WO2010060011A2 - Électrode tamis bipolaire et procédé d’assemblage - Google Patents

Électrode tamis bipolaire et procédé d’assemblage Download PDF

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Publication number
WO2010060011A2
WO2010060011A2 PCT/US2009/065462 US2009065462W WO2010060011A2 WO 2010060011 A2 WO2010060011 A2 WO 2010060011A2 US 2009065462 W US2009065462 W US 2009065462W WO 2010060011 A2 WO2010060011 A2 WO 2010060011A2
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Prior art keywords
substrate
ring electrodes
electrode
accordance
nerve
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PCT/US2009/065462
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English (en)
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WO2010060011A3 (fr
Inventor
Daniel Moran
Blaine Christiansen
Matthew Macewan
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Washington University In St. Louis
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Priority to US13/130,262 priority Critical patent/US8792973B2/en
Publication of WO2010060011A2 publication Critical patent/WO2010060011A2/fr
Publication of WO2010060011A3 publication Critical patent/WO2010060011A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0531—Brain cortex electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029—Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4041—Evaluating nerves condition
    • A61B5/4047—Evaluating nerves condition afferent nerves, i.e. nerves that relay impulses to the central nervous system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T29/00—Metal working
    • Y10T29/49—Method of mechanical manufacture
    • Y10T29/49002—Electrical device making
    • Y10T29/49117—Conductor or circuit manufacturing

Definitions

  • ECG electrocorticography
  • a number of existing apparatuses are known for interfacing an external information system with the human nervous system.
  • electrocorticography uses multiple electrode arrays that are placed directly on the surface of a subject's brain to record electrical activity within the cerebral cortex. Because ECoG interfaces cortical tissue, ECoG is a method of interfacing with the central nervous system as a whole.
  • An additional example of an apparatus for use in interfacing the central nervous system is a Utah array.
  • a Utah array is a group of microscopic tines, each containing a number of electrode sites, that are inserted directly into cerebral cortical tissue.
  • An external information system is then electrically coupled to a base portion of the array to facilitate the communication of signals from the information system to the cerebral cortical tissue and/or from the cerebral cortical tissue to the information system.
  • a spinal cord stimulation (SCS) system is another example of an apparatus for use in interfacing the central nervous system.
  • the SCS system uses small leads, containing multiple electrode sites, placed in close proximity to the spinal cord to communicate, such as delivering and/or receiving, signals between the spinal cord and an external information system.
  • a nerve cuff electrode includes electrical contacts embedded within a conduit that is wrapped around the circumference of a nerve. Connections between the ring electrodes, electrical leads, electrical contacts, and an external information system facilitate communication between the peripheral nerve and an external device.
  • Another example of an apparatus for use in interfacing the peripheral nervous system is a Utah slant array.
  • the Utah slant array is similar to the Utah array discussed above, however, the microscopic tines of the slant array have varying heights that allow the tines to interact with peripheral nervous tissue at different depths of penetration.
  • a sieve electrode is a thin-film device that contains numerous holes, some of which are surrounded by, or in proximity to, small metal ring electrodes.
  • the electrode is implanted between the two transected ends of a peripheral nerve or trunk, which are microsurgically attached and secured to either side of the device. Axons within the proximal end of the nerve then regenerate through the holes in the electrode, including a number of holes surrounded by, or in proximity to, metal ring electrodes, and functionally reconnect with distal motor and sensory targets.
  • Connections between the metal ring electrodes and an external information system facilitate communication between axons within holes surrounded by metal ring electrodes and an external device.
  • Sieve electrodes are especially useful for the communication of signals from the information system to the peripheral nervous tissue.
  • pulses of electrical current are delivered to the peripheral nerve tissue via ring electrodes.
  • the delivery of electrical current excites (e.g., depolarizes) local axons resulting in the initiation of action potentials, the basic unit of information within the nervous system.
  • an apparatus for interfacing a nerve and an external information system.
  • the apparatus includes a substrate having a first surface, an opposite second surface, and an electrode body, wherein the electrode body includes a plurality of holes or voids extending therethrough.
  • the apparatus also includes a plurality of electrical leads embedded within the substrate and a plurality of ring electrodes, wherein each of the ring electrodes circumscribes a corresponding hole, and wherein at least a portion of the ring electrodes is positioned on each of the first surface and the second surface.
  • a neural interface system in another aspect, includes a bipolar sieve electrode applied to a nerve within a subject and an information system positioned external to the subject and configured to transmit signals to the nerve via the bipolar sieve electrode and/or receive signals from the nerve via the bipolar sieve electrode.
  • the bipolar sieve electrode includes one or more substrates having a first surface, an opposite second surface, and an electrode body, wherein the electrode body includes a plurality of holes or voids extending therethrough.
  • the bipolar sieve electrode also includes a plurality of electrical leads embedded within the substrate and a plurality of ring electrodes. Each of the ring electrodes circumscribes, either partially or completely, a corresponding hole, and at least a portion of the ring electrodes is positioned on each of the first surface and the second surface.
  • a method for assembling a bipolar sieve electrode that interfaces a nerve and an external information system.
  • the method includes forming a plurality of substrates, wherein each substrate includes a plurality of holes or voids extending through the substrate, a plurality of contact pads, a plurality of electrical leads, and/or a plurality of ring electrodes positioned on a first surface and/or a second surface of the substrate.
