WO2010026788A1 - Medical image processing device and medical image processing method - Google Patents

Medical image processing device and medical image processing method Download PDF

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WO2010026788A1
WO2010026788A1 PCT/JP2009/053848 JP2009053848W WO2010026788A1 WO 2010026788 A1 WO2010026788 A1 WO 2010026788A1 JP 2009053848 W JP2009053848 W JP 2009053848W WO 2010026788 A1 WO2010026788 A1 WO 2010026788A1
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image
ray
ray transmission
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哲雄 島田
康祐 簑島
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コニカミノルタエムジー株式会社
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5229—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image
    • A61B6/5235—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from the same or different ionising radiation imaging techniques, e.g. PET and CT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/46—Arrangements for interfacing with the operator or the patient
    • A61B6/461—Displaying means of special interest
    • A61B6/463—Displaying means of special interest characterised by displaying multiple images or images and diagnostic data on one display
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/30—Determination of transform parameters for the alignment of images, i.e. image registration
    • G06T7/38—Registration of image sequences
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10116—X-ray image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10116—X-ray image
    • G06T2207/10124—Digitally reconstructed radiograph [DRR]
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30061—Lung

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  • the present invention relates to a medical image processing apparatus and a medical image processing method.
  • an inspection by a CT (Computed Tomography) apparatus is performed after an inspection by an X-ray transmission imaging apparatus or in parallel with the inspection. This is to improve inspection accuracy.
  • X-ray transmission image a medical image obtained by an X-ray transmission imaging apparatus
  • CT image a medical image obtained by a CT apparatus
  • the CT image is composed of an enormous number of slice images, and the slice image corresponding to the X-ray transmission image must be selected from the enormous number of slice images.
  • the X-ray transmission imaging apparatus is photographed in a standing position, and the CT apparatus is photographed in a prone position. In this case, it is difficult to confirm the lesion displayed on the X-ray transmission image on the CT image due to the difference in raising and lowering of the arm.
  • structures other than the lung field (calcification of ribs, etc.) are displayed as X-ray transmission images, but are not displayed as CT images, so it is difficult to compare and interpret both images.
  • Patent Document 1 a technique for facilitating comparative interpretation by sequentially displaying at least one of three or more images of the same subject and switching the other images sequentially is disclosed.
  • Patent Document 2 a technique for facilitating comparative interpretation by sequentially displaying at least one of three or more images of the same subject and switching the other images sequentially is disclosed.
  • temporal subtraction processing is performed by subtracting pixels of one image from pixels corresponding to exactly the same anatomical structure in the other image The technique of this is disclosed (refer patent document 2).
  • Patent Document 1 and Patent Document 2 cannot accurately align the X-ray transmission image and the CT image. Therefore, it is difficult and complicated to confirm the lesion displayed in the X-ray transmission image with the CT image.
  • An object of the present invention is to accurately perform alignment between an X-ray transmission image and a CT image and easily grasp the corresponding positional relationship in both images.
  • An acquisition means for acquiring a CT image and an X-ray transmission image Based on the acquired CT image, a virtual X-ray image in the same imaging direction as the acquired X-ray transmission image is generated, and the generated virtual X-ray image and the X-ray transmission image are aligned.
  • the acquisition means acquires X-ray transmission images in a plurality of imaging directions
  • the control means is provided with a medical image processing apparatus that generates virtual X-ray images in a plurality of imaging directions according to the acquired X-ray transmission images in a plurality of imaging directions.
  • the designation means designates an arbitrary position in the CT image after being aligned by the control means,
  • the determining unit projects a position corresponding to the specified arbitrary position on the virtual X-ray image, and determines the specified arbitrary position on the X-ray transmission image based on the projected position.
  • the display means is provided with a medical image processing apparatus for displaying the X-ray transmission image and identifying and displaying the determined position on the X-ray transmission image.
  • Displaying the X-ray transmission image by a display means, and identifying and displaying the determined position on the X-ray transmission image A medical image processing method is provided.
  • a CT image and an X-ray transmission image can be acquired, and a virtual X-ray image in the same imaging direction as the X-ray transmission image can be generated from the CT image.
  • the generated virtual X-ray image and X-ray transmission image can be aligned. Therefore, the corresponding positional relationship in both images can be easily grasped.
  • FIG. 1 shows an internal configuration diagram of a medical image processing apparatus 100 in the present embodiment.
  • the medical image processing apparatus 100 includes a control unit 11, an operation unit 12, a display unit 13, a communication unit 14, and a storage unit 15.
  • the control unit 11 includes a CPU (Central Processing Unit), a RAM (Random Access Memory), and the like, expands a predetermined program stored in the storage unit 15 to the RAM, and performs processing operations in cooperation with the program. Control all over.
  • CPU Central Processing Unit
  • RAM Random Access Memory
  • the operation unit 12 includes a keyboard provided with numeric keys, character keys, function keys, a mouse, and the like, and outputs an operation signal corresponding to the operated key to the control unit 11.
  • the display unit 13 includes an LCD (Liquid Crystal Display) or the like, and displays various display information such as medical images and operation screens in accordance with display control of the control unit 11.
  • the display part 13 is good also as an aspect which comprises the operation part 12 and an integrated touch panel.
  • the communication unit 14 includes a communication interface such as a network interface card or a modem.
  • the control unit 11 acquires an X-ray transmission image and a CT image via the communication unit 14.
  • the storage unit 15 includes various programs such as a control program executed by the control unit 11 and an image processing program in addition to the system program.
  • the storage unit 15 stores various parameters necessary for executing each program, and stores data processed after the execution.
