WO2010026603A3 - Novel amine salts of tenofovir, process for producing the same and use thereof in production of tenofovir dioproxil - Google Patents
Novel amine salts of tenofovir, process for producing the same and use thereof in production of tenofovir dioproxil Download PDFInfo
- Publication number
- WO2010026603A3 WO2010026603A3 PCT/IN2009/000488 IN2009000488W WO2010026603A3 WO 2010026603 A3 WO2010026603 A3 WO 2010026603A3 IN 2009000488 W IN2009000488 W IN 2009000488W WO 2010026603 A3 WO2010026603 A3 WO 2010026603A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tenofovir
- producing
- same
- novel amine
- amine salts
- Prior art date
Links
- 229960004556 tenofovir Drugs 0.000 title abstract 5
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical class OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 title abstract 5
- -1 amine salts Chemical class 0.000 title abstract 3
- 239000012453 solvate Substances 0.000 abstract 2
- JFVZFKDSXNQEJW-CQSZACIVSA-N tenofovir disoproxil Chemical compound N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N JFVZFKDSXNQEJW-CQSZACIVSA-N 0.000 abstract 2
- 229960001355 tenofovir disoproxil Drugs 0.000 abstract 2
- ADLSFYJDHWUKFP-UHFFFAOYSA-N 5-methoxy-11,12-dihydroindolo[2,3-a]carbazole-6-carbonitrile Chemical compound N1C2=C3NC4=CC=C[CH]C4=C3C(OC)=C(C#N)C2=C2[C]1C=CC=C2 ADLSFYJDHWUKFP-UHFFFAOYSA-N 0.000 abstract 1
- JHYNXXBAHWPABC-UHFFFAOYSA-N chloromethyl propan-2-yl carbonate Chemical compound CC(C)OC(=O)OCCl JHYNXXBAHWPABC-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Disclosed herein are novel amine salts of tenofovir and a process for producing the same. In addition, provided is a crystalline form of chloromethyl isopropyl carbonate solvate of tenofovir disoproxil. Furthermore, a process for producing tenofovir disoproxil and its pharmaceutically acceptable salt in high purity and yield employing the novel amine salt of tenofovir and tenofovir CMIC solvate is disclosed.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2169CH2008 | 2008-09-05 | ||
IN2169/CHE/2008 | 2008-09-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010026603A2 WO2010026603A2 (en) | 2010-03-11 |
WO2010026603A3 true WO2010026603A3 (en) | 2010-05-14 |
Family
ID=41797599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2009/000488 WO2010026603A2 (en) | 2008-09-05 | 2009-09-04 | Novel amine salts of tenofovir, process for producing the same and use thereof in production of tenofovir dioproxil |
Country Status (1)
Country | Link |
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WO (1) | WO2010026603A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101948485B (en) * | 2010-08-30 | 2012-07-25 | 杭州和素化学技术有限公司 | Alpha crystal form of tenofovir disoproxil fumarate, and preparation method and application thereof |
CN102453055B (en) * | 2010-10-29 | 2015-04-01 | 上海迪赛诺医药发展有限公司 | Method for preparing (R)-9-(2-phosphorylmethoxypropyl)adenyl-di(isopropoxycarbonylmethyl)ester |
CN107312039B (en) | 2012-08-30 | 2019-06-25 | 江苏豪森药业集团有限公司 | A kind of preparation method of tenofovir prodrug |
KR101439255B1 (en) * | 2012-08-30 | 2014-09-11 | 주식회사 종근당 | The New Tenofovir disoproxil salt and the preparation method thereof |
WO2014141092A2 (en) * | 2013-03-12 | 2014-09-18 | Shasun Pharmaceuticals Limited | Improved process for the preparation of tenofovir |
CN103396443B (en) * | 2013-07-12 | 2015-08-05 | 苏州明锐医药科技有限公司 | A kind of preparation method of tynofovir |
EP2860185A1 (en) | 2013-10-09 | 2015-04-15 | Zentiva, k.s. | An improved process for the preparation of Tenofovir disoproxil and pharmaceutically acceptable salts thereof |
JP6421873B2 (en) * | 2014-07-18 | 2018-11-14 | ジェイダブリュ ファーマセウティカル コーポレーション | New salt of tenofovir disoproxil |
KR102377262B1 (en) * | 2020-05-11 | 2022-03-22 | 연성정밀화학(주) | Crystalline Eribulin Salt |
CN112441929B (en) * | 2020-11-23 | 2022-06-21 | 浙江大学衢州研究院 | Method for separating mixture of diisopropylamine and ethanol by azeotropic distillation |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999005150A1 (en) * | 1997-07-25 | 1999-02-04 | Gilead Sciences, Inc. | Nucleotide analog composition and synthesis method |
WO2008007392A2 (en) * | 2006-07-12 | 2008-01-17 | Matrix Laboratories Limited | Process for the preparation of tenofovir |
-
2009
- 2009-09-04 WO PCT/IN2009/000488 patent/WO2010026603A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999005150A1 (en) * | 1997-07-25 | 1999-02-04 | Gilead Sciences, Inc. | Nucleotide analog composition and synthesis method |
WO2008007392A2 (en) * | 2006-07-12 | 2008-01-17 | Matrix Laboratories Limited | Process for the preparation of tenofovir |
Also Published As
Publication number | Publication date |
---|---|
WO2010026603A2 (en) | 2010-03-11 |
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