WO2010037130A3 - Compositions and methods of generating reprogrammed adipocyte cells and methods of use therefore - Google Patents

Compositions and methods of generating reprogrammed adipocyte cells and methods of use therefore Download PDF

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Publication number
WO2010037130A3
WO2010037130A3 PCT/US2009/058869 US2009058869W WO2010037130A3 WO 2010037130 A3 WO2010037130 A3 WO 2010037130A3 US 2009058869 W US2009058869 W US 2009058869W WO 2010037130 A3 WO2010037130 A3 WO 2010037130A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
adipocyte cells
reprogrammed adipocyte
generating
Prior art date
Application number
PCT/US2009/058869
Other languages
French (fr)
Other versions
WO2010037130A2 (en
Inventor
Joseph P. Vacanti
Howard I. Pryor
David H. Lum
Tim D. Ahfeldt
Chad Cowan
Original Assignee
The General Hospital Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The General Hospital Corporation filed Critical The General Hospital Corporation
Publication of WO2010037130A2 publication Critical patent/WO2010037130A2/en
Publication of WO2010037130A3 publication Critical patent/WO2010037130A3/en
Priority to US13/245,716 priority Critical patent/US20120219530A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Abstract

The invention provides therapeutic compositions comprising reprogrammed adipocyte cells for use as disease models, therapeutic compositions comprising reprogrammed adipocyte cells for the treatment of conditions characterized by a reduction in cell number or tissue mass, and methods of generating such cells.
PCT/US2009/058869 1999-04-15 2009-09-29 Compositions and methods of generating reprogrammed adipocyte cells and methods of use therefore WO2010037130A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/245,716 US20120219530A1 (en) 1999-04-15 2011-09-26 Compositions and methods of generating reprogrammed adipocyte cells and methods of use therefore

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10094608P 2008-09-29 2008-09-29
US61/100,946 2008-09-29

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13121401 A-371-Of-International 2009-09-29
US13/245,716 Continuation US20120219530A1 (en) 1999-04-15 2011-09-26 Compositions and methods of generating reprogrammed adipocyte cells and methods of use therefore

Publications (2)

Publication Number Publication Date
WO2010037130A2 WO2010037130A2 (en) 2010-04-01
WO2010037130A3 true WO2010037130A3 (en) 2010-05-27

Family

ID=42060441

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/058869 WO2010037130A2 (en) 1999-04-15 2009-09-29 Compositions and methods of generating reprogrammed adipocyte cells and methods of use therefore

Country Status (1)

Country Link
WO (1) WO2010037130A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013082106A1 (en) * 2011-12-02 2013-06-06 The General Hospital Corporation Differentiation into brown adipocytes
US10253325B2 (en) 2012-12-19 2019-04-09 Boston Medical Center Corporation Methods for elevating fat/oil content in plants
FR3024462A1 (en) * 2014-07-29 2016-02-05 Univ Pierre Et Marie Curie Paris 6 METHOD FOR IN VITRO PRODUCTION OF ADIPOCYTE PROGENITORS AND ADIPOCYTES
WO2024084082A1 (en) * 2022-10-21 2024-04-25 Meatable B.V. Adipocyte maturation

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANGHEL ET AL.: "Fat poetry: a kingdom for PPAR gamma.", CELL RES., vol. 17, no. 6, 2007, pages 486 - 511 *
HEGELE.: "Lessons from human mutations in PPARgamma.", INT J OBES (LOND), vol. 29, no. SUP.1, 2005, pages S31 - S35 *
JANDEROVA ET AL.: "Human mesenchymal stem cells as an in vitro model for human adipogenesis.", OBES RES., vol. 11, no. 1, 2003, pages 65 - 74 *
LOWELL.: "PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function.", CELL, vol. 99, no. 3, 1999, pages 239 - 242 *
SANDHU ET AL.: "LDL-cholesterol concentrations: a genome-wide association study.", LANCET, vol. 371, no. 9611, 9 February 2008 (2008-02-09), pages 483 - 491 *
SHOCKLEY ET AL.: "PPARgamma2 Regulates aMolecular Signature of Marrow Mesenchymal Stem Cells.", PPAR RESEARCH., vol. 2007, pages 13, Retrieved from the Internet <URL:http://downloads.hindawi.com/journals/ppar/2007/081219.pdf> [retrieved on 20100327] *
YUN ET AL.: "Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stral3: a mechanism for regulation of adipogenesis by hypoxia.", DEV CELL, vol. 2, no. 3, 2002, pages 331 - 341 *

Also Published As

Publication number Publication date
WO2010037130A2 (en) 2010-04-01

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