WO2010068037A3 - Anti-cancer composition containing 4-hexylresorcinol-1,3-diol as active ingredient - Google Patents
Anti-cancer composition containing 4-hexylresorcinol-1,3-diol as active ingredient Download PDFInfo
- Publication number
- WO2010068037A3 WO2010068037A3 PCT/KR2009/007361 KR2009007361W WO2010068037A3 WO 2010068037 A3 WO2010068037 A3 WO 2010068037A3 KR 2009007361 W KR2009007361 W KR 2009007361W WO 2010068037 A3 WO2010068037 A3 WO 2010068037A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cancer
- hexylresorcinol
- diol
- active ingredient
- cancer cells
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to an anti-cancer composition containing 4-hexylresorcinol-1,3-diol as an active ingredient. The active ingredient of the anti-cancer composition of the present invention, 4-hexylresorcinol-1,3-diol, suppresses proliferation of cancer cells and promotes apoptosis and differentiation of the cancer cells at cell level. As well, the 4-hexylresorcinol-1,3-diol suppresses tumor growth remarkably in a clinical trial on a xenografted animal model which is transplanted with cancer cells and a cancer patient. The anti-cancer composition of the present invention can be developed as a highly functional anti-cancer agent by having remarkable suppression activity for proliferation of various cancer cells.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2008-0125087 | 2008-12-10 | ||
KR1020080125087A KR20100066675A (en) | 2008-12-10 | 2008-12-10 | Composition for treating or preventing cancer comprising 4-hexylresorcinol-1,3-diol as an active ingredient |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2010068037A2 WO2010068037A2 (en) | 2010-06-17 |
WO2010068037A9 WO2010068037A9 (en) | 2010-09-02 |
WO2010068037A3 true WO2010068037A3 (en) | 2010-10-14 |
Family
ID=42243218
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2009/007361 WO2010068037A2 (en) | 2008-12-10 | 2009-12-09 | Anti-cancer composition containing 4-hexylresorcinol-1,3-diol as active ingredient |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR20100066675A (en) |
WO (1) | WO2010068037A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20210086463A (en) * | 2019-12-30 | 2021-07-08 | 경북대학교 산학협력단 | Pharmaceutical composition for preventing or treating bone disease comprising 4-hexylresorcinol |
-
2008
- 2008-12-10 KR KR1020080125087A patent/KR20100066675A/en not_active Application Discontinuation
-
2009
- 2009-12-09 WO PCT/KR2009/007361 patent/WO2010068037A2/en active Application Filing
Non-Patent Citations (3)
Title |
---|
BARBINI, L. ET AL.: "Induction of apoptosis on human hepatocarcinoma cell lines by an alkyl resorcinol isolated from Lithraea molleoides", WORLD JOURNAL OF GASASTROENTEROLOGY, vol. 12, no. 37, 2006, pages 5959 - 5963 * |
CHHABRA, R.S.: "Inhibition of some spontaneous tumors by 4-hexylresorcinol F344/N rats and B6C3F1 mice", FUNDAMENTAL AND APPLIED TOXICOLOGY, vol. 11, no. 4, 1988, pages 685 - 690 * |
KIM, SEONG GON ET AL.: "4-Hexylresorcinol Induced an Apoptosis and Differentiation of Oral Cancer Cells", JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, vol. 65, no. 9, 2007, pages 41E * |
Also Published As
Publication number | Publication date |
---|---|
KR20100066675A (en) | 2010-06-18 |
WO2010068037A2 (en) | 2010-06-17 |
WO2010068037A9 (en) | 2010-09-02 |
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