WO2010036773A8 - Deuterated 1-aryl-2 -aminomethyl cyclopropane carboxyamide derivatives - Google Patents

Deuterated 1-aryl-2 -aminomethyl cyclopropane carboxyamide derivatives Download PDF

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Publication number
WO2010036773A8
WO2010036773A8 PCT/US2009/058173 US2009058173W WO2010036773A8 WO 2010036773 A8 WO2010036773 A8 WO 2010036773A8 US 2009058173 W US2009058173 W US 2009058173W WO 2010036773 A8 WO2010036773 A8 WO 2010036773A8
Authority
WO
WIPO (PCT)
Prior art keywords
aryl
derivatives
deuterated
aminomethyl cyclopropane
cyclopropane carboxyamide
Prior art date
Application number
PCT/US2009/058173
Other languages
French (fr)
Other versions
WO2010036773A1 (en
Inventor
Julie F. Liu
Original Assignee
Concert Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Concert Pharmaceuticals, Inc. filed Critical Concert Pharmaceuticals, Inc.
Publication of WO2010036773A1 publication Critical patent/WO2010036773A1/en
Publication of WO2010036773A8 publication Critical patent/WO2010036773A8/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention relates to novel compounds that are 1 -aryl-2-aminomethyl cyclopropane carboxyamide derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel 1 -aryl-2-aminomethyl cyclopropane carboxyamide derivatives that are derivatives of milnacipran. This invention also provides pyrogen free compositions comprising one or more compounds of the invention and a carrier, and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering a norepinephrine/serotonin reuptake inhibitor (NSRI), such us milnacipran.
PCT/US2009/058173 2008-09-24 2009-09-24 Deuterated l-aryl-2 -aminomethyl cyclopropane carboxyamide derivatives WO2010036773A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19408008P 2008-09-24 2008-09-24
US61/194,080 2008-09-24

Publications (2)

Publication Number Publication Date
WO2010036773A1 WO2010036773A1 (en) 2010-04-01
WO2010036773A8 true WO2010036773A8 (en) 2010-06-03

Family

ID=41319401

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/058173 WO2010036773A1 (en) 2008-09-24 2009-09-24 Deuterated l-aryl-2 -aminomethyl cyclopropane carboxyamide derivatives

Country Status (1)

Country Link
WO (1) WO2010036773A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2508035A1 (en) * 1981-06-23 1982-12-24 Fabre Sa Pierre ARYL-1-AMINOMETHYL-2 CYCLOPROPANES CARBOXAMIDE (Z) DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS USEFUL IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
WO1995026325A2 (en) * 1994-03-25 1995-10-05 Isotechnika Inc. Enhancement of the efficacy of drugs by deuteration
US20090069431A1 (en) * 2007-09-12 2009-03-12 Protia, Llc Deuterium-enriched milnacipran

Also Published As

Publication number Publication date
WO2010036773A1 (en) 2010-04-01

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