WO2010005946A2 - Protection pour récipients aérosols d’inhalation de dose mesurée - Google Patents

Protection pour récipients aérosols d’inhalation de dose mesurée Download PDF

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Publication number
WO2010005946A2
WO2010005946A2 PCT/US2009/049777 US2009049777W WO2010005946A2 WO 2010005946 A2 WO2010005946 A2 WO 2010005946A2 US 2009049777 W US2009049777 W US 2009049777W WO 2010005946 A2 WO2010005946 A2 WO 2010005946A2
Authority
WO
WIPO (PCT)
Prior art keywords
cover
assembly
metered dose
dose inhaler
seal
Prior art date
Application number
PCT/US2009/049777
Other languages
English (en)
Other versions
WO2010005946A8 (fr
WO2010005946A3 (fr
Inventor
Walter Horodnik
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of WO2010005946A2 publication Critical patent/WO2010005946A2/fr
Publication of WO2010005946A3 publication Critical patent/WO2010005946A3/fr
Publication of WO2010005946A8 publication Critical patent/WO2010005946A8/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A61M15/0025—Mouthpieces therefor with caps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/38—Details of the container body
    • B65D83/384—Details of the container body comprising an aerosol container disposed in an outer shell or in an external container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/14—Containers or packages with special means for dispensing contents for delivery of liquid or semi-liquid contents by internal gaseous pressure, i.e. aerosol containers comprising propellant for a product delivered by a propellant
    • B65D83/40—Closure caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/06—Packaging for specific medical equipment

