WO2010023481A1 - Autoinjection devices - Google Patents
Autoinjection devices Download PDFInfo
- Publication number
- WO2010023481A1 WO2010023481A1 PCT/GB2009/051081 GB2009051081W WO2010023481A1 WO 2010023481 A1 WO2010023481 A1 WO 2010023481A1 GB 2009051081 W GB2009051081 W GB 2009051081W WO 2010023481 A1 WO2010023481 A1 WO 2010023481A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- actuating member
- autoinjection device
- locking
- locked
- main body
- Prior art date
Links
- 238000002347 injection Methods 0.000 claims abstract description 13
- 239000007924 injection Substances 0.000 claims abstract description 13
- 230000000903 blocking effect Effects 0.000 claims description 3
- 230000000295 complement effect Effects 0.000 claims description 3
- 230000000712 assembly Effects 0.000 abstract description 5
- 238000000429 assembly Methods 0.000 abstract description 5
- 238000003032 molecular docking Methods 0.000 abstract 1
- 230000001960 triggered effect Effects 0.000 abstract 1
- 229940090047 auto-injector Drugs 0.000 description 9
- 230000004913 activation Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 210000002105 tongue Anatomy 0.000 description 2
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229940071643 prefilled syringe Drugs 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/50—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for preventing re-use, or for indicating if defective, used, tampered with or unsterile
- A61M5/5013—Means for blocking the piston or the fluid passageway to prevent illegal refilling of a syringe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31501—Means for blocking or restricting the movement of the rod or piston
- A61M5/31505—Integral with the syringe barrel, i.e. connected to the barrel so as to make up a single complete piece or unit
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3243—Means for protection against accidental injuries by used needles being axially-extensible, e.g. protective sleeves coaxially slidable on the syringe barrel
- A61M5/326—Fully automatic sleeve extension, i.e. in which triggering of the sleeve does not require a deliberate action by the user
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/2013—Having specific accessories triggering of discharging means by contact of injector with patient body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/206—With automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2403—Ampoule inserted into the ampoule holder
- A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2485—Ampoule holder connected to rest of syringe
- A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
Definitions
- This invention relates to autoinjection devices and, in particular, but not exclusively, to reusable autoinjection devices.
- this invention provides an autoinjection device, comprising: a main body; a drive mechanism in said main body for being fired to expel a dose from a syringe in use; an actuating member associated with said main body and moveable from a first position to a second position in which said mechanism is fired; a locking member associated with said actuating member for preventing said actuating member reaching said second position, the locking member and the actuating member being relatively moveable between locked and unlocked positions when said actuating member is in said first position, wherein on moving said locking member to its unlocked position, and after moving said actuating member to its second position, return of said actuating member to its first position is accompanied by return of said locking member to its locked position.
- the locking member resets to its locking position when the actuating member returns to its first, rest position.
- the locking member may be a separate component moveably mounted with respect to the actuating member and the main body, or it may be associated with or form an integral part of the body.
- the actuating member is biased towards its first position, and the locking member may conveniently be biased towards its locked position.
- the locking member is moved to its unlocked position and the actuating member moved against its bias to fire the drive mechanism. Release of the load on the actuating member returns it to its first position whereupon the bias on the locking member resets it to its locked position.
- the actuating member is linearly moveable between the first and second positions.
- said actuating member includes a needle shroud portion and, upon completion of said injection, return of said actuating member to its first position shrouds the needle of the syringe with said shroud portion.
- the actuating member serves a dual purpose both to fire the drive mechanism but also to shroud the needle.
- the arrangement provides an effective lockout for the shroud portion.
- the locking member is preferably angularly moveable between the locked and unlocked positions.
- the locking member is capable of limited angular movement with respect to the actuating member but longitudinally fixed with respect thereto, and the locking member and the housing have cooperating abutment surfaces that are rotated out of blocking alignment when the locking member is moved to the unlocked position.
- one of the actuating member and said locking member have spaced recesses provided therein, corresponding to the locking and unlocked positions, and the other thereof has a toothed element capable of uni-directional angular movement from the locked to the unlocked recess when the actuating member is in its first position, movement of the actuating member towards said second position axially withdrawing the toothed element from the unlocked recess whereupon it is allowed to return to be in angular registration with the locking recess.
