WO2010027498A3 - Compositions and methods for inducing satiety and treating non-insulin dependent diabetes emillitus, pre-diabetic symptoms, insulin resistance and related disease states and conditions - Google Patents

Compositions and methods for inducing satiety and treating non-insulin dependent diabetes emillitus, pre-diabetic symptoms, insulin resistance and related disease states and conditions Download PDF

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Publication number
WO2010027498A3
WO2010027498A3 PCT/US2009/005016 US2009005016W WO2010027498A3 WO 2010027498 A3 WO2010027498 A3 WO 2010027498A3 US 2009005016 W US2009005016 W US 2009005016W WO 2010027498 A3 WO2010027498 A3 WO 2010027498A3
Authority
WO
WIPO (PCT)
Prior art keywords
subject
provides
dosage form
ileum
dependent diabetes
Prior art date
Application number
PCT/US2009/005016
Other languages
French (fr)
Other versions
WO2010027498A2 (en
Inventor
Joseph M. Fayad
Original Assignee
New Science Holdings, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New Science Holdings, Llc filed Critical New Science Holdings, Llc
Publication of WO2010027498A2 publication Critical patent/WO2010027498A2/en
Publication of WO2010027498A3 publication Critical patent/WO2010027498A3/en
Priority to US12/932,633 priority Critical patent/US9757346B2/en
Priority to US15/623,734 priority patent/US20180369177A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Abstract

The invention provides methods of treatment that induce satiety in a subject for a period of at least around twenty- four hours by once-daily administration to the subject of a controlled release dosage form, wherein the dosage form is administered while the subject is in the fasted state and at a time of around six to around nine hours prior to the subject's next intended meal, and wherein the dosage form comprises a controlled release composition, which comprises an enterically-coated, ileum hormone-stimulating amount of a nutritional substance and releases the majority of the nutritional substance in vivo upon reaching the subject's ileum. The invention also provides a diagnostic tool for probing the health and disease state of the ileal hormones, excess or deficiencies. The invention provides a safe vehicle for targeted deliveries of chemical, pharmaceuticals, natural substances and nutrition to the ileum. The present invention also provides a method for treating noninsulin dependent diabetes mellitus, pre-diabetic symptoms, and insulin resistance, as well as a number of disease states and conditions including gastrointestinal disorders as otherwise described herein.
PCT/US2009/005016 2008-09-03 2009-09-02 Compositions and methods for inducing satiety and treating non-insulin dependent diabetes emillitus, pre-diabetic symptoms, insulin resistance and related disease states and conditions WO2010027498A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/932,633 US9757346B2 (en) 2008-09-03 2011-03-02 Compositions and methods for treating insulin resistance and non-insulin dependent diabetes mellitus (type II diabetes)
US15/623,734 US20180369177A1 (en) 2008-09-03 2017-06-15 Compositions and methods for inducing satiety and treating non-insulin dependent diabetes mellitus, pre-diabetic symptoms, insulin resistance and related disease states and conditions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19081808P 2008-09-03 2008-09-03
US61/190,818 2008-09-03

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/932,633 Continuation-In-Part US9757346B2 (en) 2008-09-03 2011-03-02 Compositions and methods for treating insulin resistance and non-insulin dependent diabetes mellitus (type II diabetes)

Publications (2)

Publication Number Publication Date
WO2010027498A2 WO2010027498A2 (en) 2010-03-11
WO2010027498A3 true WO2010027498A3 (en) 2010-06-03

Family

ID=41797725

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/005016 WO2010027498A2 (en) 2008-09-03 2009-09-02 Compositions and methods for inducing satiety and treating non-insulin dependent diabetes emillitus, pre-diabetic symptoms, insulin resistance and related disease states and conditions

Country Status (1)

