技有限公司
Priority to US13/201,787 priority Critical patent/US9457198B2/en
Priority to PCT/CN2009/000162 priority patent/WO2010094147A1/zh
Publication of WO2010094147A1 publication Critical patent/WO2010094147A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets

Definitions

  • Ultra-low frequency magnetic stimulation device and working method thereof
  • the invention belongs to a medical device, and particularly relates to an ultra-low frequency magnetic stimulation device and a working method thereof.
  • Magnetic stimulation can improve local blood circulation, promote brain cell repair, and stimulate brain tissue vitality.
  • magnetic induction of the brain can treat and prevent mental illness.
  • magnetic shock is characterized by non-invasiveness and high safety.
  • the magnetic field used in the current applied magnetic stimulation technology is mainly a pulsed magnetic field, which is used frequently, and is mainly used for the diagnosis of neurological diseases, and the therapeutic effect on the disease is difficult to satisfy.
  • scientific research has also found that the magnetic effects of different frequency bands on the brain are different.
  • the present invention provides an ultra-low frequency magnetic stimulation device and a method for the same, which are useful for treating and relieving brain related diseases.
  • the present invention provides an ultra-low frequency magnetic stimulation device, which includes a control module, a level shifting and transforming circuit, and an output module, wherein
  • control module configured to generate a DC stimulation signal with a frequency below 20 Hz
  • a level shifting and transforming circuit for potential shifting the stimulation signal to make it an alternating current stimulation signal
  • An output module for power amplifying the AC stimulation signal and generating a current, an electric field, or a magnetic field.
  • the control module includes an ARM processor and an audio chip, and the audio chip generates the DC stimulation signal under the control of the ARM processor.
  • the control module adopts the development board of model QQ2440V3, the audio chip is UDA1341TS; UDA1341TS is short-circuited through the output capacitor (C45) and capacitor (C46), and is grounded through the output resistor (R4) and resistor (R9) R9.
  • the output module includes at least one power amplifying circuit, and the output of the power amplifying circuit is connected to a coil.
  • the output module includes at least one power amplifying circuit, and the output of the power amplifying circuit is connected to an electrode.
  • the AC stimulation signal is an AC stimulation signal based on 0V.
  • the power amplifier circuit is a chip TDA7294; the control module is also used to output a mute control signal required by the chip TDA7294.
  • the control module is an ARM processor; the level shifting and transforming circuit is further configured to convert the voltage of the mute control signal, and convert the mute control signal with a high level of 3. 3V into a mute control signal of 5V to output to the chip TDA7294.
  • the output current is a combined output of a single-frequency non-pulsating ultra-low frequency current and/or a multi-frequency non-pulsing ultra-low frequency current; a single frequency current and/or a plurality of frequency combined currents are simultaneously output or time-division output.
  • Modulated output or superimposed output is used for combined output of multiple frequencies.
  • the invention provides a working method of an ultra-low frequency magnetic stimulation device, comprising:
  • Step 1 generating a DC stimulation signal with a frequency below 20 Hz;
  • Step 2 performing a potential shift on the stimulation signal to make it an alternating stimulation signal
  • Step 3 Power amplify the AC stimulation signal and generate a current, an electric field or a magnetic field.
  • FIG. 1 is a circuit schematic diagram of an ultra-low frequency magnetic stimulation device of the present invention
  • FIG. 2 is a schematic diagram of an audio output circuit in the ultra-low frequency magnetic stimulation device of the present invention.
  • FIG. 3 is a schematic diagram of a level shifting and transforming circuit in the ultra-low frequency magnetic stimulation device of the present invention
  • FIG. 4 is a circuit schematic diagram of an adder of a level shifting and converting circuit in the ultra-low frequency magnetic stimulation device of the present invention
  • Figure 5 is a schematic diagram of a power amplifying circuit in the ultra low frequency magnetic stimulation device of the present invention.
  • FIG. 6 is a schematic diagram of a mute control circuit of a power amplifying circuit in the ultra-low frequency magnetic stimulation device of the present invention. detailed description
  • the ultra low frequency magnetic stimulation device disclosed in the present invention is shown in FIG.
  • the control module 10, the level shifting and transforming circuit 20 and the output module 30 are included.
  • the control module 10 includes an ARM processor 103, a touch color liquid crystal display 101, and an audio chip 102;
  • the output module 30 includes four power amplifying circuits 301 (the producer of the product can set the number of power amplifiers) and four corresponding The coil 303, each power amplifying circuit 301 has a channel 302.
  • the ARM processor 103 is connected to the touch color liquid crystal display 101.
  • the output terminal of the ARM processor 103 is directly connected to the level shifting and transforming circuit 20, and is also connected to the level shifting and transforming circuit 20 through the audio chip, and the level shifting and transforming
  • the circuit 20 is connected to the power amplifier circuit 301 through the parallel ultra-low frequency signal output line and the mute control line, and the output of each of the four power amplifier circuits 301 is connected to a coil 303, and the stimulation frequency is 0.001 Hz to 20 Hz ; 001Hz ⁇ 20Hz ⁇
  • the electrotherapy is also connected to the electrotherapy electrode (not shown), the frequency of the electrotherapy is 0. 001Hz ⁇ 20Hz.
