WO2010073248A3 - Signature d'expression génétique pour la classification de tissu provenant d'échantillons tumoraux - Google Patents

Signature d'expression génétique pour la classification de tissu provenant d'échantillons tumoraux Download PDF

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Publication number
WO2010073248A3
WO2010073248A3 PCT/IL2009/001212 IL2009001212W WO2010073248A3 WO 2010073248 A3 WO2010073248 A3 WO 2010073248A3 IL 2009001212 W IL2009001212 W IL 2009001212W WO 2010073248 A3 WO2010073248 A3 WO 2010073248A3
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WIPO (PCT)
Prior art keywords
classification
origin
tissue
gene expression
tumor samples
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PCT/IL2009/001212
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English (en)
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WO2010073248A2 (fr
Inventor
Ranit Aharonov
Nitzan Rosenfeld
Shai Rosenwald
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Rosetta Genomics Ltd.
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Application filed by Rosetta Genomics Ltd. filed Critical Rosetta Genomics Ltd.
Priority to CN200980157378XA priority Critical patent/CN102333888B/zh
Publication of WO2010073248A2 publication Critical patent/WO2010073248A2/fr
Publication of WO2010073248A3 publication Critical patent/WO2010073248A3/fr
Priority to IL212979A priority patent/IL212979A/en
Priority to US13/167,489 priority patent/US8802599B2/en
Priority to US13/856,190 priority patent/US9096906B2/en
Priority to US14/320,113 priority patent/US20140315739A1/en
Priority to US14/746,487 priority patent/US20150368724A1/en
Priority to US15/853,258 priority patent/US20180127835A1/en
Priority to US15/909,145 priority patent/US20190032142A1/en
Priority to US16/226,406 priority patent/US20190241966A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Databases & Information Systems (AREA)
  • Artificial Intelligence (AREA)
  • Data Mining & Analysis (AREA)
  • Software Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • General Engineering & Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioethics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Signal Processing (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La présente invention concerne un procédé pour la classification de cancers et de tissus d'origine par l'analyse de profils d'expression de micro-ARN spécifiques et de molécules d'acide nucléique qui y sont associées. La classification selon un cadre d'expression basée sur un arbre des micro-ARN permet l'optimisation de traitement, et la détermination de thérapie spécifique.
PCT/IL2009/001212 2007-03-27 2009-12-23 Signature d'expression génétique pour la classification de tissu provenant d'échantillons tumoraux WO2010073248A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
CN200980157378XA CN102333888B (zh) 2008-12-24 2009-12-23 用于肿瘤样本起源组织分类的基因表达签名
IL212979A IL212979A (en) 2008-12-24 2011-05-18 Gene expression signature to classify the source tissue of cancer tumor samples
US13/167,489 US8802599B2 (en) 2007-03-27 2011-06-23 Gene expression signature for classification of tissue of origin of tumor samples
US13/856,190 US9096906B2 (en) 2007-03-27 2013-04-03 Gene expression signature for classification of tissue of origin of tumor samples
US14/320,113 US20140315739A1 (en) 2007-03-27 2014-06-30 Gene expression signature for classification of tissue of origin of tumor samples
US14/746,487 US20150368724A1 (en) 2007-03-27 2015-06-22 Methods and materials for classification of tissue of origin of tumor samples
US15/853,258 US20180127835A1 (en) 2007-03-27 2017-12-22 Gene expression signature for classification of tissue of origin of tumor samples
US15/909,145 US20190032142A1 (en) 2007-03-27 2018-03-01 Methods and materials for classification of tissue of origin of tumor samples
US16/226,406 US20190241966A1 (en) 2007-03-27 2018-12-19 Gene Expression Signature for Classification of Tissue of Origin of Tumor Samples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14064208P 2008-12-24 2008-12-24
US61/140,642 2008-12-24

Related Parent Applications (4)

Application Number Title Priority Date Filing Date
US12/532,940 Continuation-In-Part US20100178653A1 (en) 2007-03-27 2008-03-20 Gene expression signature for classification of cancers
PCT/IL2008/000396 Continuation-In-Part WO2008117278A2 (fr) 2007-03-27 2008-03-20 Signature d'une expression génique permettant la classification des cancers
US53294009A Continuation-In-Part 2007-03-27 2009-09-24
PCT/IL2011/000849 Continuation-In-Part WO2012070037A2 (fr) 2007-03-27 2011-11-01 Procédés et matériaux pour la classification de tissus originaires d'échantillons tumoraux

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/167,489 Continuation-In-Part US8802599B2 (en) 2007-03-27 2011-06-23 Gene expression signature for classification of tissue of origin of tumor samples

Publications (2)

Publication Number Publication Date
WO2010073248A2 WO2010073248A2 (fr) 2010-07-01
WO2010073248A3 true WO2010073248A3 (fr) 2010-09-16

