WO2010044708A1

WO2010044708A1 - Method for correcting attention-deficit hyperactivity disorder

Info

Publication number: WO2010044708A1
Application number: PCT/RU2009/000543
Authority: WO
Inventors: Татьяна Прохоровна ТЕТЕРИНА; Анастасия Сергеевна ГОЛУБЕВА
Original assignee: Teterina Tatyana Prokhorovna; Golubeva Anastasia Sergeevna
Priority date: 2008-10-15
Filing date: 2009-10-13
Publication date: 2010-04-22
Also published as: RU2008140851A; RU2395313C2

Abstract

The invention relates to the field of psychiatry and provides a method for treating the psychiatric disorder known as Attention-Deficit Hyperactivity Disorder. Correction of Attention-Deficit Hyperactivity Disorder is carried out by the action of pulsed light alternately on each of the patient's eyes using a series of pulses of light radiation. Each action on each of the eyes in each series of pulses is carried out at the same or a different wavelength; furthermore, when delivering a subsequent series of pulses, the wavelength is changed within the visible light range. Pulses are delivered in the frequency range 0.2-10 Hz, corresponding to the frequencies of the visual rhythms and the alpha rhythm of the brain. For this purpose, the visual rhythms and the alpha rhythm of the patient's brain are determined before commencing correction.

Description

Method for the correction of attention deficit hyperactivity disorder

Technical field

The present invention relates to the field of psychiatry and provides a method of treating a mental disorder known as Attention Deficit Hyperactivity Disorder.

State of the art

Over the past decade, scientists have come to the conclusion that a significant part of children are persistently hyperactive and suffer from attention deficit, which is why they do not keep up at school and often experience difficulties in personal relationships. Symptoms of this disorder were first described and published by the American Psychiatric Association in Diagostiс apd Statistal Mapul of Medicine Disorders, fourth version, in 1994. Previously, such children were recognized as incorrigible, punished and even placed in special institutions. However, it has long been known that these children cannot control their behavior in society, cope with hyperactivity and inattention and, therefore, needed help. This syndrome is a disorder not only of childhood, but also of adolescents and adults. Therefore, this syndrome also creates serious problems in an adult's life. Recently, there have been attempts to help these patients with drugs. One of these drugs is methylphenidate (Ritalip ™), which significantly improved their health status and coexistence with other people at school and at home. However, this drug has disadvantages, such as the need for a long and repeated use (several times a day), as well as the return of the symptoms of the disease after the termination of each dose of the drug. In addition, this medicine in patients causes side effects (drowsiness, loss of appetite, etc.). Methylphenidate has both noradrenergic and dopaminergic activity. Tricyclic drugs (imipramine, desipramine, nortiprilin, amitriptyline, clomipramine) are also used to treat the syndrome, however, these drugs cause a number of side effects.

A known method for the correction of attention deficit / hyperactivity disorder, which consists in taking the drug tomoxetine orally or in injections, the effective dose of which is in the range from 5 mg to 100 mg per day (RU Na 2163802,

A61KZ 1/135, publ. 2001.03.10).

However, this method has the following disadvantages: the duration of treatment and the limitation of its use in children, especially young children (from 1 year to 6 years).

The problem of psychiatry is the search for a safe and effective non-drug method for the treatment of attention deficit / hyperactivity disorder, which is available not only for adults, but also for children, especially young children.

There is a method of non-pharmacological correction of attention deficit / hyperactivity disorder, called the BFB method Biological Feedback (BF) (Biofeebbk or Neurofbbk), through which the Department of Neurophysiology GKB No. 12, Moscow (see the official website of BOC on the Internet at: http://bos.com.ru/, discovered in 2008).

