WO2010060025A1 - Methods for altering food intake, modifying nutrient digestibility and altering stool quality and/or stool frequency - Google Patents

Methods for altering food intake, modifying nutrient digestibility and altering stool quality and/or stool frequency Download PDF

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Publication number
WO2010060025A1
WO2010060025A1 PCT/US2009/065499 US2009065499W WO2010060025A1 WO 2010060025 A1 WO2010060025 A1 WO 2010060025A1 US 2009065499 W US2009065499 W US 2009065499W WO 2010060025 A1 WO2010060025 A1 WO 2010060025A1
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Prior art keywords
dog
metabolizable
digestibility
dcab
protein
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PCT/US2009/065499
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English (en)
French (fr)
Inventor
Ryan Michael Yamka
Kim Gene Friesen
Lauren Kats
Thomas Gordon Forster
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Hill's Pet Nutrition, Inc.
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Priority to CN2009801470919A priority Critical patent/CN102223810A/zh
Priority to EP09761119.8A priority patent/EP2352387B1/en
Priority to RU2011125312/13A priority patent/RU2483570C2/ru
Priority to BRPI0922065A priority patent/BRPI0922065A8/pt
Priority to CA2742123A priority patent/CA2742123C/en
Priority to AU2009316370A priority patent/AU2009316370B2/en
Priority to JP2011537680A priority patent/JP2012509669A/ja
Publication of WO2010060025A1 publication Critical patent/WO2010060025A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the invention encompasses methods for altering food intake, modifying nutrient digestibility and altering stool quality and/or stool frequency in an animal by adjusting the balance of metabolizable cations to metabolizable anions consumed by the animal.
  • DCAB Dietary cation anion balance
  • the invention generally encompasses compositions and methods with beneficial results for companion animals achieved by adjusting the balance of metabolizable cations to metabolizable anions in the compositions consumed by an animal by an amount sufficient to alter and therefore improve stool quality and/or stool frequency of an animal.
  • the invention also encompasses kits comprising combinations of cations, anions, foods, compounds, instructions, and devices useful for altering stool quality and/or stool frequency are also provided.
  • the invention encompasses compositions including two or more ingredients that, when combined together and optionally with additional ingredients that are not a part of the composition, yield a composition for use in the methods of this invention.
  • compositions include a food intake altering amount of at least one ingredient comprising a metabolizable cation or metabolizable anion and at least one of (1) an ingredient comprising a different metabolizable cation or metabolizable anion; (2) one or more ingredients for consumption by an animal; (3) one or more weight-loss agents; and (4) one or more agents for promoting weight- gain.
  • the invention encompasses methods for improving stool quality for an animal. In another embodiment, the invention encompasses methods for altering stool frequency of an animal.
  • the invention encompasses methods for modifying nutrient digestibility in a dog in need thereof.
  • the invention encompasses methods for increasing protein digestibility in a dog in need thereof comprising administering to the dog a composition, wherein the composition has a decreased DCAB.
  • a dog in need thereof is a dog suffering from irritable bowel disease (IBD).
  • the invention encompasses methods for decreasing protein digestibility in a dog in need thereof comprising administering to the dog a composition, wherein the composition has an increased DCAB.
  • a dog in need thereof is a dog suffering from kidney disease.
  • the invention encompasses methods for increasing fat digestibility in a dog in need thereof including administering to the dog a composition, wherein the composition has a decreased DCAB.
  • a dog in need thereof is a dog in which weight gain is desired.
  • the invention encompasses methods for decreasing fat digestibility in a dog in need thereof comprising administering to the dog a composition, wherein the composition has a decreased DCAB.
  • a dog in need thereof is a dog in which weight reduction is desired.
  • the invention encompasses methods for treating a dog suffering from digestive problems comprising adjusting the balance of metabolizable cations to metabolizable anions consumed by the dog by an amount sufficient to modify the digestibility of fat and/or protein in said dog and wherein said modification provides a beneficial therapeutic effect.
  • the balance of metabolizable cations to metabolizable anions consumed by the dog is decreased in order to increase protein digestibility and/or decrease fat digestibility in the dog.
  • the balance of metabolizable cations to metabolizable anions may be decreased by decreasing the amount of metabolizable cations consumed by the dog, increasing the amount of metabolizable anions consumed by the dog or by both decreasing the amount of metabolizable cations and increasing the amount of metabolizable anions consumed by the dog.
  • the invention encompasses methods for increasing the balance of metabolizable cations to metabolizable anions consumed by the dog in order to decrease protein digestibility and/or increase fat digestibility in the dog.
  • the balance of metabolizable cations to metabolizable anions may be increased by increasing the amount of metabolizable cations consumed by the dog, decreasing the amount of metabolizable anions consumed by the dog or by both increasing the amount of metabolizable cations and decreasing the amount of metabolizable anions consumed by the dog.
  • the invention encompasses methods for supplementing a dog's diet with protein or fat to minimize the effects of any undesired inverse changes in protein or fat digestibility.