  • the output current is 20Hz (preferably 0. 2Hz) of the non-pulse ultra-low frequency, current, electric field or magnetic field; the output current is connected to the electrode for electrical therapy, connected to the coil 303 for magnetic therapy; the output can only be connected to the electrode or coil One; the output current is a single frequency non-pulsed ultra-low frequency current, and a combination of multiple frequency non-pulsed ultra-low frequency current output, single frequency current and multiple frequency combinations simultaneously output or time-sharing output; or output current is Combined output of multiple frequencies, combined output with modulated output or superimposed output.
  • the hardware of the ultra-low frequency magnetic stimulation device is mainly composed of an ARM processor (including an operating system) 103, a level shifting and transforming circuit 20, and an output module 30.
  • the ARM processor 103 is mainly responsible for man-machine interface control, generation of ultra-low frequency stimulation signals, mute control, setting and storage of treatment plans, and magnetic field calibration.
  • the level shifting and transforming circuit 20 is responsible for potential shifting the output signal of the ARM, so that the ultra-low frequency signal which becomes the 0 reference is output to the power amplifier circuit; at the same time, the mute signal of the ARM output is level-converted to conform to the subsequent power amplifier circuit. Control requirements.
  • the output module 30 is responsible for power amplification of the ultra low frequency stimulation signal and outputting through the coil to generate an alternating ultra low frequency stimulation magnetic field.
  • the instrument is powered by a transformer with a power of 1500W, a primary input of 220VAC, a secondary of 28VAC two-way, and 12 VAC two-way. Two of the 28V outputs are serially rectified to supply power to the power amplifier board; two 12V outputs are serially rectified to supply power to the level shifting and conversion circuit and the ARM control module. Adoption
  • the ultra-low frequency continuous magnetic field magnetically induces the human brain to achieve the purpose of treating and relieving brain-related diseases.
  • the control module adopts a development board of the type QQ2440V3, and the audio chip UDA1341TS is short-circuited through the C45 and C46 capacitors of the output port, and the R4 and R9 resistors are grounded at the same time to remove the filtering function.
  • the main control board of the control module uses the QQ2440V3 burst board produced by Guangzhou Friendly Arms Co., Ltd., and the liquid crystal display uses its matching 7-inch color LCD screen. Minor changes were made to the ARM development board as needed. Shorten the C45 and C46 capacitors of the UDA1341TS output port of the audio chip and remove the R4 and R9 resistors. The reason is: this design uses the audio chip to output the ultra-low frequency stimulation signal, and the audio output of the original development board is filtered below 10HZ, so the filter component of this design is removed to generate the ultra-low frequency signal.
  • the dedicated WinCE5.0 kernel is customized, and the user program on the SD card can be automatically loaded after the system is started.
  • a special ultra-low frequency magnetic stimulation system application has also been designed, which can conveniently perform setting functions such as setting of waveform parameters, magnetic field calibration, setting and saving of 8 kinds of stimulation schemes, stimulation timing, and online adjustment of strength.
  • the pins 1, 5, 11, and 27 of the audio chip UDA1341TS are directly grounded; the legs 23, 9, 21, and 20 are grounded through RK, R78, R79, and R80 of 10K, respectively; 0. ⁇ capacitor C44 is grounded; 2.
  • the level shifting of the level shifting and transforming circuit is to convert the ultra-low frequency reference outputted by the control module 10 to 1.75V DC signal to 0V as the reference AC signal, and the level shifting is to use the open collector of the collector.
  • the chip realizes that the mute signal outputted by the control module outputs a level conversion of 3. 3V to 5V. So designed, the level shifting and transforming circuit 20 is an interface circuit between the control module 10 and the output module 30. Its main role is two:
  • the ultra low frequency signal reference output from the control module 10 is 1.75V, which is a DC signal. number.
  • the purpose of level shifting is to transform this signal into an ac-based AC signal. In this way, an alternating ultra-low frequency magnetic field can be generated by subsequent power amplification.
  • the output of the mute signal outputted by the control module 10 is 3. 3V, and the voltage and the driving capability are not sufficient to complete the mute of the power amplifier. Therefore, the design uses an open-collector inverter chip 74LS06 to achieve 3. 3V and 5V. Level conversion and increase drive capability.
  • the level shifting and transforming circuit 20 includes a rectifier bridge, a voltage regulator, an electrolytic capacitor, a potentiometer, a resistor, a NE5532 amplifier, a 74LS06 inverter, and a power input, a signal input, and an output.
  • External port Two 12-volt AC lines of the 1 and 2 interfaces of the ACINPUT power connector are connected to the 2 and 3 interfaces of the rectifier bridge J0.
  • the positive and negative voltages generated by the rectifier bridge J0 are connected to the 7805 through the 4 and 1 interfaces respectively.
  • the 3 interface of the negative voltage regulator chip J2 is connected in series with the 4 interface of the amplifier JP1, and is grounded through the 10K adjustment potentiometer R1.
  • the 2 interface of the amplifier JP1 is connected to the 2 interface of the INPUT input connector J4 through the 6K resistor R3, the amplifier JP1
  • the 2 interface is also connected to the potentiometer R1 through the 15K resistor R2; the 3 interface of the positive voltage regulator chip JI, the capacitor C3 and the 8 interface of the amplifier JP1 are connected in series, and the 14 interface of the inverter of the 74LS06 open collector JP2 is connected, and 33K is also passed.
