WO2010092597A3 - Liposomal citicoline injection - Google Patents

Liposomal citicoline injection Download PDF

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Publication number
WO2010092597A3
WO2010092597A3 PCT/IN2010/000074 IN2010000074W WO2010092597A3 WO 2010092597 A3 WO2010092597 A3 WO 2010092597A3 IN 2010000074 W IN2010000074 W IN 2010000074W WO 2010092597 A3 WO2010092597 A3 WO 2010092597A3
Authority
WO
WIPO (PCT)
Prior art keywords
liposomal
citicoline
injection
citicoline injection
entrapped
Prior art date
Application number
PCT/IN2010/000074
Other languages
French (fr)
Other versions
WO2010092597A2 (en
Inventor
Ambikanandan Rajnarayan Misra
Narendra Ishwarlal Gandhi
Mannalal Ramgopal Bajaj
Bharat Babulal Shah
Rajan Shantaram Samant
Ahmad Sattar Pinjari Jamil
Original Assignee
Lyka Labs Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lyka Labs Limited filed Critical Lyka Labs Limited
Priority to EP10719637A priority Critical patent/EP2395977A2/en
Priority to JP2011548849A priority patent/JP2012517421A/en
Priority to CN201080007338XA priority patent/CN102316852A/en
Publication of WO2010092597A2 publication Critical patent/WO2010092597A2/en
Publication of WO2010092597A3 publication Critical patent/WO2010092597A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed herein is a stable sustained release liposomal injection comprising Citicoline entrapped in the ammonium sulfate liposomes, useful to enhance brain uptake efficiency.
PCT/IN2010/000074 2009-02-11 2010-02-10 Liposomal citicoline injection WO2010092597A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP10719637A EP2395977A2 (en) 2009-02-11 2010-02-10 Liposomal citicoline injection
JP2011548849A JP2012517421A (en) 2009-02-11 2010-02-10 Liposome citicoline injection
CN201080007338XA CN102316852A (en) 2009-02-11 2010-02-10 Liposomal citicoline injection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN295/MUM/2009 2009-02-11
IN295MU2009 2009-02-11

Publications (2)

Publication Number Publication Date
WO2010092597A2 WO2010092597A2 (en) 2010-08-19
WO2010092597A3 true WO2010092597A3 (en) 2011-03-24

Family

ID=42335080

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000074 WO2010092597A2 (en) 2009-02-11 2010-02-10 Liposomal citicoline injection

Country Status (4)

Country Link
EP (1) EP2395977A2 (en)
JP (1) JP2012517421A (en)
CN (1) CN102316852A (en)
WO (1) WO2010092597A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102078299B (en) * 2011-01-04 2012-09-26 海南美大制药有限公司 Citicoline sodium liposome solid preparation
US10905705B2 (en) * 2012-10-30 2021-02-02 Kyowa Hakko Bio Co., Ltd. Agent for preventing or improving decline in brain function
CN103006550A (en) * 2012-12-11 2013-04-03 哈药集团三精制药股份有限公司 Citicoline sodium injection and preparation method thereof
IT201600103956A1 (en) * 2016-10-17 2018-04-17 Omikron Italia S R L OPHTHALMIC FORMULATION INCLUDING CYTICOLINE VEHICULATED BY LIPOSOMAS FOR THE TREATMENT OF GLAUCOMA

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0114577A1 (en) * 1983-01-21 1984-08-01 MAGIS FARMACEUTICI S.p.A. New pharmaceutical composition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3993754A (en) 1974-10-09 1976-11-23 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome-encapsulated actinomycin for cancer chemotherapy
US4086257A (en) 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
CH624011A5 (en) 1977-08-05 1981-07-15 Battelle Memorial Institute
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4522803A (en) 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4588578A (en) 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
CN101264056A (en) * 2008-04-22 2008-09-17 复旦大学 Epirubicin hydrochloride liposome and preparation thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0114577A1 (en) * 1983-01-21 1984-08-01 MAGIS FARMACEUTICI S.p.A. New pharmaceutical composition

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FRESTA MASSIMO ET AL: "Reduction of maturation phenomenon in cerebral ischemia with CDP-choline-loaded liposomes", PHARMACEUTICAL RESEARCH (NEW YORK), vol. 16, no. 12, December 1999 (1999-12-01), pages 1843 - 1849, XP002615517, ISSN: 0724-8741 *
HARAN G ET AL: "Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases", BIOCHIMICA ET BIOPHYSICA ACTA. BIOMEMBRANES, AMSTERDAM, NL, vol. 1151, no. 2, 19 September 1993 (1993-09-19), pages 201 - 215, XP023128292, ISSN: 0005-2736, [retrieved on 19930919], DOI: DOI:10.1016/0005-2736(93)90105-9 *
REDDY JANNAPALLY SURESH ET AL: "Radioprotective effect of transferrin targeted citicoline liposomes", JOURNAL OF DRUG TARGETING, vol. 14, no. 1, January 2006 (2006-01-01), pages 13 - 19, XP008130967, ISSN: 1061-186X *

Also Published As

Publication number Publication date
EP2395977A2 (en) 2011-12-21
JP2012517421A (en) 2012-08-02
CN102316852A (en) 2012-01-11
WO2010092597A2 (en) 2010-08-19

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