  • the method also includes exposing the plurality of contact pads and/or the plurality of ring electrodes on the first surface and/or the second surface of each substrate, wherein each of the plurality of ring electrodes circumscribes, either partially or completely, a corresponding hole of the plurality of holes.
  • the method also includes coupling a second surface of a first substrate of the plurality of substrates to a second surface of a second substrate of the plurality of substrates such that at least a portion of the plurality of ring electrodes is positioned on the first surface of each of the first and second substrates.
  • Figure 1 is a schematic view showing an exemplary bipolar sieve electrode.
  • FIG 2 is a schematic diagram showing an electrode body that may be used with the bipolar sieve electrode shown in Figure 1.
  • Figure 3 is a schematic view of an alternative embodiment of a bipolar sieve electrode assembly.
  • Figure 4 is a schematic diagram showing an electrode body that may be used with the bipolar sieve electrode assembly shown in Figure 3.
  • Figure 5 is an alternative embodiment of the electrode body used with the bipolar sieve electrode assembly shown in Figure 3.
  • Figure 6 is an optical micrograph demonstrating small groups of regenerated axons passing through the holes in the electrode body of a sieve electrode.
  • Figure 7 is a schematic, cross-sectional representation of a number of axons, as shown in Figure 6, passing through a hole circumscribed by a ring electrode of a unipolar sieve electrode that is known in the art.
  • Figure 8 is a schematic, cross-sectional representation of a number of axons, as shown in Figure 6, passing through a hole circumscribed by a ring electrode of a bipolar sieve electrode.
  • Figure 9 is a block diagram showing an exemplary neural interface system that includes a bipolar sieve electrode.
  • Figure 10 is a flowchart illustrating an exemplary method of assembling a bipolar sieve electrode for providing an interface between a nerve and an external information system.
  • the subject matter disclosed herein relates generally to neural interfaces and, more particularly, to an electrode that facilitates achieving communication between the human nervous system and an external system.
  • embodiments of the invention provide a bipolar sieve electrode that provides an interface between a nerve, such as a nerve, nerve root, nerve trunk, nerve division, nerve cord, or nerve branch, within a subject's peripheral nervous system or central nervous system, and an external information system, such as a computer, processor, or controller.
  • the bipolar sieve electrode includes one or more substrates having a first surface, an opposite second surface, and an electrode body, wherein the electrode body includes a plurality of holes or voids extending therethrough.
  • the apparatus also includes a plurality of electrical leads embedded within the substrate and a plurality of ring electrodes, wherein each of the ring electrodes circumscribes, either partially or completely, a corresponding hole, and wherein at least a portion of the plurality of ring electrodes is positioned on each of the first surface and the second surface.
  • the bipolar sieve electrode may include two or more unipolar sieve electrodes that are positioned adjacent each other such that the ring electrodes of each of the unipolar sieve electrodes circumscribe corresponding, aligned holes and face in opposite directions.
  • the bipolar sieve electrode may include two or more joined or linked unipolar sieve electrodes that are folded and coupled such that the ring electrodes of each of the unipolar sieve electrodes circumscribe corresponding, aligned holes and face in opposite directions.
  • Bipolar sieve electrodes such as those described in the embodiments included herein, have a unique potential to selectively interface (e.g., stimulate and/or record) small groups of axons within a target nerve. Moreover, bipolar sieve electrodes have a potential to induce unidirectional action potential in local axons within the nerve via bipolar electrical stimulation. In effect, bipolar sieve electrodes are capable of simultaneously recording action potentials, thereby decoding neural signals in multiple sets of sensory and/or motor axons, and initiating action potentials, thereby inducing or modulating neural signals in identical and/or different sets of sensory and/or motor axons.
  • bipolar sieve electrodes enable bipolar sieve electrodes to achieve a real-time interface with peripheral nerve tissue and to access and/or control the neural signals traveling therethrough. Given a general uniformity in peripheral nerve tissue, bipolar sieve electrodes are capable of achieving such a selective interface with any peripheral nerve tissue. Therefore, any procedure and/or event in which neural impulses need to be monitored, recorded, analyzed, controlled, and/or modulated may benefit from the use of a bipolar sieve electrode.
  • a bipolar sieve electrode is with neuroprosthetic systems. Such systems enable functional electrical stimulation for use in externally controlling muscle activity via motor axon stimulation. External control of muscle activity may be useful in promoting recovery, rehabilitation, and/or remobilization in subjects following injury due to stroke, cerebral palsy, facial nerve palsy or injury, multiple sclerosis, peripheral nerve injury, traumatic brain injury, spinal cord injury, and/or other neurological disabilities.
  • such systems may provide significant functional recovery following spinal cord injuries by facilitating control of arm and/or hand function including reaching, grasping, and/or feeding actions, by facilitating control of trunk and/or leg function including standing, transfer, and walking actions, and by facilitating control of autonomic processes including urination, continence, and/or sexual function.
  • Such systems may also provide recovery for such patients by facilitating graded control of muscle contraction for strengthening purposes and/or development of advanced neuroprosthetic systems.
  • Such systems also enable functional electrical stimulation for use in externally controlling sensory stimuli via sensory axon stimulation.
  • External control of sensory feedback may be useful in promoting recovery of auditory input including control of afferent neural signals in the cochlear nerve, and/or for use in development of advanced auditory prostheses.
  • Such external control may also be useful in promoting recovery of visual input including control of afferent fibers in the optic nerve, and/or for use in development of advanced visual prostheses.
