WO2010008886A3 - Procédés de préparation de promédicaments contenant de la gabapentine et de leurs intermédiaires - Google Patents

Procédés de préparation de promédicaments contenant de la gabapentine et de leurs intermédiaires Download PDF

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Publication number
WO2010008886A3
WO2010008886A3 PCT/US2009/048455 US2009048455W WO2010008886A3 WO 2010008886 A3 WO2010008886 A3 WO 2010008886A3 US 2009048455 W US2009048455 W US 2009048455W WO 2010008886 A3 WO2010008886 A3 WO 2010008886A3
Authority
WO
WIPO (PCT)
Prior art keywords
intermediates
gabapentin
processes
preparing prodrugs
prodrugs
Prior art date
Application number
PCT/US2009/048455
Other languages
English (en)
Other versions
WO2010008886A2 (fr
Inventor
Elena Ben Moha-Lerman
Valerie Niddam-Hildesheim
Original Assignee
Teva Pharmaceutical Industries Ltd.
Teva Pharmaceuticals Usa, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd., Teva Pharmaceuticals Usa, Inc. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of WO2010008886A2 publication Critical patent/WO2010008886A2/fr
Publication of WO2010008886A3 publication Critical patent/WO2010008886A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/96—Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/02—Monothiocarbonic acids; Derivatives thereof
    • C07C329/04—Esters of monothiocarbonic acids
    • C07C329/06—Esters of monothiocarbonic acids having sulfur atoms of thiocarbonic groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00—Preparation of esters of carbonic or haloformic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention porte sur des promédicaments contenant de la gabapentine et sur leurs intermédiaires.
PCT/US2009/048455 2008-06-24 2009-06-24 Procédés de préparation de promédicaments contenant de la gabapentine et de leurs intermédiaires WO2010008886A2 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US13309708P 2008-06-24 2008-06-24
US61/133,097 2008-06-24
US13465208P 2008-07-10 2008-07-10
US61/134,652 2008-07-10
US19297008P 2008-09-22 2008-09-22
US61/192,970 2008-09-22

Publications (2)

Publication Number Publication Date
WO2010008886A2 WO2010008886A2 (fr) 2010-01-21
WO2010008886A3 true WO2010008886A3 (fr) 2010-04-15

Family

ID=41137524

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/048455 WO2010008886A2 (fr) 2008-06-24 2009-06-24 Procédés de préparation de promédicaments contenant de la gabapentine et de leurs intermédiaires

Country Status (3)

Country Link
US (1) US20090318728A1 (fr)
TW (1) TW201014818A (fr)
WO (1) WO2010008886A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8596390B2 (en) * 2007-12-05 2013-12-03 Ford Global Technologies, Llc Torque control for hybrid electric vehicle speed control operation
US20140024621A1 (en) 2012-07-23 2014-01-23 Ms Therapeutics Limited Aminopyridine compounds and their uses
CN108863873A (zh) * 2018-06-26 2018-11-23 台州学院 一种硫烯丙基碳酸酯类化合物及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401868A (en) * 1990-01-22 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Aryloxymethylcarbonochloridate ester intermediates for use in synthesizing pro drugs and their use therefor
US20050137174A1 (en) * 2003-07-09 2005-06-23 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
WO2007027599A1 (fr) * 2005-08-31 2007-03-08 Wyeth Derives de glycylcyclines substitues par 9-aminocarbonyle
US7227028B2 (en) * 2003-12-30 2007-06-05 Xenoport, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818787B2 (en) * 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) * 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
JP4308263B2 (ja) * 2003-10-14 2009-08-05 ゼノポート，インコーポレイティド γ−アミノ酪酸アナログの結晶形

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5401868A (en) * 1990-01-22 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Aryloxymethylcarbonochloridate ester intermediates for use in synthesizing pro drugs and their use therefor
US20050137174A1 (en) * 2003-07-09 2005-06-23 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
US7227028B2 (en) * 2003-12-30 2007-06-05 Xenoport, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
WO2007027599A1 (fr) * 2005-08-31 2007-03-08 Wyeth Derives de glycylcyclines substitues par 9-aminocarbonyle

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MENG Q ET AL: "Synthesis and evaluation of carbamate prodrugs of SQ109 as antituberculosis agents", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 19, no. 10, 15 May 2009 (2009-05-15), pages 2808 - 2810, XP026085973, ISSN: 0960-894X, [retrieved on 20090326] *
STEVEN V. LEY AND PETER R. WOODWARD: "The use of beta-ketothioesters for the exceptionally mild preparation of beta-ketoamides", TETRAHEDRON LETTERS, vol. 28, no. 26, 1987, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, pages 3019 - 3020, XP002567438, ISSN: 0040-4039, DOI: 10.1016/S0040-4039(00)96273-7 *

Also Published As

Publication number Publication date
US20090318728A1 (en) 2009-12-24
WO2010008886A2 (fr) 2010-01-21
TW201014818A (en) 2010-04-16

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