WO2010069317A8 - Bursts of electrical pulses in the treatment of pelvic disorders by electrical nerve stimulation - Google Patents

Bursts of electrical pulses in the treatment of pelvic disorders by electrical nerve stimulation Download PDF

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Publication number
WO2010069317A8
WO2010069317A8 PCT/DK2009/000256 DK2009000256W WO2010069317A8 WO 2010069317 A8 WO2010069317 A8 WO 2010069317A8 DK 2009000256 W DK2009000256 W DK 2009000256W WO 2010069317 A8 WO2010069317 A8 WO 2010069317A8
Authority
WO
WIPO (PCT)
Prior art keywords
electrical
pulses
bursts
treatment
nerve stimulation
Prior art date
Application number
PCT/DK2009/000256
Other languages
French (fr)
Other versions
WO2010069317A1 (en
Inventor
Morten Fjordback
Thomas Borup
Michael Eriksen
Nico J. M. Rijkhoff
Dianna Mærsk KNUDSEN
Original Assignee
Neurodan A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurodan A/S filed Critical Neurodan A/S
Priority to EP09802104A priority Critical patent/EP2376188A1/en
Publication of WO2010069317A1 publication Critical patent/WO2010069317A1/en
Publication of WO2010069317A8 publication Critical patent/WO2010069317A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36007—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of urogenital or gastrointestinal organs, e.g. for incontinence control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36157—Current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36178—Burst or pulse train parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36132—Control systems using patient feedback

Abstract

In a system and method for the treatment of urge urinary incontinence by electrical stimulation of pudendal nerve afferents of a living being a first sequence of electrical stimulation pulses are initially provided at a first setting. The pulses are provided continuously or cyclically to an electrode configured to be placed on a portion of a pudendal nerve or its branches. Upon an external control signal preferably provided by the patient to the pulse generator, the pulse generator enters a burst mode providing a sequence of pulses comprising a number of electrical bursts. The continuous or cyclical stimulation according to the first mode is resumed upon completion of the bursts of electrical pulses.
PCT/DK2009/000256 2008-12-19 2009-12-14 Bursts of electrical pulses in the treatment of pelvic disorders by electrical nerve stimulation WO2010069317A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09802104A EP2376188A1 (en) 2008-12-19 2009-12-14 Bursts of electrical pulses in the treatment of pelvic disorders by electrical nerve stimulation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13931808P 2008-12-19 2008-12-19
EPEP08172446.0 2008-12-19
EP08172446 2008-12-19
US61/139,318 2008-12-19

Publications (2)

Publication Number Publication Date
WO2010069317A1 WO2010069317A1 (en) 2010-06-24
WO2010069317A8 true WO2010069317A8 (en) 2011-08-25

Family

ID=40940243

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2009/000256 WO2010069317A1 (en) 2008-12-19 2009-12-14 Bursts of electrical pulses in the treatment of pelvic disorders by electrical nerve stimulation

Country Status (2)

Country Link
EP (1) EP2376188A1 (en)
WO (1) WO2010069317A1 (en)