  • the invention encompasses methods for altering average food intake by an animal.
  • the methods include adjusting the balance of metabolizable cations to metabolizable anions consumed by the animal by an amount effective to alter average food intake.
  • the invention encompasses methods for controlling weight of an animal.
  • the methods include adjusting the balance of metabolizable cations to metabolizable anions consumed by the animal to alter average food intake in an amount effective to influence the animal's weight.
  • the invention encompasses kits suitable for altering and improving stool quality and/or stool frequency.
  • the invention encompasses the use of metabolizable anions and metabolizable cations in the manufacture of a dog food composition to modify protein and/or fat digestibility in a dog in need thereof wherein a decrease in DCAB can increase protein digestibility and decrease fat digestibility and an increase in DCAB can decrease protein digestibility and increase fat digestibility in a dog.
  • the invention encompasses means for communicating information about the methods and kits of this invention and their use for altering and improving stool quality and/or stool frequency.
  • the invention encompasses methods for increasing protein digestibility in a dog in need thereof comprising administering to the dog a composition, wherein the composition has a decreased dietary cation anion balance (DCAB).
  • DCAB dietary cation anion balance
  • the dog is suffering from irritable bowel disease (IBD).
  • IBD irritable bowel disease
  • the invention also encompasses methods for decreasing protein digestibility in a dog in need thereof comprising administering to the dog a composition, wherein the composition has an increased DCAB.
  • the dog is suffering from kidney disease.
  • the invention also encompasses methods for increasing fat digestibility in a dog in need thereof comprising administering to the dog a composition, wherein the composition has an increased DCAB.
  • the dog is a dog in which weight gain is desired.
  • the invention also encompasses methods for decreasing fat digestibility in a dog in need thereof comprising administering to the dog a composition, wherein the composition has a decreased DCAB.
  • the dog is a dog in which weight reduction is desired.
  • the invention also encompasses methods for treating a dog suffering from digestive problems comprising adjusting the balance of metabolizable cations to metabolizable anions consumed by the dog by an amount sufficient to modify the digestibility of fat and/or protein in said dog and wherein said modification provides a beneficial therapeutic effect.
  • the balance of metabolizable cations to metabolizable anions consumed by the dog is decreased in order to increase protein digestibility and/or decrease fat digestibility in the dog.
  • the balance of metabolizable cations to metabolizable anions may be decreased by decreasing the amount of metabolizable cations consumed by the dog, increasing the amount of metabolizable anions consumed by the dog or by both decreasing the amount of metabolizable cations and increasing the amount of metabolizable anions consumed by the dog.
  • the balance of metabolizable cations to metabolizable anions consumed by the dog is increased in order to decrease protein digestibility in the dog and/or increase fat digestibility in the dog.
  • the balance of metabolizable cations to metabolizable anions may be increased by increasing the amount of metabolizable cations consumed by the dog, decreasing the amount of metabolizable anions consumed by the dog or by both increasing the amount of metabolizable cations and decreasing the amount of metabolizable anions consumed by the dog.
  • the method further comprises supplementing the dog's diet with protein or fat to minimize the effects of any undesired inverse changes in protein or fat digestibility.
  • the invention also encompasses uses of metabolizable anions and metabolizable cations in the manufacture of a dog food composition to modify protein and/or fat digestibility in a dog in need thereof wherein a decrease in DCAB can increase protein digestibility and decrease fat digestibility and an increase in DCAB can decrease protein digestibility and increase fat digestibility in a dog.
  • animal means any animal susceptible to or suffering from poor stool quality and/or irregular stool frequency.
  • An animal is "susceptible to” a disease or condition if the animal exhibits symptoms that indicate that the animal is likely to develop the condition or disease.
  • An animal is "suffering from” a disease or condition if the animal exhibits symptoms that are indicative that the animal has developed the condition or disease.
  • a "beneficial therapeutic effect” as used herein refers to a desirable change in a dog's physical well being which may be discerned by one of skill in the art.
  • a "decrease in DCAB” includes changes from a greater positive DCAB to a smaller positive DCAB, from a positive DCAB to a negative DCAB as well as a change from a smaller negative DCAB to a larger negative DCAB. All reflect changes to a more negative DCAB.
  • an "increase in DCAB” includes changes from a greater negative DCAB to a smaller negative DCAB, from a negative DCAB to a positive DCAB as well as a change from a smaller positive DCAB to a larger positive DCAB. All reflect changes to a greater positive DCAB.
