WO2010054102A3 - Inhibiteurs polybasiques de pompe à efflux bactérienne et leurs utilisations thérapeutiques - Google Patents

Inhibiteurs polybasiques de pompe à efflux bactérienne et leurs utilisations thérapeutiques Download PDF

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Publication number
WO2010054102A3
WO2010054102A3 PCT/US2009/063426 US2009063426W WO2010054102A3 WO 2010054102 A3 WO2010054102 A3 WO 2010054102A3 US 2009063426 W US2009063426 W US 2009063426W WO 2010054102 A3 WO2010054102 A3 WO 2010054102A3
Authority
WO
WIPO (PCT)
Prior art keywords
efflux pump
polybasic
bacterial
pump inhibitors
therapeutic uses
Prior art date
Application number
PCT/US2009/063426
Other languages
English (en)
Other versions
WO2010054102A2 (fr
Inventor
Tomasz Glinka
Olga Rodny
Keith A. Bostian
David M. Wallace
Robert Higuchi
Chun Chow
Chi Ching Mak
Gavin Hirst
Brian Eastman
Original Assignee
Mpex Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mpex Pharmaceuticals, Inc. filed Critical Mpex Pharmaceuticals, Inc.
Publication of WO2010054102A2 publication Critical patent/WO2010054102A2/fr
Publication of WO2010054102A3 publication Critical patent/WO2010054102A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

L'invention porte sur des composés ayant des fonctionnalités polybasiques. Les composés inhibent des inhibiteurs de pompe à efflux bactérienne et sont utilisés en combinaison avec un agent antibactérien pour traiter ou prévenir des infections bactériennes. Ces combinaisons peuvent être efficaces contre les infections bactériennes qui ont développé une résistance à des agents antibactériens à travers un mécanisme de pompe à efflux.
PCT/US2009/063426 2008-11-05 2009-11-05 Inhibiteurs polybasiques de pompe à efflux bactérienne et leurs utilisations thérapeutiques WO2010054102A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11167408P 2008-11-05 2008-11-05
US61/111,674 2008-11-05

Publications (2)

Publication Number Publication Date
WO2010054102A2 WO2010054102A2 (fr) 2010-05-14
WO2010054102A3 true WO2010054102A3 (fr) 2010-08-12

Family

ID=41606591

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/063426 WO2010054102A2 (fr) 2008-11-05 2009-11-05 Inhibiteurs polybasiques de pompe à efflux bactérienne et leurs utilisations thérapeutiques

Country Status (1)

Country Link
WO (1) WO2010054102A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201008267D0 (en) * 2010-05-18 2010-06-30 Univ Edinburgh Cationic lipids
US9282738B2 (en) 2011-07-11 2016-03-15 Wisconsin Alumni Research Foundation Antimicrobial compositions and methods of use thereof
US10314816B2 (en) 2012-06-08 2019-06-11 Wisconsin Alumni Research Foundation Antimicrobial compounds, compositions and methods of use thereof
US9440920B2 (en) 2014-07-03 2016-09-13 Wisconsin Alumni Research Foundation Antimicrobial compounds, compositions and methods of use thereof
JP2018513193A (ja) * 2015-04-20 2018-05-24 ニューメキシコ テック リサーチ ファウンデーションＮｅｗ Ｍｅｘｉｃｏ Ｔｅｃｈ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 抗生物質感受性回復及び感光性薬剤
WO2017042099A1 (fr) * 2015-09-09 2017-03-16 Basilea Pharmaceutica Ag Inhibiteurs de pompes à efflux et leurs utilisations thérapeutiques
CN113214106B (zh) * 2021-06-22 2023-05-09 河南师范大学 一种高效合成伯酰胺、n-甲基仲酰胺类化合物的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008141010A2 (fr) * 2007-05-11 2008-11-20 Mpex Pharmaceuticals, Inc. Inhibiteurs de pompes à efflux bactériennes polybasiques et leurs utilisations thérapeutiques

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008141010A2 (fr) * 2007-05-11 2008-11-20 Mpex Pharmaceuticals, Inc. Inhibiteurs de pompes à efflux bactériennes polybasiques et leurs utilisations thérapeutiques

Also Published As

Publication number Publication date
WO2010054102A2 (fr) 2010-05-14

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