  • Resistor R5 is connected to the 2 interface of the inverter JP2, and the 14 interface of the inverter JP2 is passed through 0.
  • the capacitor C5 is grounded. Before the capacitor C5 is grounded, the 3 interface of the INPUT input connector J4, the 3 interface of the OUTPUT output connector J5, and the reverse are also connected.
  • the 7 interface of JP2, the 1 interface of the inverter JP2 is connected to the 1 interface of the INPUT input connector J4, and the 2 interface of the inverter JP2 is connected to the 1 interface of the OUTPUT output connector.
  • the output signal LINE0UT L in Figure 2 is connected to the 2 interface of the INPUT input connector J4, and the output signal LINE0UT B is left floating.
  • the circuit is mainly composed of rectifier bridge, voltage regulator, electrolytic capacitor, potentiometer, resistor, NE5532 amplifier, 74LS06 inverter, and three external ports: power input, signal input and output.
  • the working principle is as follows: The two 12-volt ACs provided by the power supply are connected in series through the rectifier bridge, and the positive and negative voltages are generated.
  • the positive voltage regulator 7805 and the negative voltage regulator chip 7905 respectively output positive and negative 5 volts. Current, powering the amplifier E5532.
  • the adder circuit is built using the amplifier NE5532, the resistor and the potentiometer, and the level shift is performed by adjusting the potentiometer.
  • Rectifier bridge It adopts 3A row bridge, two channels of 12 volts AC enter from two input terminals, and there are positive and negative two-way rectified output.
  • Regulator Adopt 7805 and 7905 two voltage regulator blocks, the output voltage of the rectifier bridge, the forward voltage is converted into 5V DC positive voltage through 7805, and the negative voltage is converted to 5V DC negative voltage through 7905.
  • Electrolytic Capacitor The 0. luF/25 volt electrolytic capacitor at both ends of the regulator is a bypass capacitor, which suppresses the self-excited oscillation that may occur in the circuit and acts to suppress interference.
  • Operational amplifier It adopts the operational amplifier NE5532, which is a dual op amp in DIP8 package.
  • the internal is JFET (junction FET structure). It has strong driving force and wide voltage adaptation range from positive and negative 3V to plus or minus 20V. Can work normally.
  • the audio amplifying chip of the power amplifying circuit is of the TDA7294 type, and the power amplifying circuit has a rated output power of 100 W and an operating voltage of ⁇ 32 V. So designed, the output module 30 is responsible for power amplification of the ultra-low frequency stimulation signal and outputting the coil to generate an alternating ultra-low frequency stimulation magnetic field.
  • the power amplifying circuit is grounded by the 1st interface STBY-GND of the audio amplifying chip TDA7294, and the 8 and 15 interfaces of the audio amplifying chip TDA7294 are connected in series, and then grounded through the capacitor C9 of the lnnF, and the input signal is connected.
  • audio amplifier chip TDA7294 7 and 13 interfaces are connected in series through 100nF capacitor C7 ground, input signal +VS, through 100OnF capacitor C6 ground; audio amplifier chip TDA7294 4 interface Grounding, the 3 interface of the audio amplifier chip TDA7294 is grounded through the 22K resistor R1, the 2 interface of the audio amplifier chip TDA7294 is grounded through the 680 ⁇ resistor R2, and the 14 interface of the audio amplifier chip TDA7294, 22 ⁇ capacitor C5 and coil 303 are also connected through the 22K resistor R3.
  • the capacitor C5 is connected to the 6 interface of the audio amplification chip TDA7294, and the coil 303 is grounded again.
  • the output signal outputl in Figure 3 is used as input Connected to the 3 interface of the audio amplification chip TDA7294 (four audio amplification chips receive the output signal outputl), the output signal output2 in Figure 3 is connected to the 10 interface of the audio amplification chip TDA7294 (four audio amplification chips receive the output signal) Output2 ).
  • the power amplifier circuit uses the audio amplifier chip TDA7294, and its rated output power can reach 100W (when the operating voltage is ⁇ 32V).
  • the function of each device is shown in the table below.
  • the above electronic components can be larger or smaller than the recommended value, where: R1 is used for input impedance, when the value is greater than the recommended value, it is used to increase the input impedance, when it is less than the recommended value, it is used to reduce the input impedance; R2 is used for the closed-loop gain to 30DB, which is greater than the recommended value.
  • R3 is used for the closed-loop gain to 30DB, increase the gain when it is larger than the recommended value, decrease the gain when it is less than the recommended value
  • R4 is used for the STBY time, higher than the recommended value, higher standby Time, smaller standby time than recommended value
  • R5 is used for MUTE time, higher mute time than recommended value, lower mute time than recommended value
  • C3 is used for MJTE time, higher mute time than recommended value, Less than the recommended value, the lower mute time
  • C4 is used for STBY time, higher than the recommended value, higher standby time, smaller than the recommended value
  • C5 is the bootstrap capacitor, less than the recommended value, low frequency signal attenuation
  • C6, C8 Used for power supply filtration.
  • C7, C9 are used for power supply filtration.
  • the audio amplifying chip of the power amplifying circuit is of the TDA7294 type, and the power amplifying circuit has a rated output power of 100 W and an operating voltage of ⁇ 32V. So designed, the matching is good.