- the drive mechanism may take many forms but in a preferred in embodiment includes a drive spring, a drive member longitudinally moveable within said housing, and a latch for latching the drive member in a primed position, wherein said actuating member is operable to release to said latch.
- said latch includes at least one side portion extending generally parallel to the axis of the drive spring and having an inclined surface adapted to cooperate with a respective complementary inclined surface on said actuating member to release said latch, when said actuating member moves towards its second position.
- the latch preferably includes two side portions with there being two respective inclined surfaces on the actuating member.
- the main body is conveniently formed of separable forward and rearward parts, with the rearward part containing at least a major portion of the drive mechanism and the forward part supporting said actuating member and said locking member.
- the actuating member extends forwardly of said main body, generally to surround the needle and to contact the injection site in use.
- the actuating member may include a moveable adjustable portion associated therewith for adjusting the effective length of said actuating member and therefore the penetration depth of the syringe needle in use.
- this invention provides an autoinjection device comprising a main body having separable forward and rearward parts, the rearward part containing a drive mechanism operated by a latch, and the forward part of said main body having an actuating member extending forwardly of the body and adapted to be driven rearwardly into the body to release said latch when applied to an injection site and pressed.
- this invention provides an autoinjection device comprising front and rear separable rear housing portions, the rear housing portion containing a drive mechanism including a drive energy store, a drive member and a latch arrangement to latch the drive member in a primed position for being unlatched for forward movement, the forward housing portion including an actuating member having a needle shroud sleeve portion extending forwardly of the housing portion, the actuating member being moveable rearwardly to unlatch the drive member, and a syringe carrier mounted on or in said actuating member for longitudinal movement with respect thereto.
- a drive mechanism including a drive energy store, a drive member and a latch arrangement to latch the drive member in a primed position for being unlatched for forward movement
- the forward housing portion including an actuating member having a needle shroud sleeve portion extending forwardly of the housing portion, the actuating member being moveable rearwardly to unlatch the drive member, and a syringe carrier mounted on or in said
- Figure 1 is a general perspective view of an autoinjector in accordance with this invention.
- Figures 2(a) and (b) are side and longitudinal views respectively of the autoinjector of Figure 1 in a rest position;
- Figure 3 is a perspective view of the autoinjector in a rest position with the outer case separated for clarity;
- Figures 4(a) and (b) are side and longitudinal views respectively illustrating the priming operation;
- Figures 5(a) and (b) are side and longitudinal views respectively of the autoinjector primed and with a pre-filled syringe loaded;
- Figures 6(a), (b) and (c) are longitudinal section, transverse section and side views respectively on the autoinjector unlocked and ready to inject;
- FIGS 7(a), (b) and (c) are respective detailed views on the locking mechanism, showing it in the locked position, the unlocked position and the reset position respectively;
- Figures 8(a) and (b) are side and longitudinal views respectively showing activation of the injection
- Figure 9 is a view of the autoinjector with the outer case separated for clarity, at the activation stage;
- Figures 10(a) and (b) are respective side and longitudinal sections views when the injection is complete but with the device still pressed against the skin;
- Figure 11 (a) and (b) are respective side and longitudinal section showing the autoinjector device following withdrawal from the injection site;
- Figure 12 is an exploded view of the front assembly
- Figure 13 is an exploded view of the rear assembly
- Figure 14 is a detailed view of the rear end of the sleeve 14 in an alternative embodiment.
- the illustrated embodiment of autoinjector comprises separable front and rear assemblies 10, 12 respectively.
- the front and rear assemblies are connected by a bayonet type fitting to allow easy insertion and withdrawal of a syringe containing medicament.
- the rear assembly comprises a drive mechanism to be described in more detail below
- the forward assembly includes a longitudinal moveable sleeve 14, the forward portion of which is visible in Figure 1 , and a rotary locking dial 16.
- the front assembly 10 comprises a front case 18 through which projects the sleeve 14 and the forward portion of the dial 16.
- a depth adjuster 20 Threadedly received in the front end of the sleeve is a depth adjuster 20 having marked thereon penetration depth indicia that are visible through a window 22 in the sleeve.
- the rear end of the sleeve has twin aft extending prongs 24 each having a ramp surface 26.
- the prongs 26 pass rearwardly through slots 28 in a collar 30, the collar being secured in the front case by means of diametrically opposed pips 32 that seat in diametrically opposed recesses 34 on the front case 18.
