WO2010041263A1 - Increasing low platelets instantly - Google Patents

Increasing low platelets instantly Download PDF

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Publication number
WO2010041263A1
WO2010041263A1 PCT/IN2008/000585 IN2008000585W WO2010041263A1 WO 2010041263 A1 WO2010041263 A1 WO 2010041263A1 IN 2008000585 W IN2008000585 W IN 2008000585W WO 2010041263 A1 WO2010041263 A1 WO 2010041263A1
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Prior art keywords
thrombocytopenia
disorders
papaya
leaves
stage
Prior art date
Application number
PCT/IN2008/000585
Other languages
French (fr)
Inventor
Jitesh Alva
Mukta Thapar
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Jitesh Alva
Mukta Thapar
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Application filed by Jitesh Alva, Mukta Thapar filed Critical Jitesh Alva
Publication of WO2010041263A1 publication Critical patent/WO2010041263A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • Platelets or thrombocytes, are the cells circulating in the blood that are involved in the cellular mechanisms of primary hemostasis leading to the formation of blood clots. Dysfunction or low levels of platelets predisposes to bleeding, while high levels, although usually asymptomatic, may increase the risk of thrombosis. An abnormality or disease of the platelets is called a thrombocytopathy.
  • platelets in mammals are anuclear (no cell nucleus) and discoid (disc shaped); they measure 1.5-3.0 ym in diameter.
  • the body has a very limited reserve of platelets, so they can be rapidly depleted.
  • They contain RNA. mitochondria, a canalicular system, and several different types of granules; lysosomes (containing acid hydrolases), dense bodies (containing ADP. ATP. serotonin, histamine, and calcium) and alpha granules (containing fibrinogen, factor V, vitronectin, thrombospondin and von Willebrand factor), the contents of which are released upon activation of the platelet.
  • a normal platelet count in a healthy person is between 150,000 and 400,000 per mm 3 of blood (150-400 x 10 9 /L). 95% of healthy people will have platelet counts in this range. Some will have statistically abnormal platelet counts while having no abnormality, although the likelihood increases if the platelet count is either very low or very high.
  • thrombocytopenia or thrombopenia
  • thrombocytosis may present with coagulation problems.
  • Low Blood Platelet counts increase bleeding risks (although there are exceptions, e.g. immune heparin-induced thrombocytopenia) and thrombocytosis (high counts) may lead to thrombosis (although this is mainly when the elevated count is due to myeloproliferative disorder).
  • Low Blood Platelet counts are generally not corrected by transfusion unless the patient is bleeding or the count has fallen below 5 x 10 ⁇ /L; it is contraindicated in thrombotic thrombocytopenic purpura (TTP) as it fuels the coagulopathy.
  • TTP thrombotic thrombocytopenic purpura
  • a level below 50 x 10 9 /L is associated with abnormal surgical bleeding, and regional anaesthetic procedures such as epidurals are avoided for levels below 80-100.
  • Normal platelet counts are not a guarantee of adequate function.
  • the platelets while being adequate in number, are dysfunctional.
  • aspirin irreversibly disrupts platelet function by inhibiting cvcloo ⁇ yqenase-1 (COX1), and hence normal hemostasis; normal platelet function may not return until the aspirin has ceased and all the affected platelets have been replaced by new ones, which can take over a week.
  • uremia (a consequence of renal failure) leads to platelet dysfunction that may be ameliorated by the administration of desmopressin.
  • thrombocytopenia Idiopathic thrombocytopenic purpura - also known as immune thrombocytopenic purpura (ITP) o Thrombotic thrombocytopenic purpura o Drug-induced thrombocytopenia, e.g. heparin-induced thrombocytopenia (HIT)
  • LOW PLATELETS is one of the leading causes of death in the above said diseases and is on the rise all over the world. Till now medication to increase the number of Platelets is not found.
  • the present invention relates with the discovery of one such Papaya Leaf / Leaves and Papaya Stem. Which has been found having efficacy in increasing the Platelet count Instantly.
  • Scientific classification of PAPAYA Kingdom Plantae Division: Ma ⁇ noliophvta Class: Ma ⁇ noliopsida Order: Brassicales Family: Caricaceae Genus: Carica Species: C. papaya Binomial name Carica papaya
  • Juice of Papaya Leaf / leaves and the leaves stem could be developed.
  • Various dosage forms of Juice of Papaya Leaf / leaves and the leaves stem could be introduced containing Juice of Papaya Leaf / leaves and the leaves stem as the single drug or in combination of other drugs.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The Present Invention relates to Juice of Papaya Leaf / leaves and the leaves stem was found to increase the Low Blood Platelet count instantly

