WO2010035002A1 - Liquid delivery system - Google Patents

Liquid delivery system Download PDF

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Publication number
WO2010035002A1
WO2010035002A1 PCT/GB2009/002284 GB2009002284W WO2010035002A1 WO 2010035002 A1 WO2010035002 A1 WO 2010035002A1 GB 2009002284 W GB2009002284 W GB 2009002284W WO 2010035002 A1 WO2010035002 A1 WO 2010035002A1
Authority
WO
WIPO (PCT)
Prior art keywords
liquid
delivery system
substrate
porous
wall member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB2009/002284
Other languages
French (fr)
Inventor
Richard Edward Haxby
Jonathan Paul Foulkes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith and Nephew PLC
Original Assignee
Smith and Nephew PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith and Nephew PLC filed Critical Smith and Nephew PLC
Publication of WO2010035002A1 publication Critical patent/WO2010035002A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Definitions

  • the invention relates to a liquid delivery system.
  • the invention relates to a transdermal medicament delivery system for the controlled delivery of a liquid to a selected area of skin of a patient.
  • actives for drug delivery systems are required or it is beneficial at least, if the active is in aqueous solution.
  • the active in aqueous solution can be transported through skin pores and into deep tissue. What is often required is a delivery system which when applied to the skin will deliver a consistent dose of liquid to the skin, without the need for specific user input.
  • the actives and delivery media can bind to the adhesives, foams or fibres of current delivery systems, preventing release to the skin.
  • the present invention allows the active and delivery system to be delivered directly to the skin at a steady rate.
  • a liquid delivery system comprising; (i) a non-porous wall member; and
  • a porous wall member wherein said wall members define a liquid retaining chamber, wherein said porous wall member has a substrate-contacting surface and wherein upon contact with said substrate the liquid egresses through the pores.
  • the liquid delivery system consists of a non- porous wall member and a porous wall member, as illustrated in Figure 1.
  • the peripheral edges of the two wall members are sealed together. Sealing techniques include, but are not limited to; heat sealing, ultrasonic welding, radio-frequency welding and adhesives.
  • the liquid delivery system is substantially triangular, having two wall members which are non-porous and third wall member which is porous, wherein the porous wall member contacts a substrate.
  • the liquid delivery system is substantially square, having three wall members which are non-porous and fourth wall member which is porous, wherein the porous wall member contacts a substrate.
  • the liquid delivery system is substantially rectangular, having three wall members which are non-porous and fourth wall member which is porous, wherein the porous wall member contacts a substrate.
  • the peripheral edges of the wall members are sealed in a similar manner as to that of the embodiment disclosed in Figure 1.
  • the porous wall member is such that it will hold a liquid throughout the manufacture, storage and transport of the liquid delivery device, but will release liquid upon contact with a substrate. Liquid from the liquid retaining chamber can flow across the porous wall member at a desired steady rate to the substrate with which the porous wall member is in contact.
  • the pore size may vary from about 1 ⁇ m to 500 ⁇ m, more particularly from 1 - 100//m, or from 50-100/ym, or from 100-150 ⁇ m, or 100-250 ⁇ m, or 100-500 ⁇ m, or 250-500/ym, and can be varied and optimised depending on what flow rate is required.
  • the non-porous wall member may comprise of a film or other flexible material but could also be inflexible in some embodiments.
  • the porous wall member may comprise a porous film.
  • the porous wall member may comprise a double-layered porous material, which can for instance be formed by the co-extrusion of two materials.
  • the first material being substantially hydrophobic and the second material being substantially hydrophilic.
  • the orientation of the double-layered material i.e which material forms the substrate-contacting surface (outer surface) and which material forms the liquid-contacting surface (inner surface) is dependent on the affinity of the retained liquid for water.
  • porous and non-porous films may be used to make the porous and non-porous films. Different weights of films may be used to make the porous and non-porous films.
  • a non-porous safety cover layer or film may be adhered to the porous wall member to ensure liquid does not escape, during manufacture and transport of the product. Prior to use the safety cover/layer is removed.
