WO2010011117A3 - Ndga-containing composition for the suppression of transglutaminase - Google Patents

Ndga-containing composition for the suppression of transglutaminase Download PDF

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Publication number
WO2010011117A3
WO2010011117A3 PCT/KR2009/004175 KR2009004175W WO2010011117A3 WO 2010011117 A3 WO2010011117 A3 WO 2010011117A3 KR 2009004175 W KR2009004175 W KR 2009004175W WO 2010011117 A3 WO2010011117 A3 WO 2010011117A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
transglutaminase
ndga
present
relates
Prior art date
Application number
PCT/KR2009/004175
Other languages
French (fr)
Korean (ko)
Other versions
WO2010011117A2 (en
Inventor
김수열
이창훈
정경채
이병일
Original Assignee
국립암센터
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 국립암센터 filed Critical 국립암센터
Publication of WO2010011117A2 publication Critical patent/WO2010011117A2/en
Publication of WO2010011117A3 publication Critical patent/WO2010011117A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a novel use of nordihydroguaiaretic acid (NDGA) for suppressing transglutaminase activity. More specifically, the present invention relates to a pharmaceutical composition which contains NDGA as an active ingredient and which is used for the prevention or treatment of neurological diseases, inflammatory diseases and cancerous diseases which are medical conditions induced by increased transglutaminase activity. Further, the present invention relates to a method for preventing or treating neurological diseases, inflammatory diseases and cancerous diseases, which are induced by increased transglutaminase activity, by the administration of the pharmaceutical composition. The novel method of the present invention for suppressing transglutaminase by using NDGA is advantageous in that it can be applied safely and without side effects in subjects having diseases involving the abnormal expression of transglutaminase, and can effectively treat or prevent such diseases.
PCT/KR2009/004175 2008-07-25 2009-07-27 Ndga-containing composition for the suppression of transglutaminase WO2010011117A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0072912 2008-07-25
KR20080072912 2008-07-25

Publications (2)

Publication Number Publication Date
WO2010011117A2 WO2010011117A2 (en) 2010-01-28
WO2010011117A3 true WO2010011117A3 (en) 2010-03-25

Family

ID=41570759

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/004175 WO2010011117A2 (en) 2008-07-25 2009-07-27 Ndga-containing composition for the suppression of transglutaminase

Country Status (2)

Country Link
KR (1) KR20100011963A (en)
WO (1) WO2010011117A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107449848A (en) * 2017-09-22 2017-12-08 完美（中国）有限公司 A kind of method of La Ruia extracts in discriminating cosmetic material

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008294A (en) * 1985-02-11 1991-04-16 Chemex Pharmaceuticals, Inc. Methods of treating tumors with compositions of catecholic butanes
US6214874B1 (en) * 1999-10-15 2001-04-10 John Hopkins University Treatment of HPV induced cancer using in situ application of two nordihydroguiaretic acid derivatives, tetramethyl NDGA M4N and tetraglycinal NDGA G4N
WO2003103583A2 (en) * 2002-06-10 2003-12-18 Oklahoma Medical Research Foundation A method for using tethered bis(polyhydroxyphenyls) and o-alkyl derivatives thereof in treating inflammatory conditions of the central nervous system
US20060141029A1 (en) * 2003-05-20 2006-06-29 Erimos Pharmaceuticals Llc Methods and compositions for delivery of catecholic butanes for treatment of diseases
WO2008042921A2 (en) * 2006-10-02 2008-04-10 Erimos Pharmaceuticals Llc Tetra-o-substituted butane-bridge modified ndga derivatives, their synthesis and pharmaceutical use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008294A (en) * 1985-02-11 1991-04-16 Chemex Pharmaceuticals, Inc. Methods of treating tumors with compositions of catecholic butanes
US6214874B1 (en) * 1999-10-15 2001-04-10 John Hopkins University Treatment of HPV induced cancer using in situ application of two nordihydroguiaretic acid derivatives, tetramethyl NDGA M4N and tetraglycinal NDGA G4N
WO2003103583A2 (en) * 2002-06-10 2003-12-18 Oklahoma Medical Research Foundation A method for using tethered bis(polyhydroxyphenyls) and o-alkyl derivatives thereof in treating inflammatory conditions of the central nervous system
US20060141029A1 (en) * 2003-05-20 2006-06-29 Erimos Pharmaceuticals Llc Methods and compositions for delivery of catecholic butanes for treatment of diseases
WO2008042921A2 (en) * 2006-10-02 2008-04-10 Erimos Pharmaceuticals Llc Tetra-o-substituted butane-bridge modified ndga derivatives, their synthesis and pharmaceutical use

Also Published As

Publication number Publication date
WO2010011117A2 (en) 2010-01-28
KR20100011963A (en) 2010-02-03

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