Definitions

  • This invention relates to covers for metered dose inhaler aerosol cans.
  • MDIs Metered dose inhalers
  • aerosol cans which include pressurized drugs, with propellant, for inhalation.
  • the typical design of the aerosol can includes a metallic can body formed to withstand the pressure of the medication therein.
  • a cap or ferrule is secured to the can body by crimping or other techniques.
  • An actuable valve extends from the can body, through the cap, which is configured to dispense a dose of medication upon actuation.
  • the valving of the aerosol can includes seals and other moving parts, which may permit gas leakage or ingress during storage.
  • common propellants used in MDIs such as 1,1,1,2 tetrafluoroethane (HFA 134) and 1,1,1,2,3,3,3 heptafluorpropane (HFA 227) have been found to leak with MDIs being stored over time, due to the internal pressure of the aerosol can.
  • certain components of the medication itself have been found to leak, such as ethanol. Ingress of air or contaminants into MDI' s has been also found.
  • seals or moving parts leakage or ingress may be present through the interface between the cap and the can body.
  • Plastic containers and foil bags have been used for storing MDI aerosol cans.
  • Plastic containers are cylindrical packages formed to encompass entire MDI cans in a single volume.
  • foil bags encompass entire MDI cans in a single volume.
  • These containers have been provided with desiccant material to absorb gas or moisture contained within the container.
  • desiccant material to absorb gas or moisture contained within the container.
  • extensive gas loss may be experienced within the containers due to the relatively larger volume therein.
  • gas leakage occurs until the higher internal pressure of the MDI can reaches equilibrium with the contained volume within the container or bag.
  • sufficiently high pressure build-up could cause the foil bag to break or leak. If gas leaks through the container or bag, transmurally, or otherwise, equilibrium will never be reached.
  • the desiccant material may absorb certain gas vapor(s), such as ethanol gas vapor, thereby causing additional leakage.
  • a metered dose inhaler aerosol can assembly which includes a metered dose inhaler aerosol can having a body defining a reservoir for accommodating at least one pressurized dose of active pharmaceutical agent, a cap fixed to the body, and a selectably actuable valve extending through the cap and from the body to have an externally exposed portion.
  • the valve is configured to selectively dispense contents from the reservoir.
  • the assembly further includes a metallic cover for encompassing at least a volume about the externally exposed portion of the valve, and a seal disposed between the can and the cover such that a fluid-tight seal is defined therebetween. The encompassed volume is sealed fluid-tightly from the ambient environment by the cover and the seal.
  • any pressure leakage from the can may be contained within the encompassed volume such that equilibrium may be achieved between the gas pressure inside the can and the encompassed volume. Equilibrium minimizes further gas leakage.
  • An interface is defined between the body and the cap, the interface being within the encompassed volume.
  • the seal may be mounted on the can or the cover.
  • the cover may be formed from a generally non-corrosive metal, such as stainless steel, aluminum, zinc-based alloys and combinations thereof.
  • the seal may be formed from any suitable material such as a fluoroelastomer or butyl rubber.
  • a desiccant material may be disposed in the cover.
  • the encompassed volume may be static and from about 0.1 to about 5.0 cubic inches or from about 0.25 to about 0.75 cubic inches.
  • Other embodiments provide a pharmaceutical product that includes the metered dose inhaler aerosol can assemblies of the present invention along with at least one pharmaceutical active agent in the metered dose inhaler aerosol can.
  • a metered dose inhaler aerosol can assembly wherein in the assembly includes a metered dose inhaler aerosol can, the can having a body defining a reservoir for accommodating at least one pressurized dose of active pharmaceutical agent, a cap fixed to the body, and a selectively actuable valve extending through the cap and from the body to have an externally exposed portion, the valve configured to selectively dispense contents from the reservoir.
  • a metallic cover for encompassing at least a volume about the externally exposed portion of the valve is provided.
  • a seal may be disposed between the can and the cover such that a fluid-tight seal is defined therebetween with the encompassed volume being sealed fluid-tightly from the ambient environment by the cover and the seal.
  • a secondary cover portion releasably connected to the cover may be included so that the cover and the secondary cover portion collectively encompassing the metered dose inhaler aerosol can, the releasable connection configured to permit the cover to be separated from the secondary cover portion.
  • a metered dose inhaler aerosol can assembly wherein in the assembly includes a metered dose inhaler aerosol can, the can having a body defining a reservoir for accommodating at least one pressurized dose of active pharmaceutical agent, a cap fixed to the body, and a selectively actuable valve extending through the cap and from the body to have an externally exposed portion, the valve configured to selectively dispense contents from the reservoir.
  • a metallic cover for encompassing at least a volume about the externally exposed portion of the valve is provided.
  • a secondary cover portion releasably connected to the cover may be included so that the cover and the secondary cover portion collectively encompassing the metered dose inhaler aerosol can, the releasable connection configured to permit the cover to be separated from the secondary cover portion.
  • a seal disposed between the secondary cover and the cover may be provided such that a fluid-tight seal is defined therebetween with the encompassed volume being sealed fluid-tightly from the ambient environment by the cover and the seal.
  • a metered dose inhaler aerosol can assembly that includes a metered dose inhaler aerosol can, the can having a body defining a reservoir for accommodating at least one pressurized dose of active pharmaceutical agent, a cap fixed to the body, and a selectively actuable valve extending through the cap and from the body to have an externally exposed portion, wherein the valve can be configured to selectively dispense contents from the reservoir.
  • a metallic cover for encompassing at least a volume about the externally exposed portion of the valve provided and a fluid-tight cover over the can wherein the encompassed volume is from about 0.1 to about 5.0 cubic inches. Alternatively, the encompassed volume is from about 0.25 to about 0.75 cubic inches or about .75 cubic inches.
  • the encompassed volume may be static.
  • Figure 1 is a depiction of a MDI aerosol can having a cover mounted thereto in accordance with the subject invention
  • Figure IA is a cross-sectional view taken along line 1A-1A of Figure 1;
  • Figures 2 and 3 are depictions of a MDI aerosol can having a seal mounted thereto, and a cover formed in accordance with the subject invention.
  • Figures 4-8 depict a cover and secondary cover portion formed in accordance with the subject invention. DETAILED DESCRIPTION OF THE INVENTION;
  • a metered dose inhaler aerosol can assembly is provided herein and generally designated with the reference numeral 10 in the drawings.
  • the assembly 10 includes a metered dose inhaler aerosol can 12, a cover 14 and a seal 16, as described below.