  • the liquid delivery system can be referred to as a pouch or sachet, similar to those used in the detergent industry, but differing in that the liquid is not discharged from the system by means of the degradation of the wall members.
  • the liquid delivery system can be simply held in place on the substrate by the user until a sufficient discharge of liquid has been achieved.
  • securing means for example adhesive tape placed over the liquid delivery system can be used to temporarily secure the system to the substrate.
  • the liquid delivery system can be moved across a substrate so as to distribute the liquid over a wider area than the surface area of the substrate-contacting surface.
  • a handle means may be provided on the liquid delivery system for ease of use.
  • liquid delivery device can be used in medical/surgical applications.
  • the substrate is skin and the liquid is an antiseptic solution, such as iodine solution, used in surgical preparation techniques.
  • an antiseptic solution such as iodine solution
  • the substrate is skin and the liquid is a topical antibiotic.
  • the substrate is skin and the liquid comprises a medicament.
  • the liquid delivery system can thereby facilitate the transdermal delivery of the medicament.
  • a medical dressing comprising a liquid delivery system according to claim 1.
  • the medical dressing comprises;
  • a liquid delivery device according to the first aspect of the invention; ii) a securing means, for securing the liquid delivery device to the skin.
  • the securing means may be in the form of a strip of adhesive tape.
  • the securing means may be in the form of an adhesive-coated filmic dressing which is placed over the upper surface of the liquid delivery device and which secures the device to the skin. An island dressing is thus formed.
  • the dosing i.e rate of release of the liquid from the liquid retaining chamber across the porous side or film to the skin can be controlled by optimising the pore size in the porous film.
  • the liquid delivery device can be used in non- medical/surgical applications in which a liquid is contacted with a substrate.
  • the liquid could be a cleaning agent, such as a disinfectant or a polish.
  • liquid delivery device or medical dressing as substantially herein described with reference to the accompanying Examples and Figures 1 , 2, 3 or 4.
  • Fig 1 shows a dressing of the present invention.
  • Fig 2 shows a dressing of the present invention on the skin (arm) of a patient.
  • Fig 3 shows another embodiment of the present invention with heat sealed joins.
  • Fig 4 shows a fluid reservoir with covering/holding layer.
  • Fig 5 shows another embodiment of the present invention.
  • the porous film used in the reservoir may be a 46 gsm (grams per square metre) 2 layer (co-extruded) net (available from Smith & Nephew Extruded Films, CE46 ® .
  • the outer layer may be HDPE (High density polyethylene).
  • the inner layer is LLDPE/EVA, (Linear Low Density Polyethylene/Ethylene Vinyl Acetate).
  • the nonporous film may be a 30 gsm PU (polyurethane) film.
  • the dressing itself may be a medical adhesive coated 30 gsm PV film on a PE (Polyethylene/ PET polyethylene Terephtalate) carrier.
  • the adhesive liner may be a poly coated siliconised paper.
  • Figure 1 shows a dressing (10) of the present invention having a non-porous wall member (1 ) and a porous wall member (2) enclosing a fluid reservoir (3).
  • Figure 2 shows a dressing (10) of the present invention with porous (2) and non-porous (1 ) wall members on a patients arm (4). Liquid from the fluid reservoir (3) wicks upon contact with the skin of the patients arm (4), from the fluid reservoir to the skin of the patient (4).
  • FIG. 3 Another design embodiment is shown in Figure 3 with a non-porous wall member (1) and porous wall member(2) heat sealed together at the sides (5) and with an active (6) present in the fluid reservoir (3).
  • the present invention may also include a place on dressing (20) as shown in Figure 4 where a fluid reservoir (3) enclosed by a porous wall layer (2) is placed on the skin (4) of a user and covered by a non-porous layer.
  • the present invention may also include more complex designs such as a construct type dressing (30) as shown in Figure 5.
  • the embodiment may have an occlusive film carrier (7) over a PU film (8) with adhesive (9).
  • the PU film (8) may have the adhesive (9) on its inner/skin-facing side to adhere itself and to hold in place the fluid reservoir (3) containing an active (6).
  • the fluid reservoir having a non-porous film side (1 ) and porous side/film (2) with the selectively porous side facing the skin (4) of a patient.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicinal Preparation (AREA)