- the sleeve 14 is biased forwardly by means of a spring 36 acting between the collar 30 and the sleeve 14.
- a syringe carrier 38 is slideably received within the forward end of the sleeve 14 and biased rearwardly by a carrier spring 40. Axial movement of the syringe carrier 38 within the sleeve 14 is limited by means of two inwardly directed lugs 42 that run in slots 44 in the syringe carrier 38. The out-turned rearward end 46 of the syringe carrier 38 cooperates with an internally facing rib 48 on a forward cylindrical extension of the collar 30.
- the locking dial has two diametrically opposed part- cylindrical rearward extensions 50 which upstand radially from the outer surface of the dial 16. Immediately forward of this are two sprung tongues 58, each having an externally facing tooth 60 at the free, clockwise end as viewed from the front.
- a torsion spring 52 acts between the sleeve 14 and the dial 16 to bias the dial in a counter-clockwise direction as viewed from the front.
- the inside wall of the front case 18 has two diametrically opposed upstanding webs 66, which cooperate with the extensions 50 on the dial 16 selectively to allow or prevent rearward movement of the dial 16 within the front case 18, dependent on whether the dial is in an unlocked position (teeth 60 in 'unlocked' recesses 64) or a locked position (teeth 60 in 'locked' recesses 62).
- the front case has a pointer 68 which cooperates with indicia 70 on the dial 16 to indicate whether the dial is locked or unlocked.
- the dial 16 is rotatable on the front end of the sleeve 14, but the two move longitudinally together as the dial 16 is clipped onto the front end of the sleeve by means of an outwardly facing sprung tooth 72.
- the dial 16 and the sleeve 14 are urged forwardly by the spring 36 so that, at rest, the tooth 60 is urged forwardly into engagement with the 'locked' recess 62.
- rearward movement of the sleeve and dial as the injector device is pressed against the skin moves the tooth 60 out of the 'unlocked' recess 64 axially, so that, under the influence of the torsion spring 52, the dial then rotates back part way towards the position in which the teeth 60 are axially aligned with the 'locked' recesses 62, put held short of exact alignment by the webs 66.
- the rear assembly 12 comprises an outer casing formed by a case bottom 80 onto which is snap-fitted a case top 82.
- the forward end of the case bottom 80 is formed with a bayonet fitting 84 that cooperates with a complementary fitting 86 provided on the inside of the collar 30 forming part of the front assembly 10.
- Located in the casing is the main drive spring 88 fitting within a hollow tubular piston 90.
- a latch 92 of saddle form has forwardly extending arms 94 having ramp surfaces 96 designed to cooperate with the ramp surfaces 26 on the arms 24 of the sleeve 14 in the front assembly 10.
- Rearward extensions of the arms 94 are provided with pivot lugs 98 which are received in seats 100 in the case bottom to allow the latch 92 to pivot.
- Extending forwardly of the central portion of the latch 92 is a leaf spring 100 which acts on the case top 82 to bias the latch downwardly to a latching position.
- a latch abutment 102 To the rear of the leaf spring, on the underside of the latch is a latch abutment 102.
- the piston 90 has a latch surface 104 on its front end that cooperates with the latch abutment 102 to latch the piston in its primed position.
- the piston 90 also has lateral stub guides 106 that run in guide grooves 108 in the case bottom 80 to guide the piston and prevent its rotation.
- the piston is formed of a plastics material of a distinctive colour such as red and the case top 82 has an injection complete window 110 through which the piston is visible when in a forward position to indicate injection complete.
- the rear assembly 12 is firstly uncoupled from the front assembly 10 and inverted so that a needle cap remover 21 located in the end of the depth adjuster faces the piston 90.
- the front assembly and rear assembly are pushed together so that the piston 90 is pushed by the needle cap remover against the bias of the main drive spring 88 until the piston is latched by the latch abutment 102 engaging the latch surface 104 on the piston (see Figures 4(a) and (b)).
- a syringe comprising a barrel 2, a plunger 4, a needle 6 and a needle cap 8 is loaded into the front assembly 10 by inserting the syringe into the syringe carrier 38 and pushing until the needle cap passes a tooth 23 on the rear end of the needle cap remover 21 (see Figure 5(b)).
