WO2010034006A3 - Micro-arn-101 suppresseur de tumeur putatif modulant l'epigenome cancereux par repression de la proteine ezh2 du groupe polycomb - Google Patents
Micro-arn-101 suppresseur de tumeur putatif modulant l'epigenome cancereux par repression de la proteine ezh2 du groupe polycomb Download PDFInfo
- Publication number
- WO2010034006A3 WO2010034006A3 PCT/US2009/057890 US2009057890W WO2010034006A3 WO 2010034006 A3 WO2010034006 A3 WO 2010034006A3 US 2009057890 W US2009057890 W US 2009057890W WO 2010034006 A3 WO2010034006 A3 WO 2010034006A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- repressing
- modulates
- tumor suppressor
- group protein
- polycomb group
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/10—Production naturally occurring
Abstract
L'invention concerne en général le profilage de micro-ARN pour certaines maladies. L'invention concerne plus particulièrement des méthodes et des compostions de micro-ARN destinées à inhiber la croissance et la formation de tumeurs.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/119,699 US20110224284A1 (en) | 2008-09-22 | 2009-09-22 | Putative tumor suppressor microrna-101 modulates the cancer epigenome by repressing the polycomb group protein ezh2 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9911408P | 2008-09-22 | 2008-09-22 | |
US61/099,114 | 2008-09-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010034006A2 WO2010034006A2 (fr) | 2010-03-25 |
WO2010034006A3 true WO2010034006A3 (fr) | 2010-05-27 |
Family
ID=42040204
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/057890 WO2010034006A2 (fr) | 2008-09-22 | 2009-09-22 | Micro-arn-101 suppresseur de tumeur putatif modulant l'epigenome cancereux par repression de la proteine ezh2 du groupe polycomb |
Country Status (2)
Country | Link |
---|---|
US (1) | US20110224284A1 (fr) |
WO (1) | WO2010034006A2 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109745316B (zh) * | 2012-04-13 | 2023-01-24 | Epizyme股份有限公司 | 用于治疗癌症的联合治疗 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009006577A2 (fr) * | 2007-07-03 | 2009-01-08 | The Regents Of The University Of Michigan | Compositions et méthodes pour inhiber la protéine ezh2 |
US20120059159A1 (en) * | 2009-05-25 | 2012-03-08 | Carola Ponzetto | Differentiation therapy for sarcomas |
SG180031A1 (en) * | 2010-10-15 | 2012-05-30 | Agency Science Tech & Res | Combination treatment of cancer |
US20140107176A1 (en) * | 2012-10-12 | 2014-04-17 | Agency For Science, Technology And Research | Method of modulating a prostate cancer cell |
WO2020227604A1 (fr) * | 2019-05-08 | 2020-11-12 | Nova Southeastern University | Régulation de la réparation d'excision de nucléotides (ner) par microarn pour le traitement du cancer du sein |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050059682A1 (en) * | 2003-09-12 | 2005-03-17 | Supergen, Inc., A Delaware Corporation | Compositions and methods for treatment of cancer |
US20050159382A1 (en) * | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1713938A2 (fr) * | 2004-02-09 | 2006-10-25 | Thomas Jefferson University | Diagnostic et traitement de cancers a l'aide de microarn present dans ou au voisinage de caracteristiques chromosomiennes liees aux cancers |
EP2471924A1 (fr) * | 2004-05-28 | 2012-07-04 | Asuragen, INC. | Procédés et compositions impliquant du microARN |
WO2009006577A2 (fr) * | 2007-07-03 | 2009-01-08 | The Regents Of The University Of Michigan | Compositions et méthodes pour inhiber la protéine ezh2 |
-
2009
- 2009-09-22 WO PCT/US2009/057890 patent/WO2010034006A2/fr active Application Filing
- 2009-09-22 US US13/119,699 patent/US20110224284A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050159382A1 (en) * | 2001-05-18 | 2005-07-21 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of polycomb group protein EZH2 gene expression using short interfering nucleic acid (siNA) |
US20050059682A1 (en) * | 2003-09-12 | 2005-03-17 | Supergen, Inc., A Delaware Corporation | Compositions and methods for treatment of cancer |
Non-Patent Citations (1)
Title |
---|
SAUNDERS ET AL.: "Human polymorphism at microRNAs and microRNA target sites.", PNAS, vol. 104, no. 9, 2007, pages 3301 - 3305 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109745316B (zh) * | 2012-04-13 | 2023-01-24 | Epizyme股份有限公司 | 用于治疗癌症的联合治疗 |
Also Published As
Publication number | Publication date |
---|---|
WO2010034006A2 (fr) | 2010-03-25 |
US20110224284A1 (en) | 2011-09-15 |
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