  • the control unit 11 inputs an X-ray transmission image and a CT image via the communication unit 14 (Steps S1 and S2). Both images input here are the same part of the same patient.
  • the control unit 11 generates a virtual X-ray image in the same imaging direction as the X-ray transmission image input in Step S1 from the CT image input in Step S1 (Step S3).
  • the control unit 11 generates a virtual X-ray image by adding pixel values of a plurality of slice images constituting the CT image.
  • the control unit 11 When X-ray transmission images in a plurality of imaging directions are input in step S1, the control unit 11 generates corresponding virtual X-ray images in a plurality of imaging directions.
  • the control unit 11 uses affine transformation to align the input X-ray transmission image and the generated virtual X-ray image (step S4).
  • affine transformation a plurality of corresponding points are set for two images to be aligned, and one image is rigidly deformed so that the corresponding points set in the two images coincide with each other.
  • the control unit 11 displays the X-ray transmission image on the display unit 13 (step S5).
  • the control unit 11 inputs the designated lesion position (step S6).
  • the control unit 11 determines a position corresponding to the input lesion position on the virtual X-ray image (step S7).
  • the control unit 11 extracts a CT image including the determined position (step S8). That is, the control unit 11 extracts a slice image including a lesion position from among a plurality of slice images constituting the CT image.
  • the control unit 11 displays the extracted CT image on the display unit 13 and identifies and displays the position or projection range determined in step S7 (step S9), and ends the alignment process.
  • a lesion position is designated from the CT image, and the corresponding position is identified and displayed on the X-ray transmission image.
  • Steps S11 to S14 are the same as steps S1 to S4 in FIG. 2, and a description thereof will be omitted here.
  • the control unit 11 displays the CT image on the display unit 13 (step S15).
  • the control unit 11 inputs the designated lesion position (step S16).
  • the control unit 11 projects the input lesion position on the virtual X-ray image (step S17).
  • the control unit 11 determines a position corresponding to the projected lesion position on the X-ray transmission image (step S18).
  • the control unit 11 displays the X-ray transmission image on the display unit 13 and identifies and displays the position or the peripheral area determined in step S18 (step S19), and ends the other alignment processing.
  • the X-ray transmission image G1 shown in FIG. 4A is an X-ray transmission image whose imaging direction is the front of the chest.
  • the CT image G2 is a CT image of the chest and is composed of a plurality of slice images.
  • the virtual X-ray image G21 is a pseudo X-ray transmission image generated by combining a plurality of slice images constituting the CT image G2, and is a pseudo X-ray transmission image whose imaging direction is the front of the chest. .
  • the corresponding projection range is identified on the CT image G2. Is displayed.
  • An X-ray transmission image G11 illustrated in FIG. 4B is an X-ray transmission image in which the imaging direction is the chest side surface.
  • the virtual X-ray image G22 is a pseudo X-ray transmission image generated in the same manner as the virtual X-ray image G21, and is a pseudo X-ray transmission image in which the imaging direction is the chest side surface.
  • the X-ray transmission image G1 and the virtual X-ray image G21 are aligned, and further, the X-ray transmission image G11 and the virtual X-ray image G22 are aligned. Thereafter, when the lesion position displayed in the X-ray transmission image G1 or the X-ray transmission image G11 is designated with a mouse or the like, the corresponding lesion position is identified and displayed on the CT image G2.
  • the X-ray transmission image G1, the CT image G2, and the virtual X-ray image G21 shown in FIG. 4C are the same as the image shown in FIG. 4A.
  • the lesion position displayed on the CT image G2 is designated with a mouse or the like, the corresponding position is identified and displayed on the X-ray transmission image G1.
  • the X-ray transmission images G1 and G11, the CT image G2, and the virtual X-ray images G21 and G22 shown in FIG. 4D are the same as the image shown in FIG. 4B.
  • the X-ray transmission image G1 and the virtual X-ray image G21 are aligned, and the X-ray transmission image G11 and the virtual X-ray image G22 are aligned. Thereafter, when the lesion position displayed on the CT image G2 is designated with a mouse or the like, the corresponding position is identified and displayed on the X-ray transmission image G1 or the X-ray transmission image G11.
  • the CT image G2 and the X-ray transmission image G1 can be input, and the alignment of both images can be performed. Therefore, comparative interpretation can be easily performed.
  • a virtual X-ray image G21 (G22) corresponding to the imaging direction can be generated and the images can be aligned. it can.
  • the lesion position displayed on the X-ray transmission image G1 (G11) is designated after the alignment, the position corresponding to the designated position can be identified and displayed on the CT image G2. Therefore, a lesion that can be confirmed on the X-ray transmission image G1 (G11) can be easily confirmed on the CT image G2, and comparative interpretation can be performed.
  • the lesion position displayed on the CT image G2 is designated after the alignment, the position corresponding to the designated position can be identified and displayed on the X-ray transmission image G1 (G11). Therefore, the lesion that can be confirmed on the CT image G2 can be easily confirmed on the X-ray transmission image G1 (G11), and comparative interpretation can be performed.
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Abstract

It is possible to accurately match an X-ray transmission image with a CT image so as to easily understand the corresponding positional relationship in the both images. Provided is a medical image processing device (10) including: a communication unit (14) which inputs a CT image and an X-ray transmission image; and a control unit (11) which generates a virtual X-ray image in the same imaging direction as the inputted the X-ray transmission image according to the inputted CT image and matches the position of the generated virtual X-ray image with the X-ray transmission image.