Family

ID=42288202

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PCT/IL2009/001212 WO2010073248A2 (fr) 2007-03-27 2009-12-23 Signature d'expression génétique pour la classification de tissu provenant d'échantillons tumoraux

Country Status (2)

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CN (1) CN102333888B (fr)
WO (1) WO2010073248A2 (fr)

Families Citing this family (28)

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US9096906B2 (en) 2007-03-27 2015-08-04 Rosetta Genomics Ltd. Gene expression signature for classification of tissue of origin of tumor samples
WO2012070037A2 (fr) 2010-11-22 2012-05-31 Rosetta Genomics Ltd. Procédés et matériaux pour la classification de tissus originaires d'échantillons tumoraux
AU2009253675A1 (en) 2008-05-28 2009-12-03 Genomedx Biosciences, Inc. Systems and methods for expression-based discrimination of distinct clinical disease states in prostate cancer
JP6257125B2 (ja) 2008-11-17 2018-01-10 ベラサイト インコーポレイテッド 疾患診断のための分子プロファイリングの方法および組成物
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
US9074258B2 (en) 2009-03-04 2015-07-07 Genomedx Biosciences Inc. Compositions and methods for classifying thyroid nodule disease
EP3360978A3 (fr) 2009-05-07 2018-09-26 Veracyte, Inc. Procédés pour le diagnostic d'affections thyroïdiennes
US10446272B2 (en) 2009-12-09 2019-10-15 Veracyte, Inc. Methods and compositions for classification of samples
WO2011154008A1 (fr) * 2010-06-11 2011-12-15 Rigshospitalet Classification de micro-arn de néoplasie folliculaire de la thyroïde
WO2012010584A1 (fr) * 2010-07-20 2012-01-26 Febit Holding Gmbh Ensembles de miarn complexes en tant que nouveaux biomarqueurs pour le cancer gastrique
WO2012068400A2 (fr) 2010-11-17 2012-05-24 Asuragen, Inc. Micro-arn utilisés comme biomarqueurs pour faire la distinction entre des néoplasmes thyroïdiens bénins et malins
EP2505663A1 (fr) 2011-03-30 2012-10-03 IFOM Fondazione Istituto Firc di Oncologia Molecolare Procédé pour identifier des individus asymptomatiques à haut risque touchés par un cancer du poumon à l'état précoce au moyen de la détection d'ARNmi dans les liquides corporels
EP2691545B1 (fr) * 2011-03-28 2017-06-14 Rosetta Genomics Ltd Procédés pour la classification des cancers du poumon
US9568483B2 (en) * 2011-04-18 2017-02-14 Cornell University Molecular subtyping, prognosis and treatment of prostate cancer
JP6011945B2 (ja) * 2011-05-20 2016-10-25 公一 中城 マイクロｒｎａ又はその発現系を含む組成物
US8831327B2 (en) 2011-08-30 2014-09-09 General Electric Company Systems and methods for tissue classification using attributes of a biomarker enhanced tissue network (BETN)
ES2688619T3 (es) * 2011-12-22 2018-11-05 Interna Technologies B.V. MiARN para tratar el cáncer de cabeza y de cuello
EP2653558B1 (fr) 2012-04-18 2015-10-07 Roche Diagniostics GmbH Procédé de détection de cibles d'acide nucléique à l'aide d'un classificateur statistique
US11035005B2 (en) 2012-08-16 2021-06-15 Decipher Biosciences, Inc. Cancer diagnostics using biomarkers
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
CN114606309A (zh) 2014-11-05 2022-06-10 威拉赛特公司 使用机器学习和高维转录数据的诊断系统和方法
EP3504348B1 (fr) 2016-08-24 2022-12-14 Decipher Biosciences, Inc. Utilisation de signatures génomiques en vue d'une prédiction de la réactivité de patients atteints d'un cancer de la prostate à une radiothérapie postopératoire
US11208697B2 (en) 2017-01-20 2021-12-28 Decipher Biosciences, Inc. Molecular subtyping, prognosis, and treatment of bladder cancer
EP3593140A4 (fr) 2017-03-09 2021-01-06 Decipher Biosciences, Inc. Sous-typage du cancer de la prostate pour prédire la réponse à une thérapie hormonale
AU2018266733A1 (en) 2017-05-12 2020-01-16 Veracyte, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness
US11217329B1 (en) 2017-06-23 2022-01-04 Veracyte, Inc. Methods and systems for determining biological sample integrity
CN110706749B (zh) * 2019-09-10 2022-06-10 至本医疗科技（上海）有限公司 一种基于组织器官分化层次关系的癌症类型预测系统和方法

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WO2010073248A2 (fr) 2010-07-01
CN102333888A (zh) 2012-01-25
CN102333888B (zh) 2013-07-10

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