  • this external control may be useful in promoting recovery of peripheral sensation including control of afferent neural signals in the peripheral nerve, and/or for use in development of advanced prosthetic limbs for amputees or sensory feedback systems for individuals with other sensory impairments.
  • Such external control may also be useful in promoting modulation and/or treatment of pain disorders by controlling afferent neural signals in a peripheral nerve, leading to development of new approaches to pain management. Additionally, external control may be useful in promoting modulation of afferent vagal nerve activity, cortical activity, and/or visceral, or autonomic sensation. Modulating afferent vagal nerve activity may be useful in promoting the development of advanced treatments for depression and/or development of advanced vagal stimulator systems. Modulating afferent cranial nerve and/or peripheral nerve activity may also effectively modulate cortical activity, which may be useful in influencing and/or studying cortical plasticity and/or re-assignment following neurological injury.
  • Modulating afferent neural signals in gastric nerves and/or in the enteric nervous system may also be useful in modulating appetite, satiety, weight gain, digestion, and/or bowel function. Further, such systems are capable of controlling bioelectric potentials and producing focal electric fields around the ring electrodes in the electrode body, which may enable bioelectric modulation of peripheral nerve regeneration following peripheral nerve injury and/or healing, remodeling, or growth of other types of tissue in proximity to the electrode body. This facilitates development of advanced biomedical systems and methods that are particularly useful within the field of regenerative medicine.
  • Such systems also enable functional electrical recording of efferent motor signals and/or afferent sensory signals.
  • Recording efferent motor signals may be useful in predicting and/or planning a subject's movements and controlling artificial limbs, robot devices, or graphic interfaces. This facilitates the development of advanced prosthetic limbs and/or neuroprosthetic systems, as well as development of advanced brain-computer interface technology that enables users to directly interface with, for example, vehicles, computers, and/or electronic devices.
  • Recording afferent sensory signals may be useful in re-establishing a sensory connection to the central nervous system, as well as development of advanced visual prostheses and/or development of sensory feedback systems for individuals with central sensory impairments.
  • Bipolar sieve electrodes such as those described herein, may also be used in basic science research.
  • bipolar sieve electrodes may be used to acquire single-unit recordings in the peripheral nervous system for studies in sensory and/or motor feedback pathways.
  • Bipolar sieve electrodes may also be used to evoke action potentials in peripheral nervous tissue for studying cortical activity and plasticity in response to altered peripheral input and/or output, and/or studying motor behavior in response to an altered and varied neural input.
  • FIG. 1 is a schematic view showing an exemplary bipolar sieve electrode 100
  • Figure 2 is a schematic diagram showing a central portion that may be used with bipolar sieve electrode 100.
  • Sieve electrode 100 includes a substrate 102 that is composed of, for example, silicon, polyimide, or parylene.
  • sieve electrode 100 includes two substrates 102 coupled together, or one substrate 102 folded and coupled to itself.
  • substrate 102 includes a first end 104 and an opposite second end 106, as well as a first surface 108 and an opposite second surface 110.
  • Substrate 102 also includes an electrode body 112 that includes a plurality of holes or voids 114 extending therethrough.
  • sieve electrode 100 includes approximately 330 holes extending through electrode body 112. However, it will be understood that sieve electrode 100 may include more or fewer than 330 holes, and that the holes or voids may take a variety of shapes and/or sizes.
  • a plurality of ring electrodes 116 are present in or on the substrate 102, wherein each ring electrode 116 completely circumscribes a corresponding hole 114.
  • sieve electrode 100 includes sixteen ring electrodes 116, wherein at least a portion of the plurality of ring electrodes 116 are present on or applied to each of first surface 108 and second surface 110.
  • sieve electrode 100 may include more or fewer than sixteen ring electrodes 116, each of which is electrically isolated, that each ring electrode may either partially or completely circumscribe a corresponding hole, and that each ring electrode may take a variety of shapes and/or sizes.
  • each ring electrode 116 circumscribes a corresponding hole 114 on first surface 108 and another ring electrode 116 circumscribes the same hole 114 on second surface 110.
  • each ring electrode 116 circumscribes a corresponding hole 114 on first surface 108 and a different corresponding hole 114 on second surface 110.
  • electrode body 112 also includes one or more tabs 118.
  • Each tab 118 may or may not include a reference electrode 120 and/or contact pad 122.
  • Substrate 102 is fabricated and manipulated similar to microchips or integrated circuits in order to form a plurality of electrical leads 124, ring electrodes 116, and connector pads 130 embedded within or applied on substrate 102. More specifically, substrate 102 is subjected to a process such as sacrificial photolithography to expose a portion of the plurality of embedded ring electrodes 116 and connector pads 130.
  • a first connecting tab 126 is located at first end 104 and a second connecting tab 128 is located at second end 106, and electrode body 112 is positioned between the first and second connecting tabs 126 and 128.
  • a plurality of contact pads 130 are formed on first surface 108 of substrate 102 and/or second surface 110 of substrate 102. More specifically, contact pads 130 are formed on first connecting tab 126. Moreover, a plurality of contact pads 130 is also formed on first surface 108 of substrate 102 and, more specifically, on second connecting tab 128.
  • Each electrical lead 124 connects a particular contact pad 130 to a corresponding ring electrode 116. Further, reference electrode 120 and contact pad 122 are also connected to a separate contact pad 130 on either first connecting tab 126 or second connecting tab 128 by one electrical lead 124.