Description

医用画像処理装置及び医用画像処理方法Medical image processing apparatus and medical image processing method
　本発明は、医用画像処理装置及び医用画像処理方法に関する。 The present invention relates to a medical image processing apparatus and a medical image processing method.
　X線透過像撮影装置による検査を行った後又は検査と並行して、ＣＴ（Computed Tomography）装置による検査を行う場合がある。これは、検査精度の向上を図るためである。
　X線透過像撮影装置によって得られた医用画像（以下、「X線透過画像」という）に表示された病変をＣＴ装置によって得られた医用画像（以下、「ＣＴ画像」という）で確認する場合、両画像において対応する位置関係を把握する必要がある。 In some cases, an inspection by a CT (Computed Tomography) apparatus is performed after an inspection by an X-ray transmission imaging apparatus or in parallel with the inspection. This is to improve inspection accuracy.
When confirming a lesion displayed on a medical image obtained by an X-ray transmission imaging apparatus (hereinafter referred to as “X-ray transmission image”) with a medical image obtained by a CT apparatus (hereinafter referred to as “CT image”) It is necessary to grasp the corresponding positional relationship in both images.
　ここで、X線透過画像とＣＴ画像との位置関係を把握することは極めて煩雑な作業を要する。ＣＴ画像は膨大な枚数のスライス画像から構成されており、膨大な枚数の中からX線透過画像に対応するスライス画像を取捨選択しなければならないためである。
　また、胸部検査の場合、X線透過像撮影装置では立位で撮影し、ＣＴ装置では臥位で撮影する。この場合、腕の挙げ降ろしの違いによってX線透過画像で表示された病変をＣＴ画像で確認することは困難である。更に、肺野以外の構造（肋骨の石灰化等）はX線透過画像で表示されるが、ＣＴ画像では表示されないため、両画像を比較読影することは難しい。 Here, grasping the positional relationship between the X-ray transmission image and the CT image requires extremely complicated work. This is because the CT image is composed of an enormous number of slice images, and the slice image corresponding to the X-ray transmission image must be selected from the enormous number of slice images.
In the case of a chest examination, the X-ray transmission imaging apparatus is photographed in a standing position, and the CT apparatus is photographed in a prone position. In this case, it is difficult to confirm the lesion displayed on the X-ray transmission image on the CT image due to the difference in raising and lowering of the arm. Furthermore, structures other than the lung field (calcification of ribs, etc.) are displayed as X-ray transmission images, but are not displayed as CT images, so it is difficult to compare and interpret both images.
　従来、同一被写体について３以上の画像のうち、少なくとも１つを固定的に常時表示しておき、他の画像を順次切り替えて比較読影を容易にする技術が開示されている（特許文献１参照）。
　また、２枚の胸部単純Ｘ線画像の位置合わせを行う際、１枚の画像の画素を他方の画像で全く同一の解剖学的な構造に対応する画素から差し引いて位置合わせを行う経時差分処理の技術が開示されている（特許文献２参照）。
特開２００１－１５７６６７号公報 特開２００５－１７６４０２号公報 Conventionally, a technique for facilitating comparative interpretation by sequentially displaying at least one of three or more images of the same subject and switching the other images sequentially is disclosed (see Patent Document 1). .
In addition, when performing alignment of two chest simple X-ray images, temporal subtraction processing is performed by subtracting pixels of one image from pixels corresponding to exactly the same anatomical structure in the other image The technique of this is disclosed (refer patent document 2).
JP 2001-157667 A JP 2005-176402 A
　しかし、特許文献１及び特許文献２の技術では、X線透過画像とＣＴ画像との位置合わせを正確に行うことはできない。よって、X線透過画像に表示された病変をＣＴ画像で確認することは困難であり煩雑である。 However, the techniques of Patent Document 1 and Patent Document 2 cannot accurately align the X-ray transmission image and the CT image. Therefore, it is difficult and complicated to confirm the lesion displayed in the X-ray transmission image with the CT image.
　本発明の目的は、X線透過画像とＣＴ画像との位置合わせを的確に行い、両画像において対応する位置関係を容易に把握し得ることである。 An object of the present invention is to accurately perform alignment between an X-ray transmission image and a CT image and easily grasp the corresponding positional relationship in both images.
　請求の範囲第１項に記載の発明によれば、
　ＣＴ画像及びＸ線透過画像を取得する取得手段と、
　前記取得されたＣＴ画像に基づいて、前記取得されたX線透過画像と同一撮影方向の仮想Ｘ線画像を生成し、当該生成した仮想Ｘ線画像と前記X線透過画像との位置合わせを行う制御手段と、
　を備える医用画像処理装置が提供される。 According to the invention described in claim 1,
An acquisition means for acquiring a CT image and an X-ray transmission image;
Based on the acquired CT image, a virtual X-ray image in the same imaging direction as the acquired X-ray transmission image is generated, and the generated virtual X-ray image and the X-ray transmission image are aligned. Control means;
A medical image processing apparatus is provided.
　請求の範囲第２項に記載の発明によれば、請求の範囲第１項に記載の発明において、
　前記取得手段は、複数の撮影方向のX線透過画像を取得し、
　前記制御手段は、前記取得された複数の撮影方向のX線透過画像に応じて、複数の撮影方向の仮想Ｘ線画像を生成する医用画像処理装置が提供される。 According to the invention described in claim 2, in the invention described in claim 1,
The acquisition means acquires X-ray transmission images in a plurality of imaging directions,
The control means is provided with a medical image processing apparatus that generates virtual X-ray images in a plurality of imaging directions according to the acquired X-ray transmission images in a plurality of imaging directions.