Abstract

A transdermal dressing for the controlled release or delivery of a liquid to selected area of skin of a user.

Description

LIQUID DELIVERY SYSTEM
CROSS-REFERENCE TO RELATED APPLICATIONS
This application claims priority to LJK provisional application No. 0817486.4 entitled "Delivery System" filed on 24 September 2008.
FIELD OF THE INVENTION
The invention relates to a liquid delivery system.
In particular the invention relates to a transdermal medicament delivery system for the controlled delivery of a liquid to a selected area of skin of a patient.
BACKGROUND OF THE INVENTION
Current transdermal systems deliver actives by loading adhesives, foams or fibres with active ingredients. Current systems are not compatible with all actives and all delivery media.
Many actives for drug delivery systems are required or it is beneficial at least, if the active is in aqueous solution. The active in aqueous solution can be transported through skin pores and into deep tissue. What is often required is a delivery system which when applied to the skin will deliver a consistent dose of liquid to the skin, without the need for specific user input.
Current drug delivery systems are not compatible with all actives and delivery media. The actives and delivery media can bind to the adhesives, foams or fibres of current delivery systems, preventing release to the skin. The present invention allows the active and delivery system to be delivered directly to the skin at a steady rate. SUMMARY OF THE INVENTION
According to a first aspect of the invention there is provided a liquid delivery system comprising; (i) a non-porous wall member; and
(ii) a porous wall member, wherein said wall members define a liquid retaining chamber, wherein said porous wall member has a substrate-contacting surface and wherein upon contact with said substrate the liquid egresses through the pores.
In embodiments of the invention the liquid delivery system consists of a non- porous wall member and a porous wall member, as illustrated in Figure 1. In this embodiment of the invention the peripheral edges of the two wall members are sealed together. Sealing techniques include, but are not limited to; heat sealing, ultrasonic welding, radio-frequency welding and adhesives.
In an alternative embodiment of the invention the liquid delivery system is substantially triangular, having two wall members which are non-porous and third wall member which is porous, wherein the porous wall member contacts a substrate.
In an alternative embodiment of the invention the liquid delivery system is substantially square, having three wall members which are non-porous and fourth wall member which is porous, wherein the porous wall member contacts a substrate.
In an alternative embodiment of the invention the liquid delivery system is substantially rectangular, having three wall members which are non-porous and fourth wall member which is porous, wherein the porous wall member contacts a substrate. In the alternative embodiments of the invention as outlined above, the peripheral edges of the wall members are sealed in a similar manner as to that of the embodiment disclosed in Figure 1.
The porous wall member is such that it will hold a liquid throughout the manufacture, storage and transport of the liquid delivery device, but will release liquid upon contact with a substrate. Liquid from the liquid retaining chamber can flow across the porous wall member at a desired steady rate to the substrate with which the porous wall member is in contact.
The pore size may vary from about 1 μm to 500 μm, more particularly from 1 - 100//m, or from 50-100/ym, or from 100-150μm, or 100-250μm, or 100-500μm, or 250-500/ym, and can be varied and optimised depending on what flow rate is required.
The non-porous wall member may comprise of a film or other flexible material but could also be inflexible in some embodiments.
The porous wall member may comprise a porous film.
The porous wall member may comprise a double-layered porous material, which can for instance be formed by the co-extrusion of two materials. The first material being substantially hydrophobic and the second material being substantially hydrophilic. The orientation of the double-layered material (i.e which material forms the substrate-contacting surface (outer surface) and which material forms the liquid-contacting surface (inner surface) is dependent on the affinity of the retained liquid for water.
It is envisaged that currently known manufacturing processes and materials may be used to make the porous and non-porous films. Different weights of films may be used to make the porous and non-porous films. During manufacture a non-porous safety cover layer or film may be adhered to the porous wall member to ensure liquid does not escape, during manufacture and transport of the product. Prior to use the safety cover/layer is removed.
