WO2010068912A3 - Bioreactor recirculation loop device - Google Patents

Bioreactor recirculation loop device Download PDF

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Publication number
WO2010068912A3
WO2010068912A3 PCT/US2009/067739 US2009067739W WO2010068912A3 WO 2010068912 A3 WO2010068912 A3 WO 2010068912A3 US 2009067739 W US2009067739 W US 2009067739W WO 2010068912 A3 WO2010068912 A3 WO 2010068912A3
Authority
WO
WIPO (PCT)
Prior art keywords
recirculation loop
gas
temperature
reactant
bioreactor
Prior art date
Application number
PCT/US2009/067739
Other languages
French (fr)
Other versions
WO2010068912A2 (en
Inventor
Martin L. Sentmanat
Original Assignee
Smartin Technologies, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smartin Technologies, Llc filed Critical Smartin Technologies, Llc
Publication of WO2010068912A2 publication Critical patent/WO2010068912A2/en
Publication of WO2010068912A3 publication Critical patent/WO2010068912A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature

Landscapes

  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Thermal Sciences (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

A recirculation loop and device for movement of contents of a bioreactor vessel is described. The recirculation loop provides distinct zones of temperature, gas extraction and/or gas infusion control of the bioreactor contents during passage through the loop. The recirculation conduit within the distinct temperature, gas extraction and/or gas infusion control zones of the recirculation loop may contain a high surface area to volume aspect ratio thereby facilitating heat transfer as well as gas extraction and infusion. The recirculation loop device provides independent control of at least these three process control variables of a biochemical reaction, namely reactant dispersion, reactant temperature, and reactant gas concentration, in aerobic and anaerobic biochemical reaction processes.
PCT/US2009/067739 2008-12-12 2009-12-11 Bioreactor recirculation loop device WO2010068912A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61/112,302 2008-12-12
US11230208 2008-12-12

Publications (2)

Publication Number Publication Date
WO2010068912A2 WO2010068912A2 (en) 2010-06-17
WO2010068912A3 true WO2010068912A3 (en) 2010-09-23

Family

ID=42244068

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/067739 WO2010068912A2 (en) 2008-12-12 2009-12-11 Bioreactor recirculation loop device

Country Status (1)

Country Link
WO (1) WO2010068912A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8455242B2 (en) 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
WO2013184561A1 (en) * 2012-06-04 2013-12-12 Praxair Technology, Inc. System and method for micro-aeration based fermentation
CN102735828A (en) * 2012-06-21 2012-10-17 中国地质大学（武汉） Test system for determining primary productivity of river benthic algae
US9006148B2 (en) * 2012-09-13 2015-04-14 Harvey ZAR Methods using a progressive cavity pump bioreactor
ITMI20122115A1 (en) * 2012-12-11 2014-06-12 Dentro Il Sole S P A DIGESTO TH
CN103451089B (en) * 2013-08-30 2015-01-14 山西晋城无烟煤矿业集团有限责任公司 Culturing and detecting device for anaerobe of coal seam
EP3119504B1 (en) 2014-03-21 2020-10-14 Life Technologies Corporation Gas filter systems for fluid processing systems
KR102650666B1 (en) 2014-03-21 2024-03-25 라이프 테크놀로지스 코포레이션 Condenser systems for fluid processing systems
CN104634936A (en) * 2015-02-09 2015-05-20 浙江外国语学院 Simulation device for measuring succession regulations of benthic algae of rivers
WO2021195391A1 (en) * 2020-03-27 2021-09-30 Broadley-James Corporation Single-use bioreactor assembly with integrated pump heads
JP2024501109A (en) * 2020-11-30 2024-01-11 コーニング インコーポレイテッド Cell culture medium conditioning vessels and perfusion bioreactor systems

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032032A1 (en) * 2003-08-07 2005-02-10 Pearce Robert Clarence Biomass generator
US20050255584A1 (en) * 2004-04-16 2005-11-17 Sartorius Ag Bioreactor for culturing microorganisms
US20060141615A1 (en) * 2004-12-23 2006-06-29 Chao-Hui Lu Vegetable alga and microbe photosynthetic reaction system and method for the same
US20080160591A1 (en) * 2006-12-28 2008-07-03 Solix Biofuels, Inc./Colorado State University Research Foundation Diffuse Light Extended Surface Area Water-Supported Photobioreactor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032032A1 (en) * 2003-08-07 2005-02-10 Pearce Robert Clarence Biomass generator
US20050255584A1 (en) * 2004-04-16 2005-11-17 Sartorius Ag Bioreactor for culturing microorganisms
US20060141615A1 (en) * 2004-12-23 2006-06-29 Chao-Hui Lu Vegetable alga and microbe photosynthetic reaction system and method for the same
US20080160591A1 (en) * 2006-12-28 2008-07-03 Solix Biofuels, Inc./Colorado State University Research Foundation Diffuse Light Extended Surface Area Water-Supported Photobioreactor

Also Published As

Publication number Publication date
WO2010068912A2 (en) 2010-06-17

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