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CN103313754B (en) 2010-11-16 2015-09-30 小利兰·斯坦福大学理事会 Be used for the treatment of the system and method for xerophthalmia
US9821159B2 (en) 2010-11-16 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Stimulation devices and methods
AU2012239966B2 (en) * 2011-04-07 2015-11-26 Oculeve, Inc. Stimulation devices and methods
US9717627B2 (en) 2013-03-12 2017-08-01 Oculeve, Inc. Implant delivery devices, systems, and methods
WO2014145222A2 (en) 2013-03-15 2014-09-18 Boston Scientific Neuromodulation Corporation Systems and methods for delivering sub-threshold therapy to a patient
EP2968938B1 (en) 2013-03-15 2019-06-26 Myndtec Inc. Electrical stimulation system with pulse control
US9694183B2 (en) 2013-03-15 2017-07-04 Boston Scientific Neuromodulation Corporation Neuromodulation system and method for providing multiple modulation patterns in a single channel
US10155108B2 (en) 2013-04-19 2018-12-18 Oculeve, Inc. Nasal stimulation devices and methods
US9960763B2 (en) 2013-11-14 2018-05-01 Eagle Harbor Technologies, Inc. High voltage nanosecond pulser
US10978955B2 (en) 2014-02-28 2021-04-13 Eagle Harbor Technologies, Inc. Nanosecond pulser bias compensation
US10020800B2 (en) 2013-11-14 2018-07-10 Eagle Harbor Technologies, Inc. High voltage nanosecond pulser with variable pulse width and pulse repetition frequency
US11539352B2 (en) 2013-11-14 2022-12-27 Eagle Harbor Technologies, Inc. Transformer resonant converter
JP6604963B2 (en) 2014-02-25 2019-11-20 オキュリーブ， インコーポレイテッド Polymer formulations for nasolacrimal gland stimulation
US10483089B2 (en) 2014-02-28 2019-11-19 Eagle Harbor Technologies, Inc. High voltage resistive output stage circuit
DK3171928T3 (en) 2014-07-25 2020-05-18 Oculeve Inc STIMULATION PATTERNS FOR TREATMENT OF DRY EYES
EP3721938A1 (en) 2014-10-22 2020-10-14 Oculeve, Inc. Stimulation devices and methods for treating dry eye
US9764150B2 (en) 2014-10-22 2017-09-19 Oculeve, Inc. Contact lens for increasing tear production
US10426958B2 (en) 2015-12-04 2019-10-01 Oculeve, Inc. Intranasal stimulation for enhanced release of ocular mucins and other tear proteins
US10252048B2 (en) 2016-02-19 2019-04-09 Oculeve, Inc. Nasal stimulation for rhinitis, nasal congestion, and ocular allergies
EP3452166A4 (en) 2016-05-02 2019-12-18 Oculeve, Inc. Intranasal stimulation for treatment of meibomian gland disease and blepharitis
US10780274B2 (en) 2016-08-22 2020-09-22 Boston Scientific Neuromodulation Corporation Systems and methods for delivering spinal cord stimulation therapy
RU2019118600A (en) 2016-12-02 2021-01-11 Окулив, Инк. APPARATUS AND METHOD FOR MAKING DRY EYE SYNDROME PREDICTION AND TREATMENT RECOMMENDATIONS
CN110692188B (en) 2017-02-07 2022-09-09 鹰港科技有限公司 Transformer resonant converter
EP3665775A4 (en) * 2017-08-25 2020-07-22 Eagle Harbor Technologies, Inc. Arbitrary waveform generation using nanosecond pulses
US11302518B2 (en) 2018-07-27 2022-04-12 Eagle Harbor Technologies, Inc. Efficient energy recovery in a nanosecond pulser circuit
US11222767B2 (en) 2018-07-27 2022-01-11 Eagle Harbor Technologies, Inc. Nanosecond pulser bias compensation
TW202308306A (en) 2019-01-08 2023-02-16 美商鷹港科技股份有限公司 Method for creating high voltage pulses

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AU758611B2 (en) * 1998-09-16 2003-03-27 Axon Engineering, Inc. Combined stimulation of ventral and dorsal sacral roots for control of bladder function
US6466822B1 (en) * 2000-04-05 2002-10-15 Neuropace, Inc. Multimodal neurostimulator and process of using it
WO2008153726A2 (en) * 2007-05-22 2008-12-18 Ndi Medical, Inc. Systems and methods for the treatment of bladder dysfunctions using neuromodulation stimulation
WO2006078958A2 (en) * 2005-01-21 2006-07-27 Virginia Technologies, Inc Energy efficient therapeutic pulse generator system
US8768452B2 (en) * 2005-02-23 2014-07-01 Medtronic, Inc. Implantable neurostimulator supporting trial and chronic modes
US7328070B2 (en) * 2005-04-28 2008-02-05 Medtronic, Inc. Multi-tube sensor for sensing urinary sphincter and urethral pressure
US7848802B2 (en) * 2006-02-24 2010-12-07 Medtronic, Inc. Programming interface with a concentric axial view of a stimulation lead with complex electrode array geometry
US20070255333A1 (en) * 2006-04-28 2007-11-01 Medtronic, Inc. Neuromodulation therapy for perineal or dorsal branch of pudendal nerve

Also Published As

Publication number Publication date
EP2376188A1 (en) 2011-10-19
WO2010069317A1 (en) 2010-06-24

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