  • a "dog in need thereof includes any dog in which an increase or decrease in fat and/or protein digestibility is therapeutically beneficial including, but not limited to dogs with digestive problems
  • dogs in which an increase in protein digestibility is therapeutically beneficial include dogs suffering from irritable bowel disease (IBD), but also include dogs in which a reduction in stool odor is desired
  • Dogs in which a decrease in protein digestibility may be therapeutically beneficial include dogs suffering from kidney disease
  • the term "digestive problems", as in, for example, ' a dog suffering from digestive problems” refers to those conditions in which the digestion of protein and/or fat in a dog is abnormal These conditions include conditions characterized by malabsorption of nutrients, which may be caused by, for example, digestive enzyme deficiencies pancreatic insufficiency inflammatory diseases, food allergies diabetes melhtus, hypoadrenocorticism, ulcer, bacterial enteritis or colitis, or irritable bowel syndromes Generally, an increase in fat and/or protein digestibility is desired in an animal suffering from a digestive problem, however, depending on the particular condition, one of skill in the art would be familiar with regard to whether an increase or decrease in fat and/or protein digestibility would cause a therapeutic benefit in a dog
  • a "greater negative DCAB” or a greater positive DCAB ' refers to a comparison with another DCAB value
  • ' having a base excess refers to a negative DCAB value
  • ' lacking a base excess ' refers to a positive DCAB value
  • an increase in base excess refers to a greater negative DCAB value in comparison to another DCAB value
  • a decrease in base excess refers to a greater positive DCAB value in comparison to another DCAB value
  • modifying nutrient digestibility' refers to altering the break down and absorption of a nutrient in the body, e g , either increasing or decreasing nutrient digestibility in a dog, for example fat or protein digestibility
  • increasing digestibility in a dog refers to causing a beneficial increase in the digestion of a nutrient such as may be typical for a normal dog of comparable breed age and size, or otherwise as therapeutically desired in the dog.
  • decreasing digestibility in a dog refers to causing a beneficial decrease in the digestion of a nutrient to levels typical for a normal dog of comparable breed, age and size, or otherwise as therapeutically desired in the dog.
  • a modification in digestibility may be quantitated using conventional methods by comparing nutrient digestibility in a dog before and after treatment according to the methods of the present invention.
  • a dog is "suffering from” a disease or condition if the dog exhibits at least one symptom that is indicative that the dog has developed the condition or disease.
  • the metabolic acid-base status of an animal is influenced by the dietary cation (positively charged minerals) and anion (negatively charged minerals) balance consumed by an animal (“DCAB").
  • DCAB is measured as mEq.
  • the term “undesired inverse changes” refers to a change in protein or fat digestibility in a dog due to increasing or decreasing the DCAB of the composition consumed by the dog that could have a negative effect on the health of the dog. An undesirable change in digestibility of fat or protein in a dog would be easily recognizable to one of skill in the art and could be lessened by supplementing the diet with protein or fat as disclosed herein.
  • the invention encompasses compositions including metabolizable anions and metabolizable cations and the use of metabolizable anions and metabolizable cations in the manufacture of a dog food composition to modify protein and/or fat digestibility in a dog in need thereof, wherein a decrease in DCAB can increase protein digestibility and decrease fat digestibility and an increase in DCAB can decrease protein digestibility and increase fat digestibility in a dog in need thereof. Accordingly, the compositions also have utility in altering food intake and altering stool quality and/or stool frequency.
  • the cations and anions useful in the invention are any cation or anion suitable for consumption by an animal.
  • the metabolizable cations are selected from the group consisting of calcium, sodium, potassium, and magnesium and the metabolizable anions are selected from the group consisting of phosphorus, chloride, and sulfur.
  • the balance of metabohzable cations to metabolizable anions in the compositions of the invention can be determined by any means known to one of ordinary skill in the art.
  • one method for measuring the balance of metabolizable cations to metabolizable anions in a composition is to calculate the animal's dietary cation-anion balance (DCAB), which is determined by calculating the cumulative amount of sodium, potassium, calcium, and magnesium regularly consumed by the animal and subtracting the cumulative amount of chloride, sulfur, and phosphorus regularly consumed by the animal (See, e g , Baker et al , Comparative Nutrition of Cats and Dogs, Ann Rev Nutr 11 -239-63 (1991 )) [0048]
  • DCAB dietary cation-anion balance
  • increasing the balance of metabolizable cations to metabolizable anions will result in firmer stool quality and reduced stool output
  • decreasing the balance of metabolizable cations to metabolizable anions will result in looser stool and increased stool output
  • Nutritionally complete pet food compositions including nutritionally complete dog foods, are familiar to those of ordinary skill in the art For example, nutrients and ingredients suitable for dog food compositions, and recommended amounts thereof, may be found in the Official Publication of the Association of American Feed Control Officials, Inc. ("AAFCO"), Nutrient Requirements of Dogs and Cats, 2006 Nutritionally complete foods may contain protein, fat, carbohydrate, fiber, amino acids, minerals, vitamins and other ingredients at recommended levels and ratios known by those of skill in the art [0050] Protein may be supplied by any of a variety of sources known by those skilled in the art, including plant sources, animal sources, or both.
  • Meats include, for example, the flesh of poultry, fish, and mammals (e g , cattle, pigs, sheep, goats, and the like)
  • Meat by products include, for example, lungs, kidneys, brain, livers and stomachs and intestines (freed of all or essentially all their contents).