　請求の範囲第３項に記載の発明によれば、請求の範囲第１項又は第２項に記載の発明において、
　前記制御手段により位置合わせされた後に、前記X線透過画像上において任意の位置を指定するための指定手段と、
　前記指定された任意の位置に対応する位置を前記仮想Ｘ線画像上において決定する決定手段と、
　前記決定した位置を含むＣＴ画像を抽出する抽出手段と、
　前記抽出したＣＴ画像を表示するとともに、前記決定された位置を当該抽出したＣＴ画像上で識別して表示する表示手段と、
　を備える医用画像処理装置が提供される。 According to the invention described in claim 3, in the invention described in claim 1 or 2,
A designation means for designating an arbitrary position on the X-ray transmission image after being aligned by the control means;
Determining means for determining a position corresponding to the specified arbitrary position on the virtual X-ray image;
Extracting means for extracting a CT image including the determined position;
Display means for displaying the extracted CT image and identifying and displaying the determined position on the extracted CT image;
A medical image processing apparatus is provided.
　請求の範囲第４項に記載の発明によれば、請求の範囲第３項に記載の発明において、
　前記指定手段は、前記制御手段により位置合わせされた後に、前記ＣＴ画像において任意の位置を指定し、
　前記決定手段は、前記指定された任意の位置に対応する位置を前記仮想Ｘ線画像上に投影し、当該投影した位置に基づいて前記指定された任意の位置を前記X線透過画像上において決定し、
　前記表示手段は、前記X線透過画像を表示するとともに、前記決定された位置を当該X線透過画像上で識別して表示する医用画像処理装置が提供される。 According to the invention described in claim 4, in the invention described in claim 3,
The designation means designates an arbitrary position in the CT image after being aligned by the control means,
The determining unit projects a position corresponding to the specified arbitrary position on the virtual X-ray image, and determines the specified arbitrary position on the X-ray transmission image based on the projected position. And
The display means is provided with a medical image processing apparatus for displaying the X-ray transmission image and identifying and displaying the determined position on the X-ray transmission image.
　請求の範囲第５項に記載の発明によれば、
　取得手段によって、ＣＴ画像及びX線透過画像を取得する工程と、
　制御手段によって、前記取得されたＣＴ画像に基づいて、前記取得されたX線透過画像と同一撮影方向の仮想Ｘ線画像を生成し、当該生成した仮想Ｘ線画像と前記X線透過画像との位置合わせを行う工程と、
　を含む医用画像処理方法が提供される。 According to the invention described in claim 5,
A step of acquiring a CT image and an X-ray transmission image by an acquisition unit;
Based on the acquired CT image, the control means generates a virtual X-ray image in the same imaging direction as the acquired X-ray transmission image, and the generated virtual X-ray image and the X-ray transmission image A process of aligning;
A medical image processing method is provided.
　請求の範囲第６項に記載の発明によれば、請求の範囲第５項に記載の発明において、
　指定手段によって、前記制御手段により位置合わせされた後に、前記X線透過画像上において任意の位置を指定する工程と、
　決定手段によって、前記指定された任意の位置に対応する位置を前記仮想Ｘ線画像上において決定する工程と、
　抽出手段によって、前記決定した位置を含むＣＴ画像を抽出する工程と、
　表示手段によって、前記抽出したＣＴ画像を表示するとともに、前記決定された位置を当該抽出したＣＴ画像上で識別して表示する工程と、
　を含む医用画像処理方法が提供される。 According to the invention described in claim 6, in the invention described in claim 5,
A step of designating an arbitrary position on the X-ray transmission image after being aligned by the control unit by the designation unit;
Determining a position corresponding to the designated arbitrary position on the virtual X-ray image by a determining unit;
Extracting a CT image including the determined position by an extraction means;
Displaying the extracted CT image by a display means, and identifying and displaying the determined position on the extracted CT image;
A medical image processing method is provided.
　請求の範囲第７項に記載の発明によれば、請求の範囲第５項又は第６項に記載の発明において、
　指定手段によって、前記制御手段により位置合わせされた後に、前記ＣＴ画像において任意の位置を指定する工程と、
　決定手段によって、前記指定された任意の位置に対応する位置を前記仮想Ｘ線画像上に投影し、当該投影した位置に基づいて前記指定された任意の位置をX線透過画像上において決定する工程と、
　表示手段によって、前記X線透過画像を表示するとともに、前記決定された位置を当該X線透過画像上で識別して表示する工程と、
を含む医用画像処理方法が提供される。 According to the invention described in claim 7, in the invention described in claim 5 or 6,
A step of specifying an arbitrary position in the CT image after being aligned by the control unit by the specifying unit;
Projecting a position corresponding to the specified arbitrary position on the virtual X-ray image by the determining means, and determining the specified arbitrary position on the X-ray transmission image based on the projected position When,
Displaying the X-ray transmission image by a display means, and identifying and displaying the determined position on the X-ray transmission image;
A medical image processing method is provided.
　本発明によれば、ＣＴ画像とX線透過画像とを取得し、ＣＴ画像から、X線透過画像と同一撮影方向の仮想Ｘ線画像を生成することができる。また、生成した仮想Ｘ線画像とX線透過画像との位置合わせを行うことができる。よって、両画像において対応する位置関係を容易に把握することができる。 According to the present invention, a CT image and an X-ray transmission image can be acquired, and a virtual X-ray image in the same imaging direction as the X-ray transmission image can be generated from the CT image. In addition, the generated virtual X-ray image and X-ray transmission image can be aligned. Therefore, the corresponding positional relationship in both images can be easily grasped.
