WO2010027261A1 - Method for treatment of natural rubber products - Google Patents
Method for treatment of natural rubber products Download PDFInfo
- Publication number
- WO2010027261A1 WO2010027261A1 PCT/NL2009/050528 NL2009050528W WO2010027261A1 WO 2010027261 A1 WO2010027261 A1 WO 2010027261A1 NL 2009050528 W NL2009050528 W NL 2009050528W WO 2010027261 A1 WO2010027261 A1 WO 2010027261A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkaline solution
- product
- strong alkaline
- products
- natural rubber
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08C—TREATMENT OR CHEMICAL MODIFICATION OF RUBBERS
- C08C1/00—Treatment of rubber latex
- C08C1/02—Chemical or physical treatment of rubber latex before or during concentration
- C08C1/04—Purifying; Deproteinising
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C71/00—After-treatment of articles without altering their shape; Apparatus therefor
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08C—TREATMENT OR CHEMICAL MODIFICATION OF RUBBERS
- C08C1/00—Treatment of rubber latex
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
- C08J5/02—Direct processing of dispersions, e.g. latex, to articles
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/02—Chemical treatment or coating of shaped articles made of macromolecular substances with solvents, e.g. swelling agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L7/00—Compositions of natural rubber
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C71/00—After-treatment of articles without altering their shape; Apparatus therefor
- B29C71/0009—After-treatment of articles without altering their shape; Apparatus therefor using liquids, e.g. solvents, swelling agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
- B29K2007/00—Use of natural rubber as moulding material
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2307/00—Characterised by the use of natural rubber
- C08J2307/02—Latex
Definitions
- Natural Rubber Latex (herein also referred to as NRL) is being used for many products in for instance the health care industry, such as surgical gloves, and for manufacturing prophylactics, such as condoms. Due to the stretchability, the natural feeling touch, its barrier properties including puncture resistance and even some self seallability after a puncture, Natural Rubber Latex is the preferred material for examination and surgical gloves.
- the latex sap harvested from the Hevea Brasiliensis tree contains proteins, which are functional for the stability of the latex suspension used in production of such products, for instance by dipping and/or molding. However, such proteins give rise to allergic reactions to sensitive people coming into physical contact with products made of this natural material.
- Some solutions have been proposed which denature the allergens. These methods mostly use added stabilizers to keep the rubber particles of the NRL from clogging. This changes the surface properties of the suspended rubber particles, resulting in different mechanical properties of the material. Other methods include washing finished latex products in aqueous solutions to remove surface proteins. None of the existing methods is able to completely prevent allergens to leach from latex products when they are immersed in water: all methods show detectable amounts of leachable allergens.
- This invention thus relates to products made of natural rubber latex (NRL) that come into contact with humans and especially to NRL that exhibits no detectable amount of leachable allergens (and therefore or at least strongly reduced allergenicity potential) without the loss of physical properties or the introduction of new components altering the NRL formulation.
- NRL natural rubber latex
- the oxidative washes (US20020103333, US5910567) generally use a strong chlorine or hypochlorite wash, which is able to reduce the leaching of allergens from NRL upon contact with water.
- the oxidator concentration is too strong, the NRL is affected by this wash, resulting in diminished gripping, elastomeric and tactile properties.
- the product becomes stiff, exhibiting hysteresis and requiring a heavy load to stretch.
- the result is a poor fit and fatigue during use.
- the state of the art comprises the disclosures of US- 5.910.567; and GB-2.366.509. These disclosures all relate to treatment of natural rubber latex products to reduce allergenicity thereof.
- an alkaline solution at temperatures between room temperature (2O 0 C) and below 98 0 C is used to wash NLR products to reduce allergenicity thereof.
- NLR products are washed in an alkaline solution, after having been powdered with cornstarch and immersed in water heated to a temperature between 8O 0 C and 98 0 C and removed from the water. After the hot water wash, according to this disclosure, the NLR products are subjected to the alkaline solution at an undisclosed temperature.