  • first connecting tab 126 is located at first end 104 and electrode body 112 is located at second end 106.
  • Contact pads 130 are formed on first surface 108 of substrate 102 and, more specifically, on first connecting tab 126.
  • Each electrical lead 124 connects a particular contact pad 130 to a corresponding ring electrode 116.
  • reference electrode 120 and contact pad 122 are also connected to a separate contact pad 130 on first connecting tab 126 by one electrical lead 124.
  • sieve electrode 100 does not include either first connecting tab 126 or second connecting tab 128. More specifically, sieve electrode 100 includes only electrode body 112 which includes plurality of holes 114 and plurality of ring electrodes 116 as described above. In the absence of both first connecting tab 126 and second connecting tab 128, contact pads 130 are formed on first surface 108 of substrate 102 and/or second surface 110 of substrate 102 in various geometries around the periphery of electrode body 112. Alternatively, electrical circuitry may be integrated inside substrate 102, or on first surface 108 of substrate 102 and/or second surface 110 of substrate 102, around electrode body 112
  • ring electrodes 116 can be configured to communicate directly (i.e., via secured wire lead or metalized conductors) or indirectly (i.e. via wireless communication paradigms) with an external information system (not shown) via the applied electrical circuitry.
  • a nerve within a subject such as a peripheral nerve,, nerve root, nerve trunk, nerve division, nerve cord, or nerve branch, is isolated.
  • Bipolar sieve electrode 100 including an encapsulation and/or nerve guidance conduits, is inserted between the transected ends of the isolated nerve. Each end of the transected nerve is then inserted into the nerve guidance conduits (not shown) surrounding the porous area of electrode body 112 and/or secured to sieve electrode 100 such that each end of the nerve is near or in contact with electrode body 112.
  • a drug delivery system such as a hydrogel or polymeric scaffold, may also be applied within the nerve guidance conduits surrounding the porous area of electrode body 112 and/or applied directly to electrode body 112 of sieve electrode 100.
  • the drug delivery system may facilitate delivery of trophic factors, such as beta-nerve growth factor ( ⁇ -NGF) or glial-derived neurotrophic factor (GDNF), that enhance peripheral nervous tissue regeneration through plurality of holes 114 in electrode body 112.
  • trophic factors such as beta-nerve growth factor ( ⁇ -NGF) or glial-derived neurotrophic factor (GDNF)
  • ⁇ -NGF beta-nerve growth factor
  • GDNF glial-derived neurotrophic factor
  • Each hole 114 has a diameter between approximately 1.0 micrometer ( ⁇ m) and approximately 1.0 millimeter (mm) (e.g., approximately 60 ⁇ m), which enables multiple axons to grow through each hole 114.
  • Delivery of neurotrophic factors around electrode body 112 enhances regeneration of axons through plurality of holes 114 in electrode body 112 and functional reconnection of regenerating axons with distal motor and sensory targets.
  • some portion of the plurality of axons extend through holes 114 circumscribed completely by ring electrodes 116.
  • the proximity between axons passing through holes 114 circumscribed by ring electrodes 116 and the ring electrodes 116 themselves facilitates communication of electrical signals between the axons and ring electrodes 116.
  • neural signals such as action potentials
  • neural signals may be recorded from the groups of regenerated axons.
  • a neural signal may be transmitted from (1) a number of axons extending through one or more holes 114, to (2) one or more associated ring electrodes 116 circumscribing holes 114, to (3) one or more electrical leads 124 associated with each ring electrode 116, to (4) one or more contact pads 130 associated with each electrical lead 124, to (5) an external information system (not shown in Figures 1 and X).
  • FIG. 3 is a schematic view of an alternative bipolar sieve electrode assembly 200
  • Figure 4 is a schematic diagram showing an electrode body 212 of an alternative bipolar sieve electrode assembly 200.
  • Sieve electrode assembly 200 includes a first connector assembly 202 located at a first end 204 of sieve electrode assembly 200 and a second connector assembly 206 located at a second end 208 opposite first end 204.
  • Both first and second connector assemblies 202 and 206 include both conductive and non-conductive elements, and may take the form of various types of microelectrode connectors (e.g. printed circuit board, pin connector, insulated micro wire array).
  • both first and second connector assemblies 202 and 206 include a plurality of male connectors 210 and female connectors that extend therethrough.
  • Sieve electrode assembly 200 also includes a first electrode body 212 and a second electrode body 214, although alternative embodiments may include more than two electrode bodies. Both first electrode body 212 and second electrode body 214 include a first surface 216 and an opposite second surface 218. In one embodiment, first electrode body 212 and second electrode body 214 are coupled by an adhesive element (e.g. chemical adhesive, electrostatic force, mechanical force) that is applied to second surface 218 of each of first and second electrode bodies 212 and 214. In another embodiment, first and second electrode bodies 212 and 214 abut each other but are not coupled by an adhesive element.
  • an adhesive element e.g. chemical adhesive, electrostatic force, mechanical force
  • first and second electrode bodies 212 and 214 also include a plurality of contact pads 228 surrounding connector holes 220 that extend through electrode bodies 212 and 214, as well as a plurality of via holes 222 that extend through electrode bodies 212 and 214.
  • Each connector hole 220 is sized to receive an associated male connector 210 therethrough, which makes an electrical connection with connector pad 228, and each via hole 222 is sized to enable passage of a specific amount of regenerating peripheral nervous tissue.