Description

Increasing Low Platelets Instantly
Description of the Invention:-
ABOUT PLATELETS
Platelets, or thrombocytes, are the cells circulating in the blood that are involved in the cellular mechanisms of primary hemostasis leading to the formation of blood clots. Dysfunction or low levels of platelets predisposes to bleeding, while high levels, although usually asymptomatic, may increase the risk of thrombosis. An abnormality or disease of the platelets is called a thrombocytopathy.
HISTOLOGY OF PLATELETS
Like red blood cells, platelets in mammals are anuclear (no cell nucleus) and discoid (disc shaped); they measure 1.5-3.0 ym in diameter. The body has a very limited reserve of platelets, so they can be rapidly depleted. They contain RNA. mitochondria, a canalicular system, and several different types of granules; lysosomes (containing acid hydrolases), dense bodies (containing ADP. ATP. serotonin, histamine, and calcium) and alpha granules (containing fibrinogen, factor V, vitronectin, thrombospondin and von Willebrand factor), the contents of which are released upon activation of the platelet.
PLATELETS FUNCTION
Functions of Platelets can be generalised into a number of categories:
• Adhesion
• Aggregation vmvbnm
• Clot retraction
• Pro-coagulation
• Cytokine signalling β Phagocytosis
HIGH AND LOW COUNTS OF PLATELETS
A normal platelet count in a healthy person is between 150,000 and 400,000 per mm3 of blood (150-400 x 109/L). 95% of healthy people will have platelet counts in this range. Some will have statistically abnormal platelet counts while having no abnormality, although the likelihood increases if the platelet count is either very low or very high.
Both thrombocytopenia (or thrombopenia) and thrombocytosis may present with coagulation problems. Generally, Low Blood Platelet counts increase bleeding risks (although there are exceptions, e.g. immune heparin-induced thrombocytopenia) and thrombocytosis (high counts) may lead to thrombosis (although this is mainly when the elevated count is due to myeloproliferative disorder).
Low Blood Platelet counts are generally not corrected by transfusion unless the patient is bleeding or the count has fallen below 5 x 10θ/L; it is contraindicated in thrombotic thrombocytopenic purpura (TTP) as it fuels the coagulopathy. In patients having surgery, a level below 50 x 109/L) is associated with abnormal surgical bleeding, and regional anaesthetic procedures such as epidurals are avoided for levels below 80-100.
Normal platelet counts are not a guarantee of adequate function. In some states the platelets, while being adequate in number, are dysfunctional. For instance, aspirin irreversibly disrupts platelet function by inhibiting cvclooχyqenase-1 (COX1), and hence normal hemostasis; normal platelet function may not return until the aspirin has ceased and all the affected platelets have been replaced by new ones, which can take over a week. Similarly, uremia (a consequence of renal failure) leads to platelet dysfunction that may be ameliorated by the administration of desmopressin.
DISEASES
Disorders leading to a reduced platelet count: • Thrombocytopenia o Idiopathic thrombocytopenic purpura - also known as immune thrombocytopenic purpura (ITP) o Thrombotic thrombocytopenic purpura o Drug-induced thrombocytopenia, e.g. heparin-induced thrombocytopenia (HIT)
• Gaucher's disease
• Aplastic anemia
Alloimmune disorders
• Fetomatemal alloimmune thrombocytopenia
• Some transfusion reactions
Disorders leading to platelet dysfunction or reduced count:
• HELLP syndrome
• Hemolytic-uremic syndrome
• Chemotherapy
• Dengue
• Cancer [any type, any stage]
• Tumor [any type, any stage]
• Leptospirosis.
LOW PLATELETS is one of the leading causes of death in the above said diseases and is on the rise all over the world. Till now medication to increase the number of Platelets is not found.
The present invention relates with the discovery of one such Papaya Leaf / Leaves and Papaya Stem. Which has been found having efficacy in increasing the Platelet count Instantly. Scientific classification of PAPAYA Kingdom: Plantae Division: Maαnoliophvta Class: Maαnoliopsida Order: Brassicales Family: Caricaceae Genus: Carica Species: C. papaya Binomial name Carica papaya
Methods:-
Various Steps involved in the aforesaid mentioned process are:-
1. The Green Papaya Leaf / leaves and the leaves stem are collected.
2. Then these Papaya leaves and the leaves stem are cleaned with water
3. Then it is crushed so that the juice from the Papaya Leaf / leaves and/or leaves Stem is removed
4. A study was conducted to determine the effects of the Papaya leaves and the leaves stem on the low counts of Platelets. The Juice of Papaya leaves and the leaves stem was found very effective (Table 1), (Table 2), (Table 3). This is the main embodiment of the present invention.
5. The Juice of Papaya Leaf / leaves and the leaves stem was found to increase the Low Blood Platelet count instantly.
FROM THE ABOVE SAID OBSERVATION FOLLOWING COULD BE DRAWN.
1. The Juice of Papaya Leaf / leaves and the leaves stem was found to increase the Low Blood Platelet count instantly.
2. Drug Formulations Juice of Papaya Leaf / leaves and the leaves stem could be developed. Various dosage forms of Juice of Papaya Leaf / leaves and the leaves stem could be introduced containing Juice of Papaya Leaf / leaves and the leaves stem as the single drug or in combination of other drugs.
Figure imgf000007_0001
Figure imgf000007_0002
Figure imgf000008_0001