- the present invention is directed at decreasing the problems of the prior art method. More in particular, a solution is presented with which it is possible to reduce the extractable amount of allergens to extraordinarily low and even undetectable levels, according to the most modern and sensitive analyses methods. Thus, according to the invention it has become possible to achieve results which have never been reached before, at least not without affecting the physical properties of the Natural Rubber Latex matrix.
- chemical proteolysis is applied to the NRL product after the production process. Due to the fact that no formulation changes are introduced of the NRL suspension, the processability is being maintained while the products physical and mechanical properties are not being altered.
- This method is capable of removing extractable protein of the NRL product to undetectable levels, by just adding or altering one washing step in the production process to remove the protein by chemical proteolysis.
- the conditions considered necessary are applied to not only wash away the proteins but actually destroy the allergens by breaking the peptide bonds of the proteins by chemical proteolysis.
- the presented method is mainly based on chemical proteolysis of the proteins at the surface of a product made of Natural Rubber Latex.
- This proteolysis occurs by washing the product in a strong alkaline solution (e.g. pH>10) at elevated temperatures above 100 0 C.
- a strong alkaline solution e.g. pH>10
- Higher temperatures above 100 0 C have been surprisingly found to improve and evidently also speed up the proteolysis, without affecting or even deteriorating the NRL products, all far beyond the normal expectation of the skilled person, which amongst other effects also allows for shorter contact times.
- peptide bonds will be subject to nucleofillic attacks by nucleofiles like OH- (stronger nucleofiles may also be applied) , breaking the peptide bond of the proteins through a nucleofillic substitution reaction.
- the amide group of the protein bond will act as the leaving group and the remaining carboxyl group will be deprotonized due to the high pH, leaving a stabilized carboxylate group which cannot be subject to a nucleofillic attack again.
- the needed level of proteolysis is achieved by washing the NRL product using an alkaline solution at elevated temperatures above 100 0 C. Washing using alkaline solution at room temperature, or washing using elevated temperatures and a neutral pH, does not reduce extractable protein levels more than 99%, even at long contact times (e.g. 1 day) .
- pressure e.g. 2 atm.
- QuattroMed FitKit allergens testing kit ( ⁇ 0,15 ⁇ g/g for the four main allergens of NRL: ⁇ 0,050 ⁇ g/g for Hevbl, ⁇ 0.050 ⁇ g/g for Hevb3, ⁇ 0.025 ⁇ g/g for Hevb5 and ⁇ 0.025 ⁇ g/g for Hevb6.02) . It is noted here for comparison, that washing at room temperature (18-2O 0 C) in a high-pH solution enables a reduction of the allergen concentration from 30 ⁇ g/g to 1 ⁇ g/g, but it is clear that this does not suffice.
- the gloves treated in accordance with the new method of the present invention were further also tested to determine the Stress-strain curves of these treated gloves. This did not show any changes in mechanical properties of the gloves, which could have resulted from the new method according to the present invention.
- boiling/evaporation of the alkaline solution at an elevated temperature of 100 0 C or more for washing the products therein could have had an adverse effect on the NLR material itself, as well as the colour and the mechanical properties thereof. Salty alkalines could then be freed to affect the NLR material, rather than to clean the NLR products from the allergens therein or -on. This, and similar considerations with respect to gasses freed upon boiling of the solution, refrained the skilled person in the past from attempting to raise the temperature to the levels according to the present invention.
- Pressurization provides a possible means for keeping the solution from boiling and thus prevent damage to the product material from exposure to gas and freed salty alkalines, which occur at boiling of the alkaline solution.
- a pressure tank or vessel may be employed, but alternatives are readily available to the skilled person.
- the skilled person may contemplate adding an additive to the alkaline solution, for raising the boiling point thereof and/or keep salty alkalines from being freed at the elevated temperatures, to prevent the material from being affected during the treatment thereof. It is noted that the skilled person according to the state of the art disclosures had no incentive to attempt elevated temperatures to above 100 0 C in combination with either of an elevated pressure and boiling point raising additives.
- the obtained results are unique and very promising.
- the method is considered to be applicable and affordable in practice.
- the new method of the present invention can be upscaled and made suitable for the current large scale production practice without undue burden.