  • the protein can be, e.g., intact, almost completely hydrolyzed, or partially hydrolyzed
  • Fat can be supplied by any of a variety of sources known by those skilled in the art, including meat, meat by-products, fish oil, and plants
  • Plant fat sources include wheat, flaxseed, rye, barley, rice, sorghum, corn, oats, millet, wheat germ corn germ, soybeans, peanuts, and cottonseed, as well as oils derived from these and other plant fat sources.
  • Carbohydrate may be supplied by any of a variety of sources known by those skilled in the art, including oat fiber cellulose, peanut hulls, beet pulp, parboiled rice, corn starch, corn gluten meal, and any combination of those sources Grains supplying carbohydrate include, but are not limited to, wheat, corn, barley, and rice
  • Fatty acids for inclusion in pet foods include omega 3 fatty acids such as docosahexanenoic acid (DHA), eicosapentaenoic acid (EPA), alpha-linolenic acid (ALA), octadecatetraenoic acid (stearidonic acid) or mixtures thereof
  • DHA docosahexanenoic acid
  • EPA eicosapentaenoic acid
  • ALA alpha-linolenic acid
  • octadecatetraenoic acid stearidonic acid
  • Dietary fiber includes components of a plant, which are resistant to digestion by an animal's digestive enzymes. Dietary fiber includes soluble and insoluble fibers.
  • Soluble fiber are resistant to digestion and absorption in the small intestine and undergo complete or partial fermentation in the large intestine, e g , beet pulp, guar gum, chicory root, psyllium, pectin, blueberry, cranberry, squash, apples, oats, beans, citrus, barley, or peas
  • Insoluble fiber may be supplied by any of a variety of sources, including cellulose, whole wheat products, wheat oat, corn bran, flax seed grapes, celery, green beans, cauliflower, potato skins fruit skins, vegetable skins, peanut hulls, and soy fiber
  • Crude fiber includes indigestible components contained in cell walls and cell contents of plants such as grains, e.g , hulls of grains such as rice, corn, and beans
  • Amino acids including essential ammo acids, may be added to pet food compositions as free ammo acids, or supplied by any number of sources, e g , crude protein Essential amino acids are amino acids that cannot be synthesized de novo, or in sufficient quantities by an organism and thus must be supplied in the diet.
  • Essential amino acids vary from species to species depending upon the organism's metabolism For example, it is generally understood that the essential amino acids for dogs and cats (and humans) are phenylalanine, leucine, methionine, lysine, isoleucine, valine, threonine, tryptophan, histidine and arginine In addition, taurine while technically not an ammo acid but a derivative of cysteine, is an essential nutrient for cats. [0056] Nutritionally complete pet food compositions may also contain one or more minerals and/or trace elements, e.g., calcium, phosphorus, sodium, potassium, magnesium, manganese, copper, zinc, or iron salts, in amounts required to avoid deficiency and maintain health. These amounts are known by those of skill in the art, for example, as provided by AAFCO guidelines.
  • minerals and/or trace elements e.g., calcium, phosphorus, sodium, potassium, magnesium, manganese, copper, zinc, or iron salts
  • Nutritionally complete pet food compositions may also include vitamins in amounts required to avoid deficiency and maintain health. These amounts, and methods of measurement, are known by those skilled in the art. For example, AAFCO provides recommended amounts of such ingredients for dogs and cats.
  • useful vitamins may include, but are not limited to, vitamin A, vitamin B1 , vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin H (biotin), vitamin K, folic acid, inositol, niacin, choline, and pantothenic acid.
  • Pet food compositions of the invention may additionally include additives, stabilizers, fillers, thickeners, flavorants, palatability enhancers and colorants in amounts and combinations familiar to one of skill in the art.
  • the compositions of the invention are provided as a food, e.g., a nutritionally complete pet food composition.
  • the food compositions may be in the form of a treat, snack, supplement, or partially or fully edible toy.
  • Such items for consumption by a pet are known to those skilled in the art, and can include, for example, compositions that are given to a dog to eat during non meal time, for example, a dog biscuits and edible chew toys.
  • Foods of any consistency or moisture content may be used in the methods of the present invention, e.g., a dry, moist or semi-moist dog food composition.
  • “Semi-moist” refers to a food composition containing from about 25 to 35 % moisture.
  • Moist food refers to a food composition that has a moisture content of from about 60 to 90% or greater.
  • “Dry” food refers to a food composition from about 3 to 11 % moisture content and is often manufactured in the form of small bits or kibbles.
  • compositions that may comprise components of various consistency as well as components that may include more than one consistency, for example, soft, chewy meat-like particles as well as kibble having an outer cereal component and an inner cream component as described in, e.g., US Patent 6,517,877.
  • the kibble may be dried and optionally coated with one or more topical coatings known by those skilled in the art, for example, flavors, fats, oils, powders, and the like
  • the balance of metabolizable cations to metabolizable anions consumed by the dog can be adjusted in conjunction with the administration of one or more compositions comprising a gastrointestinal tract-improving agent, which may help digestion.