  • both connector assemblies 202 and 206 include a plurality of female connectors 226 that are sized to receive an associated male connector 210 therein.
  • a particular male connector 210 extends through first connector assembly 202, first electrode body 212, second electrode body 214, and into a corresponding female connector 226 in second connector assembly 206.
  • At least a portion of the plurality of connector holes 220 in electrode bodies 212 and 214 is circumscribed by an associated contact pad 228.
  • a plurality of bar electrodes 230 is spaced between each via hole 222. Each bar electrode 230, which partially circumscribes the hole, is connected to an associated contact pad 228 by an electrical lead 232.
  • ring electrodes 116 (shown in Figure 1) are embodied by bar electrodes 230.
  • FIG. 5 is an alternative embodiment of first and second electrode bodies 212 and 214.
  • Each element is identical in Figures 3 and 4.
  • each electrode body 212 and 214 includes nine via holes 222 for peripheral nervous tissue to regenerate through.
  • electrode bodies 212 and 214 as shown in Figure 5 include seven via holes 222 for peripheral nervous tissue to regenerate through.
  • a larger number of smaller via holes 222 facilitates greater control and greater specificity of the neural signals sent and/or received from a nerve using sieve electrode 200. This capability is provided in that each via hole 222 only allows the passage of small numbers of axons or smaller groups of axons, therefore providing electrical communication between individual bar electrodes 230 and smaller populations of axons within the nerve.
  • an electrode body 212 or 214 that contains a smaller number of larger via holes 222 would facilitate less control and less specificity of electrical interfacing with peripheral nervous tissue, but may enable enhanced regeneration of peripheral nerve tissue through via holes 222 and enable electrical communication with larger groups of axons.
  • Alternative electrode bodies 212 and/or 214 may simultaneously include via holes or voids 222 and/or bar electrodes 230 of varying sizes, geometries, and/or patterns.
  • sieve electrode 200 includes only first electrode body 212.
  • at least a portion of the plurality of contact pads 228, electrical leads 232, and bar electrodes 230 are provided on first surface 216 and second surface 218.
  • ring electrodes 116 (shown in Figure 1) are embodied by bar electrodes 230.
  • a nerve within a subject such as a peripheral nerve, nerve root, nerve trunk, nerve division, nerve cord, or nerve branch is isolated.
  • a bipolar sieve electrode such as sieve electrode 200, including an encapsulation and/or nerve guidance conduits (not shown) is inserted between the transected ends of the isolated nerve.
  • a first end of the transected nerve is then inserted into first connector assembly 202 and secured such that the first end is near or in contact with first electrode body 212, and a second end of the transected nerve is inserted into second connector assembly 206 and secured such that the second end is near or in contact with second electrode body 214.
  • a drug delivery system such as a hydrogel or polymeric scaffold, may also be applied within one or more connector assemblies 202 and/or 206 surrounding the porous area of electrode bodies 212 and 214 and/or applied directly to electrode bodies 212 and 214 of sieve electrode assembly 200.
  • the drug delivery system may facilitate delivery of trophic factors, such as ⁇ nerve growth factors ( ⁇ -NGF) or glial-derived neurotrophic factor (GDNF), that enhance peripheral nervous tissue regeneration through via holes 222 in electrode bodies 212 and 214.
  • ⁇ -NGF ⁇ nerve growth factors
  • GDNF glial-derived neurotrophic factor
  • Each via hole 222 is sized to enable multiple groups of axons to grow therethrough.
  • Electrotrophic factors around electrode bodies 212 and 214 enhances regeneration of axons through via holes 222 in electrode bodies 212 and 214 and functional reconnection of regenerating axons with distal motor and sensory targets. Moreover, during regeneration, some portion of the plurality of axons extends through via holes 222 such that they are in proximity to bar electrodes 230. When regeneration is complete, the proximity between axons passing through via holes 222 and bar electrodes 230 facilitates communication of electrical signals between the axons and bar electrodes 230.
  • neural signals such as action potentials, may be initiated in the interfaced axons by sending an electrical stimulus from (1) an external information system (not shown in Figures 3, 4, and 5), to (2) one or more electrically conductive male connectors 210 in connector assemblies 202 and 206, to (3) one or more contact pads 228, to (4) one or more electrical leads 232 associated with each contact pad 228, to (5) one or more bar electrodes 230 associated with each electrical lead 232, to (6) a specific group of local axons in proximity to the associated bar electrodes 230, which becomes electrically activated.
  • neural signals may be recorded from the groups of regenerated axons.
  • a neural signal may be transmitted from (1) a number of axons extending through one or more via holes 222, to (2) one or more associated bar electrodes 230 in proximity to via holes 222, to (3) one or more electrical leads 232 associated with each bar electrode 230, to (4) one or more contact pads 228 associated with each electrical lead 232, to (5) one or more associated electrically conductive male connectors 210 in connector assemblies 202 and 206, to (6) an external information system (not shown in Figures 3, 4, and 5).
  • Figure 6 is an optical micrograph demonstrating small groups of regenerated axons 300 passing through holes in an electrode body of a sieve electrode, such as those known in the art.
  • Figure 7 is a schematic, cross-sectional representation of a number of regenerated axons, similar to the small group of axons 300 shown in Figure 6, passing through a hole 314 in a substrate 302 circumscribed completely by a ring electrode 316 within the electrode body of a unipolar sieve electrode such as those known in the art.