- the method can be used as an additional step, or replace existing steps (e.g. the chlorination) .
- the new method is anticipated to result in beneficial economic effects, which may positively affect cost price, and may lead to lower prices, if the method can be used to replace a more expensive step in the production.
- NRL products are washed in a strong alkaline suspension.
- the products have been previously manufactured by dipping a mold into a NRL suspension. After manufacture, the product is washed in a strong alkaline solution.
- the alkaline solution had a pH of 10. The temperature of the solution is elevated to approximately 30 degrees. The product is washed in the solution for 10 minutes and already an improvement is then detectable.
- NRL products are washed in a strong alkaline suspension.
- the products have been previously manufactured by molding a NRL suspension, where the suspension is injected or otherwise introduced into a mold. After manufacture, the product is washed in a strong alkaline solution.
- the alkaline solution has a pH of 10. The temperature of the solution is elevated, before or even during washing, to approximately 30 degrees. The product is washed in the solution for 10 minutes and already an improvement is detectable.
- the method is the same as either of examples 1 and 2, with as a difference that the time of washing is increased to 1 hour, where a further increase in the effectiveness was detectable.
- washing time is increased one day, and all other features remain unchanged relative to example 3. Again a further increase in the effectiveness is made detectable.
- Example 5 In this comparative example, the method is the same as any one of the examples 1, 2, 3 and 4, with as a difference that the strength of the alkaline solution is increased to a pH of 14, where a further increase in the effectiveness is detectable .
- Example 10 In the third embodiment of the invention, all features of examples 1-5 are unaltered, except that the temperature is raised to approximately 118 0 C.
- the pressure in the vessel is, during treatment of the products, raised to more than one atm. (l,013*10 ⁇ 5 Pa) .
- the pressure level was selected to keep evaporation and/or freeing salty alkalines from occurring; for instance at more than 1 atm. at a temperature of 100 0 C, more than 1,5 atm. at HO 0 C and more than 2,0 atm. at 12O 0 C.
- nucleofillic substances such as H20, OH, CH3- CH2-O-, I- and CN-.
- Example 14 The features in this example are the same as in any one of the preceding examples. Additionally, in a step surfactants in a solution are provided and the product is washed or submerged in this solution.
- a surfactant may comprise or be SDS (sodium dodecyl sulfate) .
- a protease treatment is employed, where a solution comprising enzymes is provided for the products to be washed or submerged in.
- the products are subjected to an oxidative treatment, wherein for instance a chlorine solution is provided for the products to be washed or at least submerged in the solution.
- a talcum or similar type powdering for the products.
- powdering the products, such as surgical gloves, with a talcum or starch powdering has become less and less usual, since the powders used were found to provide a basis for allergens to attach to.
- powdered gloves are still being produced and sold, but less and less so, precisely because of the attachment of allergens to the powders used.
- powdering may yet again become desirable in view of the improved ease of handling. For instance, a powdered glove is far easier arranged on a user's hand than a product without powdering. As a consequence it is believed that powdering can provide a further improved result of the method in as far as the resulting product is concerned.
