WO2010005520A3 - Dérivés de 2-alkyl-3-acylpyrazolo[1,5-a]pyridines - Google Patents

Dérivés de 2-alkyl-3-acylpyrazolo[1,5-a]pyridines Download PDF

Info

Publication number
WO2010005520A3
WO2010005520A3 PCT/US2009/003888 US2009003888W WO2010005520A3 WO 2010005520 A3 WO2010005520 A3 WO 2010005520A3 US 2009003888 W US2009003888 W US 2009003888W WO 2010005520 A3 WO2010005520 A3 WO 2010005520A3
Authority
WO
WIPO (PCT)
Prior art keywords
ibudilast
acylpyrazolo
inhibitor
derivatives
alkyl
Prior art date
Application number
PCT/US2009/003888
Other languages
English (en)
Other versions
WO2010005520A2 (fr
Inventor
Julie F. Liu
Rose A. Persichetti
Original Assignee
Concert Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Concert Pharmaceuticals, Inc. filed Critical Concert Pharmaceuticals, Inc.
Publication of WO2010005520A2 publication Critical patent/WO2010005520A2/fr
Publication of WO2010005520A3 publication Critical patent/WO2010005520A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L’invention concerne de nouveaux composés, qui sont des 2-alkyl-3-acylpyrazolo[1,5-a]pyridines, leurs dérivés et leurs sels pharmaceutiquement acceptables. Plus spécifiquement, l’invention concerne des composés de 2-alkyl-3-acylpyrazolo[1,5-a]pyridines qui sont des dérivés d’ibudilast. L’invention concerne également des compositions qui comprennent un composé de cette invention et l’utilisation de telles compositions dans des procédés de traitement de maladies et de troubles qui sont avantageusement traités par administration d’un inhibiteur de phosphodiestérase (PDE), d’un antagoniste de leucotriène CysLTl (LTD4), d’un inhibiteur d’oxyde nitrique synthétase et/ou d’un suppresseur de l’activation des cellules gliales, tel qu’ibudilast.
PCT/US2009/003888 2008-06-30 2009-06-30 Dérivés de 2-alkyl-3-acylpyrazolo[1,5-a]pyridines WO2010005520A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13352308P 2008-06-30 2008-06-30
US61/133,523 2008-06-30

Publications (2)

Publication Number Publication Date
WO2010005520A2 WO2010005520A2 (fr) 2010-01-14
WO2010005520A3 true WO2010005520A3 (fr) 2010-03-04

Family

ID=41056848

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/003888 WO2010005520A2 (fr) 2008-06-30 2009-06-30 Dérivés de 2-alkyl-3-acylpyrazolo[1,5-a]pyridines

Country Status (1)

Country Link
WO (1) WO2010005520A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3850941A (en) * 1972-03-30 1974-11-26 Kyorin Seiyaku Kk 2-alkyl-3-acylpyrazolo(1,5-a)pyridines
WO1995026325A2 (fr) * 1994-03-25 1995-10-05 Isotechnika Inc. Potentialisation de medicaments par deuteration_______________
EP1570847A1 (fr) * 2002-12-03 2005-09-07 Kyorin Pharmaceutical Co., Ltd. Inhibiteurs de phosphodiesterase 10a

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3850941A (en) * 1972-03-30 1974-11-26 Kyorin Seiyaku Kk 2-alkyl-3-acylpyrazolo(1,5-a)pyridines
WO1995026325A2 (fr) * 1994-03-25 1995-10-05 Isotechnika Inc. Potentialisation de medicaments par deuteration_______________
EP1570847A1 (fr) * 2002-12-03 2005-09-07 Kyorin Pharmaceutical Co., Ltd. Inhibiteurs de phosphodiesterase 10a