  • the metered dose inhaler aerosol can 12 may be of any known design suitable for containing pressurized medication that may be provided in individual doses for inhalation.
  • the metered dose inhaler aerosol can 12 may include a can body 18, which may be of various shapes and configurations, such as being cup-shaped, a cap 20 fixed to the can body 18, and a selectively actuable valve 22 extending through the cap 20 and from the can body 18 to have an externally exposed portion 24.
  • the can body 18 defines a reservoir for accommodating at least one pressurized dose of active pharmaceutical agent.
  • the cap 20 is fixed to the can body 18 through any known technique, including crimping.
  • the can body 18 and the cap 20 are formed of generally non-corrosive metal, such as one or more of stainless steel, aluminum, or zinc-based alloys.
  • the can body may be glass.
  • the metered dose inhaler can 12 is provided with one or more active pharmaceutical agents for administration by inhalation.
  • the active pharmaceutical agent(s) is administered in individual doses under pressure, as is known in the prior art.
  • the metered dose inhaler can 12 is formed with sufficient integrity to withstand the pressure of the contents therein.
  • the valve 22 is configured in any known technique such that, upon individual actuations, doses of the active pharmaceutical agent(s) may be administered.
  • the externally exposed portion 24 may be a tube or conduit, such as formed from plastic, terminating with an outlet aperture 26 through which administered doses may be dispensed.
  • the cover 14 is preferably metal, and more preferably of a generally non- corrosive metal, such as one or more of stainless steel, aluminum, or zinc-based alloys.
  • the cover 14 is formed with an internal volume 28 formed to encompass at least a volume about the externally exposed portion 24 of the valve 22, particularly the outlet aperture 26.
  • the cover 14 may be generally cup-shaped with a base 30 from which extends a sidewall 32.
  • the sidewall 32 defines an internal diameter slightly greater than the external diameter of the can body 18.
  • the cover 14 is placed atop the metered dose can 12 such that the internal volume 28 encompasses at least the externally exposed portion 24 of the valve 22 during storage or other long-term non-use of the metered dose inhaler can 12.
  • the seal 16 is provided as one or more seal elements disposed to sealingly engage the metered dose inhaler can 12 and the cover 14 such that a fluid-tight seal is defined therebetween.
  • the internal volume 28 encloses an encompassed volume 34 which is at least a volume about the externally exposed portion 24 of the valve 22. It is preferred that the sidewall 32 of the cover 14 extend below the seal 16 with the cover 14 on the metered dose can 12.
  • the seal 16 is located to define a fluid- tight seal between the encompassed volume 34 and the ambient environment surrounding the cover 14 and the seal 16.
  • the encompassed volume 34 is significantly isolated from the ambient environment.
  • the integrity of the seal may vary from being a microbial barrier to gas tight, liquid tight or a fluid- tight seal (gas and liquid tight). Any leakage of pressurized gas or vapor, such as propellant, may collect in the encompassed volume 34 with pressure building-up until eventual equilibrium is achieved. Since the encompassed volume 34 is of limited volume, excessive losses from the metered dose inhaler can 12 may be avoided. In addition, the arrangement inhibits ingress of air or contaminants.
  • the encompassed volume is preferably static.
  • the encompassed volume 34 encompasses a volume of about 0.1 to about 5.0 cubic inches, of about 0.1 to about 4.0 cubic inches, of about 0.1 to about 3.0 cubic inches, of about 0.1 to about 2.0 cubic inches, of about 0.1 to about 1.0 cubic inches, of about 0.25 to about 0.75 cubic inches, or of about 0.75 cubic inches.
  • the encompassed volume may be static.
  • the seal 16 may be located such that any interface 36 between the can body 18 and the cap 20 is encompassed within the encompassed volume 34. In this manner, any leakage through the interface 36 is also collected within the encompassed volume 34.
  • the seal 16 may be a single elastomeric seal, such as in the form of an o-ring.
  • the seal 16 may be a fluoroelastomer o-ring (such as Viton® brand fluoroelastomer), or a butyl rubber o-ring may also be utilized.
  • other seal arrangements are possible, including a series of seal elements (e.g., a series of o-rings) and/or seals of various materials (e.g., a deflectable or deformable polymer).
  • the can body 18 may be provided with a reduced- diameter neck portion 38 adjacent to the cap 20.
  • the seal 16 may be mounted to the can body 18 about the neck portion 38.
  • the seal 16 may be located at other locations on the can body 18 and/or on the cover 14. With reference to Fig. IA, the seal 16 may be fixed to the cover 14.
  • a restraining or locking mechanism be provided to temporarily restrain the cover 14 on the metered dose inhaler can 12 during storage.
  • Any known mechanism for temporarily restraining the cover 14 may be utilized, including mechanical and/or adherent provisions.
  • latches, resilient snaps, and/or releasable or removable adhesive may be utilized.
  • a secondary cover portion 40 may be provided formed to engage the cover 14 and provide releasable restraint therefor.
  • the secondary cover portion 40 may be of various shapes and configurations, such as being cup-shaped, and, together with the cover 14, may be formed to wholly receive the metered dose inhaler 12.
  • Cooperating locking elements 42 may be provided on the cover 14 and the secondary cover portion 40 to allow for releasable unlocking therebetween.
  • the cooperating locking elements 42 may be of any known construction, including threads or a bayonet-type locking arrangement.
  • the cooperating locking elements 42 may be a tight mechanical fit where one of the cover 14 and the secondary cover portion 40 is tightly nested in the other component so as to provide resistance against separation therebetween.
  • Other modes for allowing the cover 14 and the secondary cover portion 38 to be releasably locked together may be utilized.
  • the secondary cover portion 40 be formed of the same material as the cover 14. With the secondary cover portion 40 being of metal, as shown in Figure 6, the secondary cover portion 40 defines a secondary encompassed volume 44 in which any gas that leaks pass the seal 16 during use may collect.
  • the secondary encompassed volume 44 is an additional buffer between the encompassed volume 34 and the ambient environment.
  • the cover 14 and the secondary cover portion 40 may be joined together by a frangible or otherwise releasable connection.
  • a releasable connection 46 may be imparted or defined in the assembly 10 between the cover 14 and the secondary cover portion 40 which is breakable or otherwise releasable under sufficient application of force.
  • the releasable connection 46 may be a scored line or lines, an adhesive, a fused or welded connection (e.g., tack or spot welded) and/or one or more perforations, which may shear or fail under application of force separating the cover 14 from the secondary cover portion 40.
  • one or more of the seals 16 may be located between the cover 14 and the secondary cover portion 40.
  • the seal(s) 16 between the cover 14 and the secondary cover portion 40 may be the sole sealing element(s) utilized for the assembly 10 or the seal(s) 16 may be used in conjunction with other sealing arrangements described above.
  • a desiccant material may be utilized in the assembly 10 to provide a drying effect, e.g. within the cover 14.
  • all or part of the assembly 10 may be reusable or disposable.
  • the cover 14 may be reusable, while the seal 16 may be for a single-use and disposed.

