WO2010085086A2 - 변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법 - Google Patents

변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법 Download PDF

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Publication number
WO2010085086A2
WO2010085086A2 PCT/KR2010/000368 KR2010000368W WO2010085086A2 WO 2010085086 A2 WO2010085086 A2 WO 2010085086A2 KR 2010000368 W KR2010000368 W KR 2010000368W WO 2010085086 A2 WO2010085086 A2 WO 2010085086A2
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WO
WIPO (PCT)
Prior art keywords
polypeptide fragment
modified human
manufacturing
human thrombopoietin
thrombopoietin polypeptide
Prior art date
Application number
PCT/KR2010/000368
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English (en)
French (fr)
Other versions
WO2010085086A3 (ko
Inventor
김성욱
전성수
박승국
정재갑
이성률
송연정
심원조
Original Assignee
한올바이오파마 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 한올바이오파마 주식회사 filed Critical 한올바이오파마 주식회사
Priority to US13/145,513 priority Critical patent/US20110294733A1/en
Priority to EP10733639A priority patent/EP2390261A4/en
Publication of WO2010085086A2 publication Critical patent/WO2010085086A2/ko
Publication of WO2010085086A3 publication Critical patent/WO2010085086A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/196—Thrombopoietin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

본 발명은 생체내외(in vivo, in vitro)에서 혈소판 증식능을 가지면서 생체내에 존재하는 단백질 분해효소(protease)에 대한 저항성이 향상된 변형된 인간 트롬보포이에틴 폴리펩타이드 절편(human thrombopoietin polypeptide fragment)을 제공한다.
PCT/KR2010/000368 2009-01-20 2010-01-20 변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법 WO2010085086A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US13/145,513 US20110294733A1 (en) 2009-01-20 2010-01-20 Modified human thrombopoietin polypeptide fragment and manufacturing method thereof
EP10733639A EP2390261A4 (en) 2009-01-20 2010-01-20 MODIFIED HUMAN THROMBOPOIETIN POLYPEPTIDE FRAGMENT AND METHOD FOR THE PRODUCTION THEREOF

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20090004812 2009-01-20
KR10-2009-004812 2009-01-20

Publications (2)

Publication Number Publication Date
WO2010085086A2 true WO2010085086A2 (ko) 2010-07-29
WO2010085086A3 WO2010085086A3 (ko) 2010-12-09

Family

ID=42356320

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/000368 WO2010085086A2 (ko) 2009-01-20 2010-01-20 변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법

Country Status (4)

Country Link
US (1) US20110294733A1 (ko)
EP (1) EP2390261A4 (ko)
KR (1) KR101040396B1 (ko)
WO (1) WO2010085086A2 (ko)

Citations (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
EP0036676A1 (en) 1978-03-24 1981-09-30 The Regents Of The University Of California Method of making uniformly sized liposomes and liposomes so made
EP0052322A2 (de) 1980-11-10 1982-05-26 Gersonde, Klaus, Prof. Dr. Verfahren zur Herstellung von Lipid-Vesikeln durch Ultraschallbehandlung, Anwendung des Verfahrens und Vorrichtung zur Durchführung des Verfahrens
EP0058481A1 (en) 1981-02-16 1982-08-25 Zeneca Limited Continuous release pharmaceutical compositions
JPS58118008A (ja) 1982-01-06 1983-07-13 Nec Corp デ−タ処理装置
EP0088046A2 (de) 1982-02-17 1983-09-07 Ciba-Geigy Ag Lipide in wässriger Phase
DE3218121A1 (de) 1982-05-14 1983-11-17 Leskovar, Peter, Dr.-Ing., 8000 München Arzneimittel zur tumorbehandlung
EP0102324A2 (de) 1982-07-29 1984-03-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
EP0133988A2 (de) 1983-08-02 1985-03-13 Hoechst Aktiengesellschaft Regulatorische Peptide enthaltende pharmazeutische Präparate mit protrahierter Freisetzung und Verfahren zu deren Herstellung
EP0142641A2 (de) 1983-09-26 1985-05-29 Udo Dr. Ehrenfeld Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr
EP0143949A1 (en) 1983-11-01 1985-06-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Pharmaceutical composition containing urokinase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
WO1995017062A1 (en) 1993-12-17 1995-06-22 Taligent, Inc. Object-oriented rule-based protocol system
WO1995018858A1 (en) 1994-01-03 1995-07-13 Genentech, Inc. Thrombopoietin
WO1995021920A1 (en) 1994-02-14 1995-08-17 Zymogenetics, Inc. Hematopoietic protein and materials and methods for making it
WO1995026746A1 (en) 1994-03-31 1995-10-12 Amgen Inc. Compositions and methods for stimulating megakaryocyte growth and differentiation
WO1996023888A1 (en) 1995-02-03 1996-08-08 G.D. Searle & Co. NOVEL c-MPL LIGANDS
WO1996025498A2 (en) 1995-02-15 1996-08-22 Amgen Inc. Mpl ligand analogs
WO2000000612A1 (en) 1998-06-30 2000-01-06 Daewoong Pharmaceutical Co., Ltd. A novel human thrombopoietin mutein