  • excitatory pulses of electrical current delivered via ring electrodes 316 as described previously, evoke depolarizing changes in the electrical potential across the membrane of axons 300 extending through the corresponding hole 314.
  • the degree to which the electrical potential across a given patch of axonal membrane changes depends primarily on the distance between ring electrode 316 and the specific patch of axonal membrane.
  • the degree of depolarization in the axonal membrane can be represented by a Gaussian curve 301 centered at ring electrode 316, wherein patches of axonal membrane closer to ring electrode 316 are depolarized to a greater degree than those farther away from ring electrode 316.
  • a specific threshold i.e., degree of depolarization
  • patches of axonal membrane 303 will initiate action potentials 304 and 305, which are propagating waves of depolarization which travel along the length of the axons.
  • action potentials Given the pattern of depolarization 301 evoked by stimulation via a unipolar sieve electrode, action potentials are initiated in multiple locations along interfaced axons 303.
  • evoked action potentials 304 and 305 propagate in both a distal direction 304 (i.e., toward motor or sensory organs) and in a proximal direction 305 (i.e., towards the spinal cord) along the length of the axons.
  • a distal direction 304 i.e., toward motor or sensory organs
  • a proximal direction 305 i.e., towards the spinal cord
  • Figure 8 is a schematic, cross-sectional representation of a number of regenerated axons, similar to the small group of axons 300 shown in Figure 6, passing through an aligned hole 114 in and first substrate 102 and second substrate 103 completely circumscribed by a first ring electrode 116 on the first side of the first substrate 102 and a second ring electrode 117 on the first side of the second substrate 103 within the electrode body 112 of a bipolar sieve electrode 100 (shown in Figures 1 and 2).
  • excitatory pulses of electrical current delivered via second ring electrode 117 as described previously, evoke depolarizing changes in the electrical potential across the membrane of the axons 300 extending through the corresponding hole 114.
  • Simultaneous application of inhibitory pulses of electrical current delivered via first ring electrode 116 as described previously, evoke hyperpolarizing changes in the electrical potential across the membrane of the axons
  • the degree to which the electrical potential across a given patch of axonal membrane changes due to both of these stimuli depends on: 1) the distance between first ring electrode 116 and the specific patch of axonal membrane, 2) the distance between second ring electrode 117 and the specific patch of axonal membrane, 3) the linear distance between first ring electrode 116 and second ring electrode 117, and 4) the temporal separation between the electrical activation of the first ring electrode 116 and the second ring electrode 117. Therefore, the degree of depolarization in the axonal membrane can be represented by two superimposed Gaussian curves 301 and 306 centered at second ring electrode 117 and first ring electrode 116, respectively.
  • Patches of axonal membrane closer to second ring electrode 117 will be depolarized to a greater degree than those farther away from second ring electrode 117, and patches of axonal membrane closer to first ring electrode 116 will be hyperpolarized to a greater degree than those farther away from first ring electrode 116.
  • a specific threshold i.e., degree of depolarization
  • patches of axonal membrane 303 will initiate action potentials.
  • a specific threshold i.e., degree of hyperpolarization
  • action potentials are initiated in multiple locations along interfaced axons 303 yet the evoked action potentials 304 only successfully propagate in the distal direction 304 (i.e., toward motor or sensory organs) as action potentials propagating in the proximal direction are effectively blocked by a region of unresponsive, hyperpolarized axonal membrane 307.
  • electrical stimulation via bipolar sieve electrodes could also be utilized to selectively initiate action potentials propagating solely in the proximal direction (i.e., toward the spinal cord).
  • Such unidirectional action potentials could be initiated simply by switching the polarity of the electrical stimulus delivered to the two ring electrodes, effectively delivering excitatory pulses of electrical current through first ring electrode 116 and inhibitory pulses of electrical current through second ring electrode 117. Varying the spatial and temporal separation of the electrical activation of first ring electrode 116 and second ring electrode 117 could also be utilized to control the selective initiation of unidirectional action potentials as various stimulus waveforms and temporal delays between stimuli activate different populations of axons within interfaced nervous tissue.
  • Selective initiation of unidirectional action potential in specific groups of interface axons 300 may also be achieved through the use of more than two substrates 102 and more than two electrodes 116 and 117 positioned along the length of regenerated axons, thereby enabling complex multi-polar stimulation of interfaced axons 300.
  • Such selective initiation of unidirectional action potentials (in either the proximal or distal direction) is particularly useful and sought after in the field.
  • FIG. 9 is a block diagram showing an exemplary neural interface system 400.
  • System 400 includes an information system 402 that is positioned external to a subject, and a bipolar sieve electrode 100 or 200. Alternatively, information system 402 may be positioned internal to the subject.
  • Information system 402 includes, for example, a computing device, controller, or computer 404.
  • Computer 404 includes a processor 406 and a system memory 408 coupled to processor 406.
  • Computer 406 also includes an input device 410, such as a mouse and/or a keyboard.
  • a lead wire 412 is connected to one of a plurality of outputs 414 of information system 402 and to a corresponding contact pad 130 (shown in Figures 1 and 2) to facilitate transmitting signals between information system 402 and sieve electrode 100 or 200, as described previously.
  • electrical impulses or digital signals are communicated wirelessly (i.e. without lead wire 412) from information system 402, positioned either internal or external to the subject, to a corresponding contact pad 130 on the electrode (shown in Figures 1 and 2).