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Nozzles (AREA)

Abstract

La présente invention se rapporte à un ensemble récipient aérosol d’inhalation de dose mesurée qui comprend un récipient aérosol d’inhalation de dose mesurée comportant un corps délimitant un réservoir servant à contenir au moins une dose d’agent pharmaceutique actif sous pression, un bouchon fixé au corps, et une soupape à actionnement sélectif s’étendant à travers le bouchon et depuis le corps pour comporter une partie extérieurement exposée.
PCT/US2009/049777 2008-07-08 2009-07-07 Protection pour récipients aérosols d’inhalation de dose mesurée WO2010005946A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7901008P 2008-07-08 2008-07-08
US61/079,010 2008-07-08

Publications (3)

Publication Number Publication Date
WO2010005946A2 true WO2010005946A2 (fr) 2010-01-14
WO2010005946A3 WO2010005946A3 (fr) 2010-05-27
WO2010005946A8 WO2010005946A8 (fr) 2010-07-08

Family

ID=41226877

Family Applications (1)

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PCT/US2009/049777 WO2010005946A2 (fr) 2008-07-08 2009-07-07 Protection pour récipients aérosols d’inhalation de dose mesurée

Country Status (3)

Country Link
AR (1) AR072865A1 (fr)
TW (1) TW201014623A (fr)
WO (1) WO2010005946A2 (fr)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012100014A1 (fr) 2011-01-21 2012-07-26 The Gillette Company Actionneur pour un appareil distributeur
WO2012100013A1 (fr) 2011-01-21 2012-07-26 The Gillette Company Actionneur pour un appareil distributeur
EP2526989A1 (fr) * 2011-05-23 2012-11-28 Boehringer Ingelheim International GmbH Système comportant un nébuliseur et un emballage
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9764102B2 (en) 2011-11-01 2017-09-19 Euro-Celtique S.A. Dispenser cap arrangement
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator
EP3694590A4 (fr) * 2017-10-09 2021-08-18 Pearl Therapeutics, Inc. Systèmes d'administration de médicaments et procédés associés

