WO2010066846A3 - Method for the isolation of atorvastatin - Google Patents

Method for the isolation of atorvastatin Download PDF

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Publication number
WO2010066846A3
WO2010066846A3 PCT/EP2009/066852 EP2009066852W WO2010066846A3 WO 2010066846 A3 WO2010066846 A3 WO 2010066846A3 EP 2009066852 W EP2009066852 W EP 2009066852W WO 2010066846 A3 WO2010066846 A3 WO 2010066846A3
Authority
WO
WIPO (PCT)
Prior art keywords
atorvastatin
butanol
branched
alcohol
linear
Prior art date
Application number
PCT/EP2009/066852
Other languages
French (fr)
Other versions
WO2010066846A2 (en
Inventor
De Ben Lange
Henricus Leonardus Marie Elsenberg
Original Assignee
Dsm Ip Assets B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets B.V. filed Critical Dsm Ip Assets B.V.
Publication of WO2010066846A2 publication Critical patent/WO2010066846A2/en
Publication of WO2010066846A3 publication Critical patent/WO2010066846A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a method for isolating atorvastatin comprising mixing at a temperature not exceeding 50°C a solution of atorvastatin in methanol and/or ethanol and/or n-propanol with isopropanol and/or n-butanol and/or sec-butanol and/or tert-butanol and/or a linear or branched C5-alcohol and/or a linear or branched C6-alcohol and/or a linear or branched C7-alcohol, followed by isolating the precipitate thus obtained, optionally in the presence of one or more antioxidants.
PCT/EP2009/066852 2008-12-11 2009-12-10 Method for the isolation of atorvastatin WO2010066846A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08171331.5 2008-12-11
EP08171331 2008-12-11

Publications (2)

Publication Number Publication Date
WO2010066846A2 WO2010066846A2 (en) 2010-06-17
WO2010066846A3 true WO2010066846A3 (en) 2011-03-17

Family

ID=40436318

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/066852 WO2010066846A2 (en) 2008-12-11 2009-12-10 Method for the isolation of atorvastatin

Country Status (1)

Country Link
WO (1) WO2010066846A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001042209A1 (en) * 1999-12-10 2001-06-14 Lek Pharmaceutical And Chemical Company D.D. Process for the preparation of amorphous atorvastatin
US6274740B1 (en) * 1995-07-17 2001-08-14 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethy)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1)
WO2006046109A1 (en) * 2004-10-28 2006-05-04 Warner-Lambert Company Llc Process for forming amorphous atorvastatin
US7230120B2 (en) * 2002-03-18 2007-06-12 Biocon Amorphous HMG-CoA reductase inhibitors of desired particle size
WO2008096377A2 (en) * 2007-02-09 2008-08-14 Actavis Group Ptc Ehf Stable atorvastatin formulations

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274740B1 (en) * 1995-07-17 2001-08-14 Warner-Lambert Company Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethy)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1)
WO2001042209A1 (en) * 1999-12-10 2001-06-14 Lek Pharmaceutical And Chemical Company D.D. Process for the preparation of amorphous atorvastatin
US7230120B2 (en) * 2002-03-18 2007-06-12 Biocon Amorphous HMG-CoA reductase inhibitors of desired particle size
WO2006046109A1 (en) * 2004-10-28 2006-05-04 Warner-Lambert Company Llc Process for forming amorphous atorvastatin
WO2008096377A2 (en) * 2007-02-09 2008-08-14 Actavis Group Ptc Ehf Stable atorvastatin formulations

Also Published As

Publication number Publication date
WO2010066846A2 (en) 2010-06-17

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