WO2010054015A3 - Methods of reducing the risk of cardiovascular disease in postmenopausal women - Google Patents

Methods of reducing the risk of cardiovascular disease in postmenopausal women Download PDF

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Publication number
WO2010054015A3
WO2010054015A3 PCT/US2009/063308 US2009063308W WO2010054015A3 WO 2010054015 A3 WO2010054015 A3 WO 2010054015A3 US 2009063308 W US2009063308 W US 2009063308W WO 2010054015 A3 WO2010054015 A3 WO 2010054015A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
cardiovascular disease
risk
reducing
postmenopausal women
Prior art date
Application number
PCT/US2009/063308
Other languages
French (fr)
Other versions
WO2010054015A2 (en
Inventor
Lorne M. Golub
Jeffrey B. Payne
Original Assignee
The Research Foundation Of State University Of New York
Board Of Regents Of The University Of Nebraska
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Research Foundation Of State University Of New York, Board Of Regents Of The University Of Nebraska filed Critical The Research Foundation Of State University Of New York
Priority to EP09825375.0A priority Critical patent/EP2365813A4/en
Priority to US13/126,009 priority patent/US20120046249A1/en
Publication of WO2010054015A2 publication Critical patent/WO2010054015A2/en
Publication of WO2010054015A3 publication Critical patent/WO2010054015A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

The present invention features materials and methods for reducing the risk of cardiovascular disease in postmenopausal or perimenopausal women. More specifically, these methods can be used in women who generally have no apparent cardiovascular disease. We describe herein methods of administering non-antibacterial tetracycline or a sub-antimicrobial amount of antibacterial tetracyclines or tetracycline formulations and their use in reducing the risk that cardiovascular disease will develop in a subject (e.g., in a post- or perimenopausal woman).
PCT/US2009/063308 2008-11-04 2009-11-04 Methods of reducing the risk of cardiovascular disease in postmenopausal women WO2010054015A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP09825375.0A EP2365813A4 (en) 2008-11-04 2009-11-04 Methods of reducing the risk of cardiovascular disease in postmenopausal women
US13/126,009 US20120046249A1 (en) 2008-11-04 2009-11-04 Methods of reducing the risk of cardiovascular disease in postmenopausal women

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11117108P 2008-11-04 2008-11-04
US61/111,171 2008-11-04
US11531408P 2008-11-17 2008-11-17
US61/115,314 2008-11-17

Publications (2)

Publication Number Publication Date
WO2010054015A2 WO2010054015A2 (en) 2010-05-14
WO2010054015A3 true WO2010054015A3 (en) 2010-08-12

Family

ID=42153535

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/063308 WO2010054015A2 (en) 2008-11-04 2009-11-04 Methods of reducing the risk of cardiovascular disease in postmenopausal women

Country Status (2)

Country Link
EP (1) EP2365813A4 (en)
WO (1) WO2010054015A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030082120A1 (en) * 2001-10-26 2003-05-01 Milstein Harold J. Method for reducing systemic effects of aging, effects of aging on the skin, and incidence of skin damage from sun exposure using antibiotics of the tetracycline family
US20030092684A1 (en) * 1999-04-27 2003-05-15 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US20070258951A1 (en) * 2001-06-01 2007-11-08 Victor Dzau Methods of treating cardiac disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0599397T3 (en) * 1992-11-17 1996-09-16 Univ New York State Res Found Tetracyclines, including non-microbial, chemically modified tetracyclines, inhibit excessive collagen cross-linking in diabetes
US5523297A (en) * 1993-03-02 1996-06-04 The Research Foundation Of State University Of New York Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines
US6841547B2 (en) * 2003-02-28 2005-01-11 Albert Einstein College Of Medicine Of Yeshevia University Method for decreasing low density lipoprotein

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030092684A1 (en) * 1999-04-27 2003-05-15 Fredeking Terry M. Compositions and methods for treating hemorrhagic virus infections and other disorders
US20070258951A1 (en) * 2001-06-01 2007-11-08 Victor Dzau Methods of treating cardiac disorders
US20030082120A1 (en) * 2001-10-26 2003-05-01 Milstein Harold J. Method for reducing systemic effects of aging, effects of aging on the skin, and incidence of skin damage from sun exposure using antibiotics of the tetracycline family

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2365813A4 *

Also Published As

Publication number Publication date
WO2010054015A2 (en) 2010-05-14
EP2365813A4 (en) 2013-04-24
EP2365813A2 (en) 2011-09-21

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