WO2010049590A3 - A new pharmaceutical product - Google Patents

A new pharmaceutical product Download PDF

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Publication number
WO2010049590A3
WO2010049590A3 PCT/FI2009/050869 FI2009050869W WO2010049590A3 WO 2010049590 A3 WO2010049590 A3 WO 2010049590A3 FI 2009050869 W FI2009050869 W FI 2009050869W WO 2010049590 A3 WO2010049590 A3 WO 2010049590A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
collagenous protein
blood circulation
pharmaceutical product
new pharmaceutical
Prior art date
Application number
PCT/FI2009/050869
Other languages
French (fr)
Other versions
WO2010049590A2 (en
Inventor
Raili MYLLYLÄ
Heli Ruotsalainen
Original Assignee
Oulun Yliopisto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oulun Yliopisto filed Critical Oulun Yliopisto
Priority to EP09759744A priority Critical patent/EP2349326A2/en
Publication of WO2010049590A2 publication Critical patent/WO2010049590A2/en
Publication of WO2010049590A3 publication Critical patent/WO2010049590A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • C12Y114/11004—Procollagen-lysine 5-dioxygenase (1.14.11.4), i.e. lysine-hydroxylase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention relates to methods and products for the treatment of any disorder or condition, which is associated with abnormal amount of non-collagenous protein, or abnormal oligomerization or dysfunction of non-collagenous protein, such as adiponectin in the blood circulation and/or tissue of a patient. The treatment comprises that functional form of the non-collagenous protein is adjusted in the blood circulation and/or tissue of the patient substantially to the level it is in the blood circulation and/or tissue of a healthy person, by using lysyl hydroxylase and/or glycosyl-transferase activities of LH3 or other lysyl hydroxylase to modify the non-collagenous protein to HMW or other functional form.
PCT/FI2009/050869 2008-10-29 2009-10-29 A new pharmaceutical product WO2010049590A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09759744A EP2349326A2 (en) 2008-10-29 2009-10-29 A new pharmaceutical product

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19764208P 2008-10-29 2008-10-29
FI20086024 2008-10-29
US61/197,642 2008-10-29
FI20086024A FI20086024A0 (en) 2008-10-29 2008-10-29 New pharmaceutical product

Publications (2)

Publication Number Publication Date
WO2010049590A2 WO2010049590A2 (en) 2010-05-06
WO2010049590A3 true WO2010049590A3 (en) 2010-06-24

Family

ID=39924662

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2009/050869 WO2010049590A2 (en) 2008-10-29 2009-10-29 A new pharmaceutical product

Country Status (3)

Country Link
EP (1) EP2349326A2 (en)
FI (1) FI20086024A0 (en)
WO (1) WO2010049590A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012139866A1 (en) * 2011-04-15 2012-10-18 Universität Zürich Prorektorat Mnw Collagen hydroxylases
GB201202561D0 (en) * 2012-02-15 2012-03-28 Univ Dundee Treatment of skin disorders
WO2022224015A1 (en) * 2021-04-21 2022-10-27 University Of Hong Kong Adiponectin glycopeptides and compositions and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117950A2 (en) * 2004-05-28 2005-12-15 The Regents Of The University Of California Regulation of glucose and insulin levels by gnt-4 glycosyltransferase activity
WO2007146171A2 (en) * 2006-06-08 2007-12-21 Trustees Of Tufts College Purified high molecular weight adiponectin and uses thereof
WO2009080899A2 (en) * 2007-12-21 2009-07-02 Oulun Yliopisto Products and methods affecting cell and tissue growth

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005117950A2 (en) * 2004-05-28 2005-12-15 The Regents Of The University Of California Regulation of glucose and insulin levels by gnt-4 glycosyltransferase activity
WO2007146171A2 (en) * 2006-06-08 2007-12-21 Trustees Of Tufts College Purified high molecular weight adiponectin and uses thereof
WO2009080899A2 (en) * 2007-12-21 2009-07-02 Oulun Yliopisto Products and methods affecting cell and tissue growth

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
RICHARDS A A ET AL: "ADIPONECTIN MULTIMERIZATION IS DEPENDENT ON CONSERVED LYSINES IN THE COLLAGENOUS DOMAIN: EVIDENCE FOR REGULATION OF MULTIMERIZATION BY ALTERATIONS IN POSTTRANSLATIONAL MODIFICATIONS", MOLECULAR ENDOCRINOLOGY, THE ENDOCRINE SOCIETY, US LNKD- DOI:10.1210/ME.2005-0390, vol. 20, no. 7, 1 July 2006 (2006-07-01), pages 1673 - 1687, XP009071842, ISSN: 0888-8809 *
WANG YU ET AL: "Post-translational modifications of adiponectin: mechanisms and functional implications", BIOCHEMICAL JOURNAL, THE BIOCHEMICAL SOCIETY, LONDON, GB LNKD- DOI:10.1042/BJ20071492, vol. 409, no. 3, 1 February 2008 (2008-02-01), pages 623 - 633, XP009132821, ISSN: 0264-6021 *
WANG YU ET AL: "Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, INC, US LNKD- DOI:10.1074/JBC.M513907200, vol. 281, no. 24, 18 April 2006 (2006-04-18), pages 16391 - 16400, XP002458709, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2010049590A2 (en) 2010-05-06
EP2349326A2 (en) 2011-08-03
FI20086024A0 (en) 2008-10-29

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