Claims

We Claim:-
1. The Extract / obtained from Juice of Papaya leaf /leaves and/ Or Papaya leaves stem
Kingdom: Plantae
Division: Maαnoliophvta
Class: Maqnoliopsida
Order: Brassicales
Familv:Caricaceae
Genus: Cahca
Species: C. papaya
Binomial name Carica papa for increasing Platelet counts in
a) Disorders leading to a reduced platelet count -
Thrombocytopenia .Idiopathic thrombocytopenic purpura, Thrombotic thrombocytopenic purpura, Drug-induced thrombocytopenia, e.g. heparin-induced thrombocytopenia (HIT), Gaucher's disease, Aplastic anemia, Alloimmune disorders, Fetomaternal alloimmune thrombocytopenia, Blood Platelets transfusion reactions b) Disorders leading to platelet dysfunction or reduced count:HELLP syndrome, Hemolytic-uremic syndrome, Chemotherapy, Dengue, Cancer [any type, any stage], Tumor [any type, any stage], Leptospirosis.
2. Drug products containing Papaya leaves or Papaya leaves stem and/ Or its extract alone or in combination with other drugs or herbs prepared for a) Disorders leading to a reduced platelet count -
Thrombocytopenia idiopathic thrombocytopenic purpura, Thrombotic thrombocytopenic purpura, Drug-induced thrombocytopenia, e.g. heparin-induced thrombocytopenia (HIT), Gaucher's disease, Aplastic anemia, Alloimmune disorders, Fetomatemal alloimmune thrombocytopenia, Blood Platelets transfusion reactions b) Disorders leading to platelet dysfunction or reduced count.HELLP syndrome, Hemolytic-uremic syndrome, Chemotherapy, Dengue, Cancer [any type, any stage], Tumor [any type, any stage], Leptospirosis.
3. Nutraceutical / Drug Healthcare Products containing Papaya leaves or Papaya leaves stem and/ Or its extract alone or in combination with other herbs/ ingredients prepared for treatment / Prophylaxis towards
a) Disorders leading to a reduced platelet count -
Thrombocytopenia .Idiopathic thrombocytopenic purpura, Thrombotic thrombocytopenic purpura, Drug-induced thrombocytopenia, e.g. heparin-induced thrombocytopenia (HIT), Gaucher's disease, Aplastic anemia, Alloimmune disorders, Fetomatemal alloimmune thrombocytopenia, Blood Platelets transfusion reactions b) Disorders leading to platelet dysfunction or reduced count:HELLP syndrome, Hemolytic-uremic syndrome, Chemotherapy, Dengue, Cancer [any type, any stage], Tumor [any type, any stage], Leptospirosis.
Figure imgf000010_0001
PCT/IN2008/000585 2007-12-07 2008-09-11 Increasing low platelets instantly WO2010041263A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2395/MUM/2007 2007-12-07
IN2395MU2007 2007-12-07

