WO2010081764A3 - Genome-wide analysis for endothelial dysfunction - Google Patents

Genome-wide analysis for endothelial dysfunction Download PDF

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Publication number
WO2010081764A3
WO2010081764A3 PCT/EP2010/050130 EP2010050130W WO2010081764A3 WO 2010081764 A3 WO2010081764 A3 WO 2010081764A3 EP 2010050130 W EP2010050130 W EP 2010050130W WO 2010081764 A3 WO2010081764 A3 WO 2010081764A3
Authority
WO
WIPO (PCT)
Prior art keywords
genome
endothelial dysfunction
wide analysis
analysis
wide
Prior art date
Application number
PCT/EP2010/050130
Other languages
German (de)
French (fr)
Other versions
WO2010081764A2 (en
Inventor
Nele Friedrich
Robin Haring
Marcus Dörr
Reiner Biffar
Till Ittermann
Heyo K. Kroemer
Markus Lerch
Matthias Nauck
Dörte RADKE
Henry VÖLZKE
Henry Wallaschofski
Klaus Empen
Florian Ernst
Ralf Ewert
Stephan B. Felix
Georg Homuth
Daniel M. Robinson
Alexander Teumer
Uwe Völker
Original Assignee
Siemens Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Aktiengesellschaft filed Critical Siemens Aktiengesellschaft
Publication of WO2010081764A2 publication Critical patent/WO2010081764A2/en
Publication of WO2010081764A3 publication Critical patent/WO2010081764A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to the use of point mutations identified as risk genes (single nucleotide polymorphism, SNP) for the diagnosis and therapy of diseases.
PCT/EP2010/050130 2009-01-16 2010-01-08 Genome-wide analysis for endothelial dysfunction WO2010081764A2 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
EP09150736.8 2009-01-16
EP09150736 2009-01-16
EP09161472 2009-05-29
EP09161472.7 2009-05-29
EP09161762 2009-06-03
EP09161762.1 2009-06-03
EP09167042.2 2009-08-03
EP09167042 2009-08-03
EP09167813.6 2009-08-13
EP09167813 2009-08-13

Publications (2)

Publication Number Publication Date
WO2010081764A2 WO2010081764A2 (en) 2010-07-22
WO2010081764A3 true WO2010081764A3 (en) 2010-10-14

Family

ID=42040599

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/050130 WO2010081764A2 (en) 2009-01-16 2010-01-08 Genome-wide analysis for endothelial dysfunction

Country Status (1)

Country Link
WO (1) WO2010081764A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108034723A (en) * 2017-12-19 2018-05-15 美因健康科技（北京）有限公司 The probe and primer that taqman sonde methods carry out the method for TP53 tumor susceptibility gene examinations and use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008118415A2 (en) * 2007-03-22 2008-10-02 Applera Corporation Genetic polymorphisms associated with coronary events and drug response

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008118415A2 (en) * 2007-03-22 2008-10-02 Applera Corporation Genetic polymorphisms associated with coronary events and drug response

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GLINSKY GENNADI V: "An SNP-guided microRNA map of fifteen common human disorders identifies a consensus disease phenocode aiming at principal components of the nuclear import pathway", CELL CYCLE, LANDES BIOSCIENCE, US, vol. 7, no. 16, 15 August 2008 (2008-08-15), pages 2570 - 2583, XP009122425, ISSN: 1551-4005 *
VASAN RAMACHANDRAN S ET AL: "Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study", BMC MEDICAL GENETICS, BIOMED CENTRAL, LONDON, GB LNKD- DOI:10.1186/1471-2350-8-S1-S2, vol. 8, no. Suppl 1, 19 September 2007 (2007-09-19), pages S2, XP021029000, ISSN: 1471-2350 *

Also Published As

Publication number Publication date
WO2010081764A2 (en) 2010-07-22

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