WO2010047561A3 - Diagnostic kit for predicting the prognosis of invasive or non-muscle invasive bladder cancer, method for predicting the prognosis of bladder cancer, and bladder cancer medicine screening method - Google Patents

Diagnostic kit for predicting the prognosis of invasive or non-muscle invasive bladder cancer, method for predicting the prognosis of bladder cancer, and bladder cancer medicine screening method Download PDF

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Publication number
WO2010047561A3
WO2010047561A3 PCT/KR2009/006160 KR2009006160W WO2010047561A3 WO 2010047561 A3 WO2010047561 A3 WO 2010047561A3 KR 2009006160 W KR2009006160 W KR 2009006160W WO 2010047561 A3 WO2010047561 A3 WO 2010047561A3
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WO
WIPO (PCT)
Prior art keywords
bladder cancer
prognosis
predicting
invasive
diagnostic kit
Prior art date
Application number
PCT/KR2009/006160
Other languages
French (fr)
Korean (ko)
Other versions
WO2010047561A2 (en
Inventor
김원재
배석철
김용준
김선규
Original Assignee
주식회사 바이오러넥스
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 주식회사 바이오러넥스 filed Critical 주식회사 바이오러넥스
Publication of WO2010047561A2 publication Critical patent/WO2010047561A2/en
Publication of WO2010047561A3 publication Critical patent/WO2010047561A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

The present invention relates to a diagnostic kit for predicting the prognosis of invasive or non-muscle invasive bladder cancer, to a method for predicting the prognosis of bladder cancer, and to a bladder cancer medicine screening method. More particularly, the present invention relates to a diagnostic kit for predicting the prognosis of bladder cancer, comprising, as active ingredients, primer pairs, a probe, or an antibody for a gene-classifier which statistically analyzes gene expression among normal tissues and bladder cancer tissues by using a micro-array to predict the reoccurrence or progression of non-muscle invasive bladder cancer, or for a gene-classifier which may predict the progression of invasive bladder cancer, cancer-specific survival, or total survival. The present invention also relates to a method for predicting the prognosis of bladder cancer using the primer pairs, the probe, or the antibody. The method of the present invention predicts the prognosis of bladder cancer in an inexpensive, convenient, and quick manner, and is useful in screening bladder cancer medicine.
PCT/KR2009/006160 2008-10-24 2009-10-23 Diagnostic kit for predicting the prognosis of invasive or non-muscle invasive bladder cancer, method for predicting the prognosis of bladder cancer, and bladder cancer medicine screening method WO2010047561A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020080104773A KR20100045703A (en) 2008-10-24 2008-10-24 Diagnosis kit for prognosis-prediction of invasive or non-muscle invasive bladder cancer, method for estimating prognosis of bladder cancer and method for screening therapeutic agent of bladder cancer
KR10-2008-0104773 2008-10-24

Publications (2)

Publication Number Publication Date
WO2010047561A2 WO2010047561A2 (en) 2010-04-29
WO2010047561A3 true WO2010047561A3 (en) 2010-11-18

Family

ID=42119860

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/006160 WO2010047561A2 (en) 2008-10-24 2009-10-23 Diagnostic kit for predicting the prognosis of invasive or non-muscle invasive bladder cancer, method for predicting the prognosis of bladder cancer, and bladder cancer medicine screening method

Country Status (2)

Country Link
KR (1) KR20100045703A (en)
WO (1) WO2010047561A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101683961B1 (en) * 2014-03-31 2016-12-07 동아대학교 산학협력단 Recurrence Marker for Diagnosis of Bladder Cancer
KR101750146B1 (en) * 2014-12-30 2017-06-23 충북대학교 산학협력단 Use of RSPH9 for Prognostic Marker Diagnosis of Bladder Cancer
EP3333268A1 (en) * 2016-12-09 2018-06-13 Institut Paoli Calmettes Biomarker panel for prognosis of bladder cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
EWISS ET AL.: "Gene expression profile in squamous cell carcinoma of the urinary bladder using complementary deoxyribonucleic acid microarray.", UROL. ONCOL., vol. 25, no. 2, 23 March 2007 (2007-03-23), pages 120 - 127 *
GOTTARDO ET AL.: "MicroRNA profiling in kidney and bladder cancers", UROL. ONCOL., vol. 25, no. 5, 7 September 2007 (2007-09-07), pages 387 - 392 *
KAWAKAMI ET AL.: "Identification of differentially expressed genes in human bladder cancer through genome-wide gene expression profiling", ONCOL. REP., vol. 16, no. 3, September 2006 (2006-09-01), pages 521 - 531 *
KIM ET AL.: "Molecular biomarkers in urothelial bladder cancer", CANCER SCI., vol. 99, no. 4, 28 March 2008 (2008-03-28), pages 646 - 652 *

Also Published As

Publication number Publication date
KR20100045703A (en) 2010-05-04
WO2010047561A2 (en) 2010-04-29

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