  • wireless communication between information system 402 and bipolar sieve electrode 100 or 200 may take the form of radio frequency (RF) communication, transcutaneous current routing, optical communication, and/or any other suitable wireless communication method.
  • RF radio frequency
  • Computer 404 as described herein may have more than one processor 406 as well as storage memory separate from system memory 408.
  • Computer 404 typically includes at least some form of computer readable media.
  • computer readable media include computer storage media and communication media.
  • Computer storage media include volatile and nonvolatile, removable and non-removable media implemented in any method or technology for storage of information such as computer readable instructions, data structures, program modules, or other data.
  • Communication media typically embody computer readable instructions, data structures, program modules, or other data in a modulated data signal such as a carrier wave or other transport mechanism and include any information delivery media.
  • modulated data signal such as a carrier wave or other transport mechanism and include any information delivery media.
  • processor 406 includes any programmable system including systems and microcontrollers, reduced instruction set circuits (RISC), application specific integrated circuits (ASIC), programmable logic circuits (PLC), and any other circuit or processor capable of executing the functions described herein.
  • RISC reduced instruction set circuits
  • ASIC application specific integrated circuits
  • PLC programmable logic circuits
  • information system 402 may include a database (not shown) that stores any collection of data including hierarchical databases, relational databases, flat file databases, object-relational databases, object oriented databases, and any other structured collection of records or data that is stored in a computer system.
  • aspects of the invention are operable with any memory area and means for storing or retrieving data.
  • FIG 10 is a flowchart 500 illustrating an exemplary method, and alternative methods, of assembling a bipolar sieve electrode, such as bipolar sieve electrode 100 (shown in Figures 1 and 2) or bipolar sieve electrode 300 (shown in Figures 3-5), for providing an interface between a nerve and an external information system, such as information system 402 (shown in Figure 9).
  • a bipolar sieve electrode such as bipolar sieve electrode 100 (shown in Figures 1 and 2) or bipolar sieve electrode 300 (shown in Figures 3-5), for providing an interface between a nerve and an external information system, such as information system 402 (shown in Figure 9).
  • two identical substrates 102 are formed using known techniques 502.
  • Each substrate 102 includes a first surface 108 and a second surface 110 and contains a plurality of holes 114, contact pads 130, electrical leads 124, and/or ring electrodes 116 on or in first surface 108 (each shown in Figures 1 and 2).
  • each ring electrode 116 circumscribes a corresponding hole 114 within electrode body 112 of substrate 102.
  • contact pads 130 and/or ring electrodes 116 are exposed at a first end 104 (shown in Figures 1 and 2) and additional contact pads 130 and/or ring electrodes 116 are exposed at a second end 106 (shown in Figures 1 and 2), such that electrode body 112 of each substrate 102 is located between first end 104 and second end 106.
  • contact pads 130 and/or ring electrodes 116 are exposed only at a first end 104, such that electrode body 112 forms second end 106 of substrate 102.
  • a plurality of ring electrodes 116 may also be applied or formed in or on first surface 108 of substrate 102.
  • second surface 110 of one substrate 102 is coupled 531 together with second surface 110 of another substrate 102 such that at least a portion of the plurality of ring electrodes 116 is positioned on first surface 108 of each substrate 102 and such that at least a portion of the plurality of ring electrodes 116 on first and second substrate 102 circumscribe corresponding, aligned holes 114.
  • each substrate 102 includes a first surface 108 and a second surface 110 and contains a plurality of contact pads 130, electrical leads 124, and/or ring electrodes 116 on or in first surface 108 of substrate 102, but does not initially contain any holes 114.
  • an additional step must be taken to form a plurality of holes 511 that extend through the electrode body 112 of the substrate 102 prior to exposure of a plurality of electrical elements 521, and coupling of multiple substrates 531, as described in the exemplary method.
  • bipolar sieve electrode 100 or 200 includes only a single substrate 102, rather than two coupled substrates.
  • substrate 102 is formed 504.
  • Substrate 102 includes a first surface 108 and a second surface 110 and contains a plurality of holes 114, contact pads 130, electrical leads 124, and/or ring electrodes 116 on or in both first surface 108 and second surface 110 of substrate 102.
  • Second, a plurality of contact pads 130 and/or ring electrodes 116 are exposed 522 on both first surface 108 and second surface 110 of substrate 102.
  • each ring electrode 116 is exposed such that it circumscribes a corresponding hole 114 within electrode body 112 of substrate 102, such that at least a portion of the plurality of ring electrodes 116 is positioned on both first surface 108 and second surface 110 of substrate 102, and such that at least a portion of the plurality of ring electrodes 116 on first surface 108 and second surface 110 of substrate 102 circumscribe corresponding holes 114.
  • This method of fabricating a bipolar sieve electrode 100 or 200 containing only a single substrate 102 may also be applied where substrate 102 is formed 504 and then folded, manipulated, and/or arranged in three-dimensional space prior to exposure of any plurality of contact pads 130 and/or ring electrodes 116 on either first surface 108 and/or second surface 110 of substrate 102.
  • substrate 102 is formed 503.
  • Substrate 102 includes a first surface 108 and a second surface 110 and contains a plurality of contact pads 130, electrical leads 124, and/or ring electrodes 116 on or in both first surface 108 and second surface 110 of substrate 102, but does not initially contain any holes 114.
