WO2010065957A3 - Vascularized living skin constructs and methods of use thereof - Google Patents

Vascularized living skin constructs and methods of use thereof Download PDF

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Publication number
WO2010065957A3
WO2010065957A3 PCT/US2009/067006 US2009067006W WO2010065957A3 WO 2010065957 A3 WO2010065957 A3 WO 2010065957A3 US 2009067006 W US2009067006 W US 2009067006W WO 2010065957 A3 WO2010065957 A3 WO 2010065957A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
living skin
skin constructs
vascularized living
vascularized
Prior art date
Application number
PCT/US2009/067006
Other languages
French (fr)
Other versions
WO2010065957A2 (en
Inventor
David L. Kaplan
Ira M. Herman
Jeffrey T. Borenstein
Jonathan Garlick
Original Assignee
Trustees Of Tufts College
The Charles Stark Draper Laboratory, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trustees Of Tufts College, The Charles Stark Draper Laboratory, Inc. filed Critical Trustees Of Tufts College
Publication of WO2010065957A2 publication Critical patent/WO2010065957A2/en
Publication of WO2010065957A3 publication Critical patent/WO2010065957A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60—Materials for use in artificial skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells

Abstract

While several devices and living skin substitutes have been developed over the past few years, none possess an integrated vasculature. Accordingly, the invention described herein provides, in part, controllable, three-dimensional human skin equivalents constructed using biodegradable microfluidic systems that encompass a variety of properties, including biodegradeability, bioactivity and full functionality, and a complete microcirculation.
PCT/US2009/067006 2008-12-05 2009-12-07 Vascularized living skin constructs and methods of use thereof WO2010065957A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12032308P 2008-12-05 2008-12-05
US61/120,323 2008-12-05

Publications (2)

Publication Number Publication Date
WO2010065957A2 WO2010065957A2 (en) 2010-06-10
WO2010065957A3 true WO2010065957A3 (en) 2010-09-23

Family

ID=42233911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/067006 WO2010065957A2 (en) 2008-12-05 2009-12-07 Vascularized living skin constructs and methods of use thereof

Country Status (1)

Country Link
WO (1) WO2010065957A2 (en)

Cited By (4)

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US8934965B2 (en) 2011-06-03 2015-01-13 The Board Of Trustees Of The University Of Illinois Conformable actively multiplexed high-density surface electrode array for brain interfacing
US9012784B2 (en) 2008-10-07 2015-04-21 Mc10, Inc. Extremely stretchable electronics
US9289132B2 (en) 2008-10-07 2016-03-22 Mc10, Inc. Catheter balloon having stretchable integrated circuitry and sensor array
US9617519B2 (en) 2010-09-14 2017-04-11 Tokyo Women's Medical University Method for manufacturing multilayered cell sheet, multilayered cell sheet having vascular network obtained thereby, and method of use thereof