The liquid delivery system can be referred to as a pouch or sachet, similar to those used in the detergent industry, but differing in that the liquid is not discharged from the system by means of the degradation of the wall members.
The liquid delivery system can be simply held in place on the substrate by the user until a sufficient discharge of liquid has been achieved.
Alternatively securing means, for example adhesive tape placed over the liquid delivery system can be used to temporarily secure the system to the substrate.
In other embodiments of the invention the liquid delivery system can be moved across a substrate so as to distribute the liquid over a wider area than the surface area of the substrate-contacting surface.
A handle means may be provided on the liquid delivery system for ease of use.
It is envisaged that the liquid delivery device can be used in medical/surgical applications.
For example, the substrate is skin and the liquid is an antiseptic solution, such as iodine solution, used in surgical preparation techniques.
For example, the substrate is skin and the liquid is a topical antibiotic.
For example, the substrate is skin and the liquid comprises a medicament. The liquid delivery system can thereby facilitate the transdermal delivery of the medicament. According to a second aspect of the invention there is provided a medical dressing comprising a liquid delivery system according to claim 1.
In a specific embodiment of the invention, the medical dressing comprises;
i) a liquid delivery device according to the first aspect of the invention; ii) a securing means, for securing the liquid delivery device to the skin.
The securing means may be in the form of a strip of adhesive tape.
The securing means may be in the form of an adhesive-coated filmic dressing which is placed over the upper surface of the liquid delivery device and which secures the device to the skin. An island dressing is thus formed.
The dosing i.e rate of release of the liquid from the liquid retaining chamber across the porous side or film to the skin can be controlled by optimising the pore size in the porous film.
It is further envisaged that the liquid delivery device can be used in non- medical/surgical applications in which a liquid is contacted with a substrate. For example, in cleaning applications. The liquid could be a cleaning agent, such as a disinfectant or a polish.
According to a third aspect of the invention there is provided a liquid delivery device or medical dressing as substantially herein described with reference to the accompanying Examples and Figures 1 , 2, 3 or 4.
The invention will now be described as way of example only by the following example and drawings Fig 1 shows a dressing of the present invention.
Fig 2 shows a dressing of the present invention on the skin (arm) of a patient. Fig 3 shows another embodiment of the present invention with heat sealed joins. Fig 4 shows a fluid reservoir with covering/holding layer. Fig 5 shows another embodiment of the present invention.
The porous film used in the reservoir may be a 46 gsm (grams per square metre) 2 layer (co-extruded) net (available from Smith & Nephew Extruded Films, CE46®. The outer layer may be HDPE (High density polyethylene). The inner layer is LLDPE/EVA, (Linear Low Density Polyethylene/Ethylene Vinyl Acetate).
The nonporous film may be a 30 gsm PU (polyurethane) film.
The dressing itself may be a medical adhesive coated 30 gsm PV film on a PE (Polyethylene/ PET polyethylene Terephtalate) carrier. The adhesive liner may be a poly coated siliconised paper.
Figure 1 shows a dressing (10) of the present invention having a non-porous wall member (1 ) and a porous wall member (2) enclosing a fluid reservoir (3).
Figure 2 shows a dressing (10) of the present invention with porous (2) and non-porous (1 ) wall members on a patients arm (4). Liquid from the fluid reservoir (3) wicks upon contact with the skin of the patients arm (4), from the fluid reservoir to the skin of the patient (4).
Another design embodiment is shown in Figure 3 with a non-porous wall member (1) and porous wall member(2) heat sealed together at the sides (5) and with an active (6) present in the fluid reservoir (3). The present invention may also include a place on dressing (20) as shown in Figure 4 where a fluid reservoir (3) enclosed by a porous wall layer (2) is placed on the skin (4) of a user and covered by a non-porous layer.
The present invention may also include more complex designs such as a construct type dressing (30) as shown in Figure 5. Here the embodiment may have an occlusive film carrier (7) over a PU film (8) with adhesive (9). The PU film (8) may have the adhesive (9) on its inner/skin-facing side to adhere itself and to hold in place the fluid reservoir (3) containing an active (6). The fluid reservoir having a non-porous film side (1 ) and porous side/film (2) with the selectively porous side facing the skin (4) of a patient.