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
ATARASHII GANKA , 15(4), 573-578 CODEN: ATGAEX; ISSN: 0910-1810, 1998, XP001539556 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KOMURO ET AL.: "Disposition of 0.01% ibudilast ophthalmic solution. IV. Distribution, metabolism, and excretion after a single instillation of 14C-labeled ibudilast in albino rabbits", XP002546078, retrieved from STN Database accession no. 1998:298386 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; NAGATSU; TAKAGI: "Synthesis of carbon-14 and deuterium labeled 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine", XP002546080, retrieved from STN Database accession no. 1986:207196 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TAKAGI; ENDO: "Studies on the metabolic fate of 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine (KC-404). (2). Metabolism in rats, dogs and monkeys", XP002546079, retrieved from STN Database accession no. 1986:141683 *
FOSTER: "Deuterium isotope effects in the metabolism of drugs and xenobiotics: implications for drug design", ADVANCES IN DRUG RESEARCH, vol. 14, 1 January 1985 (1985-01-01), pages 1 - 40, XP009086953, ISSN: 0065-2490 *
JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS , 22(7), 735-43 CODEN: JLCRD4; ISSN: 0362-4803, 1985 *
LEDEBOER ET AL.: "Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes", EXPERT OPINION ON INVESTIGATIONAL DRUGS, ASHLEY PUBLICATIONS LTD., LONDON, GB, vol. 16, no. 7, 1 July 2007 (2007-07-01), pages 935 - 950, XP002483491, ISSN: 1354-3784 *
O'NEIL ET AL. (EDS.): "The Merck Index, 13th ed.", 2001, MERCK & CO., INC., WHITEHOUSE STATION, NJ, XP002546076 *
OYO YAKURI, vol. 30, no. 6, 1985, pages 983 - 994, XP009122761 *
SYNFINE RESEARCH INC.: "Online Catalogue: Ibudilast-d7", 2009, SYNFINE RESEARCH INC., RICHMOND HILL (ONTARIO, CANADA), XP002546077 *
YARNELL: "Heavy-Hydrogen Drugs Turn Heads, Again", CHEMICAL & ENGINEERING NEWS, vol. 87, no. 25, 22 June 2009 (2009-06-22), pages 36 - 39, XP002546075, Retrieved from the Internet <URL:http://pubs.acs.org/cen/science/87/8725sci1.html> [retrieved on 20090916] *

Also Published As

Publication number Publication date
WO2010005520A2 (fr) 2010-01-14

Similar Documents

Publication Publication Date Title
PH12014501134A1 (en) 2&#39;,4&#39;-difluoro-2&#39;-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication
WO2008145688A3 (fr) Nouveaux composés
WO2008086462A3 (fr) Dérivés de quinalozine substitués par amino en tant qu&#39;inhibiteurs de la voie b-caténine/tcf-4 et agents de traitement du cancer
WO2008094992A3 (fr) Inhibiteurs de kinase
WO2009091374A3 (fr) Dérivés hétérocycliques réunis par fusion et procédés d&#39;utilisation associés
WO2009132202A3 (fr) Composés macrocycliques et leur utilisation à titre d&#39;inhibiteurs de kinase
WO2010021680A3 (fr) Inhibiteurs de la bêta-sécrétase
WO2012015986A3 (fr) Dérivés substitués de bioxopipéridinyl phtalimide
WO2009115517A3 (fr) Composés organiques
WO2008104175A3 (fr) Nouveaux inhibiteurs de la phosphodiestérase
WO2011158042A3 (fr) Méthodes
WO2010111406A3 (fr) Composés et leurs utilisations thérapeutiques
WO2009108383A3 (fr) Dérivés de xanthine substitués
WO2010011772A3 (fr) Inhibiteurs de la pyrazolopyridine kinase tricyclique
HK1138840A1 (en) Azabiphenylaminobenzoic acid derivatives as dhodh inhibitors
WO2010032875A3 (fr) Composés de carboxamide hétérocycliques
WO2010108074A3 (fr) Inhibiteurs de pi3 kinase
WO2012027712A3 (fr) Inhibiteurs puissants et sélectifs du virus de l&#39;hépatite c
WO2007092936A3 (fr) Procédé pour traiter des lésions gastriques
WO2012017239A3 (fr) Composés chimiques
MX2011011083A (es) Compuestos heterociclicos como inhibidores de mek.
WO2008002514A3 (fr) Combinaison de composés pour le traitement de la toux et procédé de traitement des toux courantes
WO2009030952A3 (fr) Composés hétérocycliques et leurs procédés d&#39;utilisation
WO2008049855A3 (fr) Nouveaux composés
ATE496918T1 (de) Als a2b-adenosinrezeptorantagonisten geeignete 5- phenyl-6-pyridin-4-yl-1,3-dihydro-2h-imidazoä4, - büpyridin-2-onderivate

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09788856

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09788856

Country of ref document: EP

Kind code of ref document: A2