医用画像処理装置の内部構成図である。It is an internal block diagram of a medical image processing apparatus. 位置合わせ処理を説明するフロー図である。It is a flowchart explaining an alignment process. 位置合わせ処理の他の例を説明するフロー図である。It is a flowchart explaining the other example of the alignment process. 位置合わせ処理の概念図である。It is a conceptual diagram of the alignment process. 位置合わせ処理の概念図である。It is a conceptual diagram of the alignment process. 位置合わせ処理の概念図である。It is a conceptual diagram of the alignment process. 位置合わせ処理の概念図である。It is a conceptual diagram of the alignment process.
符号の説明Explanation of symbols
１００　医用画像処理装置
１１　　制御部
１２　　操作部
１３　　表示部
１４　　通信部
１５　　記憶部 DESCRIPTION OF SYMBOLS 100 Medical image processing apparatus 11 Control part 12 Operation part 13 Display part 14 Communication part 15 Storage part
　以下、本発明に係る医用画像処理装置、及び医用画像処理方法の最適な実施形態の構成及び動作について、図面を用いて詳細に説明する。 Hereinafter, the configuration and operation of an optimal embodiment of a medical image processing apparatus and a medical image processing method according to the present invention will be described in detail with reference to the drawings.
　まず、構成について説明する。
　図１に、本実施形態における医用画像処理装置１００の内部構成図を示す。
　医用画像処理装置１００は、制御部１１、操作部１２、表示部１３、通信部１４、記憶部１５から構成される。 First, the configuration will be described.
FIG. 1 shows an internal configuration diagram of a medical image processing apparatus 100 in the present embodiment.
The medical image processing apparatus 100 includes a control unit 11, an operation unit 12, a display unit 13, a communication unit 14, and a storage unit 15.
　制御部１１は、ＣＰＵ（Central Processing Unit）、ＲＡＭ（Random Access Memory）等から構成され、記憶部１５に格納されている所定のプログラムをＲＡＭに展開し、当該プログラムとの協働により処理動作を統括的に制御する。 The control unit 11 includes a CPU (Central Processing Unit), a RAM (Random Access Memory), and the like, expands a predetermined program stored in the storage unit 15 to the RAM, and performs processing operations in cooperation with the program. Control all over.
　操作部１２は、数字キー、文字キー、機能キー等を備えたキーボードや、マウス等を備えて構成され、操作されたキーに対応する操作信号を制御部１１に出力する。 The operation unit 12 includes a keyboard provided with numeric keys, character keys, function keys, a mouse, and the like, and outputs an operation signal corresponding to the operated key to the control unit 11.
　表示部１３は、ＬＣＤ（Liquid Crystal Display）等を備えて構成され、制御部１１の表示制御に従って、医用画像や操作画面等の各種表示情報を表示する。なお、表示部１３は、操作部１２と一体型のタッチパネルを構成する態様としてもよい。 The display unit 13 includes an LCD (Liquid Crystal Display) or the like, and displays various display information such as medical images and operation screens in accordance with display control of the control unit 11. In addition, the display part 13 is good also as an aspect which comprises the operation part 12 and an integrated touch panel.
　通信部１４は、ネットワークインターフェイスカードやモデム等の通信用のインターフェイスを備えて構成される。制御部１１は、通信部１４を介して、X線透過画像やＣＴ画像を取得する。 The communication unit 14 includes a communication interface such as a network interface card or a modem. The control unit 11 acquires an X-ray transmission image and a CT image via the communication unit 14.
　記憶部１５は、システムプログラムの他、制御部１１により実行される制御プログラムや画像処理プログラム等の各種プログラムを備える。また、記憶部１５は、各プログラムの実行に必要な各種パラメータを記憶し、実行された後に処理されたデータ等を記憶する。 The storage unit 15 includes various programs such as a control program executed by the control unit 11 and an image processing program in addition to the system program. The storage unit 15 stores various parameters necessary for executing each program, and stores data processed after the execution.
　次に、動作について説明する。
　図２を参照して、医用画像処理装置１００による位置合わせ処理について説明する。
　制御部１１は、通信部１４を介して、X線透過画像及びＣＴ画像を入力する（ステップＳ１、Ｓ２）。なお、ここで入力する両画像は、同一患者の同一部位である。 Next, the operation will be described.
With reference to FIG. 2, the registration processing by the medical image processing apparatus 100 will be described.
The control unit 11 inputs an X-ray transmission image and a CT image via the communication unit 14 (Steps S1 and S2). Both images input here are the same part of the same patient.
　制御部１１は、ステップＳ１で入力したＣＴ画像から、ステップＳ１で入力したX線透過画像と同一撮影方向の仮想Ｘ線画像を生成する（ステップＳ３）。
　制御部１１は、ＣＴ画像を構成する複数のスライス画像の画素値を足し合わせることで仮想Ｘ線画像を生成する。なお、ステップＳ１で複数の撮影方向のX線透過画像を入力した場合、制御部１１は、対応する複数の撮影方向の仮想Ｘ線画像を生成する。 The control unit 11 generates a virtual X-ray image in the same imaging direction as the X-ray transmission image input in Step S1 from the CT image input in Step S1 (Step S3).
The control unit 11 generates a virtual X-ray image by adding pixel values of a plurality of slice images constituting the CT image. When X-ray transmission images in a plurality of imaging directions are input in step S1, the control unit 11 generates corresponding virtual X-ray images in a plurality of imaging directions.
