WO2010045755A8 - 葛根素糖基化衍生物、其药物组合物、及其制备方法和用途 - Google Patents

葛根素糖基化衍生物、其药物组合物、及其制备方法和用途 Download PDF

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Publication number
WO2010045755A8
WO2010045755A8 PCT/CN2008/001799 CN2008001799W WO2010045755A8 WO 2010045755 A8 WO2010045755 A8 WO 2010045755A8 CN 2008001799 W CN2008001799 W CN 2008001799W WO 2010045755 A8 WO2010045755 A8 WO 2010045755A8
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WO
WIPO (PCT)
Prior art keywords
puerarin
glycosyl
derivatives
pharmaceutically acceptable
preparation
Prior art date
Application number
PCT/CN2008/001799
Other languages
English (en)
French (fr)
Other versions
WO2010045755A1 (zh
Inventor
丁选胜
丛晓东
袁生
徐海东
于赐刚
张云
Original Assignee
南京师范大学
浙江中医药大学中药饮片厂
中国药科大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 南京师范大学, 浙江中医药大学中药饮片厂, 中国药科大学 filed Critical 南京师范大学
Priority to PCT/CN2008/001799 priority Critical patent/WO2010045755A1/zh
Publication of WO2010045755A1 publication Critical patent/WO2010045755A1/zh
Publication of WO2010045755A8 publication Critical patent/WO2010045755A8/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
PCT/CN2008/001799 2008-10-24 2008-10-24 葛根素糖基化衍生物、其药物组合物、及其制备方法和用途 WO2010045755A1 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2008/001799 WO2010045755A1 (zh) 2008-10-24 2008-10-24 葛根素糖基化衍生物、其药物组合物、及其制备方法和用途

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2008/001799 WO2010045755A1 (zh) 2008-10-24 2008-10-24 葛根素糖基化衍生物、其药物组合物、及其制备方法和用途

Publications (2)

Publication Number Publication Date
WO2010045755A1 WO2010045755A1 (zh) 2010-04-29
WO2010045755A8 true WO2010045755A8 (zh) 2010-07-15

Family

ID=42118898

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2008/001799 WO2010045755A1 (zh) 2008-10-24 2008-10-24 葛根素糖基化衍生物、其药物组合物、及其制备方法和用途

Country Status (1)

Country Link
WO (1) WO2010045755A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101885748A (zh) * 2010-07-22 2010-11-17 广州医学院第二附属医院 葛根素-7-o-葡萄糖醛酸苷及其制备方法和用途
CN103044409A (zh) * 2012-12-05 2013-04-17 东南大学 葛根素衍生物或其药学上可接受的盐及其应用
CN103382203B (zh) * 2013-08-15 2016-02-03 哈尔滨商业大学 葛根素衍生物及其合成方法和应用
CN103655458A (zh) * 2013-11-25 2014-03-26 中国中医科学院中药研究所 磷酸川芎嗪眼用在体凝胶制剂及其制备方法
CN111218013B (zh) * 2020-01-22 2022-08-23 上海应用技术大学 一种交联聚合物的制备方法及其应用
CN115715590B (zh) * 2022-11-18 2024-03-29 南昌大学 具有控释靶向性纳豆激酶-葛根素凝胶微球的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100553578B1 (ko) * 2004-01-20 2006-02-22 재단법인서울대학교산학협력재단 높은 수용성을 갖는 퓨라린 유도체 및 이의 제조방법
CN101147754A (zh) * 2006-09-19 2008-03-26 郑州博凯医药科技有限公司 一种含葛根提取物的复合泡腾制剂
CN100551481C (zh) * 2007-11-30 2009-10-21 南京师范大学 常压加长两段层析柱系统及其在葛根素糖基化衍生物分离制备中的应用

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WO2010045755A1 (zh) 2010-04-29

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