  • the power amplifying circuit further includes a mute control circuit.
  • the mute control circuit is an STBY terminal of the audio amplifying chip TDA7294 connected to the audio amplifier through a 20K resistor R20.
  • the 4 interface of the chip TDA7294 is also grounded through the ⁇ capacitor C20; the MUTE terminal of the audio amplifier chip TDA7294 is grounded through the lO F capacitor C21, and is also connected in series with the 30K resistor R21, IN4148 diode and 10K resistor R22 in parallel with the audio amplification chip TDA7294. 4 The connection between the interface and the resistor R20.
  • the output current is a non-pulsed ultra-low frequency of 0.2 Hz or less, an electric field or a magnetic field; the output current is connected to the electrode for electrical therapy, and the coil is connected for magnetic therapy; the output current is a single frequency non-pulsating ultra-low frequency Current output, combined output of non-pulsed ultra-low frequency currents of multiple frequencies, single frequency current and multiple frequency combined current simultaneous output or time-sharing output; or output current is combined output of multiple frequencies, modulation is used in combination output Output or superimposed output.
  • the maximum magnetic field strength is 200 Gauss, continuously adjustable;
  • the output waveform is a single sine wave or multiple sine waves The stack of mouths. So designed, it uses an alternating ultra-low frequency continuous magnetic field to magnetically induce the human brain to achieve the goal of treating and relieving brain-related diseases.
  • Power supply by transformer power is 1500W
  • primary input is 220VAC
  • secondary is 28VAC two
  • 12VAC two Two of the 28V outputs are serially rectified to supply power to the power amplifier board; two 12V outputs are serially rectified to supply power to the level shifting and conversion circuit and the ARM control module.
  • the invention also provides a working method of an ultra-low frequency magnetic stimulation device, comprising:
  • Step 1 generating a DC stimulation signal with a frequency below 20 Hz;
  • Step 2 performing a potential shift on the stimulation signal to cause the stimulation signal to be exchanged
  • Step 3 Power amplify the AC stimulation signal and generate a current, an electric field or a magnetic field.