THIS method allows for arbitrary regulation of many physiological parameters - bioelectric fluctuations of the brain potential (electroencephalogram), heart rate, skin temperature, degree of muscle tension, skin electrical resistance, breathing characteristics, etc. Usually, these physiological reactions are not recognized, and therefore not subject to our control. Today, with the help of computers, as well as high-tech devices, it is possible to “register” these physiological indicators “on the fly”, process them and instantly present them in an understandable form to the patient. As a result, we begin to “see” or “hear,” for example, the alpha rhythm of our brain. Biofeedback (BFB) allows you to artificially connect powerful mechanisms of plasticity, learning and memory to unconscious processes of physiological regulation. Thanks to her, the patient learns to manage his physiological reactions. The BOS method is based on the fundamental discoveries of neurobiology and medicine - a) N. Miller's data on the distribution of the laws of conditioned reflex (classical) learning to the autonomic (autonomous) nervous system; b) the detection of LKamiya conditioned reflex amplification of the EEG alpha rhythm of normal subjects using feedback informing of the current amplitude of the rhythm; c) B. Stegmap data on increasing the threshold of convulsive readiness in animals (as well as in humans) after operant enhancement of the rhythmic activity of 12-15 Hz in the sensorimotor strip of the cerebral cortex. The procedure of the BOS method is as follows. The patient sits in a comfortable chair in front of the computer monitor screen with glued sensors that remove a certain physiological parameter (determined in advance). The value of the physiological parameter corresponds, for example, the size of the circle on the monitor screen. Having received the necessary instructions, the patient during the course learns to change this physiological indicator in the right direction, for example, to strengthen the alpha rhythm of the brain, achieving an increase in the circle on the monitor screen. This is a simplified diagram, but it explains the principle well. Actual learning schemes are more diverse and include all available multimedia tools (computer games, music, etc.).

The disadvantage of this method is the significant duration of therapy: from 10 to 50 sessions of 20-40 minutes at 9 000543

Disclosure of invention

The technical result is to increase the efficiency, reduce the cost, simplify and reduce the treatment time not only for adults, adolescents, but also for preschool and young children (from 6 months to 3 years) without side effects.

This result is achieved due to the fact that in the method, the correction of attention deficit / hyperactivity disorder is carried out by alternating pulsed color exposure to each of the patient's eyes with a series of pulses of light radiation. In this case, alternating exposure to each of the eyes is carried out either with the same wavelength or with a different wavelength, and when the next series of pulses is applied, the wavelength is changed. The wavelength in a series of pulses is changed in the range of visible light. This result is also achieved due to the fact that the pulses are fed in the frequency range 0.2 ÷ 10 Hz, corresponding to the frequencies of the rhythms of vision and alpha rhythm of the brain. For this, before the start of correction, the rhythms of vision and the alpha rhythm of the patient’s brain are determined.

The best embodiment of the invention

According to the present invention, a new method for the correction of attention deficit hyperactivity disorder, which is carried out by alternating pulsed color exposure to each of the patient's eyes with a series of pulses of light radiation, is contemplated. In this case, alternating exposure to each of the eyes in each series of pulses is performed either with the same or different wavelength, and when the next series of pulses is applied, the wavelength in the range of visible light is changed. The pulses are fed in the frequency range 0.2 ÷ 10 Hz, corresponding to the frequencies of the rhythms of vision and alpha rhythm of the brain. For this, before the start of correction, the rhythms of vision and the alpha rhythm of the patient’s brain are determined.

Examples of the method. 1. Boy B. Yaroslav, 4 years old. Diagnosis: hyperactivity, enuresis. From the anamnesis established the following. Born in asphyxia due to a cord entwined in the neck. Until 4 months did not hold the head. An intracranial hypertension was established on the electroencephalogram. Suffers from frequent colds (acute respiratory infections, rhinopharyngitis), headaches, increased neuropsychic irritability, imbalance, hyperactivity, enuresis almost every night, often naughty.

Conducted 10 sessions of the course color correction method in accordance with this method using the reprogrammed apparatus Teterina T.P. (RU JCHsJCha 31721 (U), 29466 (U), 2098059 (Cl), 2230534 (Cl), 2071301 (Cl), in which the device operation mode is set depending on the pathology. For example, the electronic circuit allows generating the following radiation modes:

- alternating effects on the eyes with a period of 4-8 s; - periodic exposure to one of the eyes and continuous exposure to the other;

- any of the above modes with radiation modulation.

In this case, it is possible to affect both eyes with the same or different wavelengths: 660 nm (red). 600 nm (orange), 567 nm (green), 470 nm (blue). The timer ensures that the device turns off after a certain time (for example, 8.5 minutes). When the device is operating in a light-diffusing reflector, pulsating light emission from LEDs occurs. Light passes through the openings of the opaque screen, as a result of which the patient observes the pulsation of light stimuli.

The patient in the process of color stimulation of the retina through an opaque screen placed on a light-scattering reflector in glasses, observes a pulsation of light stimuli corresponding to openings of the screen, which testified to the response of visual neurons of the retina of the eye and brain to color stimuli.

Thus, the present invention provides increased function of the visual neurons of the retina and brain. The effect of retinal color stimulation using the proposed device on the general condition of patients with concomitant diseases (hypertension, neurasthenic syndrome, central nervous system dysfunctions, endocrine, digestive and other systems) was studied.