- the front and rear assemblies 10, 12 are then assembled together by connecting the bayonet coupling 84, 86.
- the device is then unlocked by rotating the locking dial 16 in the direction of arrow X in Figure 6(c) against the bias of the torsion spring 52.
- This action rotates the extensions 50 on the rotary dial 16 out of axial alignment with the web 66 on the inside of the front housing 18 (see Figure 7(a) and (b)).
- the tooth 60 on the locking dial 16 moves from the 'locked' recess 62 to the 'unlocked' recess 64 against the bias of the torsion spring 52.
- the autoinjector is then offered up to the injection site and pressed to cause the sleeve 14 and rotary dial 16 to move rearwardly into the housing.
- the tooth 60 on the rotary dial 16 is shifted axially clear of the 'unlocked' recess so it is now free to rotate back part way towards axial alignment with the 'locked' recess by the influence of the torsion spring 52 (but shifted rearwardly).
- Angular movement of the sleeve 16 is restrained by the extension 50 engaging the web 66.
- the front and rear assemblies may then be separated to allow withdrawal of the syringe ready for the next cycle.
- the locking function there are three main components in the locking function, i.e. the front cover, the dial and the sleeve.
- the dial is omitted and instead the sleeve is capable of limited rotation against a spring bias to lock/unlock and then reset with the respective locking abutments and recesses on the sleeve and body.
- the sleeve 14 is provided with the extensions 50 and the teeth 60, and the sleeve is rotatably carried in the front housing.
- the sleeve 14 and dial 16 would be secured together or formed integrally, and the sleeve/dial are rotatable as one relative to the front housing.
- a suitably modified configuration is provided for utilising the rearward movement of the sleeve to unlatch the piston.
- the prongs 24 extending from the rear of the sleeve 14 may be rotatably attached to the sleeve by a suitable arrangement that ensures that the prongs 24 move longitudinally with the sleeve but remain angularly fixed with respect to the housing when the sleeve 14 is rotated between locked and unlocked positions.
- the prongs 24a may be formed on a cylindrical shell 24b, that is journalled on the rear of the sleeve as shown in Figure 14.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Environmental & Geological Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011524458A JP5735424B2 (en) | 2008-08-28 | 2009-08-28 | Automatic injection device |
CN200980133862.9A CN102137691B (en) | 2008-08-28 | 2009-08-28 | Autoinjection device |
EP09785542A EP2331174A1 (en) | 2008-08-28 | 2009-08-28 | Autoinjection devices |
US13/061,007 US9242053B2 (en) | 2008-08-28 | 2009-08-28 | Autoinjection devices |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13634008P | 2008-08-28 | 2008-08-28 | |
GB0815653.1A GB2463034B (en) | 2008-08-28 | 2008-08-28 | Autoinjection devices |
GB0815653.1 | 2008-08-28 | ||
US61/136,340 | 2008-08-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010023481A1 true WO2010023481A1 (en) | 2010-03-04 |
Family
ID=39865864
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2009/051081 WO2010023481A1 (en) | 2008-08-28 | 2009-08-28 | Autoinjection devices |
Country Status (6)
Country | Link |
---|---|
US (1) | US9242053B2 (en) |
EP (1) | EP2331174A1 (en) |
JP (2) | JP5735424B2 (en) |
CN (2) | CN102137691B (en) |
GB (1) | GB2463034B (en) |
WO (1) | WO2010023481A1 (en) |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012103130A2 (en) * | 2011-01-24 | 2012-08-02 | Washington Biotech Corporation | Kits containing medicine injection devices and containers |
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Also Published As
Publication number | Publication date |
---|---|
US20110202011A1 (en) | 2011-08-18 |
CN103505782A (en) | 2014-01-15 |
CN103505782B (en) | 2017-03-01 |
US9242053B2 (en) | 2016-01-26 |
JP6039635B2 (en) | 2016-12-07 |
JP2015061664A (en) | 2015-04-02 |
JP5735424B2 (en) | 2015-06-17 |
JP2012500696A (en) | 2012-01-12 |
GB0815653D0 (en) | 2008-10-08 |
CN102137691B (en) | 2014-07-16 |
GB2463034A (en) | 2010-03-03 |
GB2463034B (en) | 2012-11-07 |
CN102137691A (en) | 2011-07-27 |
EP2331174A1 (en) | 2011-06-15 |
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