WO2010068037A3 - Anti-cancer composition containing 4-hexylresorcinol-1,3-diol as active ingredient - Google Patents

Anti-cancer composition containing 4-hexylresorcinol-1,3-diol as active ingredient Download PDF

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Publication number
WO2010068037A3
WO2010068037A3 PCT/KR2009/007361 KR2009007361W WO2010068037A3 WO 2010068037 A3 WO2010068037 A3 WO 2010068037A3 KR 2009007361 W KR2009007361 W KR 2009007361W WO 2010068037 A3 WO2010068037 A3 WO 2010068037A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer
hexylresorcinol
diol
active ingredient
cancer cells
Prior art date
Application number
PCT/KR2009/007361
Other languages
French (fr)
Korean (ko)
Other versions
WO2010068037A2 (en
WO2010068037A9 (en
Inventor
김성곤
최제용
Original Assignee
경북대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 경북대학교 산학협력단 filed Critical 경북대학교 산학협력단
Publication of WO2010068037A2 publication Critical patent/WO2010068037A2/en
Publication of WO2010068037A9 publication Critical patent/WO2010068037A9/en
Publication of WO2010068037A3 publication Critical patent/WO2010068037A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to an anti-cancer composition containing 4-hexylresorcinol-1,3-diol as an active ingredient. The active ingredient of the anti-cancer composition of the present invention, 4-hexylresorcinol-1,3-diol, suppresses proliferation of cancer cells and promotes apoptosis and differentiation of the cancer cells at cell level. As well, the 4-hexylresorcinol-1,3-diol suppresses tumor growth remarkably in a clinical trial on a xenografted animal model which is transplanted with cancer cells and a cancer patient. The anti-cancer composition of the present invention can be developed as a highly functional anti-cancer agent by having remarkable suppression activity for proliferation of various cancer cells.
PCT/KR2009/007361 2008-12-10 2009-12-09 Anti-cancer composition containing 4-hexylresorcinol-1,3-diol as active ingredient WO2010068037A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0125087 2008-12-10
KR1020080125087A KR20100066675A (en) 2008-12-10 2008-12-10 Composition for treating or preventing cancer comprising 4-hexylresorcinol-1,3-diol as an active ingredient

Publications (3)

Publication Number Publication Date
WO2010068037A2 WO2010068037A2 (en) 2010-06-17
WO2010068037A9 WO2010068037A9 (en) 2010-09-02
WO2010068037A3 true WO2010068037A3 (en) 2010-10-14

Family

ID=42243218

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/007361 WO2010068037A2 (en) 2008-12-10 2009-12-09 Anti-cancer composition containing 4-hexylresorcinol-1,3-diol as active ingredient

Country Status (2)

Country Link
KR (1) KR20100066675A (en)
WO (1) WO2010068037A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210086463A (en) * 2019-12-30 2021-07-08 경북대학교 산학협력단 Pharmaceutical composition for preventing or treating bone disease comprising 4-hexylresorcinol

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BARBINI, L. ET AL.: "Induction of apoptosis on human hepatocarcinoma cell lines by an alkyl resorcinol isolated from Lithraea molleoides", WORLD JOURNAL OF GASASTROENTEROLOGY, vol. 12, no. 37, 2006, pages 5959 - 5963 *
CHHABRA, R.S.: "Inhibition of some spontaneous tumors by 4-hexylresorcinol F344/N rats and B6C3F1 mice", FUNDAMENTAL AND APPLIED TOXICOLOGY, vol. 11, no. 4, 1988, pages 685 - 690 *
KIM, SEONG GON ET AL.: "4-Hexylresorcinol Induced an Apoptosis and Differentiation of Oral Cancer Cells", JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, vol. 65, no. 9, 2007, pages 41E *

Also Published As

Publication number Publication date
KR20100066675A (en) 2010-06-18
WO2010068037A2 (en) 2010-06-17
WO2010068037A9 (en) 2010-09-02

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