  • a gastrointestinal tract-improving agent include probiotics and prebiotics
  • Prebiotics are nondigestible food ingredients that beneficially affect host health by selectively stimulating the growth and/or activity of bacteria in the colon
  • the prebiotic, fructooligosaccha ⁇ de (FOS) is found naturally in many foods such as wheat, onions, bananas, honey, garlic, and leeks.
  • FOS can also be isolated from chicory root or synthesized enzymatically from sucrose FOS fermentation in the colon results in a large number of physiologic effects including increasing the numbers of bifidobacteria in the colon, increasing calcium absorption, increasing fecal weight, shortening of gastrointestinal transit time, and possibly lowering blood lipid levels.
  • Probiotic bacteria such as Lactobacilli or Bifidobacteria are believed to positively affect the immune response by improving the intestinal microbial balance leading to enhanced antibody production and phagocytic (devouring or killing) activity of white blood cells Bifidobacterium lactis could be an effective probiotic dietary supplement for enhancing some aspects of cellular immunity in the elderly [0063] Probiotics enhance systemic cellular immune responses and may be useful as a dietary supplement to boost natural immunity in otherwise healthy adults Probiotics include many types of bacteria but generally are selected from four genera of bacteria.
  • probiotics and prebiotics to be administered to the animal is determined by the skilled artisan based upon the type and nature of the probiotic and prebiotic and the type and nature of the animal, e g , the age, weight, general health sex, extent of microbial depletion, presence of harmful bacteria, and diet of the animal Generally, probiotics are administered to the animal in amounts of from about one to about twenty billion colony forming units (CFUs) per day for the healthy maintenance of intestinal microflora, preferably from about 5 billion to about 10 billion live bacteria per day.
  • CFUs colony forming units
  • prebiotics are administered in amounts sufficient to positively stimulate the healthy microflora in the gut and cause these "good" bacteria to reproduce Typical amounts are from about one to about 10 grams per serving or from about 5 percent to about 40 percent of the recommended daily dietary fiber for an animal
  • the balance of metabolizable cations to metabolizable anions consumed by the animal can be adjusted in conjunction with the administration of one or more compositions comprising a gastrointestinal tract improving agent selected from the group consisting of probiotics and prebiotics.
  • probiotics and prebiotics to be administered to a dog may be determined by the skilled artisan based upon the type and nature of the probiotic and prebiotic and the type and nature of the dog, e g , the age, weight, general health, sex, extent of microbial depletion, presence of harmful bacteria, and diet of the dog Generally, probiotics are administered to a dog in amounts of from about one to about twenty billion colony forming units (CFUs) per day for the healthy maintenance of intestinal microflora preferably from about 5 billion to about 10 billion live bacteria per day Generally, prebiotics are administered in amounts sufficient to positively stimulate the healthy microflora in the gut and cause these "good" bacteria to reproduce. Typical amounts are from about one to about 10 grams per serving or from about 5 percent to about 40 percent of the recommended daily dietary fiber for a dog
  • compositions of the invention it is desirable to modify the DCAB to about -200 to about -100 to achieve an increase in protein digestibility or to modify a DCAB to about +70 to about +200 to achieve an increase in fat digestibility As described in the Examples, DCAB values of -128 and +98 were effective to achieve an increase in protein and fat digestibility in dogs, respectively
  • the balance of metabolizable cations to metabolizable anions can be determined by any means known to skilled artisans
  • DCAB may be determined for a dog by calculating the cumulative amount of cations regularly consumed by the dog and subtracting the cumulative amount of anions consumed by the dog Cations may include, e g , sodium, potassium, calcium, and magnesium cations, or any other ion having a positive charge, including amino acids
  • Anions may include, e g , chloride, sulfur and phosphorus anions, or any other ion having a negative charge, including ammo acids.
  • Pharmaceutical salt forms of these cations and anions are also included herein.
  • the DCAB may be determined by calculating the cumulative amounts of sodium, potassium, calcium, and magnesium cations regularly consumed by the dog and subtracting the cumulative amount of chloride, sulfur and phosphorus anions regularly consumed by the dog, e g , according to the following equation
  • DCAB (mEq) (Na + K + Ca + Mg) - (Cl + S + P)
  • the protein digestibility is then calculated as follows 1
  • the fat content of food may be determined according to conventional methods and the apparent fat digestibility determined as follows
  • NFE nitrogen free extract
  • the carbohydrate digestibility is then calculated by the following equation'
  • DMD Dry matter digestibility
  • Energy digestibility may also be determined, e g , (amount of energy consumed- energy content of stool) X 100%/amount of energy consumed
  • Determination of energy content in food and stool may be performed according to conventional methods familiar to one of skill in the art
  • Fiber digestibility may be determined by determining the fiber content in the food and stool and employing the following equation.