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EP2650907A3 (en) 2004-06-04 2014-10-08 The Board of Trustees of the University of Illinois Methods and devices for fabricating and assembling printable semiconductor elements
US8886334B2 (en) 2008-10-07 2014-11-11 Mc10, Inc. Systems, methods, and devices using stretchable or flexible electronics for medical applications
WO2011041727A1 (en) 2009-10-01 2011-04-07 Mc10, Inc. Protective cases with integrated electronics
US8666471B2 (en) 2010-03-17 2014-03-04 The Board Of Trustees Of The University Of Illinois Implantable biomedical devices on bioresorbable substrates
US9936574B2 (en) 2009-12-16 2018-04-03 The Board Of Trustees Of The University Of Illinois Waterproof stretchable optoelectronics
JP6046491B2 (en) 2009-12-16 2016-12-21 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ In vivo electrophysiology using conformal electronics
US10441185B2 (en) 2009-12-16 2019-10-15 The Board Of Trustees Of The University Of Illinois Flexible and stretchable electronic systems for epidermal electronics
JP2013542181A (en) 2010-09-03 2013-11-21 タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ Plasmon nanoparticle-doped silk material
US9289454B2 (en) 2010-09-14 2016-03-22 Tokyo Women's Medical University Method for manufacturing multilayered cell sheet, multilayered cell sheet having vascular network obtained thereby, and method of use thereof
US9765934B2 (en) 2011-05-16 2017-09-19 The Board Of Trustees Of The University Of Illinois Thermally managed LED arrays assembled by printing
WO2012166686A2 (en) 2011-05-27 2012-12-06 Mc10, Inc. Electronic, optical and/or mechanical apparatus and systems and methods for fabricating same
KR101979354B1 (en) 2011-12-01 2019-08-29 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 Transient devices designed to undergo programmable transformations
WO2013130156A2 (en) 2011-12-05 2013-09-06 Tufts University Signal enhancement by silk photonic crystals
US9554484B2 (en) 2012-03-30 2017-01-24 The Board Of Trustees Of The University Of Illinois Appendage mountable electronic devices conformable to surfaces
US9171794B2 (en) 2012-10-09 2015-10-27 Mc10, Inc. Embedding thin chips in polymer
US10624865B2 (en) 2013-03-14 2020-04-21 Pathak Holdings Llc Methods, compositions, and devices for drug/live cell microarrays
US9789073B2 (en) 2013-03-14 2017-10-17 Pathak Holdings, Llc Compositions, methods and devices for local drug delivery
WO2014160387A2 (en) * 2013-03-14 2014-10-02 Pathak Holdings, Llc Compositions, methods and devices for local drug delivery
CN104195030B (en) * 2014-08-14 2017-01-25 国家纳米科学中心 Micro-fluidic chip and method for evaluating wound dressing by using micro-fluidic chip
WO2016196673A1 (en) 2015-06-01 2016-12-08 The Board Of Trustees Of The University Of Illinois Alternative approach to uv sensing
KR20180033468A (en) 2015-06-01 2018-04-03 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 Miniaturized electronic systems with wireless power and local communication capabilities
US10925543B2 (en) 2015-11-11 2021-02-23 The Board Of Trustees Of The University Of Illinois Bioresorbable silicon electronics for transient implants
WO2021038507A1 (en) * 2019-08-28 2021-03-04 Association For The Advancement Of Tissue Engineering And Cell Based Technologies & Therapies (A4Tec) - Associação Enzymatically crosslinked silk fibroin hydrogel microfluidic platform, methods of production and uses thereof
CN114306737A (en) * 2021-11-30 2022-04-12 厦门大学 Silk fibroin-based porous microsphere and preparation method thereof
CN114681688B (en) * 2022-04-15 2022-11-08 东南大学 Tissue regeneration membrane for promoting vascularization by using micro-channel and preparation method thereof

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US20070212730A1 (en) * 2005-04-20 2007-09-13 Trustees Of Tufts College Covalently immobilized protein gradients in three-dimensional porous scaffolds

Non-Patent Citations (4)

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CHANG, S. K. ET AL.: "Development of 3-D nanofibrous fibroin scaffold with high porosity by electrospinning: implications for bone regeneration.", BIOTECHNOL. LETT, vol. 30, 1 November 2007 (2007-11-01), pages 405 - 410 *
MIN, B. M. ET AL.: "Regenerated silk fibroin nanofibers.", MACROMOL. BIOSCI., vol. 6, 2006, pages 285 - 292 *
SOBAJO, C. ET AL.: "Silk: a potential medium for tissure engineering.", JOURNAL OF PLASTIC SURGERY, vol. 8, 10 October 2008 (2008-10-10), pages 438 - 446 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9012784B2 (en) 2008-10-07 2015-04-21 Mc10, Inc. Extremely stretchable electronics
US9289132B2 (en) 2008-10-07 2016-03-22 Mc10, Inc. Catheter balloon having stretchable integrated circuitry and sensor array
US9617519B2 (en) 2010-09-14 2017-04-11 Tokyo Women's Medical University Method for manufacturing multilayered cell sheet, multilayered cell sheet having vascular network obtained thereby, and method of use thereof
US8934965B2 (en) 2011-06-03 2015-01-13 The Board Of Trustees Of The University Of Illinois Conformable actively multiplexed high-density surface electrode array for brain interfacing

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Publication number Publication date
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