WO2010068491A3 - Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry - Google Patents

Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry Download PDF

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Publication number
WO2010068491A3
WO2010068491A3 PCT/US2009/065891 US2009065891W WO2010068491A3 WO 2010068491 A3 WO2010068491 A3 WO 2010068491A3 US 2009065891 W US2009065891 W US 2009065891W WO 2010068491 A3 WO2010068491 A3 WO 2010068491A3
Authority
WO
WIPO (PCT)
Prior art keywords
mass spectrometry
laser ablation
infrared laser
electrospray ionization
ionization mass
Prior art date
Application number
PCT/US2009/065891
Other languages
French (fr)
Other versions
WO2010068491A2 (en
Inventor
Akos Vertes
Peter Nemes
Original Assignee
The George Washington University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/323,276 external-priority patent/US7964843B2/en
Application filed by The George Washington University filed Critical The George Washington University
Priority to JP2011537736A priority Critical patent/JP2012510062A/en
Priority to EP09832362.9A priority patent/EP2356668B1/en
Priority to CA2744703A priority patent/CA2744703A1/en
Publication of WO2010068491A2 publication Critical patent/WO2010068491A2/en
Publication of WO2010068491A3 publication Critical patent/WO2010068491A3/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/145—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using chemical ionisation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0004—Imaging particle spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Electron Tubes For Measurement (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation with electrospray ionization (ESI).
PCT/US2009/065891 2008-11-25 2009-11-25 Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry WO2010068491A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2011537736A JP2012510062A (en) 2008-11-25 2009-11-25 Electrospray ionization mass spectrometry of three-dimensional molecular images by infrared laser ablation
EP09832362.9A EP2356668B1 (en) 2008-11-25 2009-11-25 Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry
CA2744703A CA2744703A1 (en) 2008-11-25 2009-11-25 Three-dimensional by infrared laser ablation molecular imaging electrospray ionization mass spectrometry

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12/323,276 US7964843B2 (en) 2008-07-18 2008-11-25 Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry
US12/323,276 2008-11-25
US26411909P 2009-11-24 2009-11-24
US61/264,119 2009-11-24

Publications (2)

Publication Number Publication Date
WO2010068491A2 WO2010068491A2 (en) 2010-06-17
WO2010068491A3 true WO2010068491A3 (en) 2010-08-26

Family

ID=42243279

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/065891 WO2010068491A2 (en) 2008-11-25 2009-11-25 Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry

Country Status (4)

Country Link
EP (2) EP2356668B1 (en)
JP (1) JP2012510062A (en)
CA (1) CA2744703A1 (en)
WO (1) WO2010068491A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102590089B (en) * 2012-01-13 2014-03-26 浙江大学 Indoor spectral observation three-dimensional objective table and application thereof
JP2023504585A (en) * 2019-11-27 2023-02-03 サーモ フィッシャー サイエンティフィック （ブレーメン） ゲーエムベーハー Systems and methods for imaging and ablating samples
WO2022080412A1 (en) * 2020-10-13 2022-04-21 花王株式会社 Method for predicting wheat yield
JPWO2023037536A1 (en) * 2021-09-13 2023-03-16

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050230635A1 (en) * 2004-03-30 2005-10-20 Zoltan Takats Method and system for desorption electrospray ionization
US20080020474A1 (en) * 2004-03-30 2008-01-24 Riken Method of Analyzing Biosample by Laser Ablation and Apparatus Therefor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10310518A1 (en) * 2003-03-09 2004-10-14 TransMIT Gesellschaft für Technologietransfer mbH Three-dimensional illustration of the chemical surface composition of objects
EP1648595B1 (en) * 2003-06-06 2016-05-04 Ionwerks Gold implantation/deposition on biological samples for laser desorption three dimensional depth profiling of tissues
US7170052B2 (en) * 2003-12-31 2007-01-30 Ionwerks, Inc. MALDI-IM-ortho-TOF mass spectrometry with simultaneous positive and negative mode detection
US8067730B2 (en) * 2007-07-20 2011-11-29 The George Washington University Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050230635A1 (en) * 2004-03-30 2005-10-20 Zoltan Takats Method and system for desorption electrospray ionization
US20080020474A1 (en) * 2004-03-30 2008-01-24 Riken Method of Analyzing Biosample by Laser Ablation and Apparatus Therefor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2356668A4 *

Also Published As

Publication number Publication date
CA2744703A1 (en) 2010-06-17
EP2356668A4 (en) 2012-05-30
WO2010068491A2 (en) 2010-06-17
JP2012510062A (en) 2012-04-26
EP2660848A1 (en) 2013-11-06
EP2356668B1 (en) 2013-07-17
EP2356668A2 (en) 2011-08-17

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