  • the invention also encompasses methods of improving the stool quality or stool frequency of a companion animal
  • the invention encompasses methods for improving stool quality for an animal
  • the invention encompasses methods for altering stool frequency for an animal
  • the methods include adjusting the balance of metabolizable cations to metabolizable anions in the compositions of the invention consumed by the animal by an amount sufficient to alter the animal's stool quality and/or stool frequency
  • compositions that include a stool quality adjusting amount of at least one ingredient selected from the group consisting of metabolizable cations and metabolizable anions.
  • the invention provides for the use of such a composition to prepare a medicament for altering stool quality or altering stool frequency.
  • medicaments are prepared by admixing a compound or composition with excipients, buffers, binders, plasticizers, colorants, diluents, compressing agents, lubricants, flavorants, moistening agents, and other ingredients known to skilled artisans to be useful for producing medicaments and formulating medicaments that are suitable for administration to an animal.
  • the methods are useful for a variety of human and non-human animals, including avian, bovine, canine, equine, feline, hicrine murine, ovine, and porcine animals and are particularly useful for companion animals such as canines and felines, including dogs and cats
  • the animal is a member of the order Carnivora
  • the animal is a canine, and in other such embodiments a feline
  • the animal is a companion animal.
  • a companion animal can be, for example, an animal of any species that is kept as a pet.
  • a companion animal can also be an animal from a variety of widely domesticated species, for example, dogs ⁇ Cams familia ⁇ s) and cats (Fete domesticus) regardless of whether or not the animal is kept solely as a pet
  • companion animals include, for example, working dogs, cats kept for rodent control, as well as pet cats and dogs
  • Stool quality may be determined according to conventional methods For example, fecal quality is commonly assessed by those of skill in the art by visual scoring, e g , ranking stool visually on a scale from grade 1-5 as follows [0080] Grade 1 Greater than two-thirds of the feces in a defecation are liquid. The feces have lost all form, appearing as a puddle or squirt
  • Grade 2 Soft-liquid feces are an intermediate between soft and liquid feces Approximately equal amounts of feces in a defecation are soft and liquid [0082] Grade 3. Greater than two-thirds of the feces in a defecation are soft. The feces retain enough form to pile but have lost their firm cylindrical appearance. [0083] Grade 4 Firm-soft feces are an intermediate between the grades of firm and soft Approximately equal amounts of feces in a defecation are firm and soft [0084] Grade 5 Greater than two-thirds of the feces in a defecation are firm They have a cylindrical shape with little flattening
  • stool quality and stool frequency may be improved by increasing the balance of metabolizable cations to metabolizable anions to provide the animal with firmer stool and/or to reduce stool output
  • the balance of cations to anions can be increased by increasing the cumulative amount of calcium sodium, potassium, and magnesium regularly consumed by the animal relative to the cumulative amount of phosphorus, chloride, and sulfur regularly consumed by the animal
  • the balance of metabolizable cations to metabolizable anions may be increased by increasing the animal s dietary intake of at least one composition comprising a cation excess of calcium, sodium, potassium, or magnesium
  • the balance may be increased by decreasing the animal s dietary intake of at least one composition comprising an anion excess of chloride phosphorus or sulfur
  • the animal is susceptible to or suffering from constipation stool quality and/or stool frequency can be improved by decreasing the balance of metaboh
  • the balance of metabolizable cations to metabolizable anions consumed by the animal can be adjusted in conjunction with the administration of one or more anti-diarrhea agents or anti-constipation agents
  • anti-diarrhea agent means any compound composition or drug useful for preventing or treating diarrhea.
  • anti-constipation agent means any compound, composition, or drug useful for preventing or treating constipation.
  • the inventors of the invention have surprisingly discovered that protein digestion in a dog can be increased by feeding the dog a composition having a greater negative DCAB and that fat digestion in a dog can be increased by feeding a dog a composition having a greater positive DCAB.
  • desired target DCAB values range from about -200 to about -100 for optimum protein digestibility while a DCAB from about +70 to about +100 is desired to achieve good fat digestibility.
  • the methods of the invention encompass the manipulation of the dietary cation anion balance in order to cause a modification in fat and/or protein digestibility in a dog.
  • a dog food composition with a greater negative DCAB in comparison to another composition possesses greater protein digestibility and a dog food composition with a greater positive DCAB in comparison to another composition possesses greater fat digestibility.
  • an increase in fat digestibility may be desired under certain situations, for example, in an animal in which a gain in weight is desired, such as may be the case for a senior or geriatric dog, dogs with cancer or other underweight dogs.
  • increasing protein digestibility in a dog may be desired under certain situations, for example, in an animal suffering from irritable bowel disease or for reducing stool odor. It is further contemplated herein, however, that there are conditions in which a decrease in protein or fat digestibility in a dog may be desired.
  • reducing protein digestibility may be beneficial in a dog suffering from kidney disease.
  • reducing fat digestibility may also be beneficial as a method for causing weight reduction in a dog.