A clear positive effect of color therapy on the state of the immune system is noted. A significant (in a very small sample) increase in the level of CD4-helper cells, a pronounced trend towards an increase in CD3 of mature T-lymphocytes and CD72-B lymphocytes, was revealed. This increase cannot be attributed to a general increase in Lm. A significant increase in IgM (by 58%) and PS (by 52%) was observed, which reflects an increase in the anti-infective and detoxification activity of the macrophage-phagocytic system. A decrease in IgA accompanies remission in the foci of chronic inflammation. Changes in immunity correlate well with the clinical improvement in patients. The data obtained indicate that ophthalmic color therapy on the proposed device is a powerful non-pharmacological method of immunocorrection.

After treatment, the boy became calm, nocturnal enuresis is observed much less frequently (1-2 times a month), headaches disappeared. 43

2. Girl M. Olesya, 4 years old. Diagnosis: hyperactivity, depressive syndrome.

According to the mother, a girl from an early age suffers from hyperactivity, emotional and mental excitability and instability, irritability, aggressiveness, sleep disturbance (she does not sleep in the kindergarten during the day and cannot fall asleep at home after 21-22 hours). An electroencephalogram revealed a displacement of the median structures of the brain.

The girl is under the supervision of a neuropsychiatrist for depressive syndrome. A long period of time takes antidepressant drugs (finlapam), but no improvement is noted.

Conducted 3 courses of color correction in accordance with this method using the reprogrammed apparatus Teterina TP. The first course was carried out in combination with treatment with an antidepressant drug. The psychoemotional state was calm for 1 month. The second course of color correction was carried out after the antidepressant drug was canceled. Signs of depressive psychosis, hyperactivity, aggressiveness did not appear for 2 months. After the third course of color correction without drugs, the psycho-emotional state and sleep improved significantly, and signs of hyperactivity and depressive syndrome did not appear. The observation period is 2 years.

3. Girl V. Daria, 5 years old. Diagnosis: attention deficit hyperactivity disorder.

From the anamnesis, it was found that from birth to the 1st year of the child there was constant anxiety, increased excitability, pronounced expressiveness, tearfulness, accompanied by a loud cry, especially at night, the automatism of the movements of the upper and lower extremities, and sleep disturbance. According to the parents, the child did not let them sleep. During the examination, intracranial hypertension was established, about which up to a year of life was under the supervision and treatment of a neuropsychiatrist. With age, the girl periodically has increased neuropsychic irritability, aggressiveness, pugnacity with peers in kindergarten. According to the teacher, when performing tasks during classes, symptoms of inattention are noted, distracted by external stimuli, fidgets when sitting, does not delve into the meaning of the explanation of tasks by the teacher. According to the parents, the girl often does not obey them, is naughty, becomes uncontrollable.

Conducted 10 sessions of the course of color correction in accordance with this method using the reprogrammed apparatus Teterina T.P. After treatment, the girl became calm, balanced, obedient, in the kindergarten classes perseverance and attentiveness when completing tasks were noted.

4. Girl A. Sasha, 7 years old, 8 months old, 1st grade student. Diagnosis: attention deficit hyperactivity disorder. From the anamnesis it was found that the girl was born in asphyxia (there was an entanglement of the neck with an umbilical cord). From birth, she often screamed, cried, did not let her parents sleep at night, she was almost always restless. At the age of 5 years, intracranial hypertension was established. No treatment has been performed. At school, the girl lags behind in school, is hyperactive, often uncontrollable, irritable. A mental breakdown is accompanied by a loud scream. During the examination, the rhythms of vision could not be determined, the visual acuity of both eyes is within normal limits (equal to 1.0).

Conducted 10 sessions of the course color correction method in accordance with this method using the reprogrammed apparatus Teterina T.P. After treatment, neuropsychic breakdowns and irritability stopped, memory and attention improved.

5. Boy F. Artyom, 6.5 years old. Diagnosis: attention deficit hyperactivity disorder, speech development delay (did not speak up to 3 years).

According to the mother, the baby was born prematurely. From birth, he was troubled, and from 2 years old, there is an imbalance in the psyche, hyperactivity, sleep disturbance, general fatigue. According to the kindergarten teacher, the child has a lack of attention.