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- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Gloves (AREA)
- Cosmetics (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011526000A JP5591242B2 (en) | 2008-09-05 | 2009-09-03 | Process for treating natural rubber products and products obtained thereby |
ES09788301T ES2386950T3 (en) | 2008-09-05 | 2009-09-03 | Method for the treatment of natural rubber products |
AU2009288946A AU2009288946B2 (en) | 2008-09-05 | 2009-09-03 | Method for treatment of natural rubber products |
CA2736054A CA2736054C (en) | 2008-09-05 | 2009-09-03 | Method for treatment of natural rubber products |
BRPI0918794A BRPI0918794B1 (en) | 2008-09-05 | 2009-09-03 | method for reducing allergenicity of natural latex products caused by allergens, and product |
US13/061,839 US8546520B2 (en) | 2008-09-05 | 2009-09-03 | Method for treatment of natural rubber products |
SI200930314T SI2321359T1 (en) | 2008-09-05 | 2009-09-03 | Method for treatment of natural rubber products |
CN2009801351021A CN102164967B (en) | 2008-09-05 | 2009-09-03 | Method for treatment of natural rubber products |
EP09788301A EP2321359B1 (en) | 2008-09-05 | 2009-09-03 | Method for treatment of natural rubber products |
EA201170418A EA018771B1 (en) | 2008-09-05 | 2009-09-03 | Method for treatment of natural rubber products |
PL09788301T PL2321359T3 (en) | 2008-09-05 | 2009-09-03 | Method for treatment of natural rubber products |
MX2011002382A MX2011002382A (en) | 2008-09-05 | 2009-09-03 | Method for treatment of natural rubber products. |
DK09788301.1T DK2321359T3 (en) | 2008-09-05 | 2009-09-03 | Process for the treatment of natural rubber products |
ZA2011/01556A ZA201101556B (en) | 2008-09-05 | 2011-02-28 | Method for treatment of natural rubber products |
IL211559A IL211559A0 (en) | 2008-09-05 | 2011-03-03 | Method for treatment of natural rubber products |
MA33738A MA32689B1 (en) | 2008-09-05 | 2011-04-01 | Method for processing products made of natural rubber |
HK11113826.0A HK1159141A1 (en) | 2008-09-05 | 2011-12-22 | Method for treatment of natural rubber products |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL1035901 | 2008-09-05 | ||
NL1035901A NL1035901C (en) | 2008-09-05 | 2008-09-05 | Method for treatment of natural rubber products. |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010027261A1 true WO2010027261A1 (en) | 2010-03-11 |
Family
ID=40675951
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/NL2009/050528 WO2010027261A1 (en) | 2008-09-05 | 2009-09-03 | Method for treatment of natural rubber products |
Country Status (23)
Country | Link |
---|---|
US (1) | US8546520B2 (en) |
EP (1) | EP2321359B1 (en) |
JP (1) | JP5591242B2 (en) |
KR (1) | KR101641150B1 (en) |
CN (1) | CN102164967B (en) |
AU (1) | AU2009288946B2 (en) |
BR (1) | BRPI0918794B1 (en) |
CA (1) | CA2736054C (en) |
CO (1) | CO6362028A2 (en) |
DK (1) | DK2321359T3 (en) |
EA (1) | EA018771B1 (en) |
ES (1) | ES2386950T3 (en) |
HK (1) | HK1159141A1 (en) |
IL (1) | IL211559A0 (en) |
MA (1) | MA32689B1 (en) |
MX (1) | MX2011002382A (en) |
MY (1) | MY152970A (en) |
NL (1) | NL1035901C (en) |
PL (1) | PL2321359T3 (en) |
PT (1) | PT2321359E (en) |
SI (1) | SI2321359T1 (en) |
WO (1) | WO2010027261A1 (en) |
ZA (1) | ZA201101556B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL2006847C2 (en) * | 2011-05-25 | 2012-11-27 | Budev Bv | Method for treatment of natural rubber latex and/or synthetic rubber products, a system for treatment and the resulting rubber products. |
WO2023063894A1 (en) * | 2021-10-14 | 2023-04-20 | Sri Trang Gloves (Thailand) Public Company Limited | Process for removing protein contents from rubber glove and rubber glove product resulting therefrom |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3466984B1 (en) * | 2012-03-06 | 2020-05-13 | Bridgestone Corporation | Processes for the removal of rubber from non-hevea plants |