  • the methods of the invention encompass not only modifying the DCAB of a composition fed to a dog to cause an increase in protein or fat digestibility but also, when therapeutically useful, to cause a reduction in protein or fat digestibility in a dog in need thereof. Furthermore, it is also contemplated herein that the methods of the invention encompass the modification of both protein and fat digestibility in an animal when therapeutically beneficial, for example, by modifying the DCAB to be more negative, protein digestibility may be increased while fat digestibility may be decreased; by modifying the DCAB to be more positive, protein digestibility may be decreased while fat digestibility may be increased.
  • one of skill in the art can supplement the dog's diet to either minimize the undesired decrease in nutrient digestibility or to cause a concomitant increase in digestibility, for example, by supplementing the diet with high quality, readily digestible forms of the nutrient the digestibility of which is to be maintained or increased.
  • High quality, highly digestible sources of protein include egg, protein hydrolysates and isolates such as soy protein isolate and poultry liver hydrolysate.
  • High quality, highly digestible sources of fat include soybean oil or fish oil.
  • a DCAB that is more or less positive or negative, as the case may be, than the DCAB of what was previously fed, may be used in the methods of the present invention to achieve an increase or decrease in fat and/or protein digestibility in a dog as particularly described herein.
  • digestibility is determined by measuring the content ingested minus the content in the feces divided by the content ingested.
  • protein content of a composition may be determined by any number of methods known by those of skill in the art, for example, as published by the Association of Official Analytical Chemists in Official Methods of Analysis ("OMA").
  • the invention encompasses methods for altering food intake by an animal.
  • the term "animal” includes any animal susceptible to or suffering from obesity as well as any animal in need of weight management including weight loss, weight maintenance or weight gain.
  • An animal is "susceptible to” a disease or condition if the animal exhibits symptoms that indicate that the animal is likely to develop the condition or disease.
  • An animal is "suffering from” a disease or condition if the animal exhibits symptoms that are indicative that the animal has developed the condition or disease.
  • the animal is a member of the order Camivora.
  • the animal is a canine, and in other such embodiments a feline.
  • the animal is a companion animal.
  • a companion animal can be, for example, an animal of any species that is kept as a pet.
  • a companion animal can also be an animal from a variety of widely domesticated species, for example, dogs (Canis familiaris) and cats (Felis domesticus) regardless of whether or not the animal is kept solely as a pet.
  • companion animals include, for example, working dogs, cats kept for rodent control, as well as pet cats and dogs.
  • the methods of the invention include adjusting the balance of metabolizable cations to metabolizable anions regularly consumed by the animal by an amount effective to alter the animal's average food intake.
  • the balance of metabolizable cations to metabolizable anions can be determined by any means known in the art.
  • the metabolizable cations are selected from the group consisting of calcium, sodium, potassium and magnesium; and the metabolizable anions are selected from the group consisting of phosphorus, chloride and sulfur
  • One method for measuring the balance of metabolizable cations to metabolizable anions is to calculate the animal's dietary cation-anion balance (DCAB).
  • DCAB is determined by calculating the cumulative amount of sodium, potassium, calcium, and magnesium regularly consumed by the animal and subtracting the cumulative amount of chloride, sulfur, and phosphorus regularly consumed by the animal. See, Baker et al , Comparative Nutrition of Cats and Dogs, Ann. Rev. Nutr. 1 1.239-63 (1991 )
  • food intake may be increased by increasing the balance of metabolizable cations to metabolizable anions
  • the balance can be increased by increasing the cumulative amount of calcium, sodium potassium and magnesium regularly consumed by the animal relative to the cumulative amount of phosphorus, chloride and sulfur regularly consumed by the animal
  • the balance of metabolizable cations to metabolizable anions may be increased by increasing the animal's dietary intake of at least one composition comprising calcium, sodium, potassium or magnesium
  • the balance may be increased by decreasing the animal's dietary intake of at least one composition comprising chloride, phosphorus or sulfur.
  • food intake can be decreased by decreasing the balance of metabolizable cations to metabolizable anions consumed by the animal
  • the balance can be decreased by decreasing the cumulative amount of calcium, sodium, potassium and magnesium regularly consumed by the animal relative to the cumulative amount of phosphorus, chloride and sulfur regularly consumed by the animal
  • the balance of metabolizable cations to metabolizable anions can be decreased by decreasing the animal's dietary intake of at least one composition comprising calcium, sodium, potassium or magnesium
  • the balance may be decreased by increasing the animal s dietary intake of at least one composition comprising chloride, phosphorus or sulfur
  • the balance of metabolizable cations to metabolizable anions consumed by the animal can be adjusted by feeding the animal a composition comprising a food intake altering amount of one or more metabolizable cations or metabolizable anions
  • Such compositions can include food compositions
  • the food composition comprises a dry food (i e , a food containing from about 3 to about 1 1 % water)
  • the food composition comprises a semi-moist food ( ⁇ e , a food containing from about 25 to about 35% water)
  • the food composition comprises a moist food ( ⁇ e , a food containing from about 60 to more than about 87% water)
  • the food composition comprises a treat, snack, supplement, or partially or fully edible toy
  • the balance of metabolizable cations to metabolizable anions consumed by the animal can be adjusted in conjunction with the administration of one or more weight-loss agents
  • weight-loss agent means any compound composition, or drug useful for regulating weight or preventing or treating obesity Examples include, but are not limited to, commercially available "low fat” or "low calorie” pet food compositions.