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19980075710A (ko) * 1997-03-31 1998-11-16 김윤배 인간 트롬보포이에틴 (hTPO) 활성을 나타내는 단백질 및 그의 제조방법
JP2004533812A (ja) * 2001-02-26 2004-11-11 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 低減された免疫原性を有する修飾されたトロンボポエチン
JP2003024076A (ja) * 2001-07-12 2003-01-28 Kirin Brewery Co Ltd Ｔｐｏ変異体タンパク質
AU2003276846A1 (en) * 2002-08-09 2004-02-25 Xencor Thrombopoiesis-stimulating proteins having reduced immunogenicity
WO2004022593A2 (en) * 2002-09-09 2004-03-18 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
ATE368687T1 (de) * 2003-06-26 2007-08-15 Merck Patent Gmbh Thrombopoietinproteine mit verbesserten eigenschaften

Patent Citations (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
EP0036676A1 (en) 1978-03-24 1981-09-30 The Regents Of The University Of California Method of making uniformly sized liposomes and liposomes so made
EP0052322A2 (de) 1980-11-10 1982-05-26 Gersonde, Klaus, Prof. Dr. Verfahren zur Herstellung von Lipid-Vesikeln durch Ultraschallbehandlung, Anwendung des Verfahrens und Vorrichtung zur Durchführung des Verfahrens
EP0058481A1 (en) 1981-02-16 1982-08-25 Zeneca Limited Continuous release pharmaceutical compositions
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
JPS58118008A (ja) 1982-01-06 1983-07-13 Nec Corp デ−タ処理装置
EP0088046A2 (de) 1982-02-17 1983-09-07 Ciba-Geigy Ag Lipide in wässriger Phase
DE3218121A1 (de) 1982-05-14 1983-11-17 Leskovar, Peter, Dr.-Ing., 8000 München Arzneimittel zur tumorbehandlung
EP0102324A2 (de) 1982-07-29 1984-03-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
EP0133988A2 (de) 1983-08-02 1985-03-13 Hoechst Aktiengesellschaft Regulatorische Peptide enthaltende pharmazeutische Präparate mit protrahierter Freisetzung und Verfahren zu deren Herstellung
EP0142641A2 (de) 1983-09-26 1985-05-29 Udo Dr. Ehrenfeld Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr
EP0143949A1 (en) 1983-11-01 1985-06-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Pharmaceutical composition containing urokinase
WO1995017062A1 (en) 1993-12-17 1995-06-22 Taligent, Inc. Object-oriented rule-based protocol system
WO1995018858A1 (en) 1994-01-03 1995-07-13 Genentech, Inc. Thrombopoietin
WO1995021920A1 (en) 1994-02-14 1995-08-17 Zymogenetics, Inc. Hematopoietic protein and materials and methods for making it
WO1995026746A1 (en) 1994-03-31 1995-10-12 Amgen Inc. Compositions and methods for stimulating megakaryocyte growth and differentiation
WO1996023888A1 (en) 1995-02-03 1996-08-08 G.D. Searle & Co. NOVEL c-MPL LIGANDS
WO1996025498A2 (en) 1995-02-15 1996-08-22 Amgen Inc. Mpl ligand analogs
WO2000000612A1 (en) 1998-06-30 2000-01-06 Daewoong Pharmaceutical Co., Ltd. A novel human thrombopoietin mutein

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* Cited by examiner, † Cited by third party
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CHANG ET AL., J. BIOL. CHEM., vol. 270, 1995, pages 511 - 514
DE SAUVAGE ET AL., NATURE, vol. 369, 1994, pages 533 - 538
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See also references of EP2390261A4
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 556
W. A PEARSON: "Methods in Enzymology", vol. 183, 1990, ACADEMIC PRESS, article "Rapid and Sensitive Sequence Comparison with FASTP and FASTA", pages: 63 - 98

Also Published As

Publication number Publication date
EP2390261A4 (en) 2012-11-14
EP2390261A9 (en) 2012-02-22
US20110294733A1 (en) 2011-12-01
EP2390261A2 (en) 2011-11-30
KR20100085879A (ko) 2010-07-29
KR101040396B1 (ko) 2011-06-09
WO2010085086A3 (ko) 2010-12-09

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