WO2010026603A3 - Novel amine salts of tenofovir, process for producing the same and use thereof in production of tenofovir dioproxil - Google Patents

Novel amine salts of tenofovir, process for producing the same and use thereof in production of tenofovir dioproxil Download PDF

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Publication number
WO2010026603A3
WO2010026603A3 PCT/IN2009/000488 IN2009000488W WO2010026603A3 WO 2010026603 A3 WO2010026603 A3 WO 2010026603A3 IN 2009000488 W IN2009000488 W IN 2009000488W WO 2010026603 A3 WO2010026603 A3 WO 2010026603A3
Authority
WO
WIPO (PCT)
Prior art keywords
tenofovir
producing
same
novel amine
amine salts
Prior art date
Application number
PCT/IN2009/000488
Other languages
French (fr)
Other versions
WO2010026603A2 (en
Inventor
Umamaheswar Rao Vasireddy
Siva Rama Prasad Vellanki
Arabinda Sahu
Raja Babu Balusu
Ramakrishna Pilli
Debashish Datta
Original Assignee
Matrix Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Limited filed Critical Matrix Laboratories Limited
Publication of WO2010026603A2 publication Critical patent/WO2010026603A2/en
Publication of WO2010026603A3 publication Critical patent/WO2010026603A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Abstract

Disclosed herein are novel amine salts of tenofovir and a process for producing the same. In addition, provided is a crystalline form of chloromethyl isopropyl carbonate solvate of tenofovir disoproxil. Furthermore, a process for producing tenofovir disoproxil and its pharmaceutically acceptable salt in high purity and yield employing the novel amine salt of tenofovir and tenofovir CMIC solvate is disclosed.
PCT/IN2009/000488 2008-09-05 2009-09-04 Novel amine salts of tenofovir, process for producing the same and use thereof in production of tenofovir dioproxil WO2010026603A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2169/CHE/2008 2008-09-05
IN2169CH2008 2008-09-05

Publications (2)

Publication Number Publication Date
WO2010026603A2 WO2010026603A2 (en) 2010-03-11
WO2010026603A3 true WO2010026603A3 (en) 2010-05-14

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000488 WO2010026603A2 (en) 2008-09-05 2009-09-04 Novel amine salts of tenofovir, process for producing the same and use thereof in production of tenofovir dioproxil

Country Status (1)

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WO (1) WO2010026603A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101948485B (en) * 2010-08-30 2012-07-25 杭州和素化学技术有限公司 Alpha crystal form of tenofovir disoproxil fumarate, and preparation method and application thereof
CN102453055B (en) * 2010-10-29 2015-04-01 上海迪赛诺医药发展有限公司 Method for preparing (R)-9-(2-phosphorylmethoxypropyl)adenyl-di(isopropoxycarbonylmethyl)ester
CN103665043B (en) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 A kind of tenofovir prodrug and its application in medicine
KR101439255B1 (en) * 2012-08-30 2014-09-11 주식회사 종근당 The New Tenofovir disoproxil salt and the preparation method thereof
WO2014141092A2 (en) * 2013-03-12 2014-09-18 Shasun Pharmaceuticals Limited Improved process for the preparation of tenofovir
CN103396443B (en) * 2013-07-12 2015-08-05 苏州明锐医药科技有限公司 A kind of preparation method of tynofovir
EP2860185A1 (en) 2013-10-09 2015-04-15 Zentiva, k.s. An improved process for the preparation of Tenofovir disoproxil and pharmaceutically acceptable salts thereof
CA2954491C (en) 2014-07-18 2018-12-04 Jw Pharmaceutical Corporation Novel salt of tenofovir disoproxil
KR102377262B1 (en) * 2020-05-11 2022-03-22 연성정밀화학(주) Crystalline Eribulin Salt
CN112441929B (en) * 2020-11-23 2022-06-21 浙江大学衢州研究院 Method for separating mixture of diisopropylamine and ethanol by azeotropic distillation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005150A1 (en) * 1997-07-25 1999-02-04 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
WO2008007392A2 (en) * 2006-07-12 2008-01-17 Matrix Laboratories Limited Process for the preparation of tenofovir

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999005150A1 (en) * 1997-07-25 1999-02-04 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
WO2008007392A2 (en) * 2006-07-12 2008-01-17 Matrix Laboratories Limited Process for the preparation of tenofovir

Also Published As

Publication number Publication date
WO2010026603A2 (en) 2010-03-11

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