  • an additional step must be taken to form a plurality of holes 511 that extend through electrode body 112 of substrate 102 prior to exposure of a plurality of electrical elements 522 on both first surface 108 and second surface 110 of substrate 102.
  • This method of fabricating a bipolar sieve electrode 100 or 200 containing only a single substrate 102 may also be applied where substrate 102 is formed 504 and then folded, manipulated, and/or arranged in three- dimensional space prior to formation of a plurality of holes 511 that extend through electrode body 112 of substrate 102 and prior to exposure of a plurality of electrical elements 522 on either first surface 108 and/or second surface 110 of substrate 102.
  • compositions and methods of this invention have been described in terms of preferred embodiments, it will be apparent to those of skill in the art that variations may be applied to the compositions and/or methods and in the steps or in the sequence of steps of the method described herein without departing from the concept, spirit and scope of the invention. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims.

Abstract

On décrit un appareil destiné à former une interface entre un nerf et un système d’information externe. L’appareil comprend un substrat présentant une première surface, une deuxième surface opposée et un corps d’électrode, ledit corps d’électrode comprenant une pluralité de trous s’étendant à travers celui-ci. L’appareil comprend également une pluralité de fils électriques encastrés dans le substrat et une pluralité d’électrodes annulaires, chacune de ces électrodes annulaires circonscrivant un trou correspondant et au moins une partie des électrodes annulaires étant positionnée sur chacune des première et deuxième surfaces.
PCT/US2009/065462 2008-11-21 2009-11-23 Électrode tamis bipolaire et procédé d’assemblage WO2010060011A2 (fr)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011159631A3 (fr) * 2010-06-18 2012-03-08 Boston Scientific Neuromodulation Corporation Réseau d'électrodes ayant des électrodes intégrées et procédés de fabrication de celui-ci
US8792973B2 (en) 2008-11-21 2014-07-29 Washington University Bipolar sieve electrode and method of assembly

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8515510B2 (en) * 2009-03-31 2013-08-20 Covidien Lp Electroadhesive medical devices
KR101370003B1 (ko) * 2012-12-07 2014-03-19 한국과학기술연구원 손상된 신경의 기능을 복구하기 위한 신경 도관
WO2017078819A2 (fr) * 2015-08-13 2017-05-11 University Of Southern California Électrode souple à agent de lyse
US20180117313A1 (en) 2016-10-31 2018-05-03 The Alfred E. Mann Foundation For Scientific Research Nerve cuff electrodes fabricated using over-molded lcp
AU2021455531A1 (en) 2021-07-09 2024-01-18 The Alfred E. Mann Foundation For Scientific Research Electrode leads having multi-application helical nerve cuffs and associated systems and methods
CN114795238B (zh) * 2022-04-22 2023-05-05 清华大学 多模态检测装置及其制造方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5400784A (en) * 1993-10-15 1995-03-28 Case Western Reserve University Slowly penetrating inter-fascicular nerve cuff electrode and method of using
US20020122770A1 (en) * 2000-07-05 2002-09-05 Hiroaki Oka Apparatus and method for screening, olfactory mucosa stimulating compound found by the screening method, and therapeutic apparatus and electrode section for measurement
US20040111140A1 (en) * 2001-01-11 2004-06-10 Thomas Stieglitz Sieve electrode which can be connected to a nerve stump
US20080228240A1 (en) * 2004-06-17 2008-09-18 Edell David J Long Term Bi-Directional Axon-Electronic Communication System

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59510409D1 (de) * 1994-07-13 2002-11-07 Fraunhofer Ges Forschung Flexible künstliche nervenplatte
DE4433111A1 (de) * 1994-09-16 1996-03-21 Fraunhofer Ges Forschung Cuff-Elektrode
US5487756A (en) * 1994-12-23 1996-01-30 Simon Fraser University Implantable cuff having improved closure
US20080027347A1 (en) * 2006-06-23 2008-01-31 Neuro Vista Corporation, A Delaware Corporation Minimally Invasive Monitoring Methods
US8792973B2 (en) 2008-11-21 2014-07-29 Washington University Bipolar sieve electrode and method of assembly

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5400784A (en) * 1993-10-15 1995-03-28 Case Western Reserve University Slowly penetrating inter-fascicular nerve cuff electrode and method of using
US20020122770A1 (en) * 2000-07-05 2002-09-05 Hiroaki Oka Apparatus and method for screening, olfactory mucosa stimulating compound found by the screening method, and therapeutic apparatus and electrode section for measurement
US20040111140A1 (en) * 2001-01-11 2004-06-10 Thomas Stieglitz Sieve electrode which can be connected to a nerve stump
US20080228240A1 (en) * 2004-06-17 2008-09-18 Edell David J Long Term Bi-Directional Axon-Electronic Communication System

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8792973B2 (en) 2008-11-21 2014-07-29 Washington University Bipolar sieve electrode and method of assembly
WO2011159631A3 (fr) * 2010-06-18 2012-03-08 Boston Scientific Neuromodulation Corporation Réseau d'électrodes ayant des électrodes intégrées et procédés de fabrication de celui-ci
US8868206B2 (en) 2010-06-18 2014-10-21 Boston Scientific Neuromodulation Corporation Electrode array having embedded electrodes and methods of making the same
US9855417B2 (en) 2010-06-18 2018-01-02 Boston Scientific Neuromodulation Corporation Method of making an electrode array having embedded electrodes

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