WO2010061382A3 - A process for substitution on aromatic rings - Google Patents

A process for substitution on aromatic rings Download PDF

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Publication number
WO2010061382A3
WO2010061382A3 PCT/IL2009/001099 IL2009001099W WO2010061382A3 WO 2010061382 A3 WO2010061382 A3 WO 2010061382A3 IL 2009001099 W IL2009001099 W IL 2009001099W WO 2010061382 A3 WO2010061382 A3 WO 2010061382A3
Authority
WO
WIPO (PCT)
Prior art keywords
aromatic compound
substitution
aromatic rings
substituted
electrophile
Prior art date
Application number
PCT/IL2009/001099
Other languages
French (fr)
Other versions
WO2010061382A2 (en
Inventor
Magal Saphier
Original Assignee
Magal Saphier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Magal Saphier filed Critical Magal Saphier
Publication of WO2010061382A2 publication Critical patent/WO2010061382A2/en
Publication of WO2010061382A3 publication Critical patent/WO2010061382A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/02—Formation or introduction of functional groups containing nitrogen of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/02—Preparation of compounds containing amino groups bound to a carbon skeleton by substitution of hydrogen atoms by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/66—Preparation of compounds containing amino groups bound to a carbon skeleton from or via metallo-organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups

Abstract

A process for preparing a substituted aromatic compound, comprising combining an aromatic compound and cuprous (Cu+) ions in a reaction vessel in an essentially oxygen-free environment, and adding to said reaction vessel a source of an electrophile or a nucleophile substituent, to form an aromatic compound product which is ring-substituted with said electrophile or nucleophile at a position which was originally occupied by hydrogen, and isolating the substituted aromatic compound from the reaction mixture.
PCT/IL2009/001099 2008-11-25 2009-11-23 A process for substitution on aromatic rings WO2010061382A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11757908P 2008-11-25 2008-11-25
US61/117,579 2008-11-25

Publications (2)

Publication Number Publication Date
WO2010061382A2 WO2010061382A2 (en) 2010-06-03
WO2010061382A3 true WO2010061382A3 (en) 2010-08-19

Family

ID=42110959

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2009/001099 WO2010061382A2 (en) 2008-11-25 2009-11-23 A process for substitution on aromatic rings

Country Status (1)

Country Link
WO (1) WO2010061382A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108546237A (en) * 2018-06-15 2018-09-18 那坡康正天然植物提取有限责任公司 A method of extracting levodopa by raw material of cat beans

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4533763A (en) * 1983-12-14 1985-08-06 Air Products And Chemicals, Inc. Hydroxy aromatic compounds from alkali metal hydroxide and mononuclear aromatic compound
EP0343048A1 (en) * 1988-05-18 1989-11-23 Sumitomo Chemical Company, Limited Process for producing nitrobenzenes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4533763A (en) * 1983-12-14 1985-08-06 Air Products And Chemicals, Inc. Hydroxy aromatic compounds from alkali metal hydroxide and mononuclear aromatic compound
EP0343048A1 (en) * 1988-05-18 1989-11-23 Sumitomo Chemical Company, Limited Process for producing nitrobenzenes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHIOCCARA F ET AL: "Selective ortho-hydroxylation of phenols in copper (I) complexes", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL LNKD- DOI:10.1016/S0040-4020(01)87111-8, vol. 47, no. 25, 1 January 1991 (1991-01-01), pages 4429 - 4434, XP026614945, ISSN: 0040-4020, [retrieved on 19910101] *
PATRICE CAPDEVIELLE, MICHEL MAUMY: "Ortho-hydroxylation selective des phenols : II - un nouveau systeme catalytique a caractere preparatif", TETRAHEDRON LETTERS, vol. 23, no. 15, 1982, pages 1577 - 1580, XP002583714 *
SHINZO SEKO, KUNIHITO MIYAKE AND NORIO KAWAMURA: "A convenient copper-catalyzed direct amination of nitroarenes with O-alkylhydroxylamines", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, no. 11, 1999, pages 1437 - 1444, XP002583713 *

Also Published As

Publication number Publication date
WO2010061382A2 (en) 2010-06-03

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