  • the balance of metabolizable cations to metabolizable anions consumed by the animal can be adjusted in conjunction with the administration of one or more agents for promoting weight gain
  • agents for promoting weight gain means any compound, composition, or drug useful for increasing weight and may include, but is not limited to, commercial and/or prescription diet formulations available for nutritional supplementation
  • the present invention provides for a use of a composition that comprises a food intake altering amount of at least one ingredient selected from the group consisting of metabolizable cations and metabolizable anions to prepare a medicament
  • the invention provides for the use of such a composition to prepare a medicament for altering food intake
  • medicaments are prepared by admixing a compound or composition with excipients, buffers, binders, plasticizers, colorants, diluents, compressing agents, lubricants, flavora ⁇ ts, moistening agents, and other ingredients known to skilled artisans to be useful for producing medicaments and formulating medicaments that are suitable for administration to an animal.
  • Seventy dogs were randomly assigned to one of 7 groups containing 10 dogs per group. Each group received one of 7 foods formulated to contain a different balance of metabolizable cations to metabolizable anions. The balance of metabolizable cations to metabolizable anions was calculated as DCAB described above comprising the cumulative amount of sodium, potassium, calcium, and magnesium minus the cumulative amount of chloride, sulfur and phosphorus. The dogs were fed the foods for 7 days over which time the dog s stools were collected and scored. Each stool sample was scored on a scale of 1 to 5 with 1 being watery and loose and 5 being ideal.
  • Results showing the nutrient analysis of each food, the average stool score for each food, and the number of stools scored for each food are presented in Table 1.
  • Twenty dogs are randomly assigned to one of two groups containing 10 dogs per group. Each group receives one of two foods formulated to contain a different balance of metabolizable cations to metabolizable anions.
  • the balance of metabolizable cations to metabolizable anions is calculated as DCAB according to conventional methods comprising the cumulative amount of sodium, potassium, calcium, and magnesium minus the cumulative amount of chloride, sulfur and phosphorus, taking into account the need to convert data for cations and anions from percentage to milliequivalents (mEq) as provided in Table 5.
  • the dogs are fed the foods for seven days over which time the dog's average food intake is quantified.

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PCT/US2009/065499 2008-11-21 2009-11-23 Methods for altering food intake, modifying nutrient digestibility and altering stool quality and/or stool frequency WO2010060025A1 (en)

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CN2009801470919A CN102223810A (zh) 2008-11-21 2009-11-23 用于改变食物摄取、改善营养素消化率和改变粪便质量和/或排便次数的方法
EP09761119.8A EP2352387B1 (en) 2008-11-21 2009-11-23 Method for modifying fat digestibility
RU2011125312/13A RU2483570C2 (ru) 2008-11-21 2009-11-23 Способы изменения потребления корма, модифицирующие перевариваемость нутриентов и изменяющие качество и/или частоту стула
BRPI0922065A BRPI0922065A8 (pt) 2008-11-21 2009-11-23 Métodos para aumentar a digestibilidade de proteína e de gordura, e para diminuir a digestibilidade de gordura em um cão, método para tratar um cão, e, uso de ânions metabolizáveis e cátions metabolizáveis
CA2742123A CA2742123C (en) 2008-11-21 2009-11-23 Methods for altering food intake, modifying nutrient digestibility and altering stool quality and/or stool frequency
AU2009316370A AU2009316370B2 (en) 2008-11-21 2009-11-23 Methods for altering food intake, modifying nutrient digestibility and altering stool quality and/or stool frequency
JP2011537680A JP2012509669A (ja) 2008-11-21 2009-11-23 食物摂取量を変化させ、栄養素消化率を改変し、糞便の質および／または排便回数を変化させるための方法

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CN102885234B (zh) * 2012-10-16 2014-01-08 中国科学院东北地理与农业生态研究所 一种减少肉牛粪便磷素排放量的添加剂
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WO2014149280A1 (en) * 2013-03-15 2014-09-25 Nusirt Sciences, Inc. Treatment of pets with sirtuin activators
EP3554263B1 (en) * 2016-12-15 2023-07-19 Société des Produits Nestlé S.A. Compositions and methods that modulate digestibility in a companion animal
JP6889338B2 (ja) * 2019-04-16 2021-06-18 株式会社電通 ペットフードレコメンド装置および、ペットフードレコメンド方法、サプリメントレコメンド装置、サプリメントレコメンド方法ならびに腸年齢算出式決定方法および腸年齢算出方法
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