　制御部１１は、アフィン変換を用いて、入力したX線透過画像と、生成した仮想Ｘ線画像との位置合わせを行う（ステップＳ４）。
　アフィン変換は、位置合わせを行う２つの画像についてそれぞれ複数の対応点を設定し、この２つの画像において設定された対応点がそれぞれ一致するように一方の画像を剛体変形するものである。 The control unit 11 uses affine transformation to align the input X-ray transmission image and the generated virtual X-ray image (step S4).
In the affine transformation, a plurality of corresponding points are set for two images to be aligned, and one image is rigidly deformed so that the corresponding points set in the two images coincide with each other.
　制御部１１は、X線透過画像を表示部１３に表示する（ステップＳ５）。
　操作部１２から、X線透過画像上で表示される病変位置が指定されると、制御部１１は指定された病変位置を入力する（ステップＳ６）。 The control unit 11 displays the X-ray transmission image on the display unit 13 (step S5).
When a lesion position displayed on the X-ray transmission image is designated from the operation unit 12, the control unit 11 inputs the designated lesion position (step S6).
　制御部１１は、入力した病変位置に対応する位置を仮想Ｘ線画像上において決定する（ステップＳ７）。
　制御部１１は、決定した位置を含むＣＴ画像を抽出する（ステップＳ８）。つまり、制御部１１は、ＣＴ画像を構成する複数のスライス画像のうち、病変位置を含むスライス画像を抽出する。 The control unit 11 determines a position corresponding to the input lesion position on the virtual X-ray image (step S7).
The control unit 11 extracts a CT image including the determined position (step S8). That is, the control unit 11 extracts a slice image including a lesion position from among a plurality of slice images constituting the CT image.
　制御部１１は、抽出したＣＴ画像を表示部１３に表示するとともに、ステップＳ７で決定した位置又は投影範囲を識別表示して（ステップＳ９）、位置合わせ処理を終了する。 The control unit 11 displays the extracted CT image on the display unit 13 and identifies and displays the position or projection range determined in step S7 (step S9), and ends the alignment process.
　次に、図３を参照して、位置合わせ処理の他の例について説明する。
　図３に示す他の位置合わせ処理では、ＣＴ画像から病変位置を指定し、対応する位置をX線透過画像上に識別して表示する処理が行われる。 Next, another example of the alignment process will be described with reference to FIG.
In the other alignment processing shown in FIG. 3, a lesion position is designated from the CT image, and the corresponding position is identified and displayed on the X-ray transmission image.
　ステップＳ１１～Ｓ１４までは、図２のステップＳ１～Ｓ４までと同様であるため、ここでの説明は省略する。
　制御部１１は、ＣＴ画像を表示部１３に表示する（ステップＳ１５）。
　操作部１２から、ＣＴ画像上で表示される病変位置が指定されると、制御部１１は指定された病変位置を入力する（ステップＳ１６）。 Steps S11 to S14 are the same as steps S1 to S4 in FIG. 2, and a description thereof will be omitted here.
The control unit 11 displays the CT image on the display unit 13 (step S15).
When the lesion position displayed on the CT image is designated from the operation unit 12, the control unit 11 inputs the designated lesion position (step S16).
　制御部１１は、入力した病変位置を仮想Ｘ線画像上に投影する（ステップＳ１７）。制御部１１は、投影した病変位置に対応する位置をX線透過画像上において決定する（ステップＳ１８）。 The control unit 11 projects the input lesion position on the virtual X-ray image (step S17). The control unit 11 determines a position corresponding to the projected lesion position on the X-ray transmission image (step S18).
　制御部１１は、X線透過画像を表示部１３に表示するとともに、ステップＳ１８で決定した位置又は周辺領域を識別して表示し（ステップＳ１９）、他の位置合わせ処理を終了する。 The control unit 11 displays the X-ray transmission image on the display unit 13 and identifies and displays the position or the peripheral area determined in step S18 (step S19), and ends the other alignment processing.
　図４Ａ～図４Ｄに、位置合わせ処理の概念図を示す。
　図４Ａに示すX線透過画像Ｇ１は、撮影方向が胸部正面のX線透過画像である。
　また、ＣＴ画像Ｇ２は、胸部のＣＴ画像であり、複数のスライス画像から構成される。仮想Ｘ線画像Ｇ２１は、ＣＴ画像Ｇ２を構成する複数のスライス画像を合成して生成される擬似的なX線透過画像であって、撮影方向が胸部正面の擬似的なX線透過画像である。 4A to 4D are conceptual diagrams of the alignment process.
The X-ray transmission image G1 shown in FIG. 4A is an X-ray transmission image whose imaging direction is the front of the chest.
The CT image G2 is a CT image of the chest and is composed of a plurality of slice images. The virtual X-ray image G21 is a pseudo X-ray transmission image generated by combining a plurality of slice images constituting the CT image G2, and is a pseudo X-ray transmission image whose imaging direction is the front of the chest. .
　X線透過画像Ｇ１と仮想Ｘ線画像Ｇ２１との位置合わせを行った後、X線透過画像Ｇ１に表示されている病変位置をマウス等で指定すると、対応する投影範囲がＣＴ画像Ｇ２上で識別表示される。 After positioning the X-ray transmission image G1 and the virtual X-ray image G21, when the lesion position displayed on the X-ray transmission image G1 is designated with a mouse or the like, the corresponding projection range is identified on the CT image G2. Is displayed.