WO2013192182A1 (en) | 2012-06-18 | 2013-12-27 | Bridgestone Corporation | Systems and methods for the management of waste associated with processing guayule shrubs to extract rubber |
ES2936462T3 (en) | 2012-06-18 | 2023-03-17 | Bridgestone Corp | Bagasse desolventization method |
US9567457B2 (en) | 2013-09-11 | 2017-02-14 | Bridgestone Corporation | Processes for the removal of rubber from TKS plant matter |
CN103554566B (en) * | 2013-11-12 | 2015-09-16 | 镇江苏惠乳胶制品有限公司 | A kind of natural rubber medical gloves and preparation method thereof |
JP6485771B2 (en) * | 2015-06-30 | 2019-03-20 | 住友ゴム工業株式会社 | Method for producing agglomerated rubber particles, method for producing pneumatic tire, and method for producing rubber product |
US10775105B2 (en) | 2018-11-19 | 2020-09-15 | Bridgestone Corporation | Methods for the desolventization of bagasse |
JP7011354B1 (en) | 2021-03-22 | 2022-01-26 | 雪ヶ谷化学工業株式会社 | Discoloration-prevented natural rubber latex sponge and its manufacturing method |
Citations (3)
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---|---|---|---|---|
US5910567A (en) * | 1995-03-14 | 1999-06-08 | Fuji Latex Co., Ltd. | Process for preparing deproteinized natural rubber latex molding and deproteinizing agent for natural rubber latex |
US6107455A (en) * | 1995-06-27 | 2000-08-22 | Novo Nordisk A/S | Removal of protein from natural rubber latex articles |
GB2366509A (en) * | 2000-09-06 | 2002-03-13 | Deprotin Inc | Method of removing protein from dipped latex rubber goods |
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GB305531A (en) | 1928-02-06 | 1930-03-06 | Goodyear Tire & Rubber | Apparatus and method for cleaning molds |
US1918069A (en) * | 1932-06-08 | 1933-07-11 | Sadye E Wallace | Fountain brush |
JP2717493B2 (en) * | 1993-01-11 | 1998-02-18 | 不二ラテックス株式会社 | Method for removing allergenic substance from natural rubber latex and method for producing natural rubber molded article |
DE4406584C2 (en) | 1994-03-01 | 2000-01-05 | Baur Xaver | Process for modifying allergens in a natural rubber latex and in a product made from natural rubber latex |
JP3604445B2 (en) * | 1995-03-14 | 2004-12-22 | 不二ラテックス株式会社 | Method for producing deproteinized natural rubber latex molded article |
JP3742196B2 (en) * | 1997-06-24 | 2006-02-01 | 住友ゴム工業株式会社 | Method for producing refined solid natural rubber |
JP2000109596A (en) | 1998-10-02 | 2000-04-18 | Yukigaya Kagaku Kogyo Kk | Deproteinized natural rubber latex sponge and its production |
JP2001081107A (en) | 1999-09-10 | 2001-03-27 | Sumitomo Rubber Ind Ltd | Deproteinization treating agent and production of cationic deproteinized natural rubber latex using the same |
AU781386B2 (en) | 2000-11-08 | 2005-05-19 | Kao Corporation | Method of preparing low allergic natural rubber latex and deproteinized natural rubber latex, and low allergic natural rubber and deproteinized natural rubber |
US20020103333A1 (en) | 2000-12-06 | 2002-08-01 | Honeycutt Travis W. | Latex with decreased allergic reaction and improved physical properties |
JP5133479B2 (en) | 2001-07-06 | 2013-01-30 | 住友ゴム工業株式会社 | Method for producing hypoallergenic natural rubber latex |
-
2008
- 2008-09-05 NL NL1035901A patent/NL1035901C/en not_active IP Right Cessation
-
2009
- 2009-09-03 AU AU2009288946A patent/AU2009288946B2/en not_active Ceased
- 2009-09-03 CN CN2009801351021A patent/CN102164967B/en not_active Expired - Fee Related
- 2009-09-03 PT PT09788301T patent/PT2321359E/en unknown
- 2009-09-03 EA EA201170418A patent/EA018771B1/en not_active IP Right Cessation
- 2009-09-03 MY MYPI20110980 patent/MY152970A/en unknown