  • the output current of the ultra-low frequency magnetic stimulation device of the invention is a non-pulsed ultra-low frequency current (below 20 Hz), an electric field or a magnetic field; the output current can be connected to the electrode for electrical treatment, and can be connected to the coil for Magnetic therapy; the output current is a single frequency continuous non-pulsating ultra-low frequency current, and a combination of multiple frequency non-pulse continuous ultra-low frequency current output, can output simultaneously or time-sharing; can be combined output treatment of multiple frequencies, Modulated output or superimposed output; it uses alternating ultra-low frequency non-pulsating magnetic field to magnetically induce human brain to achieve the purpose of treating and alleviating mental disorders related to the brain.
  • alternating ultra-low frequency non-pulsating magnetic field to magnetically induce human brain to achieve the purpose of treating and alleviating mental disorders related to the brain.

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Description

一种超低频磁刺激装置及其工作方法 技术领域
本发明属于医疗器械， 特别涉及一种超低频磁刺激装置及其工作方法。
当代医学研究表明， 包括大脑和小脑在内的人脑组织对磁信号非常敏感。 磁刺激能改善大脑局部血液循环， 促进脑细胞修复， 激发脑组织活力。利用大 脑对磁场的敏感性，对大脑进行磁确诱导，可以治疗和预防精神疾病。而且磁剌激 具有无创性和安全性高的特点。当前应用的磁刺激技术所用的磁场主要是脉冲 磁场， 使用频率较高， 主要用于神经科疾病本的诊断， 对疾病的治疗效果难以让 人满意。 同时， 科学研究还发现， 不同频段的磁场刺激对大脑所产生的生物学 效应是有所不同的。
现有技术中还没有下述的医疗器械：通过产生超低频的电流，通过电极或 线圈作用于大脑， 调节脑内的神经递质的功能， 进而调节大脑的功能； 而随着 社会竞争压力逐渐增大，精神和心理疾病已成为人类面临的一项挑战， 因此对 大脑的功能进行调解是现代人非常需要的。 发明内容
为了解决上述的技术问题，本发明提供了一种超低频磁刺激装置及其工作 方法， 用于治疗和缓解大脑相关疾病。
本发明提供了一种超低频磁刺激装置， 该装置包括控制模块、 电平平移与 变换电路、 输出模块， 其中，
控制模块， 用于生成频率为 20Hz以下的直流刺激信号；
电平平移与变换电路， 用于对刺激信号进行电位平移，使之成为交流刺激 信号；
输出模块，用于对交流刺激信号进行功率放大，并产生电流、电场或磁场。 控制模块包括 ARM处理器以及音频芯片，音频芯片在 ARM处理器的控制下 产生所述直流刺激信号。
还包括人机界面， 与 ARM通信以实现人机界面控制。 控制模块采用型号为 QQ2440V3的开发板， 所述音频芯片为 UDA1341TS; UDA1341TS通过输出口的电容 （C45 )和电容 （C46 ) 短接， 通过输出口的电阻 ( R4 ) 和电阻 ( R9 ) R9接地。
输出模块包括至少一个功率放大电路，功率放大电路的输出端和一个线圈 连接。
输出模块包括至少一个功率放大电路，功率放大电路的输出端和一个电极 连接。
所述交流刺激信号是以 0V为基准的交流刺激信号。
所述功率放大电路为芯片 TDA7294; 控制模块还用于输出芯片 TDA7294所 需的静音控制信号。
控制模块为 ARM处理器；电平平移与变换电路还用于将静音控制信号的电 压变换，将高电平为 3. 3V的静音控制信号变换为 5V的静音控制信号输出至芯 片 TDA7294。
输出电流为单一频率的非脉冲超低频的电流和 /或多种频率的非脉冲超低 频电流的组合输出； 单一频率电流和 /或多种频率组合电流同时输出或分时输 出。
多种频率的组合输出时采用调制输出或叠加输出。
本发明提供了一种超低频磁刺激装置的工作方法， 包括：
步骤 1， 生成频率为 20Hz以下的直流刺激信号；
步骤 2， 对刺激信号进行电位平移， 使之成为交流刺激信号；
步骤 3， 对交流刺激信号进行功率放大， 并产生电流、 电场或磁场。 附图说明
图 1为本发明超低频磁刺激装置的电路原理图；
图 2为本发明超低频磁刺激装置中音频输出电路的原理图；
图 3为本发明超低频磁刺激装置中电平平移与变换电路原理图； 图 4 为本发明超低频磁刺激装置中电平平移与变换电路的加法器的电路 原理图；
图 5为本发明超低频磁刺激装置中功率放大电路的原理图；
图 6为本发明超低频磁刺激装置中功率放大电路的静音控制电路原理图。 具体实施方式