Claims

Claims
1. A liquid delivery system comprising; . (i) a non-porous wall member; and (ii) a porous wall member, wherein said wall members define a liquid retaining chamber, wherein said porous wall member has a substrate-contacting surface and wherein upon contact with said substrate, the liquid egresses through the pores towards the substrate.
2. A liquid delivery system according to claim 1 , wherein the substrate is skin.
3. A medical dressing comprising a liquid delivery system according to claim 1.
4. A medical dressing according to claim 3, wherein the substrate is skin.
5. A medical dressing according to claim 4, wherein the dressing is for the transdermal delivery of a medicament.
6. A medical dressing according to any of claims 3 to 5, wherein the pore size of the porous wall member is between about 1 and 500 μm.
7. A medical dressing according to claim 6, wherein the pore size of the porous wall member is between about 100 and 250 μm.
8. A medical dressing according to any of claims 3 to 7, wherein the liquid delivery system is held in place on the substrate by a material with adhesive on the substrate contacting surface of the material.
9. A liquid delivery system or medical dressing as substantially herein described with reference to the accompanying Examples and Figures 1 , 2, 3 or 4.
PCT/GB2009/002284 2008-09-24 2009-09-24 Liquid delivery system Ceased WO2010035002A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0817486.4 2008-09-24
GBGB0817486.4A GB0817486D0 (en) 2008-09-24 2008-09-24 Delivery system

Publications (1)

Publication Number Publication Date
WO2010035002A1 true WO2010035002A1 (en) 2010-04-01

Family

ID=39952125

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/002284 Ceased WO2010035002A1 (en) 2008-09-24 2009-09-24 Liquid delivery system

Country Status (2)

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GB (1) GB0817486D0 (en)
WO (1) WO2010035002A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013101884A1 (en) * 2011-12-29 2013-07-04 3M Innovative Properties Company Filled incise drape

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4698062A (en) * 1985-10-30 1987-10-06 Alza Corporation Medical device for pulsatile transdermal delivery of biologically active agents
EP0916339A1 (en) * 1988-10-28 1999-05-19 Pharmacia & Upjohn Aktiebolag Prolonged activity nicotine patch
US20050058711A1 (en) * 2003-09-16 2005-03-17 Roger Massengale Fluid medication delivery device

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4698062A (en) * 1985-10-30 1987-10-06 Alza Corporation Medical device for pulsatile transdermal delivery of biologically active agents
EP0916339A1 (en) * 1988-10-28 1999-05-19 Pharmacia & Upjohn Aktiebolag Prolonged activity nicotine patch
US20050058711A1 (en) * 2003-09-16 2005-03-17 Roger Massengale Fluid medication delivery device

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013101884A1 (en) * 2011-12-29 2013-07-04 3M Innovative Properties Company Filled incise drape
CN104334113A (en) * 2011-12-29 2015-02-04 3M创新有限公司 Filled incise drape

Also Published As

Publication number Publication date
GB0817486D0 (en) 2008-10-29

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