　図４Ｂに示すX線透過画像Ｇ１１は、撮影方向が胸部側面のX線透過画像である。
　また、仮想Ｘ線画像Ｇ２２は、仮想Ｘ線画像Ｇ２１と同様にして生成された擬似的なX線透過画像であって、撮影方向が胸部側面の擬似的なX線透過画像である。
　図４Ａに示した場合と同様に、X線透過画像Ｇ１と仮想Ｘ線画像Ｇ２１とを位置合わせし、更に、X線透過画像Ｇ１１と仮想Ｘ線画像Ｇ２２とを位置合わせする。その後、X線透過画像Ｇ１又はX線透過画像Ｇ１１に表示されている病変位置をマウス等で指定すると、対応する病変位置がＣＴ画像Ｇ２上で識別表示される。 An X-ray transmission image G11 illustrated in FIG. 4B is an X-ray transmission image in which the imaging direction is the chest side surface.
The virtual X-ray image G22 is a pseudo X-ray transmission image generated in the same manner as the virtual X-ray image G21, and is a pseudo X-ray transmission image in which the imaging direction is the chest side surface.
As in the case shown in FIG. 4A, the X-ray transmission image G1 and the virtual X-ray image G21 are aligned, and further, the X-ray transmission image G11 and the virtual X-ray image G22 are aligned. Thereafter, when the lesion position displayed in the X-ray transmission image G1 or the X-ray transmission image G11 is designated with a mouse or the like, the corresponding lesion position is identified and displayed on the CT image G2.
　図４Ｃに示すX線透過画像Ｇ１、ＣＴ画像Ｇ２、及び仮想Ｘ線画像Ｇ２１は、図４Ａに示した画像と同様である。位置合わせした後、ＣＴ画像Ｇ２上に表示されている病変位置をマウス等で指定すると、対応する位置がX線透過画像Ｇ１上で識別表示される。 The X-ray transmission image G1, the CT image G2, and the virtual X-ray image G21 shown in FIG. 4C are the same as the image shown in FIG. 4A. After the alignment, when the lesion position displayed on the CT image G2 is designated with a mouse or the like, the corresponding position is identified and displayed on the X-ray transmission image G1.
　図４Ｄに示すX線透過画像Ｇ１、Ｇ１１、ＣＴ画像Ｇ２、及び仮想Ｘ線画像Ｇ２１、Ｇ２２は、図４Ｂに示した画像と同様である。X線透過画像Ｇ１と仮想Ｘ線画像Ｇ２１とを位置合わせし、X線透過画像Ｇ１１と仮想Ｘ線画像Ｇ２２とを位置合わせする。その後、ＣＴ画像Ｇ２上に表示されている病変位置をマウス等で指定すると、対応する位置がX線透過画像Ｇ１又はX線透過画像Ｇ１１上で識別表示される。 The X-ray transmission images G1 and G11, the CT image G2, and the virtual X-ray images G21 and G22 shown in FIG. 4D are the same as the image shown in FIG. 4B. The X-ray transmission image G1 and the virtual X-ray image G21 are aligned, and the X-ray transmission image G11 and the virtual X-ray image G22 are aligned. Thereafter, when the lesion position displayed on the CT image G2 is designated with a mouse or the like, the corresponding position is identified and displayed on the X-ray transmission image G1 or the X-ray transmission image G11.
　以上のように、本実施形態によれば、ＣＴ画像Ｇ２及びX線透過画像Ｇ１を入力し、両画像の位置合わせを行うことができる。よって、容易に比較読影することができる。 As described above, according to the present embodiment, the CT image G2 and the X-ray transmission image G1 can be input, and the alignment of both images can be performed. Therefore, comparative interpretation can be easily performed.
　また、撮影方向の異なるX線透過画像Ｇ１（Ｇ１１）を入力した場合であっても、対応する撮影方向の仮想Ｘ線画像Ｇ２１（Ｇ２２）を生成して、両画像の位置合わせを行うことができる。 Even when an X-ray transmission image G1 (G11) having a different imaging direction is input, a virtual X-ray image G21 (G22) corresponding to the imaging direction can be generated and the images can be aligned. it can.
　また、位置合わせ後に、X線透過画像Ｇ１（Ｇ１１）上に表示された病変位置を指定すると、指定された位置に対応する位置をＣＴ画像Ｇ２上に識別して表示することができる。よって、X線透過画像Ｇ１（Ｇ１１）上で確認できる病変をＣＴ画像Ｇ２上で容易に確認することができ、比較読影することができる。 In addition, when the lesion position displayed on the X-ray transmission image G1 (G11) is designated after the alignment, the position corresponding to the designated position can be identified and displayed on the CT image G2. Therefore, a lesion that can be confirmed on the X-ray transmission image G1 (G11) can be easily confirmed on the CT image G2, and comparative interpretation can be performed.
　また、位置合わせ後に、ＣＴ画像Ｇ２上に表示された病変位置を指定すると、指定された位置に対応する位置をX線透過画像Ｇ１（Ｇ１１）上に識別して表示することができる。よって、ＣＴ画像Ｇ２上で確認できる病変をX線透過画像Ｇ１（Ｇ１１）上で容易に確認することができ、比較読影することができる。 Further, if the lesion position displayed on the CT image G2 is designated after the alignment, the position corresponding to the designated position can be identified and displayed on the X-ray transmission image G1 (G11). Therefore, the lesion that can be confirmed on the CT image G2 can be easily confirmed on the X-ray transmission image G1 (G11), and comparative interpretation can be performed.
　医療分野において利用することが可能であり、医用画像について画像処理が可能なＰＣ（Personal Computer）に適用可能である。 It can be used in the medical field and can be applied to a PC (Personal Computer) capable of image processing for medical images.