Country Link
WO (1) WO2010027498A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8828953B2 (en) 2009-04-20 2014-09-09 NaZura BioHealth, Inc. Chemosensory receptor ligand-based therapies
US9901551B2 (en) 2009-04-20 2018-02-27 Ambra Bioscience Llc Chemosensory receptor ligand-based therapies
US8999721B2 (en) 2009-10-23 2015-04-07 Therabrake, Inc. Method and system to provide personalized pharmaceutical compositions and dosages
US20130273154A1 (en) * 2011-03-02 2013-10-17 Joseph M. Fayad Oral formulations Mimetic of Roux-en-Y gastric bypass actions on the ileal brake; Compositions, Methods of Treatment, Diagnostics and Systems for treatment of metabolic syndrome manifestations including insulin resistance, fatty liver disease, hpperlipidemia, and type 2 diabetes
US20190262367A1 (en) * 2010-03-03 2019-08-29 Volant Holdings Gmbh Oral formulations mimetic of roux-en-y gastric bypass actions on the ileal brake; compositions, methods of treatment, diagnostics and systems for treatment of metabolic syndrome manifestations including insulin resistance, fatty liver disease, hyperlipidemia, and type 2 diabetes
EP2407034A1 (en) * 2010-07-17 2012-01-18 Cognis IP Management GmbH Particles
BR112013009635A2 (en) * 2010-10-19 2016-07-12 Elcelyx Therapeutics Inc chemosensory receptor ligand-based therapies
KR20190060879A (en) 2011-03-02 2019-06-03 제롬 쉔타그 Compositions, methods of treatment and diagnostics for treatment of hepatic steatosis alone or in combination with a hepatitis c virus infection
US20180099001A1 (en) 2011-04-29 2018-04-12 Volant Holdings Gmbh Diagnostics and methods for treatment of non-alcoholic hepatic steatosis and hepatic steatohepatitis, and prevention of complications thereof
CA3107450A1 (en) 2012-03-29 2013-10-03 Therabiome, Llc Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix
CA2897448A1 (en) * 2013-01-08 2014-07-17 Jerome Schentag Activation of the endogenous ileal brake hormone pathway for organ regeneration and related compositions, methods of treatment, diagnostics, and regulatory systems
MX2015011462A (en) 2013-03-14 2016-05-31 Jerome J Schentag Cholestosome vesicles for incorporation of molecules into chylomicrons.
US9907755B2 (en) 2013-03-14 2018-03-06 Therabiome, Llc Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents
CN112074197A (en) * 2018-03-07 2020-12-11 安纳生物科技有限公司 Compositions for type II diabetes and for providing sustained energy release over time
WO2020120519A1 (en) 2018-12-10 2020-06-18 Aphaia Pharma Ag Combinatorial oral treatment of metabolic disorders through orchestrated release of enterokines
ES2906316T3 (en) 2018-12-10 2022-04-18 Aphaia Ip Ag Pharmaceutical oral dosage forms for the treatment of metabolic disorders and related diseases through the orchestrated release of enterocins
IL298948A (en) 2020-06-10 2023-02-01 Aphaia Ip Ag Pharmaceutical compositions containing enterokine-releasing substances in multiple dosage forms in combination with gelling agents

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5322697A (en) * 1992-05-28 1994-06-21 Meyer James H Composition and method for inducing satiety
WO2000018377A1 (en) * 1998-09-28 2000-04-06 Warner-Lambert Company Enteric and colonic delivery using hpmc capsules
US20050244518A1 (en) * 2000-06-12 2005-11-03 Ruo Huang Dietary supplement and related method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5322697A (en) * 1992-05-28 1994-06-21 Meyer James H Composition and method for inducing satiety
WO2000018377A1 (en) * 1998-09-28 2000-04-06 Warner-Lambert Company Enteric and colonic delivery using hpmc capsules
US20050244518A1 (en) * 2000-06-12 2005-11-03 Ruo Huang Dietary supplement and related method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MELA, D. J.: "Novel food technologies: enhancing appetite control in liquid meal replacers", OBESITY, vol. 14, no. SUPP., July 2006 (2006-07-01), pages 179S - 181S *

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Publication number Publication date
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