本发明公开的超低频磁刺激装置如图 1所示。 包括控制模块 10， 电平平 移与变换电路 20和输出模块 30。控制模块 10包括 ARM处理器 103、触摸式彩 色液晶显示屏 101和音频芯片 102; 输出模块 30包括四个功率放大电路 301 (该产品的生产者可以设置功率放大器的个数） 以及相应的四个线圈 303， 每 个功率放大电路 301具有一个通道 302。 ARM处理器 103连接触摸式彩色液晶 显示屏 101， ARM处理器 103的输出端子直接连接电平平移与变换电路 20的同 时， 还通过音频芯片连接电平平移与变换电路 20， 电平平移与变换电路 20再 通过并列的超低频信号输出线和静音控制线连接功率放大电路 301， 四个功率 放大电路 301的输出端各连接一个线圈 303， 刺激频率为 0. 001Hz〜20Hz; 功 率放大电路输出端还可以连接有电疗电极 （图中未示出）， 电疗频率为 0. 001Hz〜20Hz。
输出电流为非脉冲超低频的 20Hz (优选 0. 2Hz ) 以下电流、 电场或磁场； 输出的电流与电极连接用于电治疗， 与线圈 303连接用于磁治疗； 输出端只能 连接电极或线圈之一； 输出电流为单一频率的非脉冲超低频的电流，和多种频 率的的非脉冲超低频电流的组合输出，单一频率电流和多种频率组合同时输出 或分时输出； 或输出电流为多种频率的组合输出， 组合输出时采用调制输出或 叠加输出。 刺激频率 0. 001Hz〜20Hz按 1毫赫兹连续可调； 最大磁场强度为 200高斯，连续可调； 输出波形为单个正弦波或多个正弦波的叠加。
如此设计， 超低频磁刺激装置的硬件主要由 ARM处理器 （含有操作系统） 103、 电平平移与变换电路 20、 和输出模块 30三部分组成。 其中， ARM处理器 103主要负责人机界面控制， 超低频刺激信号的生成， 静音控制， 治疗方案的 设置与存储， 以及磁场标定等功能。 电平平移与变换电路 20负责对 ARM的输 出信号进行电位平移， 使之成为 0基准的超低频信号输出给功放电路； 同时对 ARM输出的静音信号进行电平变换， 使之符合后续功放电路的控制要求。 输出 模块 30负责对超低频刺激信号进行功率放大， 并通过线圈输出， 产生交变的 超低频刺激磁场。本仪器采用变压器供电，功率为 1500W,初级输入为 220VAC, 次级为 28VAC两路， 12 VAC两路。其中两路 28V输出串联整流后为功放板供电； 两路 12V输出串联整流后为电平平移与变换电路和 ARM控制模块供电。其采用 超低频连续磁场，对人的大脑进行磁诱导， 从而达到治疗和缓解大脑精神相关 疾病的目的。
作为优化， 所述控制模块采用型号为 QQ2440V3 的开发板， 其音频芯片 UDA1341TS通过输出口的 C45， C46电容短接， 同时将 R4和 R9电阻接地去掉 滤波功能。 如此设计， 控制模块的主控板采用广州友善之臂公司生产的 QQ2440V3幵发板， 液晶显示采用其配套的 7寸彩色液晶屏。根据需要， 对 ARM 开发板做了少量改动。即将音频芯片 UDA1341TS输出口的 C45， C46电容短接， 同时将 R4和 R9电阻去掉。原因在于：本设计采用音频芯片进行超低频刺激信 号输出， 而原开发板上音频输出 10HZ以下被滤波， 所以本设计将的滤波器件 去掉， 以产生超低频信号。
针对本仪器的特殊用途， 定制了专用的 WinCE5. 0内核， 该系统启动后可 自动加载 SD卡上的用户程序。
还设计了专用的超低频磁刺激系统应用程序，该程序可以方便的进行对波 形参数的设置， 磁场定标， 8种刺激方案的设定和保存， 刺激计时， 强度在线 调整等实用功能。
作为优化， 如图 2所示， 所述音频芯片 UDA1341TS的 1、 5、 11、 27脚直 接接地； 23、 9、 21、 20脚分别通过 10K的 R77、 R78、 R79、 R80接地； 28脚 通过 0. ΐμΡ电容 C44接地； 2、 4脚串接后通过 ΙΟμΡ电容 C47并接 MIC I 和 47K的 R3、 R3再通过 100K的 R11并接 VDD33V和通过 ΙΟμΡ电容 C48接地； 26 脚通过 ΙΟμΡ电容 C45并接 LINEOUT L和通过 10K的 R9接地； 24脚通过 lO F 电容 C46并接 LINE0UT B和通过 10K的 R4接地； 12、 16、 17、 18、 19、 13、 14、 15脚分别接 CDCLK、 I2SSCLK, I2SLRCK, I2SSDI、 I2SSD0、 L3M0DE、 L3CL0CK、 L3DATA; 3、 7、 25脚串接后接 AU-AVDD33V， 通过 lO F电容 C71接地， 通过电 感 L4连接 VDD33V; 10脚连接 VDD33V。 如此设计， 结构简单，性能可靠。
作为优化， 电平平移与变换电路的电平平移是将控制模块 10输出的超低 频基准为 1. 75V直流信号变换为 0V为基准的交流信号， 电平变换是采用集电 极开路的反相器芯片实现控制模块输出的静音信号输出高电平 3. 3V到 5V的电 平转化。 如此设计， 电平平移与变换电路 20是控制模块 10和输出模块 30之 间的接口电路。 其主要作用有二：
1 ) 电平平移。 从控制模块 10输出的超低频信号基准为 1. 75V, 是直流信 号。 电平平移的目的是将此信号变换为以 ov为基准的交流信号。 这样经过后 续功率放大放可产生交变的超低频磁场。
2) 电平变换。 控制模块 10输出的静音信号输出高电平为 3. 3V， 此电压 和驱动能力都不足以完成功放的静音， 因此，本设计采用集电极开路的反相器 芯片 74LS06实现 3. 3V与 5V的电平转化， 并增加驱动能力。