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US2456451A (en) * 1946-05-31 1948-12-14 Scovill Manufacturing Co Inhaler
US2737416A (en) * 1953-03-24 1956-03-06 Leo J Behr Nonclog cap for spray dispensers
FR2750405A1 (fr) * 1996-07-01 1998-01-02 Guillemot Georges Boitier pour recipient sous pression et vehicule automobile comportant un tel boitier
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WO2001017597A1 (fr) * 1999-09-08 2001-03-15 Sapphire Designs, Inc. Dispositif d'inhalation muni d'un compteur
US20030051727A1 (en) * 2002-11-04 2003-03-20 Haan Richard J Aerosol mdi overcap containing desiccant
US20040187865A1 (en) * 1995-04-14 2004-09-30 Smithkline Beecham Corp. Metered dose inhaler for fluticasone propionate
WO2005014078A2 (fr) * 2003-07-28 2005-02-17 3M Innovative Properties Company Fermeture par membrane utilisee dans un aerosol medicamenteux
WO2005049450A1 (fr) * 2003-11-18 2005-06-02 Thomas Kiepe Emballage
WO2007109606A2 (fr) * 2006-03-17 2007-09-27 Csp Technologies, Inc. Emballage primaire étanche à l'humidité pour un inhalateur de poudre sèche

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Publication number Priority date Publication date Assignee Title
US2297178A (en) * 1940-03-21 1942-09-29 Scovill Manufacturing Co Inhaler container
US2456451A (en) * 1946-05-31 1948-12-14 Scovill Manufacturing Co Inhaler
US2737416A (en) * 1953-03-24 1956-03-06 Leo J Behr Nonclog cap for spray dispensers
US20040187865A1 (en) * 1995-04-14 2004-09-30 Smithkline Beecham Corp. Metered dose inhaler for fluticasone propionate
FR2750405A1 (fr) * 1996-07-01 1998-01-02 Guillemot Georges Boitier pour recipient sous pression et vehicule automobile comportant un tel boitier
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US20030051727A1 (en) * 2002-11-04 2003-03-20 Haan Richard J Aerosol mdi overcap containing desiccant
WO2005014078A2 (fr) * 2003-07-28 2005-02-17 3M Innovative Properties Company Fermeture par membrane utilisee dans un aerosol medicamenteux
WO2005049450A1 (fr) * 2003-11-18 2005-06-02 Thomas Kiepe Emballage
WO2007109606A2 (fr) * 2006-03-17 2007-09-27 Csp Technologies, Inc. Emballage primaire étanche à l'humidité pour un inhalateur de poudre sèche

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
WO2012100013A1 (fr) 2011-01-21 2012-07-26 The Gillette Company Actionneur pour un appareil distributeur
WO2012100014A1 (fr) 2011-01-21 2012-07-26 The Gillette Company Actionneur pour un appareil distributeur
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9381311B2 (en) 2011-05-23 2016-07-05 Boehringer Ingelheim International Gmbh System comprising a nebulizer and a packaging
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
EP2526989A1 (fr) * 2011-05-23 2012-11-28 Boehringer Ingelheim International GmbH Système comportant un nébuliseur et un emballage
WO2012159914A1 (fr) * 2011-05-23 2012-11-29 Boehringer Ingelheim International Gmbh Système comportant un nébuliseur et un emballage
US9764102B2 (en) 2011-11-01 2017-09-19 Euro-Celtique S.A. Dispenser cap arrangement
EA036468B1 (ru) * 2011-11-01 2020-11-13 Эро-Селтик С.А. Конструкция колпачка дозатора
US10688258B2 (en) 2011-11-01 2020-06-23 Euro-Celtique S.A. Dispenser cap arrangement
US10220163B2 (en) 2012-04-13 2019-03-05 Boehringer Ingelheim International Gmbh Nebuliser with coding means
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US10894134B2 (en) 2013-08-09 2021-01-19 Boehringer Ingelheim International Gmbh Nebulizer
US11642476B2 (en) 2013-08-09 2023-05-09 Boehringer Ingelheim International Gmbh Nebulizer
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
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TW201014623A (en) 2010-04-16
WO2010005946A8 (fr) 2010-07-08
AR072865A1 (es) 2010-09-29
WO2010005946A3 (fr) 2010-05-27

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