WO2010009392A3 - Compositions and methods for increasing microbial production of coenzyme q - Google Patents

Compositions and methods for increasing microbial production of coenzyme q Download PDF

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Publication number
WO2010009392A3
WO2010009392A3 PCT/US2009/050987 US2009050987W WO2010009392A3 WO 2010009392 A3 WO2010009392 A3 WO 2010009392A3 US 2009050987 W US2009050987 W US 2009050987W WO 2010009392 A3 WO2010009392 A3 WO 2010009392A3
Authority
WO
WIPO (PCT)
Prior art keywords
coenzyme
methods
compositions
increasing microbial
microbial production
Prior art date
Application number
PCT/US2009/050987
Other languages
French (fr)
Other versions
WO2010009392A2 (en
Inventor
Adam Burja
Corinne Cluis
Andy Ekins
Vincent Martin
Original Assignee
Ocean Nutrition Canada Limited
Valorbec Societe En Commandite
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ocean Nutrition Canada Limited, Valorbec Societe En Commandite filed Critical Ocean Nutrition Canada Limited
Publication of WO2010009392A2 publication Critical patent/WO2010009392A2/en
Publication of WO2010009392A3 publication Critical patent/WO2010009392A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/66—Preparation of oxygen-containing organic compounds containing the quinoid structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Disclosed herein are compositions and methods for increasing microbial expression of Coenzyme Q. These methods generally involve recombinant expression of heterologous enzymes in the microbe in order to increase metabolic production of Coenzyme Q generally or selectively produce Coenzyme QlO specifically.
PCT/US2009/050987 2008-07-17 2009-07-17 Compositions and methods for increasing microbial production of coenzyme q WO2010009392A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8171608P 2008-07-17 2008-07-17
US61/081,716 2008-07-17

Publications (2)

Publication Number Publication Date
WO2010009392A2 WO2010009392A2 (en) 2010-01-21
WO2010009392A3 true WO2010009392A3 (en) 2010-03-11

Family

ID=41202505

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/050987 WO2010009392A2 (en) 2008-07-17 2009-07-17 Compositions and methods for increasing microbial production of coenzyme q

Country Status (1)

Country Link
WO (1) WO2010009392A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102676595A (en) * 2012-03-15 2012-09-19 苏州海吉亚生物科技有限公司 Method for producing reduced coenzyme Q10 by fermentation of recombinant strains
PL2838998T3 (en) 2012-04-18 2018-04-30 Cell Signaling Technology, Inc. Egfr and ros1 in cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006018211A1 (en) * 2004-08-19 2006-02-23 Dsm Ip Assets B.V. Production of isoprenoids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006018211A1 (en) * 2004-08-19 2006-02-23 Dsm Ip Assets B.V. Production of isoprenoids

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GULMEZIAN ET AL: "The role of UbiX in Escherichia coli coenzyme Q biosynthesis", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS, US, vol. 467, no. 2, 6 November 2007 (2007-11-06), pages 144 - 153, XP022332310, ISSN: 0003-9861 *
WHEELER KERRY A ET AL: "Control of metabolic flux through the quinate pathway in Aspergillus nidulans", BIOCHEMICAL JOURNAL, vol. 315, no. 1, 1996, pages 195 - 205, XP002552223, ISSN: 0264-6021 *
ZAHIRI ET AL: "Coenzyme Q10 production in recombinant Escherichia coli strains engineered with a heterologous decaprenyl diphosphate synthase gene and foreign mevalonate pathway", METABOLIC ENGINEERING, ACADEMIC PRESS, US, vol. 8, no. 5, 1 September 2006 (2006-09-01), pages 406 - 416, XP005611309, ISSN: 1096-7176 *

Also Published As

Publication number Publication date
WO2010009392A2 (en) 2010-01-21

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