作为优化， 如图 3所示， 电平平移与变换电路 20包括整流桥、 稳压器、 电解电容、 电位器、 电阻、 NE5532放大器、 74LS06反向器、 以及电源输入、 信号输入和输出三个外接端口； 电源接头 ACINPUT的 1、 2接口的两路 12伏的 交流电串接后连接整流桥 J0的 2、 3接口， 整流桥 J0产生的正负两路电压分 别通过其 4、 1接口连接 7805正稳压芯片 JI的 1接口和 7905负稳压芯片 J2 的 2接口； 电源接头 ACINPUT的负极接口 3接地、 并连接正稳压芯片 JI的 2 接口和 7905负稳压芯片 J2的 1接口， 还分别通过 lOOO F电容 Cl、 1000μΡ 电容 C3、 1000μΡ电容 C2、 1000μΡ电容 C4分别连接正稳压芯片 JI的 1、 3接 口、 负稳压芯片 J2的 2、 3接口； 正稳压芯片 JI的 3接口连接 E5532放大器 JP1的 8接口， 放大器 JP1的 1接口连接 INPUT输出入接头 J5的 1接口， 放 大器 JP1的 1接口和 2接口通过 6K电阻 R4串连， 负稳压芯片 J2的 3接口与 放大器 JP1的 4接口串接后通过 10K调节电位器 R1接地， 放大器 JP1的 2接 口通过 6K电阻 R3连接 INPUT输入接头 J4的 2接口， 放大器 JP1的 2接口还 通过 15K电阻 R2连接调节电位器 R1; 正稳压芯片 JI的 3接口、 电容 C3和放 大器 JP1的 8接口串接后连接 74LS06集电极开路的反向器 JP2的 14接口、还 通过 33K电阻 R5连接反向器 JP2的 2接口， 反向器 JP2的 14接口通过 0. 电容 C5接地， 电容 C5接地前还连接 INPUT输入接头 J4的 3接口、 OUTPUT输 出入接头 J5的 3接口和反向器 JP2的 7接口，反向器 JP2的 1接口连接 INPUT 输入接头 J4的 1接口， 反向器 JP2的 2接口连接 OUTPUT输出接头】5的 1接 口。 图 2中的输出信号 LINE0UT L与 INPUT输入接头 J4的 2接口连接， 输出 信号 LINE0UT B悬空。
如此设计，该电路主要由整流桥、稳压器、电解电容、电位器、电阻、 NE5532 放大器、 74LS06反向器、 以及电源输入、 信号输入和输出三个外接端口组成。 工作原理为： 电源提供的两路 12伏的交流电串接后通过整流桥， 产生的正负 两路电压， 通过正稳压芯片 7805和负稳压芯片 7905， 分别输出正负 5伏的直 流电， 为放大器 E5532供电。 利用放大器 NE5532、 电阻和电位器搭建加法器 电路， 通过调节电位器进行电平平移。
1 ) 整流桥： 采用 3A排桥， 两路 12伏交流电从两个输入端进入， 有正负 两路整流后的输出。
2 ) 稳压器： 采用 7805和 7905两稳压块， 整流桥的输出电压， 正向电压 经过 7805转化为 5伏直流正电压，负向电压经过 7905转化为 5伏直流负电压。
3 ) 电解电容： 稳压器两端的 0. luF/25伏的电解电容是旁路电容， 抑制电 路中可能产生的自激振荡， 起到抑制干扰的作用。
4) 运算放大器： 采用运算放大器 NE5532, 其为 DIP8封装的双运放， 内 部为 JFET (结型场效应管结构），驱动力强， 电压适应范围非常宽， 从正负 3V 至正负 20V都能正常工作。
加法器： 原理图 4所示， 利用计算公式：
^ ϋ (^¾χ (- 5)] 选择 10K电位器， 选择 15K电阻，
Figure imgf000008_0001
A选择 6K电阻， 带入上述公 式可得： 输出电压在原信号上加入 0V〜- 2V的平移电压。
作为优化， 所述功率放大电路的音频放大芯片为 TDA7294 型， 所述功率 放大电路的其额定输出功率达 100W、 工作电压为 ±32V。 如此设计， 输出模块 30 负责对超低频刺激信号进行功率放大， 并通过线圈输出， 产生交变的超低 频刺激磁场。
作为优化， 如图 5所示， 所述功率放大电路是音频放大芯片 TDA7294的 1 接口 STBY-GND接地， 音频放大芯片 TDA7294的 8和 15接口串接后分别通过 lOOnF的电容 C9接地、 接输入信号 _VS、 通过 1000nF的电容 C8接地； 音频放 大芯片 TDA7294的 7和 13接口串接后分别通过 100nF的电容 C7接地、接输入 信号 +VS、通过 lOOOnF的电容 C6接地； 音频放大芯片 TDA7294的 4接口接地， 音频放大芯片 TDA7294的 3接口通过 22K电阻 R1接地，音频放大芯片 TDA7294 的 2接口通过 680 Ω的电阻 R2接地， 还通过 22K电阻 R3连接音频放大芯片 TDA7294的 14接口、 22μ 电容 C5和线圈 303， 电容 C5再连接音频放大芯片 TDA7294的 6接口， 线圈 303再接地。 图 3中的输出信号 outputl与作为输入 与音频放大芯片 TDA7294的 3接口连接（四个音频放大芯片均接收该输出信号 outputl ), 图 3中的输出信号 output2与音频放大芯片 TDA7294的 10接口连 接 （四个音频放大芯片均接收该输出信号 output2 )。
如此设计， 功率放大电路采用了音频放大芯片 TDA7294,其额定输出功率 可达到 100W (工作电压为 ±32V时）。 各器件的作用如下表所示。
Figure imgf000009_0001
以上电子部件可以大于或小于推荐值， 其中： R1 用于输入阻抗、 大于推 荐值时用于提高输入阻抗、 小于推荐值时用于减小输入阻抗； R2 用于闭环增 益到 30DB, 大于推荐值时减小增益、 小于推荐值时增大增益； R3用于闭环增 益到 30DB, 大于推荐值时增大增益、 小于推荐值时减小增益； R4 用于 STBY 时间，大于推荐值时更高待机时间、小于推荐值时更小待机时间； R5用于 MUTE 时间，大于推荐值时更高静音时间、小于推荐值时更低静音时间； C3用于 MJTE 时间，大于推荐值时更高静音时间、小于推荐值时更低静音时间； C4用于 STBY 时间， 大于推荐值时更高待机时间、 小于推荐值时更小待机时间； C5 属于自 举电容、 小于推荐值时低频信号衰减； C6，C8用于电源过滤。 C7，C9用于电源 过滤。
作为优化， 所述功率放大电路的音频放大芯片为 TDA7294 型， 所述功率 放大电路的其额定输出功率达 100W、 工作电压为 ± 32V。 如此设计，匹配性好。
