WO2010023688A3 - An improved process for the preparation of eprosartan - Google Patents

An improved process for the preparation of eprosartan Download PDF

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Publication number
WO2010023688A3
WO2010023688A3 PCT/IN2009/000464 IN2009000464W WO2010023688A3 WO 2010023688 A3 WO2010023688 A3 WO 2010023688A3 IN 2009000464 W IN2009000464 W IN 2009000464W WO 2010023688 A3 WO2010023688 A3 WO 2010023688A3
Authority
WO
WIPO (PCT)
Prior art keywords
formula
compound
eprosartan
preparation
improved process
Prior art date
Application number
PCT/IN2009/000464
Other languages
French (fr)
Other versions
WO2010023688A2 (en
Inventor
Saswata Lahiri
Purandhar Koilkonda
Nageswara Rao Achanta
Sreedhar Rapolu
Mouneshwar Achar
Hemaraj Lande
Jitendra Sharma
Venkanna Dachapalli
Debashish Datta
Original Assignee
Matrix Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Limited filed Critical Matrix Laboratories Limited
Publication of WO2010023688A2 publication Critical patent/WO2010023688A2/en
Publication of WO2010023688A3 publication Critical patent/WO2010023688A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides an improved process for the preparation of Eprosartan or its pharmaceutically acceptable salt comprising the steps of: condensing compound of formula (a) with compound of formula (b) in presence of a catalyst, in a solvent to get a compound of formula (c), and hydrolyzing the compound of formula (c) to get Eprosartan and optionally converting Eprosartan to its pharmaceutically acceptable salt. The present invention also relates to process for the preparation of compound of formula (c) by condensing compound of formula (a) with compound of formula (b) in presence of dehydrating agent.
PCT/IN2009/000464 2008-08-25 2009-08-21 An improved process for the preparation of eprosartan WO2010023688A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN2059/CHE/2008 2008-08-25
IN2059CH2008 2008-08-25
IN166CH2009 2009-01-27
IN166/CHE/2009 2009-01-27

Publications (2)

Publication Number Publication Date
WO2010023688A2 WO2010023688A2 (en) 2010-03-04
WO2010023688A3 true WO2010023688A3 (en) 2010-12-23

Family

ID=41722050

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000464 WO2010023688A2 (en) 2008-08-25 2009-08-21 An improved process for the preparation of eprosartan

Country Status (1)

Country Link
WO (1) WO2010023688A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011051975A1 (en) 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of pure eprosartanand its pharmaceutical acceptable salts

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035963A1 (en) * 1997-02-14 1998-08-20 Smithkline Beecham Corporation Process for preparing eprosartan
WO2008078330A1 (en) * 2006-12-27 2008-07-03 Hetero Drugs Limited Improved process for eprosartan
US20100166850A1 (en) * 2007-07-25 2010-07-01 Hetero Drugs Limited Eprosartan mesylate crystalline particles and a process for preparing pure eprosartan

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998035963A1 (en) * 1997-02-14 1998-08-20 Smithkline Beecham Corporation Process for preparing eprosartan
US6172237B1 (en) * 1997-02-14 2001-01-09 Smithkline Beecham Corporation Process for preparing eprosartan
WO2008078330A1 (en) * 2006-12-27 2008-07-03 Hetero Drugs Limited Improved process for eprosartan
US20100137613A1 (en) * 2006-12-27 2010-06-03 Hetero Drugs Limited Process for eprosartan
US20100166850A1 (en) * 2007-07-25 2010-07-01 Hetero Drugs Limited Eprosartan mesylate crystalline particles and a process for preparing pure eprosartan

Also Published As

Publication number Publication date
WO2010023688A2 (en) 2010-03-04

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