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WO2010041263A1 true WO2010041263A1 (en) 2010-04-15

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019244133A1 (en) * 2018-06-22 2019-12-26 Enzene Biosciences Limited Succinic acid and derivatives for the treatment of haemotological disorders

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Papays leaves juice a natural cure for dengue", INTERNET ARTICLE, 6 December 2007 (2007-12-06), XP002550251, Retrieved from the Internet <URL:http://web.archive.org/web/20071206112142/http://www.keral.com/articles/Papaya_leaves_juice_a_natural_cure_for_dengue.htm> [retrieved on 20091013] *
CARLEE: "Cure for low blood platelets", INTERNET ARTICLE, 27 December 2005 (2005-12-27), XP002550248, Retrieved from the Internet <URL:http://www.lab-retriever.net/board/cure-low-blood-t63536.html> [retrieved on 20091013] *
JOEWEIN ET AL: "Dengue fever and papaya juice", INTERNET ARTICLE, 21 July 2009 (2009-07-21), XP002550252, Retrieved from the Internet <URL:http://message.snopes.com/showthread.php?t=48383> [retrieved on 20091013] *
RAJA: "Dengue cure", INTERNET ARTICLE, 16 October 2006 (2006-10-16), XP002550250, Retrieved from the Internet <URL:http://web.archive.org/web/20071127063204/http://raja.vox.com/library/post/dengue-cure.html> [retrieved on 20091013] *
RANI PAKISTANII: "Papaya leaves-cure for dengue fever", INTERNET ARTICLE, 25 October 2006 (2006-10-25), XP002550249, Retrieved from the Internet <URL:http://web.archive.org/web/20070304082518/http://forum.chatdd.com/information-center/15833-subject-papaya-leaves-cure-dengue-fever.html> [retrieved on 20091013] *
RJ ANUJ KAPOOR: "Papaya juice - cure for dengue", INTERNET ARTICLE, 31 October 2006 (2006-10-31), XP002550247, Retrieved from the Internet <URL:http://www.pressmart.com/blog/rj/2006/10/papaya-juice-cure-for-dengue.html> [retrieved on 20091013] *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019244133A1 (en) * 2018-06-22 2019-12-26 Enzene Biosciences Limited Succinic acid and derivatives for the treatment of haemotological disorders
CN112292123A (en) * 2018-06-22 2021-01-29 恩泽生物科学有限公司 Succinic acid and derivatives for the treatment of hematological disorders
US20210267923A1 (en) * 2018-06-22 2021-09-02 Enzene Biosciences Limited Succinic acid and derivatives for the treatment of haemotological disorders

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