WO2010089760A3 - Controlled release, multiple unit pharmaceutical compositions - Google Patents

Controlled release, multiple unit pharmaceutical compositions Download PDF

Info

Publication number
WO2010089760A3
WO2010089760A3 PCT/IN2009/000310 IN2009000310W WO2010089760A3 WO 2010089760 A3 WO2010089760 A3 WO 2010089760A3 IN 2009000310 W IN2009000310 W IN 2009000310W WO 2010089760 A3 WO2010089760 A3 WO 2010089760A3
Authority
WO
WIPO (PCT)
Prior art keywords
coating layer
controlled release
multiple unit
pharmaceutical compositions
unit pharmaceutical
Prior art date
Application number
PCT/IN2009/000310
Other languages
French (fr)
Other versions
WO2010089760A2 (en
Inventor
Rampal Ashok
V. Sathyanarayana
Agarwala Udit
Kumar Singh Dinesh
Tallam Satyanarayan
Original Assignee
Alkem Laboratories Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkem Laboratories Ltd. filed Critical Alkem Laboratories Ltd.
Publication of WO2010089760A2 publication Critical patent/WO2010089760A2/en
Publication of WO2010089760A3 publication Critical patent/WO2010089760A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug

Abstract

The present invention relates to a controlled release, multiple unit pharmaceutical composition comprising a plurality of the same type of controlled release units, wherein each unit comprises of a core, a first coating layer surrounding the outer surface of the said core, wherein the coating layer comprises carvedilol or a pharmaceutically acceptable salt thereof; a second coating layer surrounding the outer surface of the first coating layer comprising one or more enteric polymers; and optionally, one or more additional coating layer(s) which are the first coating layer and/or second coating layer surrounding the outer surface of the second coating layer.
PCT/IN2009/000310 2008-05-29 2009-05-29 Controlled release, multiple unit pharmaceutical compositions WO2010089760A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1154/MUM/2008 2008-05-29
IN1154MU2008 2008-05-29

Publications (2)

Publication Number Publication Date
WO2010089760A2 WO2010089760A2 (en) 2010-08-12
WO2010089760A3 true WO2010089760A3 (en) 2010-11-25

Family

ID=42542461

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000310 WO2010089760A2 (en) 2008-05-29 2009-05-29 Controlled release, multiple unit pharmaceutical compositions

Country Status (1)

Country Link
WO (1) WO2010089760A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056336A2 (en) * 2002-12-20 2004-07-08 Ranbaxy Laboratories Limited Controlled release, multiple unit drug delivery systems
WO2005051322A2 (en) * 2003-11-25 2005-06-09 Sb Pharmco Puerto Rico Inc. Controlled release pharmaceutical formulations comprising carvedilol, free based and its salts
WO2008083130A2 (en) * 2006-12-26 2008-07-10 Dr. Reddy's Laboratories Limited Amorphous and crystalline form a of carvedilol phosphate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056336A2 (en) * 2002-12-20 2004-07-08 Ranbaxy Laboratories Limited Controlled release, multiple unit drug delivery systems
WO2005051322A2 (en) * 2003-11-25 2005-06-09 Sb Pharmco Puerto Rico Inc. Controlled release pharmaceutical formulations comprising carvedilol, free based and its salts
WO2008083130A2 (en) * 2006-12-26 2008-07-10 Dr. Reddy's Laboratories Limited Amorphous and crystalline form a of carvedilol phosphate

Also Published As

Publication number Publication date
WO2010089760A2 (en) 2010-08-12

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