WO2010063998A3 - Antibiotic nanomaterial - Google Patents

Antibiotic nanomaterial Download PDF

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Publication number
WO2010063998A3
WO2010063998A3 PCT/GB2009/002795 GB2009002795W WO2010063998A3 WO 2010063998 A3 WO2010063998 A3 WO 2010063998A3 GB 2009002795 W GB2009002795 W GB 2009002795W WO 2010063998 A3 WO2010063998 A3 WO 2010063998A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanoparticles
composition
infection
coatings
allicin
Prior art date
Application number
PCT/GB2009/002795
Other languages
French (fr)
Other versions
WO2010063998A2 (en
Inventor
Ian Thompson
Francisco Rodrigo Molina
Peter Dobson
Original Assignee
Isis Innovation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation Limited filed Critical Isis Innovation Limited
Publication of WO2010063998A2 publication Critical patent/WO2010063998A2/en
Publication of WO2010063998A3 publication Critical patent/WO2010063998A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
    • A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
    • A01N41/04—Sulfonic acids; Derivatives thereof
    • A01N41/08—Sulfonic acid halides; alpha-Hydroxy-sulfonic acids; Amino-sulfonic acids; Thiosulfonic acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Ceramic Engineering (AREA)
  • Agronomy & Crop Science (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Dermatology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention provides a composition comprising nanoparticles, which nanoparticles comprise Allicin and an inorganic carrier. Further provided is a process for producing the composition of the invention, the process comprising treating precursor nanoparticles, comprising said inorganic carrier, with Allicin. The composition of the invention may be used as an antimicrobial agent or for treating a bacterial infection, a fungal infection, a viral infection, an infection by a pathogenic protozoan, a tumour, cancer or thrombosis, or to stimulate or enhance the immune system. The invention further provides antimicrobial films, coatings, coated products, packaging materials, and polymer compositions, all of which comprise said nanoparticles, and processes for producing the films, coatings and coated products.
PCT/GB2009/002795 2008-12-01 2009-12-01 Antibiotic nanomaterial WO2010063998A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0821928.9 2008-12-01
GBGB0821928.9A GB0821928D0 (en) 2008-12-01 2008-12-01 Antibiotic nanomaterial

Publications (2)

Publication Number Publication Date
WO2010063998A2 WO2010063998A2 (en) 2010-06-10
WO2010063998A3 true WO2010063998A3 (en) 2010-12-29

Family

ID=40262485

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/002795 WO2010063998A2 (en) 2008-12-01 2009-12-01 Antibiotic nanomaterial

Country Status (2)

Country Link
GB (1) GB0821928D0 (en)
WO (1) WO2010063998A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9033956B2 (en) 2011-09-06 2015-05-19 Cook Medical Technologies Llc Electrically charged medical device
CN102864137B (en) * 2012-09-26 2014-08-06 中国海洋大学 Microbial particle preparation for aquacultural water quality purification and preparation method
ES2908958T3 (en) 2013-02-01 2022-05-04 Grace W R & Co Porous silica gel as a carrier for liquid technologies
CN104693513A (en) * 2014-09-05 2015-06-10 中国热带农业科学院农产品加工研究所 Method for preparing gold and silver nano particle/ colored natural rubber nano composite material
CN104288174B (en) * 2014-10-17 2017-03-15 复旦大学附属中山医院 A kind of sustained release hydrogen sulfide donor and preparation method thereof, application
US9763814B2 (en) 2014-10-24 2017-09-19 Cook Medical Technologies Llc Elongate medical device
CN104434781A (en) * 2014-11-08 2015-03-25 新疆埃乐欣药业有限公司 Application of allicin injection in preparation of medicines for treating infectious diseases caused by fungi/bacteria
US9894896B2 (en) 2015-06-09 2018-02-20 King Saud University Method of using a clay suspension to prevent viral and phytoplasma diseases in plants
GB201615196D0 (en) 2016-09-07 2016-10-19 Univ Limerick Method for stabilising and isolating nanoparticles
CN111684019B (en) * 2018-02-13 2022-08-02 住友化学株式会社 Composition and molded article
CN110744067B (en) * 2019-09-29 2022-06-07 济南大学 Method for preparing carbon nano tube loaded gold nano by ultrasonic spraying
CN112587670B (en) * 2021-03-02 2021-05-11 中国农业大学 Preparation method of DNA nanoflower medicine for targeted regulation and control of browning of white fat