作为优化， 所述功率放大电路还包括静音控制电路， 如图 5所示， 静音控 制电路是音频放大芯片 TDA7294的 STBY端子通过 20K电阻 R20连接音频放大 芯片 TDA7294的 4接口， 还通过 ΙΟμΡ电容 C20接地； 音频放大芯片 TDA7294 的 MUTE端子通过 lO F电容 C21接地， 还依次通过相互并联的 30K电阻 R21、 IN4148二极管和 10K电阻 R22串接音频放大芯片 TDA7294的 4接口与电阻 R20 之间的连线。如此设计， 为了使在不需要磁场输出时， 线圈中没有任何干扰电 流， 其的输出为 0， 在功放电路中增加了静音控制。 其电路图如图 5所示， 当 MUTE端为高电平（+5V )时， TDA7294芯片正常工作， 对输入信号进行功率放 大。 当 MUTE端为低电平 （〈2. 5V) 时， TDA7294芯片静音， 即无论有无输入信 号， 输出电流为 0。
作为优化， 输出电流为非脉冲超低频的 0. 2Hz以下电流、 电场或磁场； 输 出的电流与电极连接用于电治疗， 与线圈连接用于磁治疗； 输出电流为单一频 率的非脉冲超低频的电流，和多种频率的的非脉冲超低频电流的组合输出，单 一频率电流和多种频率组合电流同时输出或分时输出；或输出电流为多种频率 的组合输出， 组合输出时采用调制输出或叠加输出。
作为优化，刺激频率 0. 001Hz〜20Hz按 1毫赫兹连续可调，可以通过调节 选择相应的频率，例如 0. 001Hz， 0. 002Hz, 0. 003Hz， 0. 005 Hz, 0. 01Hz, 0. 1Hz, 0. 2Hz, 0. 5Hz， 1Hz, 2Hz, 4Hz， 8Hz， 10Hz, 16Hz, 18Hz 等不同的频率； 最 大磁场强度为 200高斯，连续可调； 输出波形为单个正弦波或多个正弦波的叠 力口。 如此设计， 其采用交变的超低频连续磁场， 对人的大脑进行磁诱导， 从而 达到治疗和缓解大脑精神相关疾病的目的。
需要说明的是： 采用变压器供电， 功率为 1500W, 初级输入为 220VAC, 次 级为 28VAC两路， 12VAC两路。 其中两路 28V输出串联整流后为功放板供电； 两路 12V输出串联整流后为电平平移与变换电路和 ARM控制模块供电。
本发明还提供了一种超低频磁刺激装置的工作方法， 包括：
步骤 1， 生成频率为 20Hz以下的直流刺激信号；
步骤 2， 对刺激信号进行电位平移， 使之交流刺激信号；
步骤 3， 对交流刺激信号进行功率放大， 并产生电流、 电场或磁场。 工业应用性
本发明超低频磁刺激装置的输出电流为非脉冲超低频的电流 （20Hz 以 下）、 电场或磁场； 输出的电流可与电极连接用于电治疗， 可与线圈连接用于 磁治疗； 输出电流为单一频率的连续非脉冲超低频的电流，和多种频率的非脉 冲连续超低频电流的组合输出，可同时输出或分时输出； 可多种频率的组合输 出治疗， 可采用调制输出或叠加输出； 其采用交变的超低频非脉冲磁场， 对人 的大脑进行磁诱导， 从而达到治疗和缓解大脑精神相关疾病的目的。

Claims

1 . 一种超低频磁刺激装置， 其特征在于， 该装置包括控制模块、 电平平 移与变换电路、 输出模块， 其中，
控制模块， 用于生成频率为 20Hz以下的直流刺激信号；
电平平移与变换电路，用于对刺激信号进行电位平移，使之成为交流刺激 信号；
权
输出模块，用于对交流刺激信号进行功率放大，并产生电流、电场或磁场。
2. 如权利要求 1所述的超低频磁刺激装置， 其特征在于， 控制模块包括 ARM处理器以及音频芯片， 音频芯片在 ARM处理器的控制下产生所述直流刺激 信号。
3. 如权利要求 1所述的超低频磁刺激装置， 其特征在于， 还包括人机界 书
面， 与 ARM通信以实现人机界面控制。
4. 如权利要求 2所述的超低频磁刺激装置， 其特征在于， 控制模块采用 型号为 QQ2440V3的开发板，所述音频芯片为 UDA1341TS; UDA1341TS通过输出 口的电容 （C45 ) 和电容 （C46 ) 短接， 通过输出口的电阻 （R4) 和电阻 （R9 ) R9接地。
5. 如权利要求 1所述的超低频磁刺激装置， 其特征在于， 输出模块包括 至少一个功率放大电路， 功率放大电路的输出端和一个线圈连接。
6. 如权利要求 2所述的超低频磁刺激装置， 其特征在于， 输出模块包括 至少一个功率放大电路， 功率放大电路的输出端和一个电极连接。
7. 如权利要求 1所述的超低频磁刺激装置， 其特征在于， 所述交流刺激 信号是以 0V为基准的交流刺激信号。
8. 如权利要求 5所述的超低频磁刺激装置， 其特征在于， 所述功率放大 电路为芯片 TDA7294;控制模块还用于输出芯片 TDA7294所需的静音控制信号。
9.如权利要求 8所述的超低频磁刺激装置，其特征在于，控制模块为 ARM 处理器； 电平平移与变换电路还用于将静音控制信号的电压变换，将高电平为 3. 3V的静音控制信号变换为 5V的静音控制信号输出至芯片 TDA7294。
10. 根据权利要求 1-9任一项所述超低频磁刺激装置， 其特征在于， 输出 电流为单一频率的非脉冲超低频的电流和 /或多种频率的非脉冲超低频电流的 组合输出； 单一频率电流和 /或多种频率组合电流同时输出或分时输出。
11. 根据权利要求 10所述超低频磁刺激装置， 其特征在于， 多种频率的 组合输出时采用调制输出或叠加输出。
12. 一种超低频磁刺激装置的工作方法， 其特征在于， 包括：
步骤 1， 生成频率为 20Hz以下的直流刺激信号；
步骤 2， 对刺激信号进行电位平移， 使之成为交流刺激信号；
步骤 3， 对交流刺激信号进行功率放大， 并产生电流、 电场或磁场。
PCT/CN2009/000162 2009-02-18 2009-02-18 一种超低频磁刺激装置及其工作方法 WO2010094147A1 (zh)

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