WO2010046801A3 - A process for the preparation of tolterodine tartrate - Google Patents

A process for the preparation of tolterodine tartrate Download PDF

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Publication number
WO2010046801A3
WO2010046801A3 PCT/IB2009/054473 IB2009054473W WO2010046801A3 WO 2010046801 A3 WO2010046801 A3 WO 2010046801A3 IB 2009054473 W IB2009054473 W IB 2009054473W WO 2010046801 A3 WO2010046801 A3 WO 2010046801A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
tolterodine tartrate
methylphenyl
methoxy
formula
Prior art date
Application number
PCT/IB2009/054473
Other languages
French (fr)
Other versions
WO2010046801A2 (en
Inventor
Ravi Ponnaiah
Sanjay Desai
Chankrakant Chunilal Shah
Kalpesh Shantibhai Patel
Viral Maheshbhai Parekh
Original Assignee
Alembic Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alembic Limited filed Critical Alembic Limited
Publication of WO2010046801A2 publication Critical patent/WO2010046801A2/en
Publication of WO2010046801A3 publication Critical patent/WO2010046801A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to provide an improved process for the preparation of tolterodine or salt thereof, comprises a step of reducing 3-(2-methoxy-5-methylphenyl) -3-phenyl propionic acid of formula (III) in the presence of a reducing agent, an acidic reagent and a solvent to obtain 3-(2-methoxy-5-methylphenyl) -3-phenyl propanol of formula (IV).
PCT/IB2009/054473 2008-10-21 2009-10-12 A process for the preparation of tolterodine tartrate WO2010046801A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2263/MUM/2008 2008-10-21
IN2263MU2008 2008-10-21

Publications (2)

Publication Number Publication Date
WO2010046801A2 WO2010046801A2 (en) 2010-04-29
WO2010046801A3 true WO2010046801A3 (en) 2011-04-21

Family

ID=42119763

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2009/054473 WO2010046801A2 (en) 2008-10-21 2009-10-12 A process for the preparation of tolterodine tartrate

Country Status (1)

Country Link
WO (1) WO2010046801A2 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050131067A1 (en) * 2003-04-08 2005-06-16 Parthasaradhi Reddy B. Novel polymorphs of tolterodine tartrate
WO2006074479A1 (en) * 2005-01-10 2006-07-13 Teva Pharmaceutical Industries, Ltd. Process for preparing tolterodine tartrate
US20070254959A1 (en) * 2003-12-22 2007-11-01 Ragactives, S.L. Process for Obtaining Tolterodine
WO2007126217A1 (en) * 2006-05-03 2007-11-08 Estechpharma Co., Ltd. Process for preparing tolterodine or its salt and synthetic intermediate
WO2008020332A2 (en) * 2006-07-04 2008-02-21 Uquifa México, S.A. De C.V. Method for the preparation of (r)-tolterodine tartrate
US20080097127A1 (en) * 2005-02-18 2008-04-24 Dipharma S.P.A. Process for the preparation of tolterodine
US20080146844A1 (en) * 2004-10-28 2008-06-19 Dr. Reddy's Laboratories Limited Process for preparing tolterodine

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050131067A1 (en) * 2003-04-08 2005-06-16 Parthasaradhi Reddy B. Novel polymorphs of tolterodine tartrate
US20070254959A1 (en) * 2003-12-22 2007-11-01 Ragactives, S.L. Process for Obtaining Tolterodine
US20080146844A1 (en) * 2004-10-28 2008-06-19 Dr. Reddy's Laboratories Limited Process for preparing tolterodine
WO2006074479A1 (en) * 2005-01-10 2006-07-13 Teva Pharmaceutical Industries, Ltd. Process for preparing tolterodine tartrate
US20060194876A1 (en) * 2005-01-10 2006-08-31 Kovacs Laszlo Z Substantially pure tolterodine tartrate and process for preparing thereof
US20060194987A1 (en) * 2005-01-10 2006-08-31 Kovacs Laszlo Z Process for preparing tolterodine tartrate
US20080097127A1 (en) * 2005-02-18 2008-04-24 Dipharma S.P.A. Process for the preparation of tolterodine
WO2007126217A1 (en) * 2006-05-03 2007-11-08 Estechpharma Co., Ltd. Process for preparing tolterodine or its salt and synthetic intermediate
WO2008020332A2 (en) * 2006-07-04 2008-02-21 Uquifa México, S.A. De C.V. Method for the preparation of (r)-tolterodine tartrate

Also Published As

Publication number Publication date
WO2010046801A2 (en) 2010-04-29

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