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0305968A2 (en) * 1987-08-31 1989-03-08 Yeda Research And Development Company Limited Compositions against protozoal diseases
US5556699A (en) * 1987-06-30 1996-09-17 Shingawa Fuel Co. Ltd. Antibiotic zeolite-containing film
CN1618424A (en) * 2003-11-19 2005-05-25 中国科学院生物物理研究所 Single particle nano-garlicin micro-capsule, and its prepn. method
WO2007015105A2 (en) * 2005-08-04 2007-02-08 Thomas William Rademacher Nanoparticles comprising antibacterial ligands
CN101313772A (en) * 2008-06-10 2008-12-03 东莞市广益食品添加剂实业有限公司 Bacterium-restraining deoxidization dual-purpose food antistaling agent and preparation thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5556699A (en) * 1987-06-30 1996-09-17 Shingawa Fuel Co. Ltd. Antibiotic zeolite-containing film
EP0305968A2 (en) * 1987-08-31 1989-03-08 Yeda Research And Development Company Limited Compositions against protozoal diseases
CN1618424A (en) * 2003-11-19 2005-05-25 中国科学院生物物理研究所 Single particle nano-garlicin micro-capsule, and its prepn. method
WO2007015105A2 (en) * 2005-08-04 2007-02-08 Thomas William Rademacher Nanoparticles comprising antibacterial ligands
CN101313772A (en) * 2008-06-10 2008-12-03 东莞市广益食品添加剂实业有限公司 Bacterium-restraining deoxidization dual-purpose food antistaling agent and preparation thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 20 January 2006 (2006-01-20), HE, RONGQIAO; YANG, JIARONG; HE, JIAN: "Single particle nanoallicin capsule and its preparation", XP002606677, Database accession no. 144:135134 *
DATABASE CAPLUS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 9 December 2008 (2008-12-09), LIANG, JIAZHEN: "Bacteriostatic and deoxygenating food preservative and preparation method thereof", XP002606676, Database accession no. 150:54761 *
GU HONGWEI ET AL: "Presenting vancomycin on nanoparticles to enhance antimicrobial activities", NANO LETTERS, ACS, WASHINGTON, DC, US LNKD- DOI:10.1021/NL034396Z, vol. 3, no. 9, 1 January 2003 (2003-01-01), pages 1261 - 1263, XP002446943, ISSN: 1530-6984 *
LUO DONG QING ET AL: "Anti-fungal efficacy of polybutylcyanoacrylate nanoparticles of allicin and comparison with pure allicin.", JOURNAL OF BIOMATERIALS SCIENCE. POLYMER EDITION 2009 LNKD- PUBMED:19105898, vol. 20, no. 1, 1 January 2009 (2009-01-01), pages 21 - 31, XP002606518, ISSN: 0920-5063 *
LUO PENGJU G ET AL: "Nanotechnology in the detection and control of microorganisms.", ADVANCES IN APPLIED MICROBIOLOGY 2008 LNKD- PUBMED:18395127, vol. 63, 3 April 2008 (2008-04-03), pages 145 - 181, XP008128245, ISSN: 0065-2164 *
NIRMALA GRACE ET AL: "Antibacterial efficacy of aminoglycosidic antibiotics protected gold nanoparticles-A brief study", COLLOIDS AND SURFACES. A, PHYSICACHEMICAL AND ENGINEERING ASPECTS, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/J.COLSURFA.2006.10.024, vol. 297, no. 1-3, 20 February 2007 (2007-02-20), pages 63 - 70, XP005895492, ISSN: 0927-7757 *
ROSEMARY M J ET AL: "Investigations of the antibacterial properties of ciprofloxacin@SiO2.", LANGMUIR : THE ACS JOURNAL OF SURFACES AND COLLOIDS 21 NOV 2006 LNKD- PUBMED:17107009, vol. 22, no. 24, 21 November 2006 (2006-11-21), pages 10125 - 10129, XP002606517, ISSN: 0743-7463 *

Also Published As

Publication number Publication date
GB0821928D0 (en) 2009-01-07
WO2010063998A2 (en) 2010-06-10

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