In the study of the phenomenon of binocular rivalry, the rhythms of vision could not be determined. Visual acuity within normal limits (equal to 1.0). 10 sessions of a color correction course were carried out in accordance with this method using the reprogrammed apparatus Teterina TP. After treatment, speech, sleep, attention and general condition of the body improved. The child became calm, obedient, balanced, the rhythms of vision were restored. 6. Boy Arkady, 8 years old. Diagnosis: attention deficit hyperactivity disorder.

According to my mother, from birth, the child was troubled. In the first year of life, a neuropsychiatrist diagnosed with encephalopathy, hypertensive type of muscle dystonia syndrome, right-sided hemisyndrome. The child was excited, tense, shy, involuntary movements of arms and legs were made, muscle tone was increased on the left, and dystonic on the right.

At the age of 5 years, a neurologist in a child found disinhibition, distraction, decreased attention, difficulty writing, held a pencil or pen in his hand with great difficulty.

At the age of 6, the same symptoms as well as hyperactivity were also observed. The child was ill from the medications prescribed by the neurologist.

At the age of 8 years, the child was disinhibited, distracted, hyperactive, and restless sleep. During classes at school, he experienced difficulties in learning, poorly absorbed subjects due to reduced attention.

After the course of color correction in accordance with this method, according to the mother, the child became more collected, obedient, calm, improved perseverance and academic performance during school hours.

7. Boy M. Yasha, 13 years old, a student of 7th grade. Diagnosis: attention deficit hyperactivity disorder. According to the parents, the boy was born prematurely and in asphyxiation. From birth he was restless, marked irritability to external stimuli was noted. From preschool age, excessive hyperactivity, imbalance, neuropsychic irritability are noted. In school, from the first grade there is impulsivity, restless behavior, restlessness. During lessons there is a fidget when sitting or jumping from a place, often interrupting the teacher’s explanation. The boy is intellectually developed, but lags behind in studies and does not have an interest in studying at school, cannot concentrate on writing and school tasks, is distracted by external stimuli, forgetful, naughty. The rhythms of vision (the phenomenon of binocular rivalry) could not be determined.

Parents experience excessive fatigue and irritability from his behavior and uncontrollability. However, as the parents themselves note, in childhood they also had similar problems with behavior, both in preschool and school age. As adults, they experience periodic bouts of neuropsychic arousal, intolerance to the people around them, headaches, imbalance in communication with relatives, decreased attention and memory.

10 sessions of a color correction course were carried out in accordance with this method using the reprogrammed apparatus Teterina TP .. After treatment, the boy became more balanced, attentive, calm, obedient, the rhythms of vision were restored, and interest in learning appeared.

8. Patient K. Andrey, 32 years old. Diagnosis: attention deficit hyperactivity disorder, stuttering. From childhood, he notes periodic neuropsychic arousal, imbalance, impulsivity, and in school age difficulties with academic performance and in relations with teachers and peers. Stuttering suffers from childhood. During the examination it was found that the patient is intellectually developed, but when communicating with him, he often interrupts, imposes his opinion, interferes in the conversations of people around him, is eccentric, often talks too much, is not attentive, which makes it difficult to get a job. When studying the rhythms of vision at synoptophore (the phenomenon of binocular rivalry), their violation was established.

The patient was given 4 courses of 10 sessions of the color correction method in accordance with this method using the reprogrammed apparatus Teterina TP After treatment, there was a noticeable improvement in communication with others. The patient became more balanced, calm, improved attention, restored rhythms of vision, stuttering disappeared, which made it possible to get a good job, from which he was satisfied.

Thus, this method is effective for the treatment of patients, children, adolescents and adults.

Industrial applicability

The present invention is industrially applicable, used in the practice of the Center of color therapy of Dr. Teterina "TETTA", Moscow, in the treatment of a mental disorder known as attention deficit / hyperactivity disorder.

Claims

Claim

1. The method of correction of attention deficit hyperactivity disorder, characterized in that the correction is carried out by pulsed alternating color exposure on each of the patient’s eyes with a series of pulses of light radiation, with alternating exposure in each series on each eye with the same or different wavelength, and when the next series of pulses of light radiation is applied, the wavelength is changed.

2. The method according to p. 1, characterized in that the wavelength in the series of pulses of light radiation is changed in the range of visible light.

3. The method according to p. 1, characterized in that the pulses of light radiation are supplied in the frequency range of 0.2 ÷ 10 Hz.

4. The method according to p. 4, characterized in that the pulses of light radiation are supplied with a frequency of the rhythm of vision and the alpha rhythm of the patient’s brain.

5. The method according to p. 5, characterized in that before the start of correction determine the frequency of the rhythm of vision and the alpha rhythm of the patient’s brain.