WO2010042600A3 - Photo-activatable therapeutic agents and methods of using - Google Patents

Photo-activatable therapeutic agents and methods of using Download PDF

Info

Publication number
WO2010042600A3
WO2010042600A3 PCT/US2009/059816 US2009059816W WO2010042600A3 WO 2010042600 A3 WO2010042600 A3 WO 2010042600A3 US 2009059816 W US2009059816 W US 2009059816W WO 2010042600 A3 WO2010042600 A3 WO 2010042600A3
Authority
WO
WIPO (PCT)
Prior art keywords
photo
therapeutic agents
pro
methods
activatable
Prior art date
Application number
PCT/US2009/059816
Other languages
French (fr)
Other versions
WO2010042600A2 (en
Inventor
Pengfei Wang
Original Assignee
The Uab Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Uab Research Foundation filed Critical The Uab Research Foundation
Publication of WO2010042600A2 publication Critical patent/WO2010042600A2/en
Publication of WO2010042600A3 publication Critical patent/WO2010042600A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Abstract

Novel photo-activatable pro-therapeutic agents and methods for their synthesis and use are described. The photo-activatable pro-therapeutic agents are inactive pro-forms of compounds that can be activated in situ, for example, by providing a pro-therapeutic agent to a subject and photo-activating the pro-therapeutic agent at a selected area of the subject. Also disclosed are methods for administering the photo-activatable pro-therapeutic agents to a subject then activating the pro-therapeutic agents at a selected area of the subject by exposing that area to light.
PCT/US2009/059816 2008-10-08 2009-10-07 Photo-activatable therapeutic agents and methods of using WO2010042600A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10380608P 2008-10-08 2008-10-08
US61/103,806 2008-10-08

Publications (2)

Publication Number Publication Date
WO2010042600A2 WO2010042600A2 (en) 2010-04-15
WO2010042600A3 true WO2010042600A3 (en) 2010-07-22

Family

ID=42101180

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/059816 WO2010042600A2 (en) 2008-10-08 2009-10-07 Photo-activatable therapeutic agents and methods of using

Country Status (1)

Country Link
WO (1) WO2010042600A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11970482B2 (en) 2019-01-08 2024-04-30 Ligand Pharmaceuticals Inc. Acetal compounds and therapeutic uses thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014028189A2 (en) * 2012-05-18 2017-06-27 Sanofi Sa benzo [1,3] dioxin derivatives and their use as lpar5 antagonists
CN106061984A (en) 2014-02-13 2016-10-26 配体药物公司 Prodrug compounds and their uses

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858746A (en) * 1992-04-20 1999-01-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US20060216324A1 (en) * 2004-03-26 2006-09-28 Stucke Sean M Composition and method for preparing biocompatible surfaces

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5858746A (en) * 1992-04-20 1999-01-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
US20060216324A1 (en) * 2004-03-26 2006-09-28 Stucke Sean M Composition and method for preparing biocompatible surfaces

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BLANC A. ET AL: "Wavelength-Controlled Orthogonal Photolysis of Protecting Groups", J. ORG. CHEM., vol. 67, 2002, pages 5567 - 5577 *
KOTZUR N. ET AL: "Wavelength-Selective Photoactivatable Protecting Groups for Thiols", J.AM.CHEM. SOC., vol. 131, 2009, pages 16927 - 16931 *
WANG P. ET AL: "Novel Photolabile Protecting Group for Carbonyl Compounds", ORGANIC LETTERS, vol. 9, no. 8, 2007, pages 1533 - 1535 *
WANG P. ET AL: "Sequential Removal of Photolabile Protecting Groups for Car -bonyls with Controlled Wavelength", J.ORG.CHEM., vol. 73, 2008, pages 6152 - 6157 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11970482B2 (en) 2019-01-08 2024-04-30 Ligand Pharmaceuticals Inc. Acetal compounds and therapeutic uses thereof

Also Published As

Publication number Publication date
WO2010042600A2 (en) 2010-04-15

Similar Documents

Publication Publication Date Title
TW200745124A (en) Azepinoindole derivatives as pharmaceutical agents
SG155188A1 (en) Pyrrole derivatives as pharmaceutical agents
ECSP088904A (en) ARILIMIDAZOLONAS AND ARILTRIAZOLONAS REPLACED AS INHIBITORS OF VASOPRESINE RECEPTORS
MX2010004494A (en) Use of trkb antibodies for the treatment of respiratory disorders.
BRPI0915084B8 (en) compound, and, pharmaceutical composition
NO20081975L (en) Diarylamine-containing compounds and compositions, and their use as modulators of C-kit receptors
NO20083002L (en) Method for using CD40 binding compounds
EA201300121A1 (en) DPP-4 INHIBITOR IN A COMBINATION WITH AN ADDITIONAL ANTI-DIABETIC AGENT, TABLETS INCLUDING THE SPECIFIED COMPOSITIONS, THEIR APPLICATION AND METHOD OF THEIR PREPARATION
EA200900202A1 (en) SELECTIVE ANDROGEN RECEPTOR MODULATORS, THEIR ANALOGUES AND DERIVATIVES AND THEIR USE
AR047928A1 (en) TETRAHYDROPIRIDOINDOL DERIVATIVES
CL2008001815A1 (en) Indazole derived compounds; process for preparing said compounds; pharmaceutical composition comprising them; and its use to treat cancer.
MX2009006706A (en) Bicyclic heterocyclic compounds as fgfr inhibitors.
NI201100082A (en) ISOINDOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER.
PL2247602T3 (en) Adamantyl o-glucuronide derivatives as inhibitors of dipeptidyl peptidase iv for the treatment of diabetes
EA201070237A1 (en) Quarterly opioid carboxamides
WO2008148074A3 (en) Inhibitors of mtor and methods of treatment using same
CL2008002319A1 (en) Compounds derived from pyrrolopyrimidine; pharmaceutical composition comprising said compounds; and its use to treat cancer.
IL180872A0 (en) Substituted 8-aminoalkylthio-xanthines, and the use thereof as inhibitors of the dipeptidyl peptidase iv
WO2006020680A3 (en) Heterocyclic compounds as pharmaceutical agents
SI2176252T1 (en) 2, 3-dihydrobenzoš1, 4ćdioxin-2-ylmethyl derivatives as alpha2c antagonists for use in the treatment of peripheric and central nervous systeme diseases
TN2015000084A1 (en) NEW BICYCLIC PYRIDINONES
DOP2007000043A (en) SUBSTITUTED CHROMANOL DERIVATIVES AND THEIR USE
CL2008001323A1 (en) Triazolyl aminopyridine derived compounds; pharmaceutical composition comprising said compounds; and its use to treat cancer.
MY158428A (en) Topical composition for the treatment of actinic keratosis
MX2010006206A (en) 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressine-dependent diseases.

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09819804

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09819804

Country of ref document: EP

Kind code of ref document: A2