- 2009-09-03 KR KR1020117006581A patent/KR101641150B1/en active IP Right Grant
- 2009-09-03 CA CA2736054A patent/CA2736054C/en active Active
- 2009-09-03 WO PCT/NL2009/050528 patent/WO2010027261A1/en active Application Filing
- 2009-09-03 SI SI200930314T patent/SI2321359T1/en unknown
- 2009-09-03 EP EP09788301A patent/EP2321359B1/en active Active
- 2009-09-03 MX MX2011002382A patent/MX2011002382A/en active IP Right Grant
- 2009-09-03 BR BRPI0918794A patent/BRPI0918794B1/en not_active IP Right Cessation
- 2009-09-03 DK DK09788301.1T patent/DK2321359T3/en active
- 2009-09-03 ES ES09788301T patent/ES2386950T3/en active Active
- 2009-09-03 JP JP2011526000A patent/JP5591242B2/en not_active Expired - Fee Related
- 2009-09-03 PL PL09788301T patent/PL2321359T3/en unknown
- 2009-09-03 US US13/061,839 patent/US8546520B2/en active Active
-
2011
- 2011-02-28 ZA ZA2011/01556A patent/ZA201101556B/en unknown
- 2011-03-03 IL IL211559A patent/IL211559A0/en unknown
- 2011-04-01 CO CO11040164A patent/CO6362028A2/en not_active Application Discontinuation
- 2011-04-01 MA MA33738A patent/MA32689B1/en unknown
- 2011-12-22 HK HK11113826.0A patent/HK1159141A1/en not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5910567A (en) * | 1995-03-14 | 1999-06-08 | Fuji Latex Co., Ltd. | Process for preparing deproteinized natural rubber latex molding and deproteinizing agent for natural rubber latex |
US6107455A (en) * | 1995-06-27 | 2000-08-22 | Novo Nordisk A/S | Removal of protein from natural rubber latex articles |
GB2366509A (en) * | 2000-09-06 | 2002-03-13 | Deprotin Inc | Method of removing protein from dipped latex rubber goods |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL2006847C2 (en) * | 2011-05-25 | 2012-11-27 | Budev Bv | Method for treatment of natural rubber latex and/or synthetic rubber products, a system for treatment and the resulting rubber products. |
WO2012161578A1 (en) | 2011-05-25 | 2012-11-29 | Budev B.V. | Method for treatment of synthetic rubber products, a system for treatment, the resulting rubber products, and use of a method to reduce type iv allergenicity of synthetic rubber products |
JP2014522429A (en) * | 2011-05-25 | 2014-09-04 | ブデフ・ベスローテン・フェンノートシャップ | Use of synthetic rubber product processing methods, processing systems, resulting rubber products and methods for reducing type IV allergenicity of synthetic rubber products |
WO2023063894A1 (en) * | 2021-10-14 | 2023-04-20 | Sri Trang Gloves (Thailand) Public Company Limited | Process for removing protein contents from rubber glove and rubber glove product resulting therefrom |
Also Published As
Publication number | Publication date |
---|---|
CO6362028A2 (en) | 2012-01-20 |
PL2321359T3 (en) | 2012-12-31 |
NL1035901C (en) | 2010-03-15 |
SI2321359T1 (en) | 2012-09-28 |
BRPI0918794A2 (en) | 2016-08-16 |
PT2321359E (en) | 2012-08-03 |
JP2012502134A (en) | 2012-01-26 |
KR101641150B1 (en) | 2016-07-20 |
BRPI0918794B1 (en) | 2019-09-10 |
EP2321359B1 (en) | 2012-07-04 |
IL211559A0 (en) | 2011-05-31 |
EA201170418A1 (en) | 2011-12-30 |
HK1159141A1 (en) | 2012-07-27 |
KR20110065474A (en) | 2011-06-15 |
CN102164967A (en) | 2011-08-24 |
EA018771B1 (en) | 2013-10-30 |
EP2321359A1 (en) | 2011-05-18 |
CA2736054C (en) | 2017-06-13 |
US8546520B2 (en) | 2013-10-01 |
CN102164967B (en) | 2013-03-06 |
MA32689B1 (en) | 2011-10-02 |
DK2321359T3 (en) | 2012-10-15 |
ZA201101556B (en) | 2012-08-29 |
MX2011002382A (en) | 2011-06-09 |
AU2009288946B2 (en) | 2014-08-07 |
CA2736054A1 (en) | 2010-03-11 |
JP5591242B2 (en) | 2014-09-17 |
US20110162676A1 (en) | 2011-07-07 |
ES2386950T3 (en) | 2012-09-07 |
MY152970A (en) | 2014-12-15 |
AU2009288946A1 (en) | 2010-03-11 |
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