Claims (7)

  1. 　ＣＴ画像及びＸ線透過画像を取得する取得手段と、
    　前記取得されたＣＴ画像に基づいて、前記取得されたX線透過画像と同一撮影方向の仮想Ｘ線画像を生成し、当該生成した仮想Ｘ線画像と前記X線透過画像との位置合わせを行う制御手段と、
    　を備える医用画像処理装置。     An acquisition means for acquiring a CT image and an X-ray transmission image;
    Based on the acquired CT image, a virtual X-ray image in the same imaging direction as the acquired X-ray transmission image is generated, and the generated virtual X-ray image and the X-ray transmission image are aligned. Control means;
    A medical image processing apparatus comprising:
  2. 　前記取得手段は、複数の撮影方向のX線透過画像を取得し、
    　前記制御手段は、前記取得された複数の撮影方向のX線透過画像に応じて、複数の撮影方向の仮想Ｘ線画像を生成する請求の範囲第１項に記載の医用画像処理装置。     The acquisition means acquires X-ray transmission images in a plurality of imaging directions,
    The medical image processing apparatus according to claim 1, wherein the control unit generates virtual X-ray images in a plurality of imaging directions according to the acquired X-ray transmission images in a plurality of imaging directions.
  3. 　前記制御手段により位置合わせされた後に、前記X線透過画像上において任意の位置を指定するための指定手段と、
    　前記指定された任意の位置に対応する位置を前記仮想Ｘ線画像上において決定する決定手段と、
    　前記決定した位置を含むＣＴ画像を抽出する抽出手段と、
    　前記抽出したＣＴ画像を表示するとともに、前記決定された位置を当該抽出したＣＴ画像上で識別して表示する表示手段と、
    　を備える請求の範囲第１項又は２項に記載の医用画像処理装置。     A designation means for designating an arbitrary position on the X-ray transmission image after being aligned by the control means;
    Determining means for determining a position corresponding to the specified arbitrary position on the virtual X-ray image;
    Extracting means for extracting a CT image including the determined position;
    Display means for displaying the extracted CT image and identifying and displaying the determined position on the extracted CT image;
    The medical image processing apparatus according to claim 1 or 2, further comprising:
  4. 　前記指定手段は、前記制御手段により位置合わせされた後に、前記ＣＴ画像において任意の位置を指定し、
    　前記決定手段は、前記指定された任意の位置に対応する位置を前記仮想Ｘ線画像上に投影し、当該投影した位置に基づいて前記指定された任意の位置を前記X線透過画像上において決定し、
    　前記表示手段は、前記X線透過画像を表示するとともに、前記決定された位置を当該X線透過画像上で識別して表示する請求の範囲第３項に記載の医用画像処理装置。     The designation means designates an arbitrary position in the CT image after being aligned by the control means,
    The determining unit projects a position corresponding to the specified arbitrary position on the virtual X-ray image, and determines the specified arbitrary position on the X-ray transmission image based on the projected position. And
    The medical image processing apparatus according to claim 3, wherein the display unit displays the X-ray transmission image and identifies and displays the determined position on the X-ray transmission image.
  5. 　取得手段によって、ＣＴ画像及びX線透過画像を取得する工程と、
    　制御手段によって、前記取得されたＣＴ画像に基づいて、前記取得されたX線透過画像と同一撮影方向の仮想Ｘ線画像を生成し、当該生成した仮想Ｘ線画像と前記X線透過画像との位置合わせを行う工程と、
    　を含む医用画像処理方法。     A step of acquiring a CT image and an X-ray transmission image by an acquisition unit;
    Based on the acquired CT image, the control means generates a virtual X-ray image in the same imaging direction as the acquired X-ray transmission image, and the generated virtual X-ray image and the X-ray transmission image A process of aligning;
    A medical image processing method.
  6. 　指定手段によって、前記制御手段により位置合わせされた後に、前記X線透過画像上において任意の位置を指定する工程と、
    　決定手段によって、前記指定された任意の位置に対応する位置を前記仮想Ｘ線画像上において決定する工程と、
    　抽出手段によって、前記決定した位置を含むＣＴ画像を抽出する工程と、
    　表示手段によって、前記抽出したＣＴ画像を表示するとともに、前記決定された位置を当該抽出したＣＴ画像上で識別して表示する工程と、
    　を含む請求の範囲第５項に記載の医用画像処理方法。     A step of designating an arbitrary position on the X-ray transmission image after being aligned by the control unit by the designation unit;
    Determining a position corresponding to the designated arbitrary position on the virtual X-ray image by a determining unit;
    Extracting a CT image including the determined position by an extraction means;
    Displaying the extracted CT image by a display means, and identifying and displaying the determined position on the extracted CT image;
    The medical image processing method according to claim 5, comprising:
  7. 　指定手段によって、前記制御手段により位置合わせされた後に、前記ＣＴ画像において任意の位置を指定する工程と、
    　決定手段によって、前記指定された任意の位置に対応する位置を前記仮想Ｘ線画像上に投影し、当該投影した位置に基づいて前記指定された任意の位置をX線透過画像上において決定する工程と、
    　表示手段によって、前記X線透過画像を表示するとともに、前記決定された位置を当該X線透過画像上で識別して表示する工程と、
    　を含む請求の範囲第５項又は６項に記載の医用画像処理方法。     A step of specifying an arbitrary position in the CT image after being aligned by the control unit by the specifying unit;
    Projecting a position corresponding to the specified arbitrary position on the virtual X-ray image by the determining means, and determining the specified arbitrary position on the X-ray transmission image based on the projected position When,
    Displaying the X-ray transmission image by a display means, and identifying and displaying the determined position on the X-ray transmission image;